Standard name
Human Ortholog
Description Polyphosphatidylinositol phosphatase; dephosphorylates multiple phosphatidylinositol phosphates; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains; INP53 has a paralog, INP52, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.15 0.18 0.18 0.12 0.12 0 0 0 0 0 0 0 0.17 0.06 0.08 0.15 0.12 0.17 0.06 0.06 0.09 0.08 0.07 0.11
Bud 0 0 0.08 0.08 0 0.06 0.08 0.05 0.07 0.09 0 0 0 0.05 0.06 0 0 0 0 0.05 0 0.07 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.06 0.32 0.13 0.16 0.18 0.13 0.12 0.12 0.1 0.13 0.09 0.11 0.3 0.36 0.39 0.17 0.17 0.21 0.08 0.19 0 0.11 0.09 0
Endoplasmic Reticulum 0.12 0.15 0.14 0.08 0.18 0.08 0 0.08 0.1 0.08 0.06 0.08 0.17 0.06 0.05 0.05 0 0 0 0 0 0.1 0.09 0.14
Endosome 0 0 0 0 0.05 0 0 0 0 0 0 0 0.07 0.26 0.19 0.05 0.09 0.07 0.19 0.17 0.22 0.15 0.12 0.09
Golgi 0.67 0.35 0.11 0.08 0.07 0 0 0 0 0 0 0 0.37 0.23 0.11 0.46 0.54 0.46 0.46 0.25 0.23 0.24 0.45 0.51
Mitochondria 0 0.12 0.59 0.83 0.54 0.8 0.79 0.8 0.86 0.86 0.9 0.89 0.07 0.08 0.28 0.09 0 0.07 0.06 0.05 0.26 0.07 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0
Vac/Vac Membrane 0.12 0.07 0 0 0.07 0 0.09 0 0 0 0 0 0 0.05 0.05 0.27 0.27 0.23 0.05 0.14 0.07 0.12 0.05 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 5 41 29 14 22 9 10 13 4 8 2 5 23 8 11 87 48 84 5 18 20 6 9 20
Bud 0 5 13 9 7 12 22 17 14 24 8 9 0 7 8 3 4 8 1 13 2 6 3 3
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 1 1 1 0
Bud Site 0 0 0 0 0 1 3 3 2 2 3 5 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 4 0 0 0 1 0 3 6 4 2 7 0 0 3 17 11 13 0 0 0 0 0 0
Cytoplasm 2 73 21 19 31 26 35 39 19 36 17 24 41 52 56 96 66 103 6 56 9 9 11 7
Endoplasmic Reticulum 4 35 22 9 31 17 5 27 19 22 11 16 24 8 7 28 12 21 1 10 7 8 11 26
Endosome 1 6 5 1 8 6 10 5 0 1 1 1 9 37 27 30 34 34 15 51 49 13 15 17
Golgi 22 79 18 9 13 4 3 3 1 2 0 2 51 33 16 269 211 229 37 75 50 20 59 95
Mitochondria 1 26 95 97 95 165 222 268 164 242 167 187 10 11 40 55 13 35 4 14 56 6 5 6
Nucleus 0 1 0 0 1 1 1 3 3 3 1 2 0 0 2 4 3 0 0 2 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 1 1 0 0 0 1
Nucleolus 0 0 1 0 0 1 4 3 2 1 1 1 1 0 1 1 1 2 0 0 0 0 0 0
Peroxisomes 1 0 0 0 0 0 3 0 0 1 1 0 0 2 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 1 1 0 2 3 2 1 3 3 0 3 1 1 0 18 18 7 1 5 4 0 1 0
Vac/Vac Membrane 4 16 4 2 13 5 26 15 6 6 5 6 5 7 7 156 105 115 4 43 15 10 7 6
Unique Cell Count 33 226 160 117 177 207 282 336 191 282 185 211 138 143 142 580 390 493 82 302 221 87 132 189
Labelled Cell Count 40 287 209 160 223 251 346 400 243 355 221 268 165 166 178 764 526 651 82 302 221 87 132 189


Punctate Nuclear

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 12.3 10.9 6.5 6.2 6.6 5.8 5.5 5.3 5.0 5.1 4.8 4.8 10.4 10.4 8.9 13.3 14.3 13.8 – 11.8 12.7
Std Deviation (1e-4) 1.9 1.6 0.8 0.9 1.2 0.9 0.9 1.0 0.9 1.1 1.0 1.0 1.3 1.4 1.4 2.2 2.3 2.1 – 2.0 2.1
Intensity Change (Log2) – – – -0.07 0.01 -0.17 -0.25 -0.3 -0.37 -0.35 -0.46 -0.43 0.68 0.68 0.45 1.03 1.14 1.09 – 0.85 0.96


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -1.4 -1.5 -4.3 -5.2 -5.3 -5.1 -5.6 0 0 -0.3 -3.3 -2.7 -1.0 -1.8 -0.3
Bud -0.1 -1.6 -0.9 -0.1 -1.3 -0.3 0.1 0 0 -3.4 -1.1 -0.8 0 0 -4.1
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.7 1.1 -0.2 -0.2 -0.5 -0.9 -0.1 -1.2 -0.5 3.5 4.7 5.2 1.1 1.1 2.2
Endoplasmic Reticulum -1.6 0.9 -1.7 -5.1 -2.0 -1.1 -2.0 0 0 0.9 -2.4 -2.6 -4.0 -4.7 -4.2
Endosome 0 0.7 0 0.2 0 0 0 0 0 1.4 5.7 4.5 1.1 2.3 1.7
Golgi -1.0 -1.2 -3.7 -4.8 -5.4 -4.4 -5.1 0 0 5.2 2.7 0 8.1 9.3 8.0
Mitochondria 4.2 -1.1 4.3 4.3 4.8 5.6 6.3 0 0 -9.4 -9.4 -5.4 -13.9 -15.0 -14.4
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 2.3 0
Vacuole 0 2.0 0 2.7 1.1 0 0 0 0 0 1.1 1.1 6.6 6.5 5.9

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 6.115 8.1059 7.5494 7.0524 6.6728 7.7208 6.1071 9.3425 8.0183 7.6136 6.4192 8.0709 10.4818 11.9111 11.1819 10.0833 10.6929 10.4004
Actin 0.0726 0.022 0.0263 0.0015 0.0056 0.0128 0.0273 0.0188 0.0291 0.062 0.0392 0.016 0.0295 0.0148 0.0395 0.0007 0.0042 0.0184
Bud 0.0027 0.0034 0.0061 0.0006 0.0004 0.0016 0.0018 0.0025 0.0033 0.0025 0.0013 0.0007 0.0024 0.0022 0.0012 0.0001 0.0027 0.002
Bud Neck 0.0064 0.0026 0.0024 0.001 0.0011 0.0036 0.0027 0.0016 0.0009 0.001 0.0015 0.0047 0.001 0.0011 0.0013 0.0002 0.0013 0.0015
Bud Periphery 0.0029 0.0012 0.0052 0.0006 0.0002 0.0016 0.0014 0.0009 0.0028 0.0024 0.0014 0.0005 0.0023 0.0012 0.0006 0 0.0038 0.001
Bud Site 0.0121 0.0301 0.0093 0.0009 0.0006 0.0016 0.0149 0.0253 0.0028 0.0035 0.0026 0.0009 0.0027 0.0093 0.0065 0.0001 0.0014 0.0017
Cell Periphery 0.001 0.0004 0.0004 0.0003 0.0001 0.0004 0.0009 0.0005 0.0002 0.0002 0.0003 0.0002 0.0003 0.0002 0.0002 0 0.0001 0.0001
Cytoplasm 0.0253 0.1303 0.0437 0.017 0.0206 0.0464 0.0607 0.1001 0.0473 0.0595 0.0352 0.0567 0.0464 0.1148 0.0314 0.0133 0.0408 0.0354
Cytoplasmic Foci 0.0804 0.141 0.1151 0.0862 0.1037 0.0954 0.1503 0.2062 0.1504 0.1398 0.1523 0.124 0.14 0.1716 0.1389 0.103 0.1401 0.1179
Eisosomes 0.0004 0 0.0001 0 0 0.0001 0.0003 0.0001 0.0001 0 0.0003 0.0001 0.0001 0 0.0001 0 0 0
Endoplasmic Reticulum 0.0089 0.0054 0.0033 0.002 0.0037 0.0099 0.0152 0.004 0.0164 0.0038 0.0079 0.005 0.0031 0.0076 0.002 0.001 0.0017 0.0024
Endosome 0.3564 0.3865 0.4211 0.4793 0.5729 0.4129 0.4241 0.4118 0.428 0.5113 0.3785 0.3782 0.4289 0.3913 0.3635 0.6231 0.4077 0.3219
Golgi 0.2922 0.2062 0.306 0.289 0.2653 0.3344 0.2332 0.2004 0.2773 0.1449 0.2731 0.3682 0.3038 0.2621 0.3865 0.2469 0.3298 0.4691
Lipid Particles 0.0149 0.0028 0.0033 0.0025 0.0046 0.0058 0.0136 0.0052 0.0054 0.0068 0.0171 0.004 0.0044 0.0013 0.0021 0.0014 0.0024 0.0014
Mitochondria 0.083 0.0152 0.0296 0.0352 0.0073 0.0378 0.015 0.0041 0.0103 0.0067 0.0419 0.0245 0.0101 0.0083 0.0132 0.0015 0.0057 0.0167
None 0.0056 0.0004 0.0003 0.0001 0.0001 0.0004 0.0095 0.0011 0.001 0.0003 0.002 0.0004 0.0003 0.0003 0.0002 0.0001 0.05 0.0003
Nuclear Periphery 0.0054 0.002 0.0008 0.0006 0.0006 0.0024 0.0049 0.0008 0.0014 0.0009 0.0008 0.0005 0.0007 0.0008 0.0003 0.0002 0.0002 0.0003
Nucleolus 0.0007 0.0002 0.0001 0.0001 0 0.0001 0.0004 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0 0.0001 0
Nucleus 0.0029 0.0012 0.0005 0.0004 0.0002 0.0008 0.0016 0.0005 0.0003 0.0003 0.0004 0.0003 0.0003 0.0003 0.0002 0.0001 0.0003 0.0002
Peroxisomes 0.0057 0.006 0.0038 0.0021 0.0017 0.006 0.0089 0.0052 0.0131 0.0069 0.0296 0.0071 0.0022 0.0038 0.0057 0.0009 0.003 0.0051
Punctate Nuclear 0.0024 0.0092 0.0004 0.0001 0.0002 0.0008 0.0026 0.001 0.0005 0.0008 0.0019 0.0003 0.0003 0.0003 0.0002 0.0001 0.0003 0.0002
Vacuole 0.012 0.028 0.015 0.0683 0.0058 0.0166 0.0076 0.0073 0.0062 0.0388 0.0086 0.0047 0.0161 0.0052 0.004 0.004 0.0024 0.0022
Vacuole Periphery 0.0061 0.0058 0.0073 0.0122 0.0051 0.0086 0.0031 0.0026 0.0033 0.0076 0.0038 0.0031 0.0049 0.0037 0.0024 0.0033 0.002 0.0023

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 44.3154 27.5972 35.8921 48.7902 40.4565 42.1344 39.905 45.8674 45.9292 50.6326
Translational Efficiency 0.7773 0.9201 0.7588 0.5767 0.6515 0.8322 0.6562 0.5252 0.6408 0.614

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1357 1477 328 175 609 1288 222 127 1966 2765 550 302

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 876.93 1076.50 1583.43 1246.26 984.83 1059.52 1450.18 1313.50 910.35 1068.59 1529.65 1274.54
Standard Deviation 144.91 155.19 210.75 170.52 142.26 161.68 173.83 185.79 152.49 158.47 207.26 180.19
Intensity Change Log 2 — 0.295815 0.852519 0.507071 — 0.105464 0.558285 0.415470 — 0.198258 0.704369 0.459341

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000901 0.000723 0.003158 0.001069 0.001018 0.000864 0.006984 0.004037 0.000937 0.000788 0.004702 0.002317
Bud Neck 0.001279 0.000446 0.002440 0.003621 0.000874 0.000590 0.002722 0.002496 0.001153 0.000513 0.002554 0.003148
Bud Site 0.032395 0.019818 0.017887 0.065743 0.028045 0.025664 0.055800 0.066656 0.031048 0.022541 0.033190 0.066127
Cell Periphery 0.000196 0.000136 0.000223 0.000177 0.000165 0.000117 0.000217 0.000161 0.000186 0.000127 0.000221 0.000170
Cytoplasm 0.032076 0.018309 0.005356 0.138811* 0.020889 0.025350 0.019617 0.062599 0.028611 0.021589 0.011112 0.106762*
Cytoplasmic Foci 0.243959* 0.241950* 0.136294 0.307370* 0.272968* 0.241634* 0.274104* 0.282285* 0.252945* 0.241803* 0.191919* 0.296821*
Eisosomes 0.000038 0.000020 0.000029 0.000013 0.000031 0.000029 0.000036 0.000022 0.000036 0.000024 0.000032 0.000017
Endoplasmic Reticulum 0.000897 0.001065 0.001450 0.000216 0.001297 0.000602 0.002943 0.001560 0.001021 0.000849 0.002053 0.000781
Endosome 0.127203 0.121106 0.167399 0.141595 0.116786 0.122981 0.196996 0.192424 0.123976 0.121980 0.179346 0.162970
Golgi 0.441930* 0.519755* 0.472765* 0.147446* 0.480326* 0.498830* 0.274689* 0.197170* 0.453824* 0.510008* 0.392815* 0.168357*
Lipid Particles 0.001974 0.000796 0.010598 0.003949 0.001435 0.000415 0.006039 0.004758 0.001807 0.000619 0.008758 0.004289
Mitochondria 0.050826 0.014762 0.000779 0.002298 0.021026 0.022225 0.000331 0.000719 0.041595 0.018239 0.000598 0.001634
Mitotic Spindle 0.011011 0.010498 0.048686 0.051392 0.010985 0.014236 0.068620 0.050280 0.011003 0.012239 0.056732 0.050924
None 0.000397 0.000090 0.000025 0.000037 0.000093 0.000082 0.000015 0.000020 0.000303 0.000086 0.000021 0.000030
Nuclear Periphery 0.000042 0.000056 0.001001 0.000097 0.000032 0.000041 0.000290 0.000091 0.000039 0.000049 0.000714 0.000095
Nuclear Periphery Foci 0.001652 0.000641 0.010301 0.000788 0.000413 0.000236 0.004022 0.001403 0.001268 0.000452 0.007767 0.001047
Nucleolus 0.000465 0.000017 0.000029 0.000117 0.000017 0.000397 0.000029 0.000041 0.000326 0.000194 0.000029 0.000085
Nucleus 0.000813 0.000070 0.000064 0.000532 0.000081 0.000340 0.000142 0.000128 0.000586 0.000196 0.000095 0.000362
Peroxisomes 0.003814 0.001378 0.002120 0.014134 0.001518 0.001451 0.009625 0.015168 0.003103 0.001412 0.005149 0.014568
Vacuole 0.018048 0.019684 0.096372 0.103937 0.014792 0.018645 0.064821 0.103820 0.017039 0.019200 0.083637 0.103888
Vacuole Periphery 0.030084 0.028679 0.023024 0.016657 0.027208 0.025269 0.011957 0.014161 0.029193 0.027090 0.018557 0.015608

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 1.02 -2.75 -0.63 -1.40 2.50 0.54 -2.72 -1.50 -1.58 0.93 0.96 -3.74 -1.60 -1.78 1.78
Bud Neck 6.77 -3.60 -3.96 -5.10 -2.04 1.58 -4.55 -4.21 -4.99 0.18 6.05 -5.52 -5.17 -6.59 -1.74
Bud Site 4.75 3.75 -4.56 -6.30 -6.13 0.63 -3.90 -3.77 -4.10 -0.82 3.86 -0.90 -5.84 -7.33 -4.81
Cell Periphery 2.77 -0.99 0.27 -0.68 0.71 1.77 -0.95 -0.05 -1.53 0.88 3.58 -1.27 0.31 -1.20 1.09
Cytoplasm 4.60 9.32 -7.01 -7.88 -8.66 -1.41 -0.25 -3.76 -3.42 -3.64 3.03 6.84 -7.68 -8.35 -9.17
Cytoplasmic Foci 0.36 13.82 -3.53 -3.67 -9.79 4.05 0.05 -0.26 -2.21 -0.26 2.46 8.38 -3.25 -4.27 -7.75
Eisosomes 7.27 1.53 9.32 4.02 3.21 0.50 -0.65 1.27 1.05 1.49 5.15 0.74 5.90 2.56 3.12
Endoplasmic Reticulum -0.64 -2.84 7.03 3.46 6.92 1.67 -1.14 -0.23 -0.82 0.73 0.85 -1.78 0.44 0.11 1.67
Endosome 1.34 -4.78 -0.80 -1.42 2.59 -1.09 -7.46 -4.89 -4.58 0.47 0.56 -8.28 -3.86 -4.18 2.11
Golgi -8.35 -1.41 18.75 23.77 14.60 -1.49 11.19 13.24 14.89 3.24 -7.61 4.70 22.33 27.31 13.12
Lipid Particles 2.74 -3.31 -1.94 -3.06 2.29 2.38 -3.52 -2.00 -2.50 0.19 3.73 -4.23 -2.71 -3.85 2.05
Mitochondria 10.12 15.45 14.16 6.56 -1.07 -0.37 7.83 7.62 11.15 -0.89 8.73 17.09 16.06 12.00 -1.23
Mitotic Spindle 0.32 -4.50 -4.29 -4.34 -0.63 -1.23 -5.38 -3.35 -3.08 1.09 -0.81 -6.92 -5.45 -5.29 0.19
None 3.83 4.71 4.51 3.04 -1.85 0.48 5.60 4.92 3.58 -0.64 3.88 5.14 4.94 4.57 -1.88
Nuclear Periphery -0.93 -2.69 -2.45 -1.80 2.49 -0.95 -1.65 -3.03 -2.49 1.18 -1.08 -3.05 -3.60 -2.88 2.73
Nuclear Periphery Foci 2.11 -3.51 1.46 -1.17 3.84 1.15 -1.88 -1.72 -2.03 1.44 2.49 -3.87 0.19 -2.41 3.92
Nucleolus 2.16 2.10 1.60 -4.05 -3.50 -1.71 -1.81 -3.95 1.60 -0.92 0.74 2.06 1.62 0.97 -3.59
Nucleus 1.73 1.73 0.46 -2.21 -2.22 -1.73 -2.00 -2.46 1.21 -0.11 1.27 1.63 0.55 -1.36 -2.22
Peroxisomes 5.28 2.16 -4.68 -5.93 -5.34 0.26 -3.99 -3.94 -3.96 -1.34 5.19 -2.13 -5.90 -6.88 -4.39
Vacuole -0.96 -9.43 -7.02 -6.88 -0.76 -2.10 -7.13 -7.05 -6.78 -3.00 -1.75 -11.62 -9.85 -9.61 -2.33
Vacuole Periphery 0.60 2.20 3.61 3.28 1.60 0.74 5.83 3.57 3.47 -0.52 1.22 4.84 5.12 4.57 1.22
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Polyphosphatidylinositol phosphatase; dephosphorylates multiple phosphatidylinositol phosphates; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains; INP53 has a paralog, INP52, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (21%), Golgi (4%), mixed (46%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Inp53

Inp53


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Inp53-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available