Standard name | |
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Human Ortholog | |
Description | Autophagy receptor with a role in endoplasmic reticulum degradation; involved specifically in autophagy of cortical and cytoplasmic ER in response to nitrogen starvation or rapamycin treatment; localizes to the cortical and cytoplasmic ER; similar to human FAM134B, which is also involved in ER autophagy and is associated with sensory neuropathy |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 8 | 1 | 4 | 1 | – | 9 | 2 | – | 4 | 4 | 5 | 4 | 0 | 2 | 0 | 45 | 41 | 29 | 13 | 14 | 9 | 26 | 28 | 32 |
Bud | 2 | 2 | 1 | 0 | – | 1 | 3 | – | 8 | 3 | 4 | 4 | 0 | 0 | 0 | 12 | 10 | 4 | 2 | 4 | 0 | 4 | 3 | 7 |
Bud Neck | 0 | 1 | 0 | 0 | – | 1 | 0 | – | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 5 | 3 | 1 | 7 | 2 | 10 |
Bud Site | 0 | 0 | 0 | 0 | – | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 6 | 3 | 2 | 2 | – | 1 | 5 | – | 3 | 1 | 3 | 2 | 4 | 6 | 8 | 41 | 52 | 41 | 3 | 12 | 5 | 11 | 15 | 23 |
Cytoplasm | 68 | 196 | 24 | 42 | – | 36 | 46 | – | 36 | 20 | 23 | 33 | 148 | 176 | 238 | 72 | 45 | 64 | 37 | 137 | 12 | 121 | 73 | 97 |
Endoplasmic Reticulum | 13 | 1 | 7 | 2 | – | 7 | 3 | – | 14 | 9 | 6 | 8 | 5 | 7 | 10 | 6 | 6 | 3 | 17 | 6 | 13 | 29 | 44 | 63 |
Endosome | 0 | 1 | 1 | 0 | – | 7 | 6 | – | 1 | 3 | 3 | 1 | 0 | 0 | 2 | 4 | 2 | 3 | 2 | 3 | 2 | 2 | 1 | 5 |
Golgi | 0 | 0 | 0 | 0 | – | 1 | 0 | – | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 10 | 9 | 0 | 1 | 0 | 1 | 0 | 0 |
Mitochondria | 9 | 8 | 0 | 2 | – | 10 | 30 | – | 78 | 53 | 57 | 54 | 0 | 0 | 1 | 6 | 8 | 2 | 54 | 31 | 18 | 28 | 21 | 35 |
Nucleus | 1 | 4 | 0 | 0 | – | 3 | 0 | – | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 2 | 0 | 2 | 1 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | – | 0 | 0 | – | 0 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | – | 3 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | – | 0 | 0 | – | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
SpindlePole | 0 | 0 | 1 | 0 | – | 2 | 5 | – | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 2 | 3 | 4 | 0 | 2 | 0 | 1 | 1 | 1 |
Vac/Vac Membrane | 0 | 0 | 0 | 0 | – | 2 | 9 | – | 5 | 4 | 10 | 5 | 1 | 2 | 2 | 4 | 3 | 2 | 11 | 9 | 1 | 10 | 5 | 11 |
Unique Cell Count | 99 | 212 | 33 | 48 | 72 | 91 | 119 | 84 | 89 | 94 | 155 | 184 | 252 | 160 | 136 | 143 | 149 | 236 | 71 | 253 | 202 | 294 | ||
Labelled Cell Count | 107 | 217 | 40 | 49 | 83 | 109 | 151 | 99 | 114 | 117 | 160 | 194 | 263 | 197 | 180 | 161 | 149 | 236 | 71 | 253 | 202 | 294 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 4.6 | 3.9 | 5.9 | 5.8 | – | 6.2 | 5.4 | – | 5.3 | 5.6 | 5.6 | 5.5 | 5.9 | 6.0 | 6.3 | 10.9 | 14.4 | 13.6 | 6.4 | 7.1 | 6.9 |
Std Deviation (1e-4) | 0.6 | 0.8 | 1.4 | 2.7 | – | 2.3 | 1.1 | – | 1.4 | 1.6 | 1.6 | 2.1 | 0.9 | 1.4 | 1.8 | 2.3 | 2.9 | 2.6 | 1.8 | 2.3 | 2.1 |
Intensity Change (Log2) | – | – | – | -0.01 | – | 0.08 | -0.11 | – | -0.16 | -0.08 | -0.07 | -0.11 | 0.01 | 0.04 | 0.1 | 0.9 | 1.3 | 1.21 | 0.13 | 0.27 | 0.22 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Actin | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud Neck | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud Site | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cell Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cyto | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Endoplasmic Reticulum | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Endosome | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Golgi | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Mitochondria | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nuclear Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nuc | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nucleolus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Peroxisomes | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
SpindlePole | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Vac | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cortical Patches | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cytoplasm | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nucleus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Vacuole | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 2.4126 | 0.1331 | 0.1463 | 0.1411 | -0.2453 | 0.5388 | 7.3395 | 5.169 | 5.5861 | 5.1489 | 4.9032 | 5.3786 | 3.8409 | 2.6054 | 2.6653 | 2.6526 | 2.973 | 2.4592 |
Actin | 0.1665 | 0.0026 | 0.0084 | 0.0004 | 0.0002 | 0.0123 | 0.0906 | 0.0018 | 0.0022 | 0.0277 | 0.0719 | 0.0111 | 0.0356 | 0.007 | 0.0114 | 0.0376 | 0.0045 | 0.0035 |
Bud | 0.0031 | 0.0022 | 0.0016 | 0.0004 | 0.0001 | 0.0028 | 0.0018 | 0.0059 | 0.0028 | 0.003 | 0.0004 | 0.0016 | 0.0019 | 0.0058 | 0.0111 | 0.0002 | 0.0028 | 0.0004 |
Bud Neck | 0.0466 | 0.0004 | 0.0005 | 0.0001 | 0.0002 | 0.0081 | 0.0135 | 0.0019 | 0.0029 | 0.0006 | 0.0004 | 0.0118 | 0.0157 | 0.0011 | 0.002 | 0.001 | 0.0035 | 0.0015 |
Bud Periphery | 0.0035 | 0.0022 | 0.0035 | 0.0008 | 0.0002 | 0.0028 | 0.0048 | 0.0049 | 0.0023 | 0.0183 | 0.0007 | 0.0026 | 0.0064 | 0.0035 | 0.0254 | 0.0003 | 0.003 | 0.001 |
Bud Site | 0.0098 | 0.0062 | 0.0017 | 0.0002 | 0 | 0.0007 | 0.0141 | 0.0251 | 0.013 | 0.002 | 0.0007 | 0.0014 | 0.0041 | 0.0293 | 0.0125 | 0.0011 | 0.017 | 0.0003 |
Cell Periphery | 0.0023 | 0.0005 | 0.0011 | 0.0001 | 0.0001 | 0.0003 | 0.0022 | 0.0008 | 0.0013 | 0.0006 | 0.0003 | 0.0005 | 0.0014 | 0.0011 | 0.0007 | 0.0002 | 0.0003 | 0.0003 |
Cytoplasm | 0.085 | 0.1295 | 0.1159 | 0.1841 | 0.3081 | 0.2307 | 0.2168 | 0.1877 | 0.2123 | 0.2254 | 0.2981 | 0.312 | 0.1798 | 0.1484 | 0.1285 | 0.0747 | 0.1902 | 0.2181 |
Cytoplasmic Foci | 0.0282 | 0.0142 | 0.0124 | 0.012 | 0.0107 | 0.0242 | 0.0462 | 0.0129 | 0.0158 | 0.0197 | 0.0104 | 0.0146 | 0.0721 | 0.0136 | 0.0163 | 0.0056 | 0.0537 | 0.0108 |
Eisosomes | 0.0024 | 0.0003 | 0.0004 | 0 | 0 | 0.0002 | 0.0009 | 0.0002 | 0.0002 | 0.0002 | 0.0003 | 0.0002 | 0.0005 | 0.0002 | 0.0002 | 0.0001 | 0.0001 | 0.0001 |
Endoplasmic Reticulum | 0.0198 | 0.0033 | 0.0049 | 0.0015 | 0.001 | 0.0192 | 0.0123 | 0.0046 | 0.0048 | 0.0101 | 0.0022 | 0.0043 | 0.0116 | 0.0017 | 0.0066 | 0.007 | 0.0212 | 0.0033 |
Endosome | 0.0607 | 0.0059 | 0.0102 | 0.0062 | 0.0033 | 0.0146 | 0.0292 | 0.0057 | 0.0169 | 0.0228 | 0.0044 | 0.0087 | 0.0612 | 0.0058 | 0.012 | 0.0182 | 0.0317 | 0.0052 |
Golgi | 0.0175 | 0.0005 | 0.0016 | 0.0006 | 0.0001 | 0.0036 | 0.0131 | 0.0008 | 0.001 | 0.0041 | 0.0016 | 0.0028 | 0.0156 | 0.0016 | 0.0045 | 0.0022 | 0.0078 | 0.0058 |
Lipid Particles | 0.027 | 0.0013 | 0.0061 | 0.0003 | 0.0001 | 0.0016 | 0.0198 | 0.0015 | 0.0007 | 0.0014 | 0.0004 | 0.008 | 0.0332 | 0.0007 | 0.0013 | 0.0096 | 0.0178 | 0.0012 |
Mitochondria | 0.0291 | 0.0005 | 0.0013 | 0.0008 | 0.0003 | 0.0018 | 0.0061 | 0.0008 | 0.0009 | 0.01 | 0.0015 | 0.0036 | 0.0107 | 0.0009 | 0.017 | 0.0047 | 0.0014 | 0.0008 |
None | 0.2748 | 0.8232 | 0.8088 | 0.788 | 0.6716 | 0.6469 | 0.4447 | 0.7338 | 0.7053 | 0.6191 | 0.6035 | 0.6069 | 0.5034 | 0.7711 | 0.7169 | 0.7958 | 0.5889 | 0.7399 |
Nuclear Periphery | 0.0419 | 0.0014 | 0.006 | 0.0006 | 0.0005 | 0.0117 | 0.0186 | 0.001 | 0.0018 | 0.0045 | 0.0006 | 0.0008 | 0.0057 | 0.0007 | 0.015 | 0.0093 | 0.0011 | 0.0003 |
Nucleolus | 0.0665 | 0.0003 | 0.001 | 0.0002 | 0.0001 | 0.0006 | 0.0014 | 0.0008 | 0.0007 | 0.0003 | 0.0001 | 0.0003 | 0.0022 | 0.0004 | 0.0016 | 0.0003 | 0.0004 | 0.0004 |
Nucleus | 0.0335 | 0.0012 | 0.003 | 0.0009 | 0.0011 | 0.0061 | 0.0068 | 0.0032 | 0.0036 | 0.0028 | 0.0007 | 0.0023 | 0.0039 | 0.002 | 0.0043 | 0.0015 | 0.0006 | 0.0012 |
Peroxisomes | 0.0442 | 0.0009 | 0.0026 | 0.0003 | 0.0001 | 0.0036 | 0.0353 | 0.0016 | 0.0005 | 0.0053 | 0.0005 | 0.0019 | 0.0125 | 0.0014 | 0.0038 | 0.0081 | 0.0469 | 0.002 |
Punctate Nuclear | 0.0225 | 0.0013 | 0.0065 | 0.0006 | 0.0005 | 0.0044 | 0.0158 | 0.0022 | 0.0058 | 0.0016 | 0.0003 | 0.0026 | 0.0094 | 0.0015 | 0.0035 | 0.0004 | 0.001 | 0.0031 |
Vacuole | 0.0101 | 0.002 | 0.0019 | 0.0015 | 0.0015 | 0.0029 | 0.0042 | 0.0025 | 0.0045 | 0.0187 | 0.0011 | 0.0015 | 0.0102 | 0.0019 | 0.0039 | 0.0128 | 0.0056 | 0.0007 |
Vacuole Periphery | 0.005 | 0.0003 | 0.0007 | 0.0003 | 0.0002 | 0.0009 | 0.0016 | 0.0003 | 0.0007 | 0.0016 | 0.0003 | 0.0004 | 0.0029 | 0.0002 | 0.0014 | 0.0092 | 0.0006 | 0.0001 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 8.5868 | 15.3522 | 4.7467 | 8.8074 | 8.3499 | 17.1641 | 16.1693 | 17.4611 | 10.2539 | 16.8911 |
Translational Efficiency | – | – | – | – | – | – | – | – | – | – |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | – |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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