Standard name
Human Ortholog
Description Phosphoribosylaminoimidazole carboxylase; catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway; red pigment accumulates in mutant cells deprived of adenine
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0.05 0.06 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0.06 0 0 0 0 – 0.1 0.08 0.1 0.09 0 0 0 0 0 0.05 0 0 0 0 0 0
Cytoplasm 1.0 0.99 0.98 0.97 0.99 0.94 0.86 – 0.81 0.83 0.78 0.76 1.0 0.99 0.98 0.99 0.98 0.98 0.99 0.97 0.93 0.83 0.92 0.95
Endoplasmic Reticulum 0 0 0 0 0 0 0.11 – 0.13 0.1 0.12 0.14 0 0 0 0 0 0.05 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 1 4 – 5 6 16 18 0 0 1 0 0 0 0 0 0 0 0 0
Bud 0 0 3 1 0 2 0 – 0 0 3 2 0 0 0 0 0 0 0 1 1 0 2 1
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 2 7 14 7 8 15 15 – 26 25 32 29 2 4 9 3 4 8 0 0 0 0 0 0
Cytoplasm 205 348 229 178 263 326 306 – 212 267 250 235 87 165 210 164 184 166 195 335 222 40 119 105
Endoplasmic Reticulum 0 3 2 1 2 11 40 – 33 32 38 44 1 3 3 7 5 9 0 1 5 0 1 0
Endosome 1 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 1 – 3 2 4 5 0 0 1 2 2 0 0 0 0 0 0 0
Mitochondria 0 2 0 0 1 0 0 – 1 4 13 4 0 0 1 0 0 1 0 0 0 0 1 0
Nucleus 0 0 0 0 0 0 2 – 1 0 0 0 0 0 0 0 0 0 0 0 1 3 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 3 1 1 1 0 – 5 8 3 6 0 1 0 1 0 1 0 2 3 2 1 0
Unique Cell Count 206 352 234 184 266 346 355 262 323 320 310 87 167 215 166 187 169 198 346 239 49 130 111
Labelled Cell Count 208 360 251 188 275 356 368 286 344 359 343 90 173 225 177 195 185 198 346 239 49 130 111


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 52.1 66.7 53.4 48.4 41.5 35.0 30.3 – 26.3 23.8 22.9 21.5 72.2 68.0 67.0 58.7 60.9 55.7 – 52.2 52.5
Std Deviation (1e-4) 10.1 13.1 11.9 10.7 10.2 7.4 6.8 – 6.3 5.5 5.4 4.7 16.6 23.0 19.1 13.2 12.8 17.5 – 16.5 16.9
Intensity Change (Log2) – – – -0.14 -0.36 -0.61 -0.82 – -1.02 -1.17 -1.22 -1.31 0.43 0.35 0.33 0.14 0.19 0.06 – -0.03 -0.03

WT3RAP60RAP140RAP220RAP300RAP460RAP540RAP620RAP700020406080WT3HU80HU120HU160020406080WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3020406080WT1AF140AF180020406080
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 3.5 3.7 0 0 0 0 0 0
Bud 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery -1.0 -1.6 -0.9 -1.0 – 1.6 0.8 1.7 1.4 0 -1.7 -0.9 -2.0 -1.9 -0.5
Cytoplasm -0.7 0.9 -2.1 -4.8 – -6.0 -5.7 -6.7 -7.2 1.4 0.7 -0.1 0.7 0.4 0.3
Endoplasmic Reticulum 0 0 1.9 4.8 – 5.1 4.4 5.0 5.5 0 0 0 0 0 0
Endosome 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 – 0 0 3.1 0 0 0 0 0 0 0
Nucleus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 70.2039 82.2245 77.0893 73.7538 70.7101 75.6757 51.4515 74.8677 67.1798 61.2992 50.9428 68.361 64.1869 93.0089 86.6778 71.3607 67.8582 78.0674
Actin 0.0001 0.0001 0.0001 0 0.0001 0.0001 0.0306 0.0008 0.0043 0.0009 0.0229 0.0004 0.0161 0.0001 0.0147 0.0017 0.011 0.0007
Bud 0.0001 0.0002 0.0001 0.0001 0.0001 0.0001 0.0016 0.0002 0.0005 0.0011 0.0046 0.0013 0.0012 0.0002 0.0003 0.002 0.0008 0.0014
Bud Neck 0.0003 0.0003 0.0006 0.0003 0.0012 0.0019 0.0006 0.0001 0.0003 0.0003 0.0009 0.0007 0.0004 0.0001 0.0004 0.0005 0.0003 0.0006
Bud Periphery 0.0001 0.0002 0.0001 0.0001 0 0.0002 0.0021 0.0002 0.0005 0.0004 0.0061 0.0043 0.0013 0 0.0003 0.0044 0.0011 0.0002
Bud Site 0 0.0001 0 0 0.0001 0 0.0038 0.001 0.0038 0.0021 0.0068 0.0006 0.0012 0 0.0019 0.003 0.0007 0.0001
Cell Periphery 0.0037 0.0013 0.0019 0.0027 0.0009 0.0023 0.001 0.0004 0.0004 0.0038 0.0017 0.0003 0.0006 0.0001 0.0001 0.0004 0.0001 0.0002
Cytoplasm 0.9338 0.9653 0.9615 0.9174 0.9214 0.9392 0.8458 0.983 0.9232 0.8869 0.7524 0.9296 0.8503 0.9938 0.9595 0.8339 0.8612 0.9788
Cytoplasmic Foci 0.0006 0.0004 0.0006 0.0005 0.0032 0.001 0.0117 0.0006 0.0068 0.0064 0.0126 0.0009 0.0105 0.0003 0.0053 0.0031 0.0076 0.0022
Eisosomes 0 0 0 0 0 0 0.0005 0 0.0001 0.0007 0.0003 0 0.0003 0 0.0001 0 0.0001 0
Endoplasmic Reticulum 0.0268 0.0199 0.0179 0.0302 0.0281 0.0369 0.0143 0.0024 0.0049 0.001 0.0132 0.0106 0.0093 0.0018 0.0008 0.0028 0.002 0.0011
Endosome 0.0009 0.0005 0.001 0.0013 0.0034 0.0019 0.0147 0.0017 0.0098 0.0025 0.0725 0.0126 0.0239 0.0003 0.0017 0.0586 0.0391 0.0015
Golgi 0.0002 0.0002 0.0001 0.0001 0.0007 0.0003 0.0048 0.0002 0.0033 0.0003 0.0081 0.0008 0.0033 0 0.0012 0.0113 0.0209 0.0001
Lipid Particles 0.0009 0.0007 0.0004 0.0003 0.0054 0.0004 0.0059 0.0004 0.0041 0.0064 0.0057 0.0002 0.008 0 0.0011 0.0054 0.0132 0.0001
Mitochondria 0.0002 0.0007 0.0005 0 0.0012 0.0012 0.0205 0.0022 0.0086 0.0065 0.0235 0.0016 0.0195 0 0.0021 0.0186 0.0192 0.0002
None 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0.0049 0.0003 0.0021 0.0077 0.0106 0.0002 0.0029 0.0001 0.001 0.0004 0.0007 0.0004
Nuclear Periphery 0.0054 0.0016 0.0019 0.0028 0.0035 0.0029 0.0084 0.0013 0.0035 0.0056 0.012 0.0026 0.0134 0.0007 0.0016 0.011 0.0078 0.0026
Nucleolus 0 0 0 0.0001 0.0001 0 0.0021 0.0001 0.001 0.0261 0.0028 0.0002 0.0042 0 0.0001 0.001 0.0003 0
Nucleus 0.0019 0.0009 0.001 0.0012 0.0013 0.0014 0.0053 0.0025 0.0023 0.0092 0.0097 0.0022 0.0098 0.0006 0.0012 0.0034 0.0015 0.0033
Peroxisomes 0.0016 0 0 0 0.0086 0 0.0014 0 0.0007 0.0005 0.0013 0 0.0011 0 0.0032 0.0009 0.0049 0
Punctate Nuclear 0 0 0 0 0.0001 0 0.0014 0.0002 0.0088 0.001 0.0012 0.0001 0.0027 0 0.0016 0.0005 0.0018 0.0003
Vacuole 0.0215 0.007 0.0112 0.0404 0.0187 0.0088 0.0137 0.0019 0.0079 0.0175 0.0206 0.0247 0.0123 0.0017 0.0014 0.0244 0.0029 0.0045
Vacuole Periphery 0.0016 0.0004 0.0007 0.0022 0.0019 0.0011 0.0049 0.0003 0.0034 0.013 0.0106 0.006 0.0078 0.0003 0.0005 0.0128 0.0028 0.0018

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 29.2569 27.0161 25.1656 27.7001 22.9265 44.3431 30.9484 37.069 43.5113 35.6214
Translational Efficiency 1.9222 1.4826 1.5288 1.6479 1.6507 1.5336 1.7367 1.4674 1.5059 1.638

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
280 89 132 267 1661 2502 133 134 1941 2591 265 401

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 2071.43 3815.98 2607.54 2588.94 2821.92 3388.47 2645.54 2787.93 2713.66 3403.15 2626.61 2655.44
Standard Deviation 341.41 847.62 369.54 519.46 548.86 679.25 412.78 528.83 586.63 690.12 392.30 530.97
Intensity Change Log 2 — 0.881427 0.332062 0.321734 — 0.263957 -0.093115 -0.017483 — 0.558066 0.102341 0.135944

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000176 0.000332 0.000638 0.001113 0.000077 0.000050 0.000563 0.000563 0.000091 0.000059 0.000601 0.000929
Bud Neck 0.000398 0.002449 0.009847 0.004562 0.000291 0.000194 0.009869 0.004626 0.000306 0.000271 0.009858 0.004583
Bud Site 0.013889 0.011003 0.018358 0.036839 0.003542 0.002655 0.014933 0.032681 0.005035 0.002941 0.016639 0.035450
Cell Periphery 0.003455 0.017213 0.008669 0.012555 0.002817 0.000854 0.003515 0.005775 0.002909 0.001416 0.006082 0.010290
Cytoplasm 0.794852 0.652741 0.570711 0.694449 0.878381 0.942720 0.559793 0.709539 0.866331 0.932760 0.565231 0.699492
Cytoplasmic Foci 0.056325 0.033256 0.053079 0.025068 0.012613 0.007314 0.045156 0.020970 0.018919 0.008205 0.049103 0.023698
Eisosomes 0.000002 0.000005 0.000007 0.000012 0.000001 0.000000 0.000006 0.000007 0.000001 0.000001 0.000007 0.000010
Endoplasmic Reticulum 0.002361 0.000579 0.000458 0.001153 0.000558 0.000529 0.000808 0.000121 0.000818 0.000531 0.000634 0.000808
Endosome 0.003391 0.002632 0.007491 0.002516 0.001067 0.000523 0.011421 0.006989 0.001402 0.000595 0.009463 0.004011
Golgi 0.071558 0.077933 0.076617 0.011032 0.040807 0.011785 0.029370 0.007813 0.045243 0.014057 0.052904 0.009956
Lipid Particles 0.004346 0.018959 0.025875 0.035165 0.005868 0.001909 0.026270 0.047900 0.005649 0.002495 0.026073 0.039421
Mitochondria 0.000310 0.000133 0.000110 0.000087 0.000162 0.000119 0.000054 0.000430 0.000183 0.000119 0.000082 0.000202
Mitotic Spindle 0.002443 0.014055 0.010395 0.003093 0.001562 0.001494 0.012233 0.001353 0.001689 0.001925 0.011318 0.002512
None 0.000775 0.001764 0.001315 0.000542 0.001072 0.001812 0.000400 0.000685 0.001029 0.001810 0.000856 0.000590
Nuclear Periphery 0.000046 0.000666 0.000895 0.000443 0.000124 0.000050 0.000573 0.000094 0.000113 0.000071 0.000734 0.000326
Nuclear Periphery Foci 0.004660 0.012485 0.024413 0.007200 0.007167 0.002665 0.018195 0.006218 0.006806 0.003002 0.021292 0.006872
Nucleolus 0.000018 0.000083 0.000128 0.000137 0.000034 0.000037 0.000131 0.000151 0.000032 0.000038 0.000129 0.000141
Nucleus 0.001748 0.022066 0.025968 0.008662 0.004651 0.005387 0.020001 0.006201 0.004232 0.005960 0.022973 0.007839
Peroxisomes 0.000068 0.000044 0.000077 0.000358 0.000021 0.000023 0.000174 0.000738 0.000028 0.000024 0.000125 0.000485
Vacuole 0.007363 0.100955 0.135737 0.150452 0.018133 0.013017 0.236044 0.144490 0.016579 0.016038 0.186079 0.148460
Vacuole Periphery 0.031814 0.030648 0.029212 0.004563 0.021050 0.006862 0.010491 0.002656 0.022603 0.007679 0.019816 0.003926

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.08 -5.85 -2.94 -2.36 -1.16 1.99 -8.03 -5.52 -5.81 0.67 2.34 -10.26 -3.92 -4.06 -1.10
Bud Neck -3.54 -8.68 -8.57 -4.20 3.28 2.32 -7.35 -8.16 -8.29 3.54 0.46 -11.16 -11.40 -11.44 4.68
Bud Site 0.79 -1.61 -4.07 -4.38 -3.16 1.54 -6.78 -6.12 -6.31 -3.06 3.46 -8.14 -7.76 -8.30 -4.27
Cell Periphery -3.82 -4.11 -3.91 1.84 -0.76 5.25 -0.51 -2.63 -5.57 -1.58 4.05 -4.09 -4.90 -6.39 -1.91
Cytoplasm 3.75 7.75 5.99 0.14 -2.69 -10.93 12.38 9.03 11.63 -2.54 -11.22 16.22 13.45 17.96 -3.77
Cytoplasmic Foci 2.88 -0.17 3.16 0.51 3.15 5.53 -7.23 -2.87 -3.43 0.68 8.53 -8.02 -2.87 -5.06 2.93
Eisosomes -2.94 -6.13 -4.51 -2.72 -1.69 3.34 -8.03 -5.72 -5.96 -0.29 2.36 -10.52 -6.09 -6.24 -1.79
Endoplasmic Reticulum 2.71 3.00 1.95 -0.55 -0.89 0.11 -0.96 6.26 1.39 3.49 0.91 1.46 0.69 -0.17 0.01
Endosome 1.28 -3.68 1.09 -0.05 4.12 4.72 -7.76 -1.26 -1.41 1.52 6.64 -9.34 -1.77 -2.42 3.92
Golgi -0.28 -0.02 8.73 5.03 7.95 12.10 3.87 12.21 2.93 5.52 13.23 -0.72 13.42 3.06 8.81
Lipid Particles -3.08 -6.24 -6.70 -2.18 -1.15 5.48 -5.07 -5.78 -6.37 -2.42 4.74 -7.68 -8.57 -9.49 -2.37
Mitochondria 0.66 0.67 0.89 0.97 1.26 0.56 1.37 -0.47 -0.65 -0.87 0.83 1.13 0.32 -0.30 -0.53
Mitotic Spindle -1.03 -3.75 -1.49 0.67 1.46 -0.01 -4.00 -1.38 -1.35 2.93 -0.49 -5.64 -2.10 -1.86 2.68
None -2.14 -1.93 1.29 2.71 2.67 -2.09 7.67 2.72 3.25 -0.71 -2.28 0.51 4.46 3.63 2.03
Nuclear Periphery -3.52 -8.48 -1.79 0.81 2.06 4.96 -5.72 -1.27 -4.57 5.30 2.70 -9.62 -1.58 -1.84 2.84
Nuclear Periphery Foci -3.21 -7.22 -1.50 1.74 5.35 7.88 -5.01 0.35 -4.21 4.88 7.27 -8.19 -0.31 -3.36 6.74
Nucleolus -6.09 -7.36 -5.42 -3.08 -0.97 -0.52 -7.73 -5.49 -5.25 0.32 -1.10 -9.63 -6.30 -5.87 -0.87
Nucleus -4.74 -4.86 -6.33 2.37 3.22 -1.21 -6.86 -2.93 -2.50 5.70 -2.95 -6.92 -5.06 -3.75 5.02
Peroxisomes 1.24 -0.93 -4.83 -5.35 -4.61 -0.65 -6.49 -3.10 -3.08 -2.32 0.80 -7.46 -5.36 -5.40 -3.99
Vacuole -4.97 -8.76 -12.66 -3.64 -2.32 2.93 -10.71 -9.81 -10.09 1.66 0.17 -13.15 -15.40 -15.41 -0.04
Vacuole Periphery 0.24 0.68 4.97 4.06 3.67 8.43 5.72 11.53 6.13 4.36 8.87 1.46 11.25 4.59 4.44
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Phosphoribosylaminoimidazole carboxylase; catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway; red pigment accumulates in mutant cells deprived of adenine
Localization
Cell Percentages cytoplasm (100%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-2

Ade2

Ade2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ade2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available