Standard name
Human Ortholog
Description Cochaperone protein; regulates activity of adenylyl cyclase Cyr1p; involved in kinetochore complex assembly; associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex; acts as a linker between Skp1p and HSP90 complexes; protein abundance increases in response to DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.06
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0
Cytoplasm 0.71 0.75 0.82 0.83 0.86 0.83 0.67 0.63 0.62 0.62 0.58 0.57 0.95 0.98 0.99 0.91 0.95 0.95 0.6 0.59 0.71 0.28 0.37 0.56
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0.06 0.08 0.2 0.31 0.26 0.24 0.3 0.36 0.37 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.19 0.17 0.14 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.22 0.23 0.11 0.53 0.33 0.2
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.16 0.18 0.11 0.18 0.11 0.08 0.11 0.24 0.22 0.13 0.2 0.12 0.06 0 0 0.12 0.07 0.06 0.07 0.07 0.07 0.07 0.11 0.09
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 1 0 0 0 0 0 1 1 0 0 0 0 0 0 0 0 2 1 0 0 1
Bud 1 0 0 1 1 2 6 2 3 7 3 2 1 0 0 0 0 0 6 8 3 7 17 21
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 2 1
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 3 2 1 3 5 4 13 9 9 9 0 4 2 21 15 14 0 0 0 0 0 0
Cytoplasm 209 170 211 163 230 217 287 242 218 244 196 219 279 218 324 429 396 230 195 144 191 52 114 205
Endoplasmic Reticulum 2 2 0 0 2 2 1 2 8 11 0 7 0 0 0 13 10 4 1 1 0 1 2 1
Endosome 0 0 1 0 2 0 1 4 0 0 0 1 1 0 1 0 0 0 3 7 4 2 10 4
Golgi 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 1 1 0 0 0 0 0
Mitochondria 9 4 1 12 21 51 134 101 86 120 121 141 0 0 0 0 0 1 2 0 2 1 2 3
Nucleus 56 38 35 3 6 3 10 8 5 14 3 14 2 0 0 16 4 3 70 57 30 100 102 74
Nuclear Periphery 0 0 1 0 0 1 1 0 2 1 1 1 0 0 0 0 0 0 0 0 0 1 2 2
Nucleolus 1 0 0 1 0 0 3 0 0 0 0 1 0 0 0 0 0 0 1 0 4 1 5 5
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0
SpindlePole 1 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 12 2 7 4 11 11
Vac/Vac Membrane 46 41 29 36 29 21 48 93 76 50 69 45 18 7 7 57 30 15 22 16 17 13 32 32
Unique Cell Count 295 228 256 197 268 260 427 387 353 396 338 384 295 223 328 470 417 243 323 245 270 188 308 368
Labelled Cell Count 326 255 281 219 292 300 496 457 411 457 403 440 301 229 335 536 459 268 323 245 270 188 308 368


Bud, Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.2 9.0 8.0 7.0 7.0 6.7 6.7 6.7 6.8 6.9 6.6 6.5 9.4 9.9 10.1 15.7 14.8 15.2 9.1 9.8 10.4
Std Deviation (1e-4) 1.0 1.4 1.2 0.9 1.3 1.3 1.4 1.4 1.4 1.6 1.5 1.7 1.7 1.3 1.4 3.0 3.1 3.4 1.3 1.6 1.6
Intensity Change (Log2) – – – -0.19 -0.18 -0.26 -0.26 -0.27 -0.24 -0.22 -0.28 -0.29 0.23 0.31 0.33 0.97 0.88 0.93 0.18 0.28 0.37


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 1.9 0 1.3 0 0 0 0 2.4 1.9 2.8
Cytoplasm 0.1 1.1 0.3 -4.3 -5.4 -5.5 -5.6 -6.3 -6.7 4.5 5.5 7.1 3.5 5.3 4.3
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 3.6 4.2 7.3 9.8 8.7 8.3 9.6 10.6 10.8 0 0 0 0 0 0
Nucleus -4.6 -4.9 -5.4 -5.8 -5.8 -6.0 -4.8 -6.3 -4.7 -6.1 -5.7 -6.9 -5.2 -6.9 -5.2
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 2.1 -0.2 -1.2 0 4.0 3.3 0.5 3.0 0.2 -2.2 -3.4 -4.6 0.3 -1.8 -2.0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 3.8333 4.7922 4.3011 4.0184 3.806 4.3754 5.5591 6.3999 5.8165 4.6619 5.5943 5.9142 3.9427 5.0433 4.6485 4.1749 3.9586 4.4021
Actin 0.0081 0.0041 0.004 0.0009 0.0186 0.0022 0.0151 0.0011 0.0248 0.0014 0.0124 0.0069 0.0008 0.001 0.004 0.0166 0.0108 0.0014
Bud 0.0011 0.011 0.0048 0.001 0.0053 0.0011 0.0021 0.0016 0.0012 0.0003 0.0011 0.0011 0.0002 0.0005 0.001 0.0003 0.0006 0.0014
Bud Neck 0.0012 0.0017 0.0012 0.0008 0.0017 0.0054 0.0064 0.0007 0.0059 0.0019 0.0028 0.0065 0.0009 0.0039 0.0012 0.0007 0.0027 0.0055
Bud Periphery 0.0005 0.0024 0.001 0.0004 0.0057 0.0004 0.0024 0.0009 0.0013 0.0001 0.0016 0.0012 0.0001 0.0001 0.0004 0.0001 0.0004 0.0007
Bud Site 0.0034 0.0215 0.0018 0.0003 0.0017 0.0006 0.0056 0.003 0.0059 0.0006 0.0035 0.0008 0.0003 0.015 0.0024 0.0004 0.0023 0.0021
Cell Periphery 0.0001 0.0002 0.0001 0 0.0001 0 0.0003 0.0001 0.0002 0 0.0003 0.0001 0 0.0001 0.0001 0 0.0002 0.0001
Cytoplasm 0.5045 0.755 0.8296 0.9172 0.8194 0.5795 0.4709 0.8945 0.8128 0.8475 0.6797 0.6588 0.6453 0.8608 0.9164 0.8566 0.8424 0.691
Cytoplasmic Foci 0.0222 0.0099 0.012 0.0108 0.016 0.0115 0.0153 0.0043 0.0078 0.0167 0.0118 0.0055 0.0027 0.009 0.0045 0.0072 0.0185 0.0085
Eisosomes 0.0001 0 0 0 0 0 0.0001 0 0.0002 0 0.0001 0.0001 0 0 0 0.0001 0.0001 0
Endoplasmic Reticulum 0.0037 0.0032 0.0036 0.0027 0.003 0.003 0.0056 0.0028 0.004 0.0044 0.0067 0.0036 0.0055 0.0036 0.0032 0.0044 0.0103 0.0033
Endosome 0.0162 0.0062 0.0063 0.0048 0.0055 0.0086 0.0267 0.0034 0.0109 0.0083 0.0362 0.0087 0.0032 0.0032 0.003 0.0059 0.0327 0.0036
Golgi 0.0018 0.0003 0.0004 0.0002 0.005 0.0011 0.0044 0.0003 0.0037 0.0038 0.0073 0.0021 0.0001 0.0002 0.0003 0.0005 0.0069 0.0002
Lipid Particles 0.0018 0.0001 0.0002 0.0001 0.003 0.0012 0.0023 0.0001 0.0051 0.0005 0.0226 0.0017 0 0.0001 0.0001 0.0003 0.0046 0.0001
Mitochondria 0.0029 0.0009 0.0007 0.0007 0.0013 0.0009 0.0035 0.0012 0.0034 0.001 0.0146 0.0061 0.0006 0.0003 0.0004 0.001 0.0008 0.001
None 0.0359 0.0264 0.0395 0.0191 0.0393 0.0195 0.0152 0.0065 0.0119 0.0139 0.0069 0.0079 0.0151 0.01 0.0101 0.0144 0.0119 0.0092
Nuclear Periphery 0.008 0.0086 0.005 0.0044 0.0025 0.0095 0.0183 0.0042 0.0082 0.0039 0.042 0.0079 0.0073 0.0061 0.0038 0.0147 0.0082 0.007
Nucleolus 0.0009 0.0007 0.0003 0.0005 0.0004 0.0014 0.0014 0.0003 0.0006 0.0001 0.0032 0.0009 0.0004 0.0002 0.0002 0.0002 0.0007 0.0006
Nucleus 0.3702 0.1379 0.0795 0.0236 0.0302 0.3306 0.388 0.0706 0.0808 0.0822 0.1168 0.2695 0.3126 0.0808 0.04 0.0689 0.0244 0.2479
Peroxisomes 0.0064 0.0005 0.0023 0.0003 0.0277 0.0016 0.0018 0.0003 0.0032 0.0101 0.005 0.0019 0.0001 0.0002 0.0002 0.0003 0.0015 0.0003
Punctate Nuclear 0.0078 0.0054 0.0052 0.0094 0.0124 0.0188 0.0094 0.002 0.0055 0.0021 0.0151 0.0054 0.0024 0.0025 0.0074 0.0049 0.0149 0.0137
Vacuole 0.0029 0.0034 0.002 0.0022 0.0009 0.0025 0.0038 0.0017 0.0019 0.0009 0.0074 0.0026 0.0022 0.002 0.0012 0.0019 0.0046 0.002
Vacuole Periphery 0.0005 0.0006 0.0003 0.0005 0.0002 0.0005 0.0014 0.0004 0.0006 0.0002 0.0029 0.0008 0.0003 0.0003 0.0002 0.0005 0.0005 0.0004

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 31.5789 26.5691 20.9476 26.3265 20.4717 32.4897 29.8022 26.3471 30.02 32.5903
Translational Efficiency 1.0384 1.3326 1.5395 1.1932 1.4232 1.1125 1.2672 1.3461 1.294 1.1433

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✔
Gene Expression ✘
Translational Efficiency ✔

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1605 580 1843 1306 1740 1703 1409 1317 3345 2283 3252 2623

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 881.32 1016.38 1111.89 1291.85 887.20 872.80 1277.61 1312.73 884.38 909.28 1183.69 1302.33
Standard Deviation 143.45 155.91 172.56 210.64 143.03 288.92 209.19 222.18 143.26 268.98 206.34 216.76
Intensity Change Log 2 — 0.205702 0.335276 0.551701 — -0.023608 0.526116 0.565239 — 0.095218 0.434166 0.558508

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000593 0.000521 0.000353 0.000795 0.000142 0.000400 0.000743 0.002801 0.000358 0.000431 0.000522 0.001802
Bud Neck 0.001455 0.003658 0.012914 0.007781 0.003102 0.004652 0.004563 0.004947 0.002311 0.004400 0.009296 0.006358
Bud Site 0.004090 0.009139 0.008259 0.012700 0.003283 0.010524 0.007787 0.021079 0.003670 0.010172 0.008055 0.016907
Cell Periphery 0.000311 0.000157 0.000152 0.000209 0.000104 0.000209 0.000277 0.000164 0.000204 0.000196 0.000206 0.000187
Cytoplasm 0.631698* 0.622637* 0.415750* 0.515998* 0.640352* 0.572616* 0.374039* 0.560068* 0.636199* 0.585324* 0.397678* 0.538125*
Cytoplasmic Foci 0.050106 0.051612 0.002819 0.008154 0.041017 0.052418 0.004336 0.017820 0.045378 0.052214 0.003476 0.013007
Eisosomes 0.000019 0.000021 0.000012 0.000016 0.000016 0.000027 0.000014 0.000018 0.000018 0.000026 0.000012 0.000017
Endoplasmic Reticulum 0.002699 0.002255 0.001749 0.002406 0.001707 0.002055 0.002400 0.002930 0.002183 0.002106 0.002031 0.002669
Endosome 0.002958 0.003253 0.000515 0.003748 0.001858 0.004085 0.000816 0.008891 0.002386 0.003874 0.000646 0.006330
Golgi 0.000637 0.001970 0.000120 0.004730 0.000288 0.000759 0.000211 0.007530 0.000455 0.001067 0.000159 0.006136
Lipid Particles 0.001516 0.000739 0.000294 0.001162 0.000742 0.000997 0.000586 0.002079 0.001114 0.000931 0.000420 0.001622
Mitochondria 0.000729 0.001560 0.001714 0.001690 0.000880 0.000968 0.000943 0.002042 0.000808 0.001118 0.001380 0.001867
Mitotic Spindle 0.002241 0.005840 0.008184 0.038969 0.002423 0.008061 0.008341 0.056590 0.002336 0.007497 0.008252 0.047817
None 0.004931 0.006312 0.008157 0.005744 0.005293 0.009414 0.008822 0.006347 0.005119 0.008626 0.008445 0.006047
Nuclear Periphery 0.000562 0.000367 0.001204 0.001563 0.000369 0.000731 0.001057 0.001439 0.000462 0.000639 0.001140 0.001501
Nuclear Periphery Foci 0.002757 0.003095 0.000652 0.002873 0.001543 0.001073 0.002482 0.004762 0.002126 0.001586 0.001445 0.003821
Nucleolus 0.000769 0.001220 0.000530 0.000985 0.000490 0.001808 0.000244 0.001753 0.000624 0.001658 0.000406 0.001370
Nucleus 0.255648* 0.246948* 0.515677* 0.321088* 0.269154* 0.284655* 0.552328* 0.206403* 0.262674* 0.275076* 0.531557* 0.263505*
Peroxisomes 0.000496 0.000904 0.000091 0.000235 0.000302 0.000788 0.000078 0.000860 0.000395 0.000818 0.000085 0.000549
Vacuole 0.035321 0.037378 0.020168 0.060976 0.026657 0.042362 0.029804 0.086005 0.030814 0.041096 0.024343 0.073543
Vacuole Periphery 0.000463 0.000412 0.000686 0.008178 0.000277 0.001398 0.000129 0.005472 0.000366 0.001148 0.000445 0.006819

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 0.09 0.32 -0.56 -1.66 -2.79 -1.95 -5.64 -2.93 -2.09 -0.61 -0.42 -1.84 -2.58 -2.63 -1.51
Bud Neck -3.84 -13.94 -11.04 -4.36 7.04 -2.76 -4.82 -4.30 -1.70 0.45 -5.38 -14.01 -10.25 -4.21 6.89
Bud Site -3.52 -3.25 -4.60 0.19 -0.75 -5.50 -3.21 -5.60 -0.46 -2.49 -6.18 -4.68 -7.27 0.01 -2.39
Cell Periphery 0.69 0.75 0.54 -1.62 -2.95 -6.40 -5.34 -4.58 3.49 3.85 0.02 -0.06 0.28 1.88 2.09
Cytoplasm 1.35 28.62 16.93 11.04 -8.02 7.18 33.17 14.00 6.68 -15.45 6.97 43.35 21.87 12.40 -16.30
Cytoplasmic Foci -0.50 19.81 17.08 10.09 -8.56 -3.41 17.63 11.92 14.02 -9.02 -2.53 26.63 20.60 18.20 -12.43
Eisosomes -1.73 2.94 -0.65 1.17 -3.53 -7.56 -3.16 -1.24 6.33 1.81 -6.82 0.51 -1.31 5.48 -1.91
Endoplasmic Reticulum 0.54 1.87 1.61 0.82 -0.18 -1.27 -6.33 -0.02 0.83 3.70 0.01 -2.54 0.85 0.71 2.74
Endosome -0.56 7.97 3.85 3.26 -3.52 -7.01 5.15 -1.83 2.42 -3.81 -4.97 9.73 0.96 4.90 -5.15
Golgi -1.44 4.31 -0.86 0.68 -1.77 -2.49 1.81 -2.24 -1.48 -2.39 -2.24 4.80 -2.27 -0.86 -2.97
Lipid Particles 2.78 4.62 -0.59 -4.47 -7.49 -2.74 -4.37 -5.38 -4.17 -3.57 1.33 3.06 -3.98 -5.88 -7.61
Mitochondria -1.36 -3.89 -2.63 0.43 2.06 -0.27 -0.44 -0.66 -0.75 -0.60 -1.14 -2.60 -1.71 -0.44 1.45
Mitotic Spindle -1.75 -5.19 -7.51 -5.34 -4.47 -3.58 -3.48 -8.71 -6.70 -6.78 -4.17 -6.15 -11.46 -8.29 -8.05
None -1.11 -4.91 -0.16 1.12 7.14 -2.99 -2.72 0.67 3.43 4.12 -3.32 -5.38 0.42 3.63 7.71
Nuclear Periphery 2.27 -13.09 -8.58 -10.87 0.31 -3.34 -20.78 -7.54 -3.62 0.51 -2.30 -22.69 -11.36 -6.71 0.67
Nuclear Periphery Foci -1.36 7.76 1.59 2.44 -6.25 2.44 -5.79 -2.45 -3.68 1.33 2.41 1.67 -1.14 -2.92 -2.37
Nucleolus -0.90 0.44 0.39 1.30 0.04 -3.71 1.87 -0.96 2.54 -1.71 -3.22 0.75 -0.24 2.98 -0.98
Nucleus 0.46 -31.12 -8.05 -6.46 18.55 -1.94 -28.69 2.56 4.13 28.61 -1.98 -42.31 -4.10 -1.73 33.18
Peroxisomes -2.36 4.43 3.85 5.31 -2.53 -3.18 4.75 -0.73 2.54 -3.23 -3.32 6.04 2.21 4.48 -3.75
Vacuole -1.75 0.99 -18.13 -14.41 -18.87 -6.04 -9.92 -23.62 -20.27 -15.70 -5.12 -6.79 -29.67 -25.32 -24.67
Vacuole Periphery 0.58 0.14 -1.69 -1.75 -1.66 -3.64 4.14 -2.68 0.03 -3.07 -3.36 0.48 -2.69 -0.96 -2.72
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Cochaperone protein; regulates activity of adenylyl cyclase Cyr1p; involved in kinetochore complex assembly; associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex; acts as a linker between Skp1p and HSP90 complexes; protein abundance increases in response to DNA replication stress
Localization
Cell Percentages cytoplasm (87%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Sgt1

Sgt1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Sgt1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available