Standard name
Human Ortholog
Description Swi2/Snf2-related translocase, SUMO-Targeted Ubiquitin Ligase (STUbL); required for maintenance of NHEJ inhibition at telomeres; functions at telomeres to translocate and ubiquitinylate poly-sumoylated Rap1p for proteosomal degradation; plays role in antagonizing silencing during mating-type switching; only known STUbL with a translocase activity; contains RING finger domain; relocalizes from nucleus to cytoplasm upon DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.2 0.2 0.49 0.23 0.37 0.51 0.49 0.56 0.38 – 0.34 0.3 0.39 0.49 0.6 0.55 0.51 0.54 0.07 0.1 0.16 0.12 0.19 0.2
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0.05 0 0.06 0 0 0 0 0 0
Endosome 0 0 0 0 0.1 0 0 0 0 – 0 0 0 0 0 0.14 0.15 0.16 0 0 0 0 0 0.06
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0.3 0.23 0.6 0.34 0.54 0.54 0.51 0.69 – 0.72 0.77 0.3 0.14 0.41 0.06 0 0 0.06 0 0.11 0 0.06 0.07
Nucleus 0.51 0.3 0.22 0.27 0.14 0.1 0.08 0.06 0.09 – 0.09 0.11 0.26 0.15 0 0.1 0 0 0.47 0.46 0.25 0.45 0.21 0.1
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0.05 0 0 0 0 – 0 0 0 0 0 0 0 0 0.05 0 0 0 0.09 0.21
Vac/Vac Membrane 0.28 0.43 0.08 0.07 0.16 0.06 0.07 0 0.06 – 0 0 0.22 0.3 0.23 0.3 0.42 0.34 0.21 0.29 0.33 0.19 0.31 0.26
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 1 0 1 0 0 1
Bud 0 0 0 1 1 6 5 9 9 – 6 11 0 0 2 0 0 1 0 2 5 1 1 4
Bud Neck 0 0 0 0 2 0 1 3 1 – 0 1 0 0 0 0 0 1 1 1 1 1 1 0
Bud Site 0 0 1 1 0 2 3 2 4 – 6 11 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 1 1 0 1 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 20 44 58 33 72 111 147 205 97 – 104 100 29 60 70 105 99 110 11 28 30 9 31 38
Endoplasmic Reticulum 0 3 1 1 3 4 0 0 1 – 0 2 0 2 0 9 7 13 0 0 0 0 1 0
Endosome 2 3 5 1 19 0 1 7 1 – 0 2 0 0 1 26 29 32 6 2 0 2 6 11
Golgi 3 1 0 0 0 0 0 0 0 – 0 0 0 0 0 2 0 3 3 1 0 0 0 0
Mitochondria 3 67 27 88 65 117 164 188 176 – 218 253 22 17 48 12 5 8 9 11 22 2 9 12
Nucleus 50 66 26 39 28 21 25 23 22 – 26 35 19 18 1 19 5 7 82 128 47 37 34 19
Nuclear Periphery 1 0 0 0 1 0 1 1 0 – 1 1 0 0 0 1 0 0 3 0 0 0 0 0
Nucleolus 1 0 0 2 2 2 1 2 0 – 3 1 0 0 0 0 1 0 3 1 0 1 3 4
Peroxisomes 0 0 1 0 0 0 0 0 0 – 0 0 0 0 0 0 1 0 1 0 0 0 0 0
SpindlePole 1 0 3 5 10 1 4 6 4 – 3 3 0 0 0 2 2 2 8 12 6 2 14 40
Vac/Vac Membrane 27 96 9 10 31 12 22 14 16 – 10 10 16 37 27 57 83 70 35 80 63 16 49 50
Unique Cell Count 98 221 119 146 194 217 302 369 254 302 329 74 122 117 192 196 204 174 279 193 83 161 192
Labelled Cell Count 108 280 131 181 235 277 374 461 331 377 430 86 134 149 233 232 247 174 279 193 83 161 192


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.1 3.8 4.9 3.9 5.1 3.8 3.3 3.7 3.4 – 3.1 2.7 3.9 4.4 3.7 5.6 6.1 6.5 4.7 4.1 4.9
Std Deviation (1e-4) 1.0 0.8 2.5 2.0 3.6 2.1 1.7 2.3 2.3 – 1.8 1.4 0.8 1.2 1.1 1.7 2.1 2.5 2.0 1.5 1.6
Intensity Change (Log2) – – – -0.33 0.07 -0.36 -0.55 -0.4 -0.54 – -0.64 -0.85 -0.31 -0.16 -0.42 0.21 0.32 0.42 -0.05 -0.24 0.02

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP620RAP70002468WT3HU80HU120HU16002468WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302468WT1AF100AF140AF18002468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 0 0
Bud Neck – – – – – – – – – – – – 0 0 0
Bud Site – – – – – – – – – – – – 0 0 0
Cell Periphery – – – – – – – – – – – – 0 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 0 0
Endosome – – – – – – – – – – – – 0 0 0
Golgi – – – – – – – – – – – – 0 0 0
Mitochondria – – – – – – – – – – – – 0 0 0
Nuclear Periphery – – – – – – – – – – – – 0 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 0 0
Peroxisomes – – – – – – – – – – – – 0 0 0
SpindlePole – – – – – – – – – – – – 0 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 0 0
Cytoplasm – – – – – – – – – – – – 0 0 0
Nucleus – – – – – – – – – – – – 0 0 0
Vacuole – – – – – – – – – – – – 4.6 6.6 5.4

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration – – – – – – – – – – – – – – – – – –
Actin 0.0276 0.0007 0.0198 0.0018 0.0647 0.0036 0.0473 0.0006 0.0055 0.0014 0.007 0.0023 0.0001 0.0097 0.0022 0.0005 0.0006 0.0008
Bud 0.0002 0.0002 0.0003 0.0003 0.0006 0.0002 0.0007 0.0003 0.0004 0.0003 0.0004 0.0043 0 0.0001 0.0003 0.0008 0.0001 0.0002
Bud Neck 0.0106 0.0019 0.0014 0.0012 0.0025 0.0167 0.0032 0.0005 0.0011 0.0023 0.0008 0.0098 0.0001 0.0001 0.0005 0.0057 0.0016 0.0035
Bud Periphery 0.0003 0.0002 0.0004 0.001 0.0012 0.0003 0.0013 0.0002 0.0009 0.0006 0.0007 0.0013 0 0.0002 0.0006 0.0027 0.0001 0.0001
Bud Site 0.0013 0.0069 0.0018 0.0012 0.0023 0.0025 0.0055 0.0014 0.0018 0.0015 0.0007 0.0007 0.0003 0.0002 0.0006 0.0008 0.0003 0.0003
Cell Periphery 0.0002 0.0003 0.0002 0.0003 0.0002 0.0001 0.0002 0 0.0001 0.0001 0.0001 0.0001 0 0 0.0001 0.0003 0 0.0002
Cytoplasm 0.0352 0.0783 0.0378 0.0651 0.0389 0.0562 0.0337 0.0637 0.0206 0.072 0.0412 0.0368 0.0218 0.0443 0.0877 0.0413 0.0484 0.0934
Cytoplasmic Foci 0.0114 0.0036 0.0092 0.0022 0.0211 0.0045 0.0254 0.0014 0.0053 0.024 0.0055 0.0066 0.0001 0.0033 0.0014 0.0008 0.0022 0.0148
Eisosomes 0.0004 0.0001 0.0004 0.0001 0.0006 0 0.0004 0 0.0001 0.0001 0.0002 0 0 0.001 0.0001 0 0 0.0002
Endoplasmic Reticulum 0.0046 0.007 0.0047 0.0102 0.0038 0.0038 0.0066 0.0028 0.0018 0.0032 0.0026 0.0018 0.0008 0.0006 0.0025 0.0039 0.0022 0.0021
Endosome 0.013 0.0078 0.012 0.0098 0.0241 0.008 0.0407 0.0023 0.0077 0.0063 0.032 0.004 0.0006 0.0005 0.0039 0.0063 0.0057 0.0024
Golgi 0.0041 0.0002 0.0038 0.0004 0.0079 0.0021 0.0124 0.0001 0.0041 0.0007 0.0322 0.0023 0 0.0005 0.0006 0.0001 0.0001 0.0001
Lipid Particles 0.0076 0.0017 0.008 0.0015 0.0542 0.0062 0.0204 0.0002 0.0047 0.0018 0.0078 0.0053 0 0.0009 0.001 0.0003 0.0003 0.0008
Mitochondria 0.0144 0.0009 0.0045 0.0099 0.007 0.0017 0.0152 0.0011 0.0039 0.0039 0.0713 0.008 0.0005 0.0014 0.0021 0.0022 0.001 0.0012
None 0.0433 0.116 0.0615 0.1026 0.0532 0.0379 0.0904 0.1038 0.0823 0.1355 0.1301 0.0626 0.0028 0.4236 0.2974 0.3395 0.0313 0.2548
Nuclear Periphery 0.0303 0.0437 0.0297 0.0218 0.0312 0.022 0.0477 0.0429 0.0406 0.085 0.0219 0.0119 0.0294 0.0054 0.0466 0.1012 0.0381 0.0101
Nucleolus 0.0096 0.0114 0.0094 0.0132 0.0084 0.0196 0.0067 0.0075 0.0116 0.0242 0.0051 0.0143 0.0024 0.0011 0.0077 0.0062 0.0138 0.0122
Nucleus 0.7283 0.6859 0.7544 0.736 0.6079 0.7842 0.5842 0.7295 0.75 0.5349 0.6228 0.7721 0.9331 0.5003 0.5223 0.4556 0.7799 0.5762
Peroxisomes 0.0061 0.0001 0.0081 0.0004 0.0335 0.0044 0.0183 0.0002 0.0046 0.0146 0.0047 0.0009 0 0.0037 0.001 0.0001 0.0002 0.0002
Punctate Nuclear 0.0479 0.0244 0.0302 0.0147 0.0295 0.022 0.0301 0.0396 0.0505 0.0752 0.0084 0.0533 0.0071 0.0028 0.0189 0.0096 0.0725 0.0245
Vacuole 0.0027 0.0074 0.0019 0.005 0.006 0.003 0.0068 0.0011 0.0015 0.0076 0.0022 0.0013 0.0006 0.0003 0.0012 0.0179 0.0012 0.0018
Vacuole Periphery 0.0008 0.0011 0.0008 0.0014 0.0014 0.0008 0.0029 0.0005 0.0009 0.0046 0.0023 0.0003 0.0003 0.0001 0.001 0.0042 0.0005 0.0003

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 15.8927 15.4248 12.3495 17.6947 18.9865 19.0606 19.8541 20.2907 17.8937 22.5356
Translational Efficiency 0.6747 0.5712 0.6031 0.452 0.4581 0.4914 0.4184 0.4164 0.461 0.4566

Hit Data

Dataset Hit
Protein Concentration –
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
129 993 1086 1377 1428 1061 194 146 1557 2054 1280 1523

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 637.48 692.87 933.28 837.96 606.90 738.57 913.81 835.88 609.43 716.48 930.33 837.76
Standard Deviation 133.67 110.87 120.91 112.74 74.94 93.21 102.08 109.36 81.87 104.65 118.46 112.42
Intensity Change Log 2 — 0.120205 0.549930 0.394501 — 0.283276 0.590435 0.461837 — 0.202040 0.569827 0.427735

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000045 0.000312 0.000446 0.000731 0.000069 0.000234 0.001391 0.000434 0.000067 0.000271 0.000590 0.000703
Bud Neck 0.008077 0.008420 0.005394 0.015714 0.004032 0.006840 0.001683 0.004103 0.004367 0.007604 0.004832 0.014601
Bud Site 0.002073 0.002493 0.006047 0.029040 0.000695 0.007369 0.003746 0.004981 0.000809 0.005012 0.005698 0.026734
Cell Periphery 0.000200 0.000174 0.000112 0.000212 0.000133 0.000158 0.000196 0.000159 0.000139 0.000166 0.000125 0.000207
Cytoplasm 0.248456 0.200264 0.056929 0.211820 0.249873 0.177570 0.039152 0.200096 0.249755 0.188541 0.054235 0.210696
Cytoplasmic Foci 0.078991 0.086795 0.000889 0.009293 0.076280 0.054220 0.006630 0.014175 0.076504 0.069968 0.001759 0.009761
Eisosomes 0.000112 0.000082 0.000028 0.000038 0.000063 0.000057 0.000085 0.000073 0.000067 0.000069 0.000037 0.000041
Endoplasmic Reticulum 0.000877 0.003065 0.006971 0.005277 0.001282 0.001720 0.005883 0.004931 0.001249 0.002370 0.006806 0.005244
Endosome 0.002044 0.006640 0.000873 0.008039 0.002232 0.003413 0.004982 0.014595 0.002217 0.004973 0.001496 0.008668
Golgi 0.000205 0.001653 0.000046 0.002157 0.000566 0.001660 0.002995 0.006176 0.000536 0.001656 0.000493 0.002542
Lipid Particles 0.017591 0.014283 0.000613 0.001886 0.009947 0.011055 0.002062 0.002428 0.010580 0.012616 0.000832 0.001938
Mitochondria 0.002466 0.013209 0.000860 0.006337 0.005445 0.017124 0.001963 0.008521 0.005198 0.015232 0.001027 0.006547
Mitotic Spindle 0.000068 0.006899 0.001293 0.064866 0.001439 0.019374 0.002903 0.021093 0.001325 0.013343 0.001537 0.060670
None 0.012463 0.017797 0.002913 0.020290 0.018744 0.005994 0.004785 0.015453 0.018224 0.011700 0.003197 0.019826
Nuclear Periphery 0.001934 0.004145 0.001969 0.004784 0.002305 0.002883 0.001702 0.001664 0.002274 0.003493 0.001929 0.004485
Nuclear Periphery Foci 0.000901 0.002289 0.000755 0.001801 0.000928 0.001141 0.000808 0.001795 0.000926 0.001696 0.000763 0.001800
Nucleolus 0.006450 0.009872 0.000886 0.002749 0.006072 0.005278 0.001575 0.001303 0.006103 0.007499 0.000990 0.002611
Nucleus 0.601886 0.594973 0.898300 0.566374 0.609214 0.667003 0.891093 0.632465 0.608607 0.632180 0.897207 0.572709
Peroxisomes 0.005401 0.012921 0.000119 0.001190 0.003234 0.006011 0.000389 0.001600 0.003414 0.009352 0.000160 0.001229
Vacuole 0.009433 0.012793 0.014416 0.043071 0.007010 0.009877 0.025781 0.053499 0.007211 0.011287 0.016138 0.044071
Vacuole Periphery 0.000328 0.000919 0.000140 0.004330 0.000437 0.001020 0.000194 0.010456 0.000428 0.000971 0.000148 0.004917

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -8.80 -13.55 -12.66 -5.95 -0.76 -4.45 -2.07 -4.07 -3.18 0.53 -8.06 -7.26 -12.51 -7.66 0.13
Bud Neck -0.18 0.34 -1.65 -4.22 -5.90 -3.12 2.08 -1.13 1.22 -2.36 -4.13 -1.68 -7.68 -4.92 -6.33
Bud Site -0.37 -2.04 -6.24 -7.37 -4.16 -3.92 -1.67 -3.06 -0.12 -1.40 -4.70 -3.71 -8.72 -5.53 -4.46
Cell Periphery 0.85 3.28 2.22 2.01 -2.04 -0.90 -1.08 -1.16 -0.04 0.60 -1.69 0.89 -0.48 1.31 -1.23
Cytoplasm 2.34 9.43 3.87 3.63 -18.16 7.84 22.49 5.51 1.99 -5.10 7.71 29.69 10.29 3.44 -19.03
Cytoplasmic Foci -1.43 8.62 8.09 17.71 -7.04 4.52 16.83 14.16 9.55 -1.28 1.34 22.34 20.92 22.08 -5.72
Eisosomes 1.09 3.76 2.84 7.60 -5.85 1.45 -3.14 -3.35 -3.84 -0.44 -0.63 5.25 2.28 3.14 -3.75
Endoplasmic Reticulum -8.14 -19.62 -16.46 -10.34 2.74 -2.09 -7.95 -5.81 -5.51 -0.99 -6.27 -20.60 -16.91 -13.75 2.22
Endosome -4.03 1.89 -2.51 2.33 -4.90 -2.33 -0.79 -1.76 -1.41 -1.04 -4.51 2.02 -3.06 0.89 -4.10
Golgi -5.57 3.82 -2.35 2.71 -3.06 -2.39 -0.68 -0.86 -0.38 -0.28 -4.03 0.93 -1.13 1.91 -1.55
Lipid Particles 0.67 3.90 3.71 11.32 -3.85 -0.43 8.96 8.25 5.41 -0.57 -1.39 11.70 10.76 11.48 -3.33
Mitochondria -5.18 1.88 -1.23 4.85 -5.39 -4.29 2.81 0.60 3.84 -0.97 -5.45 4.81 1.56 6.83 -5.02
Mitotic Spindle -3.86 -2.95 -10.10 -7.61 -9.63 -5.07 -0.87 -2.21 -0.62 -2.03 -5.80 -0.67 -9.89 -5.98 -9.76
None -1.54 3.81 0.71 3.05 -5.79 6.89 7.72 2.57 -0.91 -1.55 3.48 10.11 3.90 0.85 -5.91
Nuclear Periphery -2.26 -1.92 -8.46 -2.72 -8.40 -1.48 -0.57 -2.11 -0.94 -1.59 -2.32 -1.13 -8.39 -4.74 -8.51
Nuclear Periphery Foci -1.81 -0.28 -1.74 0.84 -2.30 -0.53 -0.69 -2.15 -1.73 -1.59 -1.98 -0.71 -3.98 -0.35 -2.69
Nucleolus -2.75 4.03 2.99 9.04 -2.99 0.15 8.19 8.29 5.06 0.54 -2.19 9.82 6.73 8.52 -2.86
Nucleus 0.42 -11.18 -0.58 -2.02 27.99 -4.40 -14.01 -1.13 0.80 6.91 -1.90 -30.79 -1.00 0.80 28.33
Peroxisomes -2.29 1.65 1.52 8.08 -4.21 -3.15 8.30 4.82 6.45 -1.14 -6.08 8.29 7.25 10.64 -4.12
Vacuole -1.05 -4.49 -17.02 -17.64 -15.09 -2.97 -5.20 -7.04 -6.83 -3.35 -4.75 -9.82 -20.68 -19.53 -14.61
Vacuole Periphery -4.44 3.06 -2.23 -1.14 -2.61 -2.48 3.36 -1.09 -0.93 -1.16 -3.79 4.74 -2.31 -1.38 -2.79
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Swi2/Snf2-related translocase, SUMO-Targeted Ubiquitin Ligase (STUbL); required for maintenance of NHEJ inhibition at telomeres; functions at telomeres to translocate and ubiquitinylate poly-sumoylated Rap1p for proteosomal degradation; plays role in antagonizing silencing during mating-type switching; only known STUbL with a translocase activity; contains RING finger domain; relocalizes from nucleus to cytoplasm upon DNA replication stress
Localization
Cell Percentages nucleus (63%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-3

Uls1

Uls1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Uls1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available