Standard name
Human Ortholog
Description Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from ER to cytoplasm upon DNA replication stress; ECM3 has a paralog, YNL095C, that arose from the whole genome duplication

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.05 0.06 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.87 0.86 0.91 0.85 0.86 0.79 0.68 0.62 0.54 0.54 0.45 0.95 0.96 0.99 0.44 0.5 0.32 0.56 0.59 0.64
Endoplasmic Reticulum 0.07 0.09 0 0 0 0 0 0 0 0 0 0 0 0 0.27 0.25 0.26 0.11 0.06 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0.05 0.19 0.14 0.42 0.5 0.53 0.63 0.68 0.7 0 0 0 0.12 0.09 0.19 0.15 0.07 0.12
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 1 1 0 0 0 0 1 0 0 0 1 0 0 6 8 16 2 3 3
Bud 0 4 2 3 0 5 7 14 16 13 16 0 0 0 5 1 7 0 2 3
Bud Neck 0 0 1 0 0 0 1 2 0 0 1 1 1 1 2 5 6 0 1 2
Bud Site 0 0 0 0 0 0 3 2 2 1 2 0 0 0
Cell Periphery 1 2 2 2 6 5 9 4 4 3 1 3 4 2 2 3 7 0 1 1
Cytoplasm 192 192 269 250 288 289 412 368 284 183 182 89 134 132 117 119 99 23 38 60
Endoplasmic Reticulum 15 21 5 3 0 2 0 2 5 4 1 3 2 3 71 58 81 4 4 3
Endosome 1 0 3 5 9 2 1 6 1 0 1 0 0 0 4 5 5 0 1 1
Golgi 4 0 0 0 0 0 0 0 0 0 0 0 1 0 6 1 3 0 0 0
Mitochondria 8 7 15 56 46 155 306 312 332 232 287 0 0 0 31 21 58 6 4 10
Nucleus 0 0 2 1 0 1 0 2 3 2 2 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 1 0 1 0 0 0 1 2 1 1 0 0 0 0 0 2 0 0 0
Nucleolus 0 0 1 0 0 0 0 0 1 1 3 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 2 0 1 0 0 2 0 0 0 0 0 0 0 1 1 0 0 0
SpindlePole 0 0 3 1 0 1 7 4 4 5 10 0 0 0 1 1 5 0 0 0
Vac/Vac Membrane 6 2 5 6 12 5 17 13 11 8 16 0 0 0 11 8 6 1 2 3
Unique Cell Count 220 222 294 294 335 368 606 591 524 340 408 94 139 134 265 239 312 43 66 94
Labelled Cell Count 227 230 311 328 362 465 763 733 665 453 523 97 142 138 265 239 312 43 66 94


Endoplasmic Reticulum

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.7 4.6 4.4 4.1 4.1 3.3 3.0 3.2 2.8 2.9 2.9 5.7 5.3 5.3 4.0 4.1 4.5 6.2 6.2 5.8
Std Deviation (1e-4) 1.0 0.8 1.6 1.4 2.0 1.6 1.2 1.0 1.1 1.2 0.9 0.7 0.8 0.9 1.2 0.9 1.1 1.3 1.4 1.3
Intensity Change (Log2) -0.13 -0.13 -0.43 -0.58 -0.45 -0.65 -0.61 -0.61 0.36 0.26 0.27 -0.13 -0.11 0.02 0.48 0.48 0.4

WT3RAP60RAP140RAP220RAP300RAP380RAP540RAP620RAP7000246WT3HU80HU120HU1600246WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30246WT1AF100AF140AF1800246
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin
Bud
Bud Neck
Bud Site
Cell Periphery
Cyto
Endoplasmic Reticulum
Endosome
Golgi
Mitochondria
Nuclear Periphery
Nuc
Nucleolus
Peroxisomes
SpindlePole
Vac
Cortical Patches
Cytoplasm
Nucleus
Vacuole

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 3.095 2.4901 2.1532 2.5939 2.8991 2.7993 3.6689 5.1204 4.4678 2.7814 3.2012 4.7291 4.3133 4.5621 4.5996 4.7786 4.2854 4.8571
Actin 0.0343 0.0022 0.0294 0.0089 0.0221 0.0047 0.0054 0.0014 0.0041 0.001 0.0005 0.0008 0.0501 0.0006 0.003 0.0012 0.0136 0.0007
Bud 0.0011 0.0004 0.0019 0.0008 0.0063 0.0002 0.0001 0.0003 0.0001 0.0001 0 0 0.0008 0.0001 0.0002 0.0001 0.0002 0
Bud Neck 0.0121 0.0012 0.0027 0.0023 0.0031 0.0031 0.0003 0.0002 0.0015 0.001 0.0003 0.0021 0.0063 0.0004 0.0025 0.0008 0.0051 0.002
Bud Periphery 0.0021 0.0006 0.0042 0.0012 0.0075 0.0009 0.0002 0.0005 0.0003 0.0002 0.0001 0.0001 0.0019 0.0002 0.0003 0.0002 0.0003 0.0001
Bud Site 0.0081 0.0136 0.0214 0.0052 0.0698 0.0003 0.0005 0.0025 0.0017 0.0006 0 0 0.0035 0.0074 0.0088 0.0003 0.0008 0.0001
Cell Periphery 0.0031 0.0024 0.0019 0.002 0.0008 0.0015 0.0054 0.0027 0.0049 0.0047 0.001 0.0009 0.002 0.0047 0.0035 0.0028 0.001 0.001
Cytoplasm 0.1663 0.4866 0.3279 0.3462 0.3013 0.4201 0.2305 0.2857 0.2888 0.5793 0.3265 0.3041 0.2142 0.3428 0.2726 0.1969 0.2729 0.3789
Cytoplasmic Foci 0.06 0.012 0.0227 0.014 0.056 0.0125 0.0144 0.0118 0.0311 0.0057 0.0059 0.0054 0.0175 0.0057 0.0112 0.0035 0.0237 0.0071
Eisosomes 0.0007 0.0003 0.0003 0.0002 0.0002 0.0001 0.0002 0.0001 0.0001 0.0001 0.0001 0.0001 0.0008 0.0002 0.0002 0.0002 0.0002 0.0001
Endoplasmic Reticulum 0.3043 0.2687 0.3271 0.4457 0.1654 0.3358 0.4986 0.3977 0.4916 0.217 0.5852 0.4791 0.4205 0.4508 0.5393 0.6912 0.504 0.4475
Endosome 0.0621 0.0161 0.0252 0.0389 0.0607 0.0153 0.0361 0.0134 0.0387 0.0044 0.0104 0.0099 0.0527 0.0062 0.0078 0.0093 0.0234 0.0066
Golgi 0.0258 0.0017 0.0066 0.0123 0.0268 0.0052 0.0182 0.0023 0.0083 0.0007 0.001 0.0009 0.0113 0.0008 0.0019 0.0011 0.0053 0.0004
Lipid Particles 0.0212 0.0054 0.0134 0.0143 0.0092 0.0039 0.0124 0.0069 0.0315 0.0036 0.0017 0.0029 0.0152 0.0132 0.0098 0.0063 0.0087 0.0028
Mitochondria 0.0328 0.0011 0.0034 0.0038 0.0284 0.0061 0.0092 0.0005 0.0012 0.0004 0.0005 0.0008 0.0038 0.0002 0.0003 0.0005 0.0008 0.0003
None 0.1431 0.1563 0.1692 0.0718 0.1779 0.1499 0.1227 0.2584 0.0681 0.1692 0.0557 0.1798 0.1353 0.1495 0.1228 0.0699 0.1207 0.1394
Nuclear Periphery 0.0234 0.0104 0.013 0.014 0.0242 0.0154 0.0205 0.008 0.0096 0.0057 0.006 0.0066 0.0194 0.0082 0.007 0.0093 0.0074 0.0065
Nucleolus 0.006 0.0006 0.0019 0.0004 0.0017 0.0003 0.0004 0.0003 0.0003 0.0001 0 0.0001 0.0026 0.0002 0.0008 0.0001 0.0004 0.0001
Nucleus 0.0378 0.0095 0.0067 0.005 0.0093 0.0156 0.0123 0.0019 0.0014 0.0024 0.0015 0.0018 0.0069 0.0026 0.0014 0.0017 0.0021 0.0021
Peroxisomes 0.0261 0.0013 0.0097 0.002 0.0117 0.0021 0.0034 0.0003 0.0037 0.0001 0 0 0.0028 0.0001 0.0011 0.0001 0.0017 0.0001
Punctate Nuclear 0.0167 0.0025 0.0047 0.0024 0.0048 0.0026 0.0016 0.0015 0.007 0.0005 0.0003 0.0018 0.0186 0.0006 0.0014 0.0003 0.0034 0.0012
Vacuole 0.0095 0.0067 0.0059 0.0073 0.0103 0.0036 0.0064 0.0034 0.0051 0.0031 0.003 0.0026 0.0121 0.0054 0.0039 0.0038 0.0037 0.0029
Vacuole Periphery 0.0034 0.0005 0.001 0.0012 0.0023 0.0007 0.0013 0.0004 0.0008 0.0002 0.0003 0.0003 0.0018 0.0003 0.0003 0.0004 0.0004 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 12.879 14.4583 13.9075 15.2572 13.2033 16.7634 15.7016 14.9827 15.6417 16.6561
Translational Efficiency 0.5777 0.4866 0.4529 0.3874 0.3609 0.514 0.4543 0.4406 0.501 0.3507

Hit Data

Dataset Hit
Protein Concentration
Protein Localization
Gene Expression
Translational Efficiency

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
125 539 1443 1461 109 1884 2061 2027 234 2423 3504 3488

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 888.99 702.55 917.10 803.31 689.24 755.65 835.69 855.61 795.94 743.84 869.22 833.70
Standard Deviation 150.96 93.55 134.06 111.31 75.81 104.52 115.96 113.38 157.42 104.54 130.06 115.44
Intensity Change Log 2 -0.339566 0.044912 -0.146210 0.132712 0.277961 0.311947 -0.114119 0.151346 0.071937

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.001296 0.001040 0.001208 0.001254 0.000902 0.000963 0.000666 0.001058 0.001113 0.000980 0.000889 0.001140
Bud Neck 0.009006 0.036057 0.005647 0.011203 0.008640 0.038363 0.010981 0.010608 0.008835 0.037850 0.008784 0.010857
Bud Site 0.048133 0.017252 0.011522 0.037717 0.005562 0.018020 0.017431 0.024599 0.028303 0.017849 0.014998 0.030093
Cell Periphery 0.000323 0.000310 0.000548 0.000293 0.000854 0.000284 0.000697 0.000493 0.000571 0.000289 0.000635 0.000409
Cytoplasm 0.243980 0.338372 0.390647 0.451086 0.349342 0.373558 0.423354 0.473659 0.293059 0.365731 0.409885 0.464204
Cytoplasmic Foci 0.084631 0.294182 0.034546 0.045203 0.321195 0.252310 0.022798 0.040915 0.194825 0.261625 0.027636 0.042711
Eisosomes 0.000119 0.000475 0.000082 0.000187 0.001416 0.000376 0.000138 0.000197 0.000723 0.000398 0.000115 0.000193
Endoplasmic Reticulum 0.007301 0.009279 0.213140 0.010867 0.026735 0.008524 0.092766 0.032197 0.016353 0.008692 0.142338 0.023263
Endosome 0.031011 0.022396 0.008992 0.012320 0.015044 0.026529 0.004799 0.007234 0.023573 0.025610 0.006526 0.009364
Golgi 0.011944 0.005168 0.000685 0.004557 0.006938 0.008280 0.000325 0.001441 0.009612 0.007588 0.000473 0.002746
Lipid Particles 0.003183 0.024834 0.011825 0.006215 0.072562 0.024320 0.007732 0.008048 0.035501 0.024434 0.009418 0.007280
Mitochondria 0.001121 0.006674 0.000578 0.003870 0.006869 0.016941 0.000988 0.002243 0.003799 0.014657 0.000819 0.002925
Mitotic Spindle 0.007430 0.001036 0.001179 0.038200 0.002497 0.007343 0.002769 0.014536 0.005132 0.005940 0.002114 0.024448
None 0.000542 0.003382 0.001815 0.007868 0.001074 0.003362 0.002622 0.003627 0.000790 0.003367 0.002290 0.005404
Nuclear Periphery 0.000788 0.001588 0.017661 0.002454 0.002763 0.001420 0.010089 0.003747 0.001708 0.001457 0.013207 0.003205
Nuclear Periphery Foci 0.002040 0.002482 0.068010 0.004660 0.002144 0.000798 0.015589 0.006438 0.002088 0.001172 0.037177 0.005693
Nucleolus 0.000371 0.001574 0.000384 0.000929 0.000780 0.001652 0.000351 0.000636 0.000561 0.001634 0.000365 0.000759
Nucleus 0.129834 0.113307 0.163475 0.192661 0.112515 0.113406 0.314829 0.229806 0.121767 0.113384 0.252499 0.214247
Peroxisomes 0.002102 0.024544 0.000519 0.001698 0.014485 0.015892 0.000689 0.001369 0.007870 0.017817 0.000619 0.001507
Vacuole 0.405596 0.094425 0.067133 0.163991 0.046296 0.084732 0.069919 0.135542 0.238230 0.086888 0.068772 0.147458
Vacuole Periphery 0.009248 0.001623 0.000405 0.002766 0.001388 0.002927 0.000469 0.001608 0.005587 0.002637 0.000442 0.002093

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 0.09 -0.35 0.58 0.68 1.14 -0.08 0.48 0.15 0.26 -0.82 0.05 0.24 0.55 0.44 0.54
Bud Neck -4.95 0.59 -0.11 6.73 -2.25 -9.82 -0.88 -0.73 13.18 0.39 -9.95 -0.14 -0.50 15.01 -1.01
Bud Site 2.02 2.63 1.37 -1.68 -3.76 -3.44 -3.05 -3.74 -0.51 -1.03 0.81 1.39 0.22 -1.55 -3.25
Cell Periphery -0.37 -4.07 1.26 2.56 8.31 1.55 0.57 1.31 -2.14 3.62 1.48 -0.35 1.41 -0.46 6.50
Cytoplasm -3.79 -6.27 -6.86 -4.96 -1.27 -0.97 -2.50 -3.27 -6.41 -2.21 -4.17 -6.36 -7.32 -7.33 -2.47
Cytoplasmic Foci -19.43 3.52 3.53 27.98 0.04 2.96 13.05 12.44 43.42 -7.30 -5.30 10.93 10.36 51.70 -5.37
Eisosomes -3.29 2.18 -0.38 2.93 -1.02 1.61 1.98 1.95 5.75 -1.02 1.06 2.00 1.89 6.10 -1.41
Endoplasmic Reticulum -1.26 -26.93 -0.61 0.86 27.41 1.95 -5.40 0.53 -5.19 12.17 1.44 -19.48 -0.05 -3.89 27.35
Endosome -0.90 2.38 2.70 7.55 1.54 -4.56 4.87 4.31 15.06 -1.97 -3.31 4.45 4.36 16.26 -0.20
Golgi 0.37 1.84 1.29 2.40 -2.30 -0.53 2.83 2.54 10.54 -2.00 -0.47 3.13 2.58 9.67 -3.02
Lipid Particles -8.10 -11.76 -1.88 7.54 9.02 4.41 6.01 6.11 12.82 1.67 1.93 4.72 5.41 15.29 7.29
Mitochondria -5.48 0.27 -2.62 3.88 -3.37 -2.89 1.86 1.62 11.36 -1.89 -6.03 1.84 1.09 11.86 -3.64
Mitotic Spindle 1.92 1.82 -5.60 -8.03 -7.99 -1.87 -0.30 -4.16 -3.18 -5.65 -1.10 0.94 -6.79 -6.80 -9.69
None -2.62 -4.28 -4.75 -1.42 -3.57 -3.15 -3.20 -3.75 0.29 -1.27 -4.26 -5.10 -6.24 -0.89 -3.58
Nuclear Periphery -1.19 -12.99 -8.03 -3.34 11.22 1.57 -5.70 -1.08 -4.82 6.02 0.89 -13.32 -3.50 -6.17 12.06
Nuclear Periphery Foci -0.78 -21.74 -2.35 -1.46 20.98 1.72 -9.60 -3.15 -7.68 8.00 2.19 -22.88 -4.24 -7.85 21.27
Nucleolus -5.92 -1.45 -3.28 2.90 -2.53 -3.67 2.74 0.33 4.42 -3.62 -6.45 1.62 -2.19 4.92 -4.25
Nucleus 1.05 -1.54 -4.06 -13.02 -7.01 -0.12 -16.00 -10.80 -23.39 9.54 0.88 -10.69 -9.12 -26.57 3.73
Peroxisomes -7.68 2.77 1.24 7.87 -2.63 -0.44 4.41 4.25 14.27 -2.51 -5.60 4.53 4.21 16.03 -3.55
Vacuole 12.76 13.75 7.45 -16.97 -23.28 -4.94 -4.91 -15.48 -17.82 -17.47 8.72 9.09 2.79 -25.84 -28.48
Vacuole Periphery 1.20 1.64 1.26 0.43 -2.41 -3.19 3.00 0.79 3.76 -1.78 0.43 1.93 1.38 3.64 -2.92
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Componentsactinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from ER to cytoplasm upon DNA replication stress; ECM3 has a paralog, YNL095C, that arose from the whole genome duplication
Localization
Cell Percentages
Cell Cycle Regulation No
Subcompartmental Group N/A

Ecm3

Ecm3


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)

Molecular Function (Gene Ontology)

Cellular Component (Gene Ontology)


Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ecm3-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available