Standard name
Human Ortholog
Description Mitotic spindle midzone-localized microtubule bundling protein; microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate; relative distribution to microtubules decreases upon DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0.05 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0.18 0.15 0.12 0.1 0.14 0.09 0.09 0.07 0.14 0.13 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.77 0.75 0.72 0.69 0.74 0.76 0.77 0.78 0.77 0.74 0.64 0.59 0.91 0.96 0.97 0.67 0.66 0.64 0.49 0.46 0.41 0.55 0.68 0.72
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.05 0.06 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0.15 0 0 0 0.15 0.11 0.08 0.29 0.23 0.22 0.24 0 0 0 0.05 0 0 0.05 0.06 0.07 0.2 0.14 0.11
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0.14 0.1 0.11 0.19 0.21 0.07 0.14 0.13 0 0.05 0.1 0.14 0 0 0 0.21 0.22 0.28 0.27 0.27 0.33 0.07 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 2 0 1 0 0 0 1 2 0 0 0 1 0 0 0 1 0 0 2 0 1 1 5 10
Bud 2 2 4 1 1 2 8 6 5 5 4 3 5 0 0 1 3 0 6 8 4 6 13 11
Bud Neck 12 7 15 4 10 7 26 19 14 12 11 10 2 0 1 8 7 8 8 9 3 6 4 8
Bud Site 8 4 2 1 1 1 2 0 0 1 0 4 0 0 0 2 2 2 – – – – – –
Cell Periphery 5 0 0 0 0 0 0 1 1 0 1 0 0 0 0 5 1 0 0 1 1 2 4 8
Cytoplasm 244 195 59 18 59 52 138 167 122 122 52 46 249 346 366 163 192 161 165 133 43 138 252 332
Endoplasmic Reticulum 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1 9 9 13 0 0 0 3 5 3
Endosome 4 7 0 0 0 0 0 0 0 0 0 0 6 8 4 13 15 16 13 11 0 3 3 2
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 1 3 1 0 0 2 1
Mitochondria 9 38 2 0 1 10 20 18 46 37 18 19 8 1 4 11 12 4 17 17 6 50 53 49
Nucleus 5 5 2 1 2 2 3 3 4 4 2 1 0 1 0 4 6 0 1 3 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 1 0 0 0 0 1 1 1 0 0 0 0 0 1 0 1 0
Nucleolus 6 6 1 0 0 2 0 0 1 3 1 1 0 0 0 18 9 7 8 9 1 1 0 1
Peroxisomes 1 0 0 0 0 0 0 0 0 0 0 0 3 5 3 3 4 8 1 0 0 1 0 1
SpindlePole 43 27 9 5 17 5 26 27 6 8 8 11 6 8 5 51 63 69 90 77 34 18 3 6
Vac/Vac Membrane 3 3 0 1 0 0 0 0 1 0 0 0 1 2 1 11 9 3 8 7 1 7 16 15
Unique Cell Count 318 261 82 26 80 68 180 213 158 164 81 78 273 361 376 242 289 250 339 293 106 252 373 463
Labelled Cell Count 345 294 95 31 91 81 224 244 200 192 97 96 281 372 386 300 334 292 339 293 106 252 373 463


Microtubule

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 3.9 3.6 4.3 4.2 4.6 3.5 3.6 3.7 3.0 3.1 3.1 3.3 3.8 4.2 4.1 5.9 5.9 5.9 3.6 4.0 4.1
Std Deviation (1e-4) 1.0 0.6 1.2 0.8 1.8 1.3 1.0 1.2 1.0 1.0 1.5 1.1 1.4 2.4 1.8 1.5 1.6 1.7 1.1 1.9 1.9
Intensity Change (Log2) – – – -0.05 0.1 -0.29 -0.28 -0.22 -0.52 -0.51 -0.47 -0.39 -0.21 -0.05 -0.08 0.44 0.44 0.45 -0.26 -0.14 -0.09

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000246WT3HU80HU120HU1600246WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30246WT1AF100AF140AF1800246
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – – – –
Bud Neck – – – – – – – – – – – – – – –
Bud Site – – – – – – – – – – – – – – –
Cell Periphery – – – – – – – – – – – – – – –
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – – – –
Endosome – – – – – – – – – – – – – – –
Golgi – – – – – – – – – – – – – – –
Mitochondria – – – – – – – – – – – – – – –
Nuclear Periphery – – – – – – – – – – – – – – –
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – – – –
Peroxisomes – – – – – – – – – – – – – – –
SpindlePole – – – – – – – – – – – – – – –
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – – – –
Cytoplasm – – – – – – – – – – – – – – –
Nucleus – – – – – – – – – – – – – – –
Vacuole – – – – – – – – – – – – – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.3093 1.7226 1.4438 1.5516 1.8063 1.7596 -0.7803 -0.6915 -0.5077 -0.7725 -0.1549 -0.578 -0.7811 -0.2042 -0.4341 0.3541 0.2478 -0.3278
Actin 0.0488 0.0001 0.0107 0.0005 0.0391 0.0003 0.0551 0.0009 0.0105 0 0.04 0.0066 0.0122 0.0005 0.0059 0.0006 0.0056 0.006
Bud 0.001 0.0004 0.003 0.0004 0.0011 0.0016 0.0057 0.0136 0.0011 0 0.0035 0.0008 0.0067 0.0219 0.0106 0.0017 0.0006 0.0029
Bud Neck 0.0073 0.0008 0.0107 0.0251 0.0823 0.0586 0.001 0.0015 0.0007 0.0017 0.1024 0.0417 0.0027 0.002 0.0029 0.0382 0.1612 0.0526
Bud Periphery 0.0021 0.0006 0.0048 0.0008 0.0021 0.0017 0.0068 0.012 0.0022 0 0.0058 0.0013 0.0055 0.0072 0.0057 0.0018 0.0007 0.0017
Bud Site 0.0114 0.0039 0.0035 0.0008 0.0066 0.0005 0.0081 0.0256 0.0023 0.0001 0.004 0.0007 0.0131 0.0369 0.0227 0.0073 0.0059 0.0004
Cell Periphery 0.0008 0.0001 0.0001 0.0001 0.0002 0.0003 0.0004 0.001 0.0003 0 0.0006 0.0002 0.0007 0.0007 0.0004 0.0001 0.0003 0.0002
Cytoplasm 0.0124 0.0263 0.0247 0.0065 0.0013 0.0429 0.0908 0.0972 0.0564 0.0003 0.0029 0.1283 0.0304 0.0608 0.0275 0.0026 0.0048 0.0871
Cytoplasmic Foci 0.1163 0.0443 0.1107 0.0225 0.135 0.0624 0.1188 0.0713 0.2079 0.121 0.1127 0.1426 0.1434 0.0554 0.0912 0.0622 0.0958 0.1065
Eisosomes 0.0025 0.0001 0.0003 0.0001 0.0004 0.0001 0.0005 0.0001 0.0001 0 0.0003 0.0001 0.0006 0.0002 0.0002 0 0.001 0.0001
Endoplasmic Reticulum 0.0035 0.0004 0.0013 0.0003 0.0036 0.0005 0.0039 0.0016 0.0024 0 0.0011 0.0012 0.0043 0.0024 0.0012 0.0001 0.0024 0.0026
Endosome 0.013 0.0032 0.004 0.0016 0.0216 0.0039 0.0292 0.0102 0.0208 0.0003 0.0147 0.0101 0.0081 0.0052 0.0033 0.0006 0.0144 0.0059
Golgi 0.0139 0.0003 0.004 0.0004 0.0105 0.0009 0.0149 0.0009 0.0148 0.0003 0.0311 0.0034 0.003 0.0005 0.0008 0.0004 0.0032 0.0016
Lipid Particles 0.0197 0.0056 0.0103 0.0026 0.0109 0.0385 0.0309 0.0047 0.0267 0.0012 0.0088 0.0396 0.0139 0.0066 0.0034 0.0019 0.0194 0.0258
Mitochondria 0.0065 0.0001 0.0025 0.0006 0.0076 0.0075 0.0169 0.0013 0.0107 0 0.0379 0.0172 0.0032 0.001 0.0013 0.0002 0.0079 0.0037
None 0.62 0.7348 0.4397 0.0789 0.0034 0.6707 0.5337 0.5326 0.2464 0.0006 0.0105 0.4669 0.5808 0.5759 0.3183 0.1228 0.0279 0.5347
Nuclear Periphery 0.0034 0.0006 0.0013 0.0013 0.0251 0.0029 0.0047 0.0019 0.0022 0.0004 0.0005 0.0025 0.0041 0.0036 0.0032 0.0006 0.0077 0.0059
Nucleolus 0.0041 0.0134 0.0106 0.0284 0.0248 0.0138 0.0006 0.0261 0.002 0.0039 0.0473 0.0066 0.0093 0.0079 0.0077 0.0043 0.0446 0.0027
Nucleus 0.0032 0.0178 0.0249 0.0216 0.0052 0.0429 0.0125 0.0434 0.0033 0.0013 0.01 0.0417 0.0075 0.0194 0.023 0.0039 0.0185 0.0241
Peroxisomes 0.0234 0.0008 0.0133 0.0006 0.0218 0.011 0.0374 0.0027 0.0125 0.0014 0.0031 0.0202 0.0085 0.0014 0.002 0.001 0.0075 0.0125
Punctate Nuclear 0.081 0.1458 0.3187 0.8065 0.5926 0.0373 0.0099 0.148 0.3747 0.8675 0.5584 0.065 0.1393 0.1877 0.4675 0.7495 0.5669 0.1213
Vacuole 0.0042 0.0005 0.0005 0.0005 0.0017 0.0013 0.0094 0.003 0.0014 0 0.0035 0.0022 0.0022 0.0025 0.001 0.0003 0.0022 0.0012
Vacuole Periphery 0.0015 0.0001 0.0003 0.0001 0.0027 0.0004 0.0087 0.0003 0.0005 0 0.0008 0.0009 0.0005 0.0003 0.0002 0 0.0017 0.0004

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 5.6042 26.719 23.6818 22.974 7.2661 8.7128 30.9553 35.8342 25.6453 11.2337
Translational Efficiency 0.4348 0.606 0.7927 0.6011 0.5163 0.23 0.6281 0.6337 0.6557 0.6119

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✔

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
196 1366 1507 1567 1760 1523 205 53 1956 2889 1712 1620

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 635.83 700.26 872.19 900.22 609.12 724.28 916.33 868.54 611.80 712.92 877.48 899.18
Standard Deviation 67.90 116.71 95.94 131.11 89.21 93.31 83.91 88.60 87.68 105.71 95.66 130.06
Intensity Change Log 2 — 0.139250 0.456001 0.501637 — 0.249821 0.589141 0.511866 — 0.194408 0.522678 0.506651

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000282 0.000544 0.000450 0.000754 0.000123 0.001092 0.000505 0.001374 0.000139 0.000833 0.000457 0.000774
Bud Neck 0.043796 0.044495 0.038551 0.059513 0.039223 0.046557 0.026216 0.060747 0.039681 0.045582 0.037074 0.059553
Bud Site 0.024486 0.044190 0.047687 0.114904 0.014369 0.036239 0.019851 0.158943 0.015383 0.039999 0.044354 0.116345
Cell Periphery 0.000306 0.000264 0.000190 0.000162 0.000264 0.000400 0.000155 0.000164 0.000268 0.000335 0.000186 0.000162
Cytoplasm 0.392355 0.310200 0.133947 0.035698 0.402538 0.255801 0.058129 0.117927 0.401518 0.281522 0.124869 0.038389
Cytoplasmic Foci 0.276725 0.277025 0.008466 0.019083 0.234701 0.344741 0.018082 0.032555 0.238912 0.312723 0.009617 0.019523
Eisosomes 0.000299 0.000139 0.000044 0.000061 0.000173 0.000299 0.000121 0.000094 0.000186 0.000223 0.000053 0.000062
Endoplasmic Reticulum 0.000430 0.000659 0.003969 0.000630 0.000723 0.000471 0.003727 0.001467 0.000694 0.000560 0.003940 0.000657
Endosome 0.019559 0.029957 0.003984 0.006046 0.013100 0.029410 0.004081 0.022006 0.013747 0.029668 0.003996 0.006568
Golgi 0.002496 0.012144 0.000540 0.002975 0.002979 0.017947 0.000569 0.001183 0.002931 0.015204 0.000543 0.002916
Lipid Particles 0.007623 0.011984 0.001314 0.000896 0.013688 0.013211 0.003690 0.005489 0.013080 0.012631 0.001599 0.001047
Mitochondria 0.005525 0.019550 0.002729 0.006447 0.006536 0.023720 0.000493 0.002695 0.006435 0.021748 0.002461 0.006325
Mitotic Spindle 0.018978 0.076278 0.168401 0.684505 0.024066 0.075097 0.353842 0.399720 0.023556 0.075655 0.190607 0.675188
None 0.007334 0.010179 0.004382 0.000921 0.035643 0.008208 0.003209 0.001104 0.032806 0.009140 0.004242 0.000927
Nuclear Periphery 0.000303 0.000411 0.002274 0.000658 0.000863 0.000458 0.001451 0.000918 0.000807 0.000436 0.002175 0.000667
Nuclear Periphery Foci 0.001581 0.003014 0.002270 0.001520 0.003266 0.001950 0.003421 0.006450 0.003097 0.002453 0.002408 0.001681
Nucleolus 0.016049 0.010630 0.012761 0.013596 0.021116 0.008545 0.007430 0.002884 0.020609 0.009531 0.012122 0.013245
Nucleus 0.120029 0.069642 0.528561 0.020987 0.150326 0.049828 0.407146 0.023120 0.147290 0.059197 0.514022 0.021056
Peroxisomes 0.019599 0.038900 0.004579 0.013285 0.010707 0.058905 0.008714 0.020490 0.011598 0.049446 0.005074 0.013521
Vacuole 0.041389 0.037182 0.034178 0.015398 0.024697 0.025163 0.078843 0.140244 0.026369 0.030846 0.039526 0.019482
Vacuole Periphery 0.000855 0.002611 0.000722 0.001963 0.000900 0.001958 0.000326 0.000427 0.000896 0.002267 0.000674 0.001913

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.43 -6.70 -5.07 -2.69 0.44 -4.13 -7.03 -2.80 -0.76 0.36 -5.62 -15.48 -8.93 0.02 1.26
Bud Neck -0.17 0.10 -0.90 -1.56 -2.16 -2.30 2.56 0.69 1.37 -0.37 -2.22 -0.46 -2.99 -1.24 -2.71
Bud Site -2.76 -2.48 -9.48 -8.93 -9.16 -7.76 -2.75 -2.89 -2.12 -2.28 -10.21 -7.85 -15.92 -10.69 -9.76
Cell Periphery 0.65 1.89 2.32 3.56 1.24 -2.32 1.33 2.58 3.67 1.37 -1.82 3.15 4.49 5.01 1.55
Cytoplasm 2.21 10.16 13.00 26.55 10.83 10.96 29.11 6.62 3.13 -2.70 10.01 30.48 37.87 32.24 9.56
Cytoplasmic Foci 1.38 15.51 14.99 37.75 -5.66 -8.10 32.31 23.25 29.88 -1.53 -5.43 43.00 40.87 58.38 -5.05
Eisosomes 2.84 4.32 4.53 11.50 1.91 -4.25 -1.25 0.45 3.50 1.29 -1.98 5.55 6.87 11.89 3.95
Endoplasmic Reticulum -1.71 -18.66 -5.68 -5.30 15.28 2.08 -9.06 -3.89 -4.14 4.23 0.90 -20.78 -6.00 -7.01 16.59
Endosome -2.30 3.11 3.08 12.65 -0.13 -9.20 2.29 -0.89 1.18 -1.34 -10.63 8.58 7.74 17.91 -0.06
Golgi -7.14 4.83 1.78 8.59 -3.40 -11.46 8.34 2.61 11.44 -0.60 -13.64 12.62 2.89 14.02 -3.34
Lipid Particles -2.78 4.80 5.33 9.59 3.02 -0.61 6.70 2.28 2.57 -0.85 -0.57 11.62 12.46 14.51 3.66
Mitochondria -4.14 1.03 0.22 5.98 -1.95 -6.99 6.30 5.08 9.48 -0.79 -8.42 4.30 1.42 9.14 -2.14
Mitotic Spindle -5.74 -13.18 -47.57 -48.95 -35.14 -7.83 -9.24 -5.69 -4.80 -1.11 -10.53 -19.14 -60.02 -52.90 -34.15
None -0.59 2.33 4.09 9.48 12.99 10.73 11.38 14.29 6.96 2.69 10.52 13.25 15.01 12.48 12.43
Nuclear Periphery -2.62 -24.87 -8.55 -7.65 12.22 1.27 -5.79 -2.53 -3.67 2.81 1.45 -12.70 -3.16 -6.42 12.29
Nuclear Periphery Foci 0.00 -0.21 0.79 1.83 2.35 2.86 -3.33 -1.76 -2.14 0.49 1.79 -1.71 1.98 0.50 3.39
Nucleolus 1.76 0.39 1.65 -0.32 3.16 8.81 2.29 5.99 0.84 2.48 8.81 3.62 7.06 -1.16 3.42
Nucleus 3.35 -26.70 5.01 4.29 43.97 16.13 -8.88 4.25 -0.89 9.99 15.51 -35.33 15.72 2.46 44.80
Peroxisomes -3.67 5.12 3.58 13.43 -6.28 -16.84 2.79 0.15 8.37 -0.90 -18.77 11.02 4.51 21.64 -5.88
Vacuole 0.01 -2.31 -0.65 -1.02 2.17 -1.17 -6.71 -4.43 -4.37 -1.78 -3.53 -10.31 -5.68 -4.04 2.79
Vacuole Periphery -3.22 0.29 -1.39 2.24 -2.58 -3.69 3.21 3.90 5.42 0.88 -5.45 1.35 -2.02 2.22 -2.66
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Mitotic spindle midzone-localized microtubule bundling protein; microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate; relative distribution to microtubules decreases upon DNA replication stress
Localization
Cell Percentages —
Cell Cycle Regulation No
Subcompartmental Group N/A

Ase1

Ase1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ase1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available