Standard name
Human Ortholog
Description Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase; complex catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated
DOWNLOAD

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.06
Bud 0 0 0.05 0.05 0 0 0 0 0 0 0.07 0 0.05 0 0 0.06 0.07 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.05 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0.05 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0.06 0 0 0 0 0 0 0 0 0 0.17 0.13 0.08 0.13 0.15 0.18 0 0 0 0 0.08 0.08
Golgi 0 0 0.09 0 0.18 0 0 0 0 0 0 0 0.06 0.11 0.07 0.16 0.12 0 0.06 0.07 0 0.07 0.07 0.1
Mitochondria 0.91 0.91 0.81 0.81 0.77 0.86 0.86 0.88 0.88 0.88 0.91 0.89 0.68 0.42 0.33 0.12 0.06 0.06 0.71 0.78 0.76 0.66 0.55 0.49
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0.06 0.05 0 0 0.05 0 0.05 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.08 0 0.05 0 0.07 0.06 0.13 0.11 0.13 0.11 0.12 0.08 0.09 0.05 0.06 0.05 0.05 0.08 0 0 0 0 0 0
Peroxisomes 0.11 0 0.14 0.11 0 0 0 0 0 0 0 0 0.27 0.46 0.51 0.3 0.33 0.46 0.1 0 0.11 0.13 0.15 0.16
SpindlePole 0.05 0 0 0 0 0 0 0 0 0 0 0 0.11 0.21 0.21 0.2 0.16 0.18 0 0 0 0 0 0
Vac/Vac Membrane 0.05 0.09 0.05 0.05 0.1 0.07 0 0.05 0 0.07 0 0.05 0.07 0 0.05 0.18 0.22 0.11 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 3 6 0 6 1 6 4 0 0 1 3 3 3 4 1 5 1 1 5 2 1 13 15
Bud 6 1 8 8 3 3 14 11 7 13 17 13 10 3 8 16 14 9 1 0 1 1 4 2
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 3 0 0 0 0 0 1 1
Bud Site 4 0 2 0 0 1 4 0 5 2 2 0 0 1 0 6 0 2 – – – – – –
Cell Periphery 3 4 1 3 4 3 3 4 1 2 2 2 5 2 4 13 10 9 0 0 0 0 0 0
Cytoplasm 1 2 3 6 13 12 16 12 13 1 7 3 0 9 7 4 9 9 0 0 0 0 0 0
Endoplasmic Reticulum 2 0 0 0 1 1 2 1 0 1 1 0 0 0 0 8 4 4 0 0 0 0 1 2
Endosome 1 4 9 4 11 1 3 2 1 4 0 4 34 30 24 33 32 37 7 5 6 5 24 20
Golgi 0 7 14 7 47 6 2 5 1 2 2 9 12 25 21 40 25 6 9 12 7 9 20 27
Mitochondria 153 145 122 133 205 203 325 295 295 369 231 312 135 101 95 30 12 12 121 131 127 93 167 131
Nucleus 0 0 0 0 1 1 3 0 2 3 2 1 0 0 0 7 6 6 0 0 0 0 0 0
Nuclear Periphery 5 9 7 5 7 11 15 17 20 18 11 7 6 1 0 4 6 0 1 1 0 0 3 4
Nucleolus 13 2 8 5 18 14 49 36 45 46 31 29 17 12 18 14 11 16 0 0 0 1 2 3
Peroxisomes 18 7 21 18 6 6 11 9 7 13 4 7 53 109 147 77 71 96 17 5 17 17 44 43
SpindlePole 9 0 4 6 2 8 5 4 5 13 1 5 22 49 61 51 34 37 4 0 0 3 9 7
Vac/Vac Membrane 9 14 8 8 26 16 5 16 8 29 4 19 14 10 14 47 46 23 1 3 0 2 3 3
Unique Cell Count 168 160 151 165 267 236 376 335 336 418 255 352 198 238 290 255 213 209 172 169 167 141 307 267
Labelled Cell Count 224 198 213 203 350 287 463 416 410 516 316 414 311 355 404 351 288 267 172 169 167 141 307 267


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 7.1 11.7 9.3 10.9 16.7 15.2 14.1 15.3 12.9 13.2 13.8 15.6 9.7 12.1 13.2 10.2 11.5 10.7 9.3 9.7 11.3
Std Deviation (1e-4) 1.7 2.9 2.2 3.5 4.9 6.0 6.3 6.5 6.2 6.9 8.6 9.3 2.4 4.2 4.7 3.9 7.2 5.9 2.7 3.2 3.6
Intensity Change (Log2) – – – 0.22 0.85 0.71 0.6 0.72 0.47 0.5 0.57 0.75 0.06 0.38 0.5 0.13 0.3 0.2 -0.01 0.07 0.28

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70005101520WT3HU80HU120HU16005101520WT3rpd3Δ_1rpd3Δ_2rpd3Δ_305101520WT1AF100AF140AF18005101520
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud -0.2 0 0 -0.8 -1.1 0 -1.2 0.6 -0.8 -0.1 0 -1.4 0.4 0.5 -0.4
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 2.4 0 0
Cytoplasm 0 1.5 1.5 1.3 0 0 0 0 0 0 0 0 0 0 1.2
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome -1.6 -0.8 0 0 0 0 0 0 0 3.2 2.1 0.9 2.2 2.7 3.3
Golgi -1.8 2.3 -2.9 0 -4.1 0 0 -4.2 -3.3 -1.1 0.4 -0.7 1.8 0.7 -2.6
Mitochondria 0 -1.0 1.4 1.6 2.1 2.0 2.3 2.8 2.3 -2.6 -7.5 -9.6 -13.9 -14.6 -14.5
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery -0.7 -1.1 0 -0.3 0.2 0.6 -0.2 -0.2 0 -0.8 0 0 0 -0.9 0
Nucleolus -1.0 0.6 0.3 2.6 1.9 2.7 2.1 2.3 1.2 1.2 -0.1 0.4 0.1 -0.1 0.9
Peroxisomes -0.8 -4.7 -4.3 -4.8 -4.8 -5.2 -4.8 -5.0 -5.3 2.9 6.5 7.5 3.7 4.2 6.4
SpindlePole 0 0 0 0 0 0 0 0 0 3.0 5.0 5.2 4.9 4.1 4.4
Vacuole -0.2 1.6 0.6 0 -0.2 0 0.7 0 0 0.7 -0.5 -0.2 3.7 4.3 1.9

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 57.8071 59.8858 55.1237 51.4475 46.8292 54.9988 52.1905 52.7715 46.0093 45.4174 41.7743 48.704 49.4671 53.1279 51.7959 51.4988 43.3001 51.7125
Actin 0.0021 0.0015 0.0008 0.0001 0.0006 0.0003 0.012 0.0065 0.0041 0.0011 0.0002 0.0003 0.0171 0.0028 0.008 0.0273 0.0007 0.0007
Bud 0 0 0 0 0.0001 0 0.0001 0.0001 0.0007 0.0001 0.0001 0 0.0002 0 0 0.0001 0 0
Bud Neck 0 0 0.001 0 0 0 0.0002 0 0.0007 0 0 0 0.0003 0 0 0.0001 0 0
Bud Periphery 0.0001 0 0 0 0.0002 0 0.0002 0.0001 0.0016 0.0002 0.0001 0 0.0003 0 0.0001 0.0001 0.0001 0
Bud Site 0.0001 0 0.0002 0 0.0009 0 0.0005 0.0001 0.0022 0.0007 0.0002 0 0.0006 0 0.0001 0.0002 0.0001 0
Cell Periphery 0.0001 0.0002 0.0002 0.0001 0.0008 0.0001 0.0003 0.0006 0.0007 0.0002 0.0001 0.0001 0.0007 0.0001 0.0003 0 0.0001 0.0001
Cytoplasm 0.0002 0 0 0.0001 0.0024 0 0.0001 0 0.0002 0 0.0024 0 0.0068 0 0 0 0.0001 0
Cytoplasmic Foci 0.0087 0.0002 0.0049 0.0032 0.0026 0.0007 0.0039 0.0003 0.0063 0.0021 0.0442 0.0002 0.0136 0.0001 0.0036 0.0011 0.0104 0.0001
Eisosomes 0.0013 0.0011 0.0039 0.0002 0.0009 0.0002 0.0011 0.0009 0.002 0.0006 0.0002 0.0002 0.001 0.0012 0.0012 0.0004 0.0003 0.0009
Endoplasmic Reticulum 0 0 0 0 0.0003 0 0.0002 0 0.0002 0 0.0005 0 0.0026 0 0 0.0001 0.0001 0
Endosome 0.0005 0.0003 0.0002 0.0001 0.0019 0.0001 0.0039 0.0003 0.0068 0.0003 0.0026 0.0003 0.0091 0.0002 0.0003 0.0008 0.0008 0.0001
Golgi 0.0013 0.0028 0.0008 0.0003 0.0002 0.0004 0.0061 0.0019 0.0032 0.001 0.0008 0.0009 0.0061 0.0013 0.001 0.0039 0.0007 0.0014
Lipid Particles 0.0092 0.0116 0.0051 0.0084 0.0033 0.0049 0.0105 0.0072 0.0163 0.0074 0.0138 0.0074 0.0161 0.0126 0.0052 0.0053 0.0089 0.0099
Mitochondria 0.9598 0.9532 0.9695 0.9799 0.9535 0.9792 0.9391 0.9481 0.9193 0.9698 0.9104 0.9673 0.8961 0.9691 0.9648 0.9572 0.9484 0.9798
None 0.0004 0 0.0002 0.0004 0.0006 0 0.0002 0 0.0004 0.0002 0.0068 0 0.0023 0 0.0002 0 0.0002 0
Nuclear Periphery 0.0001 0 0.0002 0.0001 0.0121 0 0.0006 0 0.0007 0.0001 0.0015 0.0001 0.0014 0 0.0002 0 0.0003 0
Nucleolus 0.0041 0.0082 0.0021 0.0034 0.0023 0.0031 0.0026 0.0033 0.0019 0.0024 0.0025 0.0001 0.0098 0.0002 0.0011 0 0.0003 0.0001
Nucleus 0.0008 0.0006 0.0003 0.0003 0.0086 0.0003 0.0003 0.0002 0.0004 0.0002 0.0012 0 0.0009 0 0.0001 0 0.0001 0
Peroxisomes 0.0066 0.0027 0.0022 0.0005 0.0026 0.0005 0.005 0.0031 0.007 0.0043 0.0014 0.0005 0.0068 0.0014 0.0047 0.0021 0.0029 0.0012
Punctate Nuclear 0.0004 0 0.0001 0.0002 0.0013 0 0.0001 0 0.001 0 0.009 0 0.0017 0 0.0001 0.0001 0.0243 0
Vacuole 0.0005 0.0007 0.0005 0.0004 0.0012 0.0009 0.002 0.0054 0.007 0.0009 0.0008 0.0012 0.0023 0.0004 0.0006 0.0001 0.0002 0.0002
Vacuole Periphery 0.0037 0.0167 0.0078 0.0026 0.0036 0.0091 0.0109 0.0218 0.0174 0.0082 0.0014 0.0214 0.0044 0.0104 0.0081 0.0009 0.0011 0.0056

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 161.0374 154.6211 180.0161 280.2911 246.8128 264.2731 506.2991 519.3989 487.4815 503.6518
Translational Efficiency 1.6323 1.9287 1.8908 1.3658 1.6082 2.3657 1.8227 1.8368 1.9227 1.8233

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
15 1093 225 1504 1373 351 918 1486 1388 1444 1143 2990

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 3083.59 962.04 1812.50 2569.71 1197.61 1282.13 1798.84 3276.11 1217.99 1039.85 1801.53 2920.78
Standard Deviation 1906.94 348.96 412.41 917.00 393.65 320.50 496.61 1221.08 480.22 368.78 481.23 1135.23
Intensity Change Log 2 — -1.680442 -0.766630 -0.263005 — 0.098384 0.586909 1.451826 — -0.931833 -0.245481 0.449390

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.003040 0.026207 0.004708 0.015143 0.007291 0.020351 0.007613 0.012690 0.007245 0.024784 0.007041 0.013924
Bud Neck 0.001500 0.013091 0.007641 0.001618 0.003909 0.005947 0.005453 0.001512 0.003883 0.011354 0.005884 0.001566
Bud Site 0.002092 0.021469 0.003641 0.002113 0.004984 0.005333 0.006990 0.002279 0.004953 0.017547 0.006331 0.002196
Cell Periphery 0.000293 0.002600 0.000109 0.000264 0.000155 0.000138 0.000338 0.000455 0.000156 0.002001 0.000293 0.000359
Cytoplasm 0.049121 0.005371 0.000412 0.000516 0.001268 0.000767 0.000913 0.000529 0.001785 0.004252 0.000815 0.000522
Cytoplasmic Foci 0.008258 0.041484 0.048741 0.009922 0.046786 0.046590 0.033644 0.013330 0.046369 0.042725 0.036616 0.011616
Eisosomes 0.000676 0.004568 0.000611 0.002572 0.000940 0.001244 0.001035 0.002390 0.000937 0.003760 0.000952 0.002482
Endoplasmic Reticulum 0.011141 0.001247 0.000215 0.000165 0.000213 0.000369 0.000221 0.000186 0.000331 0.001034 0.000220 0.000176
Endosome 0.004064 0.023465 0.006335 0.001107 0.006426 0.010972 0.006756 0.000881 0.006400 0.020429 0.006673 0.000995
Golgi 0.041499 0.025519 0.042082 0.019394 0.028950 0.072062 0.024786 0.014458 0.029086 0.036832 0.028191 0.016940
Lipid Particles 0.003516 0.024853 0.020224 0.003027 0.011612 0.023835 0.009575 0.002454 0.011525 0.024605 0.011671 0.002742
Mitochondria 0.493413 0.682640 0.784716 0.920778 0.826857 0.742785 0.849785 0.922924 0.823254 0.697260 0.836976 0.921845
Mitotic Spindle 0.030625 0.001553 0.021727 0.000804 0.002754 0.007011 0.008278 0.001489 0.003055 0.002880 0.010926 0.001144
None 0.002332 0.007852 0.002667 0.002807 0.001156 0.001501 0.002020 0.002237 0.001168 0.006309 0.002148 0.002524
Nuclear Periphery 0.000749 0.000202 0.005660 0.000252 0.000232 0.000695 0.002087 0.000639 0.000238 0.000322 0.002790 0.000445
Nuclear Periphery Foci 0.024805 0.001880 0.002126 0.000122 0.000464 0.000627 0.000955 0.000368 0.000727 0.001575 0.001186 0.000244
Nucleolus 0.033581 0.008915 0.001340 0.000879 0.001519 0.002763 0.002012 0.000806 0.001866 0.007420 0.001879 0.000843
Nucleus 0.209533 0.004535 0.000261 0.000146 0.000171 0.000203 0.000207 0.000241 0.002434 0.003482 0.000217 0.000193
Peroxisomes 0.002510 0.087343 0.010650 0.007378 0.048323 0.043574 0.021879 0.010855 0.047828 0.076704 0.019669 0.009106
Vacuole 0.052241 0.010794 0.014981 0.003581 0.003311 0.006496 0.007719 0.003420 0.003840 0.009749 0.009149 0.003501
Vacuole Periphery 0.025011 0.004412 0.021152 0.007410 0.002680 0.006735 0.007734 0.005856 0.002921 0.004976 0.010376 0.006638

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -7.94 -0.89 -5.69 3.67 -5.84 -2.99 -0.23 -2.71 1.68 -2.40 -7.17 0.11 -4.22 4.38 -4.42
Bud Neck -6.57 -3.70 0.11 6.92 3.94 -1.22 -1.70 4.23 2.78 5.08 -5.33 -2.38 4.21 7.47 6.25
Bud Site -7.06 -1.03 -0.05 7.15 1.06 -0.18 -1.18 2.87 1.63 2.83 -5.80 -0.96 3.19 7.33 3.05
Cell Periphery -4.97 2.06 0.19 5.06 -2.41 0.77 -2.32 -1.50 -1.59 -0.56 -5.33 -2.12 -1.95 4.52 -0.58
Cytoplasm 1.07 1.19 1.19 5.09 -0.67 1.21 0.67 1.69 1.33 1.03 -2.71 1.47 2.05 5.16 0.97
Cytoplasmic Foci -6.83 -5.53 -0.44 10.73 6.23 0.06 2.97 8.99 6.93 6.21 0.89 2.30 10.01 12.27 9.02
Eisosomes -7.19 0.14 -5.66 3.46 -6.69 -0.93 -0.56 -5.30 -2.81 -4.55 -7.01 -0.10 -7.43 2.93 -6.85
Endoplasmic Reticulum 2.36 2.59 2.60 7.90 1.36 -2.60 -0.22 0.57 2.70 0.69 -5.80 1.80 2.49 8.09 1.33
Endosome -6.03 -0.94 1.54 8.97 4.84 -2.86 -0.30 7.46 7.11 6.53 -6.84 -0.28 7.39 10.11 7.55
Golgi 0.37 -0.08 0.53 2.20 3.27 -5.33 1.21 5.37 7.27 3.43 -2.33 0.26 4.74 7.18 4.07
Lipid Particles -6.99 -4.12 0.40 8.20 4.59 -2.70 1.12 6.51 4.88 5.19 -5.09 -0.10 6.64 9.61 6.87
Mitochondria -1.66 -2.41 -3.47 -20.00 -7.08 4.31 -1.91 -10.13 -9.79 -7.31 10.09 -1.21 -11.17 -22.49 -9.85
Mitotic Spindle 0.97 0.50 0.99 2.70 3.64 -2.19 -3.20 1.88 2.88 4.00 0.37 -4.11 2.78 3.23 5.56
None -3.60 -0.66 -0.98 3.45 -0.40 -1.61 -5.96 -7.46 -2.99 -1.15 -4.64 -7.18 -11.82 3.41 -2.36
Nuclear Periphery 1.58 -4.29 1.46 -1.20 5.20 -3.60 -2.54 -1.60 0.18 1.86 -1.90 -4.09 -1.60 -0.93 3.68
Nuclear Periphery Foci 1.63 1.62 1.74 4.88 4.57 -1.08 -1.50 0.52 1.21 1.62 -2.34 -1.17 2.37 4.65 3.31
Nucleolus 1.36 1.76 1.79 5.49 0.99 -0.57 -0.70 1.24 0.92 2.55 -4.14 0.01 1.71 5.41 2.61
Nucleus 2.57 2.62 2.62 4.66 0.94 -0.38 -0.70 -1.08 -0.56 -0.64 -0.73 2.18 2.19 4.59 0.22
Peroxisomes -15.84 -2.97 -3.68 14.93 1.22 0.63 5.85 9.47 4.87 3.71 -5.10 6.64 10.33 15.33 4.56
Vacuole 2.36 2.11 2.75 5.29 4.58 -2.71 -4.19 -0.33 2.36 3.68 -5.37 -5.10 0.35 5.84 5.59
Vacuole Periphery 0.92 0.12 0.78 -3.00 3.89 -3.08 -4.42 -3.53 0.55 1.33 -3.20 -6.30 -5.24 -2.13 2.92
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase; complex catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated
Localization
Cell Percentages mitochondrion (96%)
Cell Cycle Regulation No
Subcompartmental Group mito-3

Idh2

Idh2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Idh2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available