Standard name
Human Ortholog
Description Ca2+-dependent cysteine protease; may cleave specific substrates during the stress response; regulates apoptosis upon H2O2 treatment; required for clearance of insoluble protein aggregates during normal growth; implicated in cell cycle dynamics and lifespan extension; undergoes autocatalytic processing; similar to mammalian metacaspases, but exists as a monomer due to an extra pair of anti-parallel beta-strands that block potential dimerization
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.99 0.98 0.96 0.78 0.83 0.85 0.71 0.67 0.67 0.73 0.71 0.66 0.93 0.98 0.93 0.91 0.95 0.92 0.94 0.89 0.96 0.88 0.79 0.74
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05
Mitochondria 0 0 0 0 0 0.08 0.16 0.11 0.15 0.16 0.18 0.16 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.06 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0.24 0.14 0.08 0.18 0.24 0.21 0.13 0.18 0.22 0.09 0.05 0.11 0.13 0.07 0.08 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 1 0 0 0 1 0 0 0 1 0 0 0 1 0 0 3 4
Bud 0 0 0 0 0 0 6 4 8 4 6 11 0 0 0 0 0 0 1 2 0 4 8 9
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 1 2 3
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 2 2 3 1 9 5 12 9 5 7 0 2 2 1 2 1 0 0 0 0 0 0
Cytoplasm 270 284 386 208 252 379 436 357 374 430 404 376 419 632 611 143 202 177 258 256 382 349 365 402
Endoplasmic Reticulum 1 2 5 2 4 11 15 9 9 17 3 8 2 6 3 3 4 5 3 0 1 1 4 6
Endosome 0 1 1 0 1 0 0 5 0 0 1 3 2 0 2 0 1 2 1 2 0 4 9 23
Golgi 0 1 0 2 1 0 0 1 0 0 0 0 1 0 0 1 1 1 0 2 2 0 6 28
Mitochondria 1 0 0 5 11 35 97 58 83 92 100 92 1 0 0 2 2 1 0 1 0 2 2 6
Nucleus 3 0 5 1 4 9 18 15 18 16 15 10 3 16 9 2 1 3 3 9 4 24 29 24
Nuclear Periphery 0 0 0 0 0 0 1 2 1 0 1 0 0 0 0 0 0 0 0 0 0 0 1 1
Nucleolus 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 3 0 1 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
SpindlePole 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 1 0 0 0 0 0 1 5 9
Vac/Vac Membrane 1 5 18 64 44 36 110 129 115 76 105 122 39 33 72 21 15 16 0 6 3 4 16 17
Unique Cell Count 272 291 401 265 304 444 616 529 558 593 568 566 452 645 654 158 212 192 274 288 400 396 462 548
Labelled Cell Count 276 293 417 285 320 471 692 587 620 644 640 630 467 689 699 178 228 207 274 288 400 396 462 548


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 10.7 10.9 10.7 9.4 9.4 8.5 8.3 8.7 8.2 7.9 8.0 7.8 12.4 12.1 11.4 13.6 12.7 13.2 12.4 12.3 14.1
Std Deviation (1e-4) 1.8 2.4 1.9 1.7 1.8 1.8 1.8 1.9 1.8 1.7 1.8 1.8 2.3 2.0 2.0 3.6 2.9 3.0 2.5 2.5 2.8
Intensity Change (Log2) – – – -0.18 -0.18 -0.33 -0.37 -0.3 -0.39 -0.44 -0.42 -0.45 0.21 0.17 0.09 0.34 0.25 0.3 0.22 0.2 0.4

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP700051015WT3HU80HU120HU160051015WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3051015WT1AF100AF140AF180051015
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 2.1 0 0 0 0 0 0 0 0 0
Cytoplasm -7.2 -6.0 -5.4 -10.1 -10.8 -11.0 -9.6 -9.9 -11.2 -2.3 1.7 -2.0 -2.7 -0.6 -2.1
Endoplasmic Reticulum 0 0 1.3 1.3 0.6 0.5 1.7 0 0.2 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 5.7 8.4 6.8 8.1 8.3 8.9 8.5 0 0 0 0 0 0
Nucleus 0 0 0.9 1.8 1.7 2.0 1.6 1.5 0.6 0 1.4 0.2 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 7.6 4.6 2.1 6.3 8.2 7.1 4.4 6.4 7.4 2.4 0.5 3.7 3.7 1.3 1.9

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 7.1099 7.5801 7.7622 6.6917 6.8739 7.6029 4.4077 5.8866 5.4204 5.0324 4.9291 5.642 5.2444 6.0483 5.5234 5.3784 5.0271 5.5186
Actin 0.0292 0.0019 0.0093 0.0008 0.0359 0.0008 0.0454 0.0007 0.0134 0.0311 0.0044 0.0004 0.0094 0.0009 0.0108 0.0016 0.0289 0.0052
Bud 0.0009 0.0012 0.0008 0.0001 0.0003 0.0001 0.0009 0.0004 0.0023 0.0006 0.0002 0.0003 0.0011 0.0033 0.0007 0.0002 0.0019 0.0009
Bud Neck 0.009 0.0004 0.0008 0.0006 0.0005 0.0014 0.0134 0.0006 0.0131 0.0017 0.0005 0.0034 0.0065 0.0007 0.0014 0.0013 0.0067 0.0076
Bud Periphery 0.001 0.0004 0.0005 0 0.0002 0 0.0009 0.0002 0.0011 0.0005 0.0003 0.0001 0.001 0.001 0.0003 0.0001 0.001 0.0008
Bud Site 0.0033 0.0043 0.0051 0.0003 0.0004 0.0001 0.0118 0.0032 0.0081 0.0024 0.0002 0.0004 0.0059 0.0159 0.0057 0.0004 0.0021 0.0007
Cell Periphery 0.0002 0.0001 0.0001 0.0001 0 0 0.0007 0.0001 0.0004 0.0001 0.0001 0 0.0004 0.0001 0.0001 0 0.0001 0.0001
Cytoplasm 0.7426 0.906 0.8369 0.9554 0.8466 0.924 0.7667 0.9483 0.8811 0.7588 0.8412 0.9493 0.826 0.9014 0.867 0.83 0.794 0.8475
Cytoplasmic Foci 0.0235 0.0158 0.0251 0.0025 0.0171 0.006 0.0162 0.002 0.0061 0.0271 0.0054 0.0039 0.0155 0.0047 0.0065 0.0124 0.0141 0.0072
Eisosomes 0.0001 0 0.0001 0 0 0 0.0005 0 0.0001 0.0001 0.0001 0 0.0001 0 0.0001 0 0.0005 0
Endoplasmic Reticulum 0.0127 0.0029 0.0031 0.003 0.0037 0.0026 0.014 0.0033 0.0023 0.0025 0.0021 0.0024 0.0071 0.0021 0.0023 0.0028 0.0092 0.003
Endosome 0.0269 0.0038 0.0119 0.0012 0.0169 0.0019 0.0405 0.0006 0.0061 0.0492 0.0454 0.0024 0.0192 0.0042 0.0072 0.0027 0.0279 0.0059
Golgi 0.0054 0.0015 0.0036 0.0001 0.0035 0.0001 0.01 0.0001 0.0083 0.0318 0.0081 0.0001 0.0029 0.0002 0.0023 0.0003 0.009 0.0005
Lipid Particles 0.002 0.0002 0.0014 0 0.0144 0 0.004 0 0.0015 0.0031 0.0013 0 0.0052 0.0001 0.0007 0.0003 0.0107 0.0006
Mitochondria 0.0012 0.0003 0.0023 0.0002 0.0006 0.0002 0.0041 0.0001 0.0114 0.0361 0.0549 0.0002 0.0036 0.0004 0.001 0.0003 0.0023 0.0005
None 0.1117 0.038 0.0609 0.0144 0.0189 0.0366 0.028 0.0208 0.0082 0.0033 0.0193 0.0041 0.0186 0.0124 0.0144 0.0094 0.0121 0.0149
Nuclear Periphery 0.0125 0.0022 0.0028 0.0022 0.0061 0.002 0.0127 0.0015 0.0018 0.0032 0.0009 0.0023 0.0102 0.0046 0.0038 0.0062 0.017 0.0084
Nucleolus 0.0002 0.0001 0.0004 0 0.0001 0 0.001 0 0.0003 0.0001 0 0 0.0005 0.0003 0.0004 0.0002 0.0009 0.0005
Nucleus 0.0089 0.0152 0.0235 0.0169 0.0091 0.0217 0.015 0.0161 0.0308 0.0374 0.009 0.0281 0.0524 0.0408 0.0679 0.1185 0.0366 0.0789
Peroxisomes 0.0027 0.0022 0.0065 0.0001 0.0165 0.0003 0.0021 0.0001 0.0011 0.0069 0.0006 0.0001 0.0043 0.0001 0.0012 0.0006 0.0065 0.0004
Punctate Nuclear 0.0039 0.0027 0.0034 0.0016 0.0077 0.0011 0.0039 0.0013 0.001 0.0022 0.0004 0.0017 0.0063 0.0054 0.005 0.0116 0.0146 0.0151
Vacuole 0.0018 0.0007 0.0012 0.0005 0.001 0.0007 0.0062 0.0004 0.0009 0.0013 0.0035 0.0009 0.0028 0.0012 0.0009 0.0009 0.0026 0.0011
Vacuole Periphery 0.0005 0.0001 0.0003 0.0001 0.0004 0.0001 0.0022 0.0001 0.0004 0.0006 0.0019 0.0001 0.001 0.0002 0.0002 0.0001 0.0011 0.0004

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 85.3673 66.8215 58.0363 91.8814 81.4975 72.1612 73.8972 89.6466 76.6839 98.2224
Translational Efficiency 1.5431 1.541 1.7262 0.8616 1.2493 1.8303 1.3542 0.8073 1.1994 1.1271

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1544 235 226 1155 1631 1021 1056 158 3175 1256 1282 1313

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 970.55 1252.64 1545.12 1654.57 1008.86 1157.21 1461.69 1823.86 990.23 1175.07 1476.40 1674.94
Standard Deviation 135.39 197.20 207.66 290.63 170.16 173.82 230.38 336.35 155.42 182.27 228.76 301.57
Intensity Change Log 2 — 0.368097 0.670844 0.769582 — 0.197925 0.534911 0.854269 — 0.283873 0.603163 0.813366

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000491 0.000988 0.001330 0.004769 0.000581 0.000480 0.000781 0.000712 0.000537 0.000575 0.000878 0.004281
Bud Neck 0.001654 0.002441 0.005860 0.010616 0.001383 0.001669 0.003364 0.007759 0.001515 0.001813 0.003804 0.010272
Bud Site 0.008605 0.012491 0.016675 0.020410 0.003705 0.010983 0.007966 0.027711 0.006088 0.011265 0.009501 0.021289
Cell Periphery 0.000187 0.000174 0.000475 0.000573 0.000131 0.000088 0.000247 0.000374 0.000158 0.000104 0.000287 0.000549
Cytoplasm 0.759804 0.655131 0.244638 0.318532 0.723910 0.741957 0.369314 0.105627 0.741366 0.725712 0.347335 0.292912
Cytoplasmic Foci 0.061690 0.022131 0.009149 0.009821 0.038785 0.041211 0.008721 0.171705 0.049924 0.037641 0.008796 0.029301
Eisosomes 0.000023 0.000016 0.000035 0.000024 0.000022 0.000016 0.000019 0.000029 0.000023 0.000016 0.000021 0.000024
Endoplasmic Reticulum 0.002007 0.001237 0.003228 0.001358 0.002453 0.001120 0.002399 0.000913 0.002236 0.001142 0.002545 0.001304
Endosome 0.001512 0.002213 0.002403 0.004913 0.001481 0.003155 0.003193 0.081524 0.001496 0.002979 0.003053 0.014132
Golgi 0.000692 0.002620 0.000278 0.011984 0.000472 0.003736 0.003380 0.126550 0.000579 0.003527 0.002833 0.025770
Lipid Particles 0.000938 0.000662 0.002404 0.003318 0.000790 0.001455 0.001653 0.002139 0.000862 0.001307 0.001785 0.003176
Mitochondria 0.000248 0.000150 0.000788 0.020591 0.000859 0.001611 0.000958 0.014736 0.000562 0.001338 0.000928 0.019886
Mitotic Spindle 0.000661 0.010098 0.007085 0.074110 0.002189 0.014974 0.023669 0.098278 0.001446 0.014061 0.020746 0.077018
None 0.004386 0.011380 0.006366 0.009402 0.004630 0.006276 0.010357 0.008085 0.004511 0.007231 0.009654 0.009243
Nuclear Periphery 0.000134 0.000307 0.001646 0.001456 0.000389 0.000198 0.001149 0.000765 0.000265 0.000218 0.001237 0.001372
Nuclear Periphery Foci 0.004087 0.004004 0.006693 0.005842 0.004904 0.003084 0.005650 0.002704 0.004507 0.003257 0.005834 0.005464
Nucleolus 0.000430 0.000117 0.000215 0.000902 0.000473 0.000192 0.000149 0.000275 0.000452 0.000178 0.000161 0.000827
Nucleus 0.117995 0.218427 0.558647 0.419011 0.178189 0.125654 0.502919 0.042056 0.148917 0.143012 0.512743 0.373650
Peroxisomes 0.000426 0.000364 0.000163 0.000761 0.000363 0.002713 0.000600 0.002421 0.000394 0.002273 0.000523 0.000961
Vacuole 0.033574 0.053641 0.131764 0.066892 0.033969 0.037799 0.053123 0.149097 0.033777 0.040763 0.066986 0.076784
Vacuole Periphery 0.000456 0.001406 0.000158 0.014716 0.000320 0.001630 0.000390 0.156541 0.000386 0.001588 0.000349 0.031782

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.06 -5.24 -2.81 -2.12 -1.01 0.24 -1.66 -0.03 -0.67 3.86 -0.17 -3.52 -2.74 -2.79 -1.69
Bud Neck -1.17 -9.12 -13.62 -11.16 -2.18 -1.44 -11.33 -7.64 -7.14 -2.54 -1.60 -14.17 -14.84 -14.06 -7.29
Bud Site -0.52 -2.01 -5.09 -1.49 -0.98 -3.77 -4.54 -5.49 -2.73 -3.46 -2.51 -3.18 -9.25 -3.79 -5.39
Cell Periphery 0.31 -6.37 -12.24 -10.72 -0.51 4.12 -12.62 -4.96 -5.73 -0.88 3.93 -11.79 -14.28 -15.91 -6.82
Cytoplasm 9.24 43.90 63.24 20.53 -5.56 0.21 51.91 25.74 24.71 4.07 5.23 67.68 70.38 48.62 1.18
Cytoplasmic Foci 10.59 20.26 16.64 1.43 -4.89 -0.91 17.30 1.13 1.48 -3.60 4.57 26.90 15.59 7.56 -7.62
Eisosomes 1.19 -8.13 -4.83 -4.88 5.00 1.86 -4.01 -1.32 -3.30 2.24 2.79 -7.16 -5.20 -7.95 1.40
Endoplasmic Reticulum 1.82 -4.54 2.39 0.28 7.50 3.52 -1.27 5.36 3.80 12.82 4.15 -3.37 4.35 -0.20 11.66
Endosome -0.72 -3.36 0.83 1.07 3.90 -2.67 -0.38 -1.45 -0.85 -1.39 -2.78 -0.95 -0.81 1.77 -0.00
Golgi -0.62 2.47 -1.01 0.21 -1.67 -3.11 -0.98 -1.35 -0.68 -1.24 -3.07 -0.66 -1.81 1.07 -1.32
Lipid Particles 0.28 -7.72 -11.28 -11.66 -6.07 -1.94 -7.82 -6.50 -5.37 -4.73 -1.71 -9.38 -12.61 -10.78 -9.45
Mitochondria 1.02 -7.04 -2.12 -2.21 -1.43 -0.72 -0.46 -0.21 0.57 0.21 -1.11 -1.98 -1.83 -1.12 -1.37
Mitotic Spindle -2.06 -3.58 -12.21 -8.77 -9.60 -3.83 -4.88 -6.56 -6.10 -6.03 -4.50 -5.81 -13.53 -10.77 -10.66
None -1.91 -0.27 -8.85 -1.00 -6.09 -1.57 -6.50 -3.20 -2.64 -1.40 -2.55 -6.81 -9.84 -5.37 -4.16
Nuclear Periphery -8.13 -18.04 -24.74 -20.76 0.65 1.17 -11.66 -8.62 -11.38 -0.85 -0.29 -21.36 -21.41 -24.73 -4.75
Nuclear Periphery Foci -0.55 -1.49 -4.62 -3.23 -2.02 2.06 0.54 -1.12 -1.61 -1.27 2.01 -0.05 -3.97 -5.44 -3.57
Nucleolus 2.15 0.92 -1.72 -6.80 -4.54 1.35 1.08 -0.13 -2.78 -2.29 2.23 1.61 -1.94 -6.47 -5.62
Nucleus -8.52 -20.25 -30.33 -10.26 5.82 7.08 -38.50 3.04 0.15 23.89 -0.61 -47.35 -24.74 -22.17 17.09
Peroxisomes 0.62 2.13 0.97 0.10 -1.42 -2.09 0.87 -0.97 1.69 -1.46 -2.04 1.53 0.37 2.09 -1.27
Vacuole -6.17 -14.15 -24.77 -7.93 2.74 -4.49 -14.84 -13.16 -12.41 -9.49 -7.37 -19.60 -27.53 -21.33 -8.83
Vacuole Periphery -0.49 1.32 -1.08 -0.44 -1.47 -1.91 1.47 -1.26 -1.06 -1.29 -1.87 1.89 -1.73 -0.66 -1.97
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Ca2+-dependent cysteine protease; may cleave specific substrates during the stress response; regulates apoptosis upon H2O2 treatment; required for clearance of insoluble protein aggregates during normal growth; implicated in cell cycle dynamics and lifespan extension; undergoes autocatalytic processing; similar to mammalian metacaspases, but exists as a monomer due to an extra pair of anti-parallel beta-strands that block potential dimerization
Localization
Cell Percentages cytoplasm (99%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Mca1

Mca1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Mca1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available