Standard name
Human Ortholog
Description Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; high specificity for diadenosine hexa- and pentaphosphates; contains endopolyphosphatase activity with a high affinity for polyphosphates, an activity also observed for its human DIPP homologs; possesses mRNA decapping activity; nudix hydrolase family member; protein abundance increases in response to DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.98 0.97 0.99 0.98 0.9 0.9 0.69 – 0.72 0.68 0.7 0.66 0.99 0.98 0.99 0.93 0.97 0.95 0.94 0.95 0.93 0.96 0.97 0.95
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.13 0 – 0.15 0.08 0.13 0.16 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 – 0.05 0.06 0.05 0.09 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0.13 0.06 0.3 – 0.15 0.24 0.17 0.12 0 0 0 0.11 0 0.07 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 2 0 0 0 0 0 0 0 0 2 1 0 0 1 0
Bud 0 1 0 0 0 2 0 – 2 1 1 0 0 0 0 0 0 0 1 1 0 1 3 4
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 1 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 1 0 0 2 2 4 – 3 11 4 2 2 4 4 7 4 2 0 0 0 0 1 0
Cytoplasm 492 532 134 102 171 178 168 – 191 200 153 131 631 1127 1069 185 101 57 470 523 132 445 827 825
Endoplasmic Reticulum 3 8 1 0 1 0 0 – 5 3 1 8 2 5 5 3 1 2 1 1 0 2 4 8
Endosome 0 0 0 0 0 0 0 – 0 1 1 0 0 1 0 0 0 0 3 2 0 1 1 5
Golgi 4 2 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 7 2 0 5 1 1
Mitochondria 4 2 0 0 1 25 6 – 39 23 28 31 0 0 1 3 1 0 1 3 3 1 2 2
Nucleus 1 7 0 1 2 2 6 – 12 18 11 17 4 3 1 6 3 0 1 3 1 0 2 2
Nuclear Periphery 0 0 0 0 0 0 0 – 0 1 1 0 0 0 0 0 0 0 0 1 0 0 0 1
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 2
Vac/Vac Membrane 9 5 1 2 24 11 73 – 40 71 36 23 3 18 31 21 3 4 1 5 0 3 2 4
Unique Cell Count 503 549 136 104 191 198 243 266 296 218 197 635 1148 1085 200 104 60 498 551 142 466 851 865
Labelled Cell Count 513 558 136 105 201 220 257 292 331 236 213 642 1159 1111 225 113 65 498 551 142 466 851 865


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 10.9 9.9 10.2 9.3 10.7 7.1 9.4 – 8.2 8.7 8.1 8.3 12.7 13.5 13.6 10.7 11.9 11.7 10.5 11.3 12.1
Std Deviation (1e-4) 2.0 1.8 1.3 1.8 1.5 1.8 1.6 – 1.7 1.6 1.6 1.5 2.1 2.3 2.2 2.2 1.9 2.5 2.1 2.0 2.2
Intensity Change (Log2) – – – -0.14 0.07 -0.53 -0.12 – -0.31 -0.24 -0.34 -0.31 0.31 0.39 0.41 0.07 0.22 0.19 0.04 0.14 0.24

WT3RAP60RAP140RAP220RAP300RAP460RAP540RAP620RAP700051015WT3HU80HU120HU160051015WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3051015WT1AF100AF140AF180051015
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cytoplasm -0.3 -3.2 -3.1 -6.8 – -6.4 -7.1 -6.6 -7.1 1.0 -0.3 0 -2.5 -0.8 -1.4
Endoplasmic Reticulum 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 4.3 0 – 4.7 3.3 4.4 4.9 0 0 0 0 0 0
Nucleus 0 0 0 0 – 0 2.9 0 3.5 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Vacuole 0 4.0 0 6.9 – 4.5 6.0 4.7 3.8 0 0 0 3.6 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 3.241 4.1792 3.6914 2.9272 3.5959 3.6332 6.4654 7.3792 7.2154 6.3263 6.4989 6.9261 7.4928 8.8583 8.4029 7.9062 8.223 8.324
Actin 0.0138 0.0004 0.0068 0.0047 0.01 0.0075 0.0004 0.0004 0.0003 0.0013 0.0004 0.0003 0.0204 0.0017 0.0017 0.0172 0.0076 0.0022
Bud 0.0007 0.0002 0.0004 0.001 0.0018 0.0001 0.0009 0.0003 0.0025 0.0002 0.0002 0.0009 0.0004 0.0002 0.0002 0.0002 0.0002 0.0001
Bud Neck 0.0037 0.0003 0.0008 0.0009 0.0044 0.0014 0.0005 0.0004 0.0004 0.0011 0.0037 0.0016 0.0024 0.0003 0.0005 0.0005 0.0006 0.001
Bud Periphery 0.0009 0 0.0004 0.0007 0.0025 0.0001 0.0002 0.0001 0.0004 0.0001 0.0001 0.0002 0.0003 0.0001 0.0001 0.0001 0.0002 0
Bud Site 0.0039 0.0025 0.0006 0.0006 0.0067 0.0002 0.0017 0.0014 0.0005 0.0002 0.0002 0.0001 0.0006 0.0013 0.001 0.0003 0.001 0.0001
Cell Periphery 0.0002 0 0.0001 0.0001 0.0003 0 0.0001 0 0.0001 0 0 0 0.0001 0.0001 0 0.0001 0 0
Cytoplasm 0.8145 0.9434 0.9061 0.8874 0.6556 0.9181 0.9168 0.9388 0.9386 0.9009 0.9299 0.9431 0.8647 0.9369 0.9398 0.9282 0.9369 0.9659
Cytoplasmic Foci 0.0248 0.0068 0.0095 0.0121 0.0128 0.0091 0.0047 0.0055 0.0032 0.0066 0.0131 0.0049 0.0237 0.0067 0.0042 0.0113 0.0075 0.0047
Eisosomes 0.0001 0 0.0001 0 0.0002 0 0 0 0 0 0 0 0.0003 0 0 0.0001 0 0
Endoplasmic Reticulum 0.0073 0.0029 0.0054 0.002 0.0166 0.0031 0.0024 0.0017 0.0019 0.0017 0.002 0.0021 0.0057 0.0016 0.002 0.0051 0.0015 0.0019
Endosome 0.0394 0.0024 0.0146 0.0025 0.0507 0.0061 0.0032 0.0025 0.0017 0.0025 0.0076 0.0021 0.0156 0.0012 0.002 0.0065 0.0081 0.0016
Golgi 0.0064 0.0002 0.0019 0.0007 0.0035 0.0013 0.0001 0.0001 0.0001 0.0001 0.0002 0.0001 0.0024 0.0003 0.0003 0.0022 0.0032 0.0001
Lipid Particles 0.0037 0 0.0039 0.0033 0.005 0.0016 0 0 0 0 0.0001 0 0.0011 0.0002 0.0008 0.0033 0.0037 0
Mitochondria 0.0037 0.0001 0.0087 0.0006 0.0029 0.0004 0.0003 0.0008 0.0002 0.0003 0.0003 0.0002 0.0013 0.0003 0.0002 0.0002 0.0007 0.0001
None 0.0285 0.0244 0.0158 0.0117 0.0561 0.0139 0.0329 0.016 0.0232 0.0224 0.0161 0.0112 0.0348 0.0361 0.0294 0.0128 0.0047 0.0071
Nuclear Periphery 0.0168 0.0016 0.0045 0.0019 0.0519 0.0031 0.0025 0.0022 0.0016 0.0024 0.0017 0.0021 0.0035 0.001 0.0017 0.0019 0.0019 0.0013
Nucleolus 0.0015 0.0001 0.0003 0.0001 0.0092 0.0001 0.0001 0.0002 0.0001 0.0001 0.0001 0.0001 0.0005 0.0001 0.0001 0 0.0002 0
Nucleus 0.012 0.0111 0.0141 0.0173 0.0577 0.0221 0.0297 0.0244 0.0225 0.0551 0.0203 0.0279 0.0089 0.0042 0.0067 0.0078 0.0061 0.0123
Peroxisomes 0.0027 0.0002 0.0009 0.0485 0.0016 0.0043 0.0002 0.0002 0.0001 0.0002 0.0002 0.0001 0.0046 0.0005 0.0009 0.0006 0.009 0.0001
Punctate Nuclear 0.0098 0.0021 0.0022 0.0021 0.0381 0.0059 0.0023 0.0036 0.0022 0.0036 0.0021 0.0023 0.0068 0.0069 0.0079 0.001 0.0064 0.001
Vacuole 0.0044 0.0009 0.0022 0.0017 0.0092 0.0011 0.0008 0.0009 0.0006 0.001 0.0015 0.0006 0.0015 0.0003 0.0004 0.0006 0.0003 0.0003
Vacuole Periphery 0.0014 0.0001 0.0008 0.0002 0.003 0.0002 0.0001 0.0001 0.0001 0.0001 0.0003 0.0001 0.0006 0.0001 0.0001 0.0001 0.0001 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 31.1366 29.5739 28.3995 46.0689 49.2009 40.8442 40.8956 46.8933 62.2793 52.041
Translational Efficiency 3.0168 2.5004 2.9035 2.4839 1.7938 2.5858 1.8682 2.296 1.647 1.7539

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1680 469 1787 49 1975 1832 116 1515 3655 2301 1903 1564

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 991.88 1174.37 1180.59 1290.68 1042.44 1025.61 1277.00 1147.44 1019.20 1055.93 1186.47 1151.93
Standard Deviation 157.52 209.73 182.64 210.50 161.63 156.18 179.64 167.98 161.73 178.82 183.91 171.30
Intensity Change Log 2 — 0.243650 0.251271 0.379894 — -0.023482 0.292794 0.138454 — 0.112944 0.272698 0.261223

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000141 0.000242 0.000271 0.000515 0.000117 0.000370 0.001232 0.000278 0.000128 0.000344 0.000329 0.000286
Bud Neck 0.000895 0.000721 0.002921 0.002774 0.000892 0.001802 0.003330 0.002810 0.000893 0.001582 0.002946 0.002808
Bud Site 0.003493 0.003723 0.009755 0.009779 0.003207 0.006687 0.010233 0.017441 0.003338 0.006083 0.009785 0.017201
Cell Periphery 0.000062 0.000081 0.000095 0.000196 0.000051 0.000224 0.000381 0.000078 0.000056 0.000195 0.000112 0.000081
Cytoplasm 0.811155 0.822488 0.629209 0.514427 0.827123 0.797779 0.365261 0.697680 0.819783 0.802815 0.613119 0.691938
Cytoplasmic Foci 0.047245 0.038301 0.005603 0.043411 0.033030 0.048854 0.027231 0.010757 0.039564 0.046703 0.006922 0.011780
Eisosomes 0.000011 0.000007 0.000008 0.000049 0.000006 0.000017 0.000058 0.000011 0.000008 0.000015 0.000011 0.000012
Endoplasmic Reticulum 0.001053 0.000576 0.001080 0.001894 0.000661 0.000897 0.006312 0.000613 0.000841 0.000832 0.001399 0.000654
Endosome 0.001269 0.001220 0.001042 0.002467 0.000915 0.004026 0.008237 0.003863 0.001078 0.003454 0.001481 0.003819
Golgi 0.000399 0.000478 0.000162 0.000155 0.000313 0.002549 0.000337 0.002056 0.000353 0.002127 0.000172 0.001996
Lipid Particles 0.000499 0.000762 0.000484 0.001823 0.000324 0.001323 0.003243 0.000556 0.000404 0.001209 0.000653 0.000595
Mitochondria 0.000211 0.000295 0.000337 0.000117 0.000181 0.002872 0.000306 0.002297 0.000195 0.002346 0.000335 0.002229
Mitotic Spindle 0.001368 0.009712 0.008792 0.019886 0.002655 0.006672 0.001629 0.038915 0.002063 0.007292 0.008356 0.038319
None 0.005406 0.006828 0.009198 0.001229 0.008027 0.009561 0.002471 0.008691 0.006822 0.009004 0.008788 0.008458
Nuclear Periphery 0.000125 0.000123 0.000715 0.000920 0.000180 0.000239 0.001680 0.000657 0.000155 0.000215 0.000774 0.000666
Nuclear Periphery Foci 0.002283 0.005228 0.001929 0.007245 0.002625 0.001927 0.017937 0.002154 0.002468 0.002600 0.002905 0.002313
Nucleolus 0.000443 0.000124 0.000160 0.000120 0.000181 0.000424 0.000278 0.000250 0.000301 0.000362 0.000168 0.000246
Nucleus 0.089294 0.079631 0.286852 0.120407 0.099137 0.073136 0.232120 0.129570 0.094613 0.074460 0.283516 0.129283
Peroxisomes 0.000248 0.000213 0.000116 0.000340 0.000164 0.001275 0.000343 0.000235 0.000203 0.001059 0.000130 0.000238
Vacuole 0.034076 0.029112 0.040627 0.272123 0.019960 0.037836 0.317075 0.078362 0.026448 0.036058 0.057478 0.084432
Vacuole Periphery 0.000324 0.000135 0.000643 0.000123 0.000251 0.001529 0.000304 0.002728 0.000285 0.001245 0.000622 0.002646

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.14 -6.66 -4.77 -3.03 -2.47 -2.14 -8.69 -3.54 -0.01 6.05 -2.35 -9.45 -3.61 -0.22 0.36
Bud Neck -0.02 -4.82 -3.49 -3.46 0.47 -3.56 -8.38 -4.71 -1.89 3.27 -3.73 -5.25 -5.07 -2.58 1.26
Bud Site -1.72 -2.99 -4.35 -3.48 -0.47 -4.44 -6.01 -4.49 -1.83 0.56 -4.89 -3.49 -4.66 -2.27 -1.03
Cell Periphery -3.19 -7.80 -3.90 -2.97 -2.13 -1.70 -9.82 -7.03 1.41 8.87 -1.72 -12.22 -6.81 1.39 7.04
Cytoplasm 1.11 36.37 13.35 12.78 6.09 5.63 27.94 31.63 24.00 -15.19 4.82 45.22 32.97 26.40 -6.20
Cytoplasmic Foci 1.90 20.72 8.26 5.48 -2.14 -6.26 8.34 15.30 18.15 1.29 -3.52 26.65 22.91 19.95 -5.61
Eisosomes 1.81 -3.19 -5.29 -5.60 -4.80 -8.20 -13.30 -12.75 -0.11 10.38 -6.37 -10.83 -10.90 -2.05 -1.25
Endoplasmic Reticulum 2.11 -1.89 -1.87 -2.86 -1.18 -1.21 -7.07 0.09 1.38 7.14 0.08 -6.12 1.45 0.99 9.38
Endosome -0.04 0.67 -2.99 -2.53 -3.31 -5.75 -6.43 -1.94 3.96 4.78 -5.52 -2.40 -1.55 3.58 -0.53
Golgi -0.16 6.07 5.73 1.55 -0.57 -3.60 0.39 -0.99 2.85 -1.10 -3.56 5.02 -0.85 2.69 -1.59
Lipid Particles -1.41 -5.90 -4.50 -3.33 -3.78 -2.64 -11.06 -5.06 0.90 7.85 -2.69 -12.34 -4.91 0.64 -0.11
Mitochondria -0.23 -5.19 0.01 0.23 4.85 -3.74 -3.31 -1.33 2.44 -0.68 -3.74 -5.59 -1.31 2.15 -0.74
Mitotic Spindle -2.05 -6.03 -1.43 -0.92 -0.77 -2.36 -1.26 -5.96 -4.18 -4.87 -3.44 -5.69 -6.53 -4.18 -2.85
None -0.50 -2.77 5.65 4.28 10.63 -1.09 5.93 1.67 2.58 -6.22 -1.93 -0.93 0.64 2.49 1.69
Nuclear Periphery -1.66 -28.57 -7.56 -7.34 -1.11 -0.54 -11.17 -6.79 -5.72 8.09 -0.93 -23.27 -9.03 -6.87 6.52
Nuclear Periphery Foci -4.59 -0.70 -3.57 0.29 -3.36 2.24 -6.64 2.12 -0.24 7.21 -0.80 -2.05 1.61 2.14 3.44
Nucleolus 1.77 1.38 1.68 -0.43 1.83 -2.25 -1.54 -1.12 1.95 0.61 -0.55 1.19 1.04 1.76 -0.48
Nucleus 1.42 -39.42 -0.90 -1.22 9.87 8.40 -7.27 -15.15 -21.22 4.00 7.68 -40.67 -17.09 -21.18 23.12
Peroxisomes 0.58 3.04 1.80 1.01 -1.42 -4.35 -1.88 0.31 4.38 1.80 -4.17 3.18 1.32 4.41 -1.07
Vacuole -2.33 -13.39 -10.80 -10.44 -9.41 -9.15 -15.15 -27.20 -22.38 8.29 -7.09 -19.50 -27.03 -23.48 -10.85
Vacuole Periphery 2.29 -0.16 2.31 -0.10 0.94 -2.80 0.34 -1.56 1.28 -1.66 -2.63 -0.30 -1.46 0.94 -1.02
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; high specificity for diadenosine hexa- and pentaphosphates; contains endopolyphosphatase activity with a high affinity for polyphosphates, an activity also observed for its human DIPP homologs; possesses mRNA decapping activity; nudix hydrolase family member; protein abundance increases in response to DNA replication stress
Localization
Cell Percentages cytoplasm (100%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Ddp1

Ddp1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ddp1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available