Standard name
Human Ortholog
Description Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – – – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Cytoplasm 0.5 0.49 0.47 0.41 0.56 0.54 0.47 0.52 – 0.46 0.42 0.38 0.5 0.5 0.53 – – – 0.06 0.16 0.05 0.09 0 0.06
Endoplasmic Reticulum 0.12 0.4 0.17 0.13 0.05 0.05 0 0 – 0 0 0.05 0.5 0.52 0.44 – – – 0.71 0.53 0.73 0.55 0.54 0.48
Endosome 0.08 0 0.15 0.09 0.08 0 0 0 – 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Mitochondria 0 0 0 0.2 0.1 0.4 0.5 0.45 – 0.57 0.6 0.63 0 0 0 – – – 0 0 0 0.1 0.09 0.05
Nucleus 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – – 0.07 0.05 0.05 0.08 0.06 0.05
Nucleolus 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – – 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Vac/Vac Membrane 0.45 0.15 0.3 0.27 0.32 0.16 0.19 0.12 – 0.12 0.09 0.1 0 0.05 0.1 – – – 0.1 0.15 0.06 0.11 0.18 0.26
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 1 6 1 1 0 0 0 0 – 0 1 0 0 0 0 – – – 1 6 5 2 2 3
Bud 0 4 2 2 5 3 14 24 – 17 18 10 1 1 0 – – – 1 1 2 1 3 4
Bud Neck 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – – 0 3 4 0 1 1
Bud Site 0 0 0 0 0 0 0 0 – 1 3 1 0 0 0 – – – – – – – – –
Cell Periphery 0 0 1 1 1 2 2 1 – 3 6 4 3 3 6 – – – 0 0 0 0 0 0
Cytoplasm 214 201 207 133 199 332 375 399 – 345 327 281 104 104 109 – – – 30 81 27 22 13 23
Endoplasmic Reticulum 52 164 75 43 17 29 7 5 – 20 28 38 102 109 91 – – – 362 272 421 140 173 190
Endosome 34 2 66 30 28 14 12 27 – 6 3 5 3 5 1 – – – 9 15 16 5 12 17
Golgi 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – – 2 2 4 1 4 2
Mitochondria 1 8 11 66 36 244 405 347 – 432 465 464 0 0 0 – – – 8 17 22 26 29 19
Nucleus 0 1 1 1 4 2 5 9 – 9 12 12 1 1 1 – – – 0 0 0 0 0 2
Nuclear Periphery 0 0 1 11 0 3 4 4 – 11 6 14 1 1 0 – – – 35 23 29 21 17 17
Nucleolus 1 0 2 1 1 0 1 2 – 3 0 0 0 0 0 – – – 0 0 1 0 0 0
Peroxisomes 0 0 0 0 0 0 1 1 – 0 0 0 0 0 0 – – – 0 0 0 0 0 0
SpindlePole 0 2 1 0 0 0 0 0 – 1 1 1 0 0 0 – – – 0 1 0 0 0 2
Vac/Vac Membrane 193 63 133 89 114 97 155 94 – 91 69 74 9 10 20 – – – 48 78 35 26 59 102
Unique Cell Count 430 410 444 326 357 611 802 764 756 778 740 206 209 206 507 510 578 254 324 394
Labelled Cell Count 496 451 501 378 405 726 981 913 939 939 904 224 234 228 507 510 578 254 324 394


Endoplasmic Reticulum

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 7.4 6.3 5.8 5.2 5.1 4.2 3.8 4.1 – 3.6 3.7 3.8 8.2 8.2 8.5 – – – 7.6 8.3 8.6
Std Deviation (1e-4) 1.1 0.9 1.1 1.1 1.3 1.2 1.0 1.0 – 0.7 0.7 0.8 0.9 0.9 1.2 – – – 1.4 1.6 1.5
Intensity Change (Log2) – – – -0.17 -0.2 -0.47 -0.61 -0.5 – -0.71 -0.67 -0.62 0.48 0.48 0.54 – – – 0.37 0.5 0.55


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 – 0 0 0 0 0 0 – – –
Bud 0 0 0 0 0 – 0 0 0 0 0 0 – – –
Bud Neck 0 0 0 0 0 – 0 0 0 0 0 0 – – –
Bud Site 0 0 0 0 0 – 0 0 0 0 0 0 – – –
Cell Periphery 0 0 0 0 0 – 0 0 0 0 0 0 – – –
Cytoplasm -1.6 2.6 2.5 0 1.9 – -0.3 -1.6 -2.9 0.9 0.7 1.5 – – –
Endoplasmic Reticulum -1.4 -5.4 0 0 0 – 0 0 0 8.7 9.3 7.4 – – –
Endosome -2.4 -3.1 0 0 0 – 0 0 0 -5.2 -4.8 -5.6 – – –
Golgi 0 0 0 0 0 – 0 0 0 0 0 0 – – –
Mitochondria 8.1 4.6 0 0 0 – 0 0 0 0 0 0 – – –
Nucleus 0 0 0 0 0 – 0 0 0 0 0 0 – – –
Nuclear Periphery 3.5 0 0 0 0 – 0 0 0 0 0 0 – – –
Nucleolus 0 0 0 0 0 – 0 0 0 0 0 0 – – –
Peroxisomes 0 0 0 0 0 – 0 0 0 0 0 0 – – –
SpindlePole 0 0 0 0 0 – 0 0 0 0 0 0 – – –
Vacuole -0.8 0.6 -5.5 -4.3 -7.6 – -7.7 -9.5 -8.8 -7.3 -7.3 -5.7 – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 4.5185 4.4388 4.4189 4.6558 3.8484 4.4045 5.1914 5.4604 5.4961 5.0653 4.2051 5.2322 5.7289 5.7284 5.411 5.7702 5.2029 5.3446
Actin 0.0289 0.0029 0.0088 0.0004 0.0011 0.0027 0.022 0.0002 0.0158 0.0188 0.0158 0.0065 0.0369 0.0005 0.0106 0.0256 0.0047 0.0032
Bud 0.0003 0.0002 0.0001 0.0001 0.0012 0.0002 0.0005 0.0013 0.0015 0.0007 0.0006 0.0007 0.0009 0.0001 0.0002 0.0003 0.0002 0.0002
Bud Neck 0.0007 0.0004 0.0003 0.0005 0.0006 0.0028 0.0014 0.0001 0.0006 0.001 0.0002 0.0008 0.0022 0.0004 0.0008 0.001 0.001 0.0005
Bud Periphery 0.0007 0.0001 0.0001 0.0001 0.0004 0.0002 0.0007 0.0004 0.0003 0.0007 0.0007 0.0003 0.0012 0.0001 0.0002 0.0007 0.0005 0.0002
Bud Site 0.0003 0.0029 0.0004 0.0003 0.0009 0.0002 0.0031 0.0042 0.004 0.005 0.0007 0.0003 0.0099 0.0084 0.0024 0.0009 0.0002 0.0001
Cell Periphery 0.0002 0.0004 0.0002 0.0002 0.0002 0.0001 0.0006 0.0004 0.0004 0.0004 0.0002 0.0002 0.0006 0.0006 0.0004 0.0004 0.0003 0.0001
Cytoplasm 0.1225 0.3184 0.2407 0.1851 0.2974 0.2585 0.1231 0.2146 0.2001 0.1112 0.2579 0.1895 0.1067 0.3686 0.1666 0.263 0.3641 0.1719
Cytoplasmic Foci 0.0172 0.0092 0.0048 0.0024 0.0242 0.0062 0.04 0.0044 0.0134 0.0241 0.0095 0.009 0.0271 0.0098 0.0158 0.0098 0.0077 0.0075
Eisosomes 0.0002 0.0001 0 0 0 0 0.0005 0 0.0002 0.0001 0.0001 0 0.0011 0 0 0.0005 0.0001 0.0001
Endoplasmic Reticulum 0.5554 0.4508 0.5875 0.6676 0.3965 0.5377 0.4331 0.6215 0.5349 0.5858 0.5349 0.6096 0.5202 0.4843 0.6314 0.4555 0.4063 0.6164
Endosome 0.073 0.0491 0.0266 0.029 0.0738 0.0337 0.0895 0.0239 0.0316 0.0367 0.0328 0.0318 0.0613 0.0239 0.0606 0.0402 0.0417 0.0399
Golgi 0.0038 0.0013 0.0009 0.0004 0.0011 0.0029 0.0204 0.0004 0.0085 0.0238 0.0059 0.0034 0.0201 0.0005 0.0087 0.0224 0.0357 0.0087
Lipid Particles 0.0069 0.0041 0.0024 0.0011 0.0035 0.0045 0.0535 0.0032 0.0091 0.0134 0.0041 0.0091 0.0377 0.004 0.0073 0.0132 0.0093 0.0105
Mitochondria 0.0015 0.0005 0.0004 0.0006 0.0006 0.0011 0.01 0.0002 0.0092 0.0034 0.0018 0.001 0.0083 0.0003 0.0018 0.0445 0.048 0.0104
None 0.0097 0.021 0.0256 0.0026 0.0185 0.0189 0.0417 0.0451 0.0754 0.0586 0.0387 0.0256 0.0087 0.0179 0.0139 0.0723 0.0187 0.035
Nuclear Periphery 0.1316 0.0873 0.0746 0.0645 0.107 0.0756 0.0736 0.0409 0.0555 0.0466 0.0648 0.0691 0.09 0.0526 0.0536 0.0295 0.0318 0.0608
Nucleolus 0.0003 0.0008 0.0001 0.0003 0.0009 0.0002 0.0042 0.0008 0.0004 0.0015 0.0001 0.0007 0.0006 0.0002 0.0001 0.0002 0.0001 0.0001
Nucleus 0.0186 0.0197 0.011 0.0234 0.0259 0.0345 0.0275 0.0094 0.0148 0.0055 0.0089 0.0187 0.0161 0.0135 0.0059 0.0049 0.0116 0.0131
Peroxisomes 0.0022 0.0001 0.0006 0 0.0002 0.0006 0.0166 0 0.0099 0.0084 0.0044 0.0014 0.0208 0.0001 0.0008 0.0042 0.0009 0.0038
Punctate Nuclear 0.0097 0.0025 0.0011 0.0021 0.0154 0.0026 0.0158 0.0039 0.0026 0.0397 0.0014 0.0051 0.0034 0.0018 0.0008 0.0007 0.0012 0.001
Vacuole 0.0124 0.0255 0.0122 0.0166 0.0255 0.0142 0.0176 0.0237 0.0101 0.0128 0.0142 0.0147 0.0212 0.0112 0.016 0.0076 0.013 0.0139
Vacuole Periphery 0.0039 0.0027 0.0018 0.0026 0.0049 0.0027 0.0046 0.0016 0.0018 0.0019 0.0023 0.0024 0.005 0.0012 0.0019 0.0027 0.0028 0.0026

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 20.7247 11.3838 16.3977 22.2423 16.3489 15.4726 17.8859 23.0773 21.7467 23.2977
Translational Efficiency 0.3384 0.462 0.4105 0.3204 0.3567 0.4751 0.3982 0.2887 0.3142 0.3117

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1135 1198 213 93 221 1461 2519 2275 1356 2659 2732 2368

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 805.00 753.38 972.36 1010.22 697.98 840.63 938.41 908.08 787.56 801.32 941.06 912.09
Standard Deviation 101.16 107.38 103.52 137.03 91.81 118.09 116.03 115.73 107.25 121.42 115.46 118.32
Intensity Change Log 2 — -0.095611 0.272502 0.327609 — 0.268285 0.427033 0.379634 — 0.084835 0.346328 0.352003

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000442 0.000130 0.000156 0.000229 0.000173 0.000196 0.000090 0.000322 0.000398 0.000166 0.000096 0.000319
Bud Neck 0.003330 0.001859 0.003739 0.003716 0.020202 0.003049 0.003113 0.006990 0.006080 0.002513 0.003162 0.006861
Bud Site 0.014119 0.002195 0.001431 0.002863 0.014384 0.002601 0.003188 0.015755 0.014162 0.002418 0.003051 0.015249
Cell Periphery 0.000202 0.000141 0.000210 0.000193 0.000584 0.000210 0.000090 0.000183 0.000264 0.000179 0.000099 0.000183
Cytoplasm 0.282156* 0.273566* 0.115449* 0.131044* 0.302111* 0.164649* 0.197896* 0.241754* 0.285408* 0.213721* 0.191469* 0.237406*
Cytoplasmic Foci 0.060437 0.094479 0.052991 0.037815 0.150827 0.074173 0.008916 0.030644 0.075169 0.083322 0.012352 0.030926
Eisosomes 0.000069 0.000059 0.000108 0.000067 0.000384 0.000136 0.000017 0.000040 0.000121 0.000101 0.000024 0.000041
Endoplasmic Reticulum 0.110732* 0.283742* 0.078015 0.113525* 0.128949* 0.413751* 0.203895* 0.249490* 0.113701* 0.355176* 0.194081* 0.244150*
Endosome 0.025774 0.022890 0.036636 0.028960 0.041753 0.030000 0.013309 0.030420 0.028379 0.026797 0.015128 0.030363
Golgi 0.006646 0.002731 0.000203 0.000244 0.007331 0.005554 0.000107 0.000690 0.006757 0.004282 0.000114 0.000673
Lipid Particles 0.029785 0.063176 0.024593 0.025806 0.155576* 0.079449 0.007899 0.025789 0.050286 0.072117 0.009200 0.025790
Mitochondria 0.009364 0.003474 0.000911 0.000175 0.008056 0.006187 0.001244 0.001879 0.009150 0.004965 0.001218 0.001812
Mitotic Spindle 0.009625 0.001173 0.000205 0.001304 0.005201 0.000992 0.002341 0.008783 0.008904 0.001073 0.002174 0.008489
None 0.003002 0.004892 0.001119 0.000386 0.008210 0.002629 0.000796 0.001289 0.003851 0.003649 0.000822 0.001254
Nuclear Periphery 0.078345 0.060700 0.114985* 0.039668 0.014071 0.035933 0.261729* 0.082841 0.067870 0.047092 0.250288* 0.081145
Nuclear Periphery Foci 0.053825 0.048057 0.052815 0.191643* 0.015171 0.013803 0.053792 0.068538 0.047525 0.029236 0.053716 0.073373
Nucleolus 0.000825 0.002184 0.007089 0.000481 0.003112 0.000929 0.000965 0.000986 0.001198 0.001494 0.001443 0.000967
Nucleus 0.112771 0.056664 0.253575* 0.027724 0.056685 0.046538 0.124332 0.061861 0.103630 0.051100 0.134408* 0.060520
Peroxisomes 0.001479 0.001350 0.001519 0.000643 0.005722 0.002428 0.000163 0.000557 0.002170 0.001942 0.000269 0.000561
Vacuole 0.193780 0.072194 0.249160* 0.392526* 0.059035 0.111020 0.114759 0.167792 0.171819 0.093528 0.125238 0.176618
Vacuole Periphery 0.003293 0.004346 0.005091 0.000988 0.002462 0.005773 0.001359 0.003395 0.003157 0.005130 0.001650 0.003300

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 3.42 3.07 1.77 -3.17 -2.40 -0.26 1.64 -1.48 -1.21 -2.37 2.78 3.80 0.50 -1.67 -2.39
Bud Neck 3.47 -0.71 -1.08 -2.67 -0.51 3.60 3.51 2.64 -5.55 -5.47 4.10 2.89 -1.19 -7.13 -5.50
Bud Site 5.15 5.65 4.67 -1.29 -2.64 2.65 2.43 -0.48 -7.65 -7.13 5.74 5.14 -0.72 -8.11 -7.26
Cell Periphery 3.66 -0.60 1.13 -1.32 1.56 4.06 5.41 4.32 1.31 -7.16 3.91 8.08 3.25 -0.49 -6.64
Cytoplasm 0.92 12.82 6.65 6.21 -0.66 7.79 5.80 3.19 -11.25 -6.62 8.71 11.31 5.26 -4.07 -7.20
Cytoplasmic Foci -7.57 0.99 5.31 10.54 3.11 7.45 14.49 12.17 13.33 -17.25 -2.59 21.33 14.19 19.38 -14.04
Eisosomes 2.36 -3.85 0.39 -1.03 3.61 5.36 10.37 9.61 3.17 -4.52 1.09 13.43 9.21 3.51 -3.40
Endoplasmic Reticulum -18.20 2.81 1.48 12.46 -0.21 -15.43 -4.27 -6.25 16.24 -4.96 -30.00 -13.01 -16.40 14.77 -5.66
Endosome 0.71 -2.70 -0.28 -0.77 2.26 2.08 5.28 2.16 0.07 -13.87 0.18 7.08 -1.30 -1.93 -12.15
Golgi 2.49 4.62 4.63 8.20 0.16 1.56 8.34 7.66 6.63 -5.72 1.65 5.78 5.26 8.36 -5.68
Lipid Particles -10.64 1.45 2.07 10.18 0.93 6.23 12.60 11.10 16.12 -18.04 -6.71 14.53 8.37 19.97 -16.81
Mitochondria 2.41 3.75 4.13 7.41 6.18 0.62 2.31 2.11 6.00 -3.57 1.88 4.08 3.76 6.88 -3.48
Mitotic Spindle 3.55 4.04 2.53 -1.18 -2.01 1.21 0.86 -0.80 -6.15 -4.75 3.78 3.03 -0.43 -6.23 -4.91
None -1.81 2.05 2.66 4.70 1.28 1.20 1.60 1.47 1.66 -1.28 0.02 2.85 2.17 3.48 -1.20
Nuclear Periphery 2.12 -2.91 4.84 3.66 5.46 -5.75 -38.52* -15.73 -11.45 28.26* 3.67 -27.84 -2.97 -8.67 28.09
Nuclear Periphery Foci 0.84 -0.30 -5.26 -5.44 -4.93 0.36 -9.95 -12.64 -19.44 -4.14 5.40 -2.35 -6.72 -14.14 -5.26
Nucleolus -4.06 -5.40 2.47 4.85 5.66 1.65 1.59 1.59 -0.70 -0.05 -0.93 -0.81 0.92 2.94 3.08
Nucleus 10.39 -7.30 12.17 4.86 11.51 1.49 -9.37 -1.02 -5.48 15.61 11.83 -6.31 9.07 -4.21 18.12
Peroxisomes -0.13 -0.38 3.30 4.73 4.89 3.29 5.95 5.52 4.88 -4.08 0.38 7.10 5.72 6.10 -3.02
Vacuole 18.62 -1.93 -8.00 -12.66 -6.39 -6.77 -8.71 -15.87 -11.61 -11.01 14.32 8.39 -0.34 -18.81 -10.97
Vacuole Periphery -1.77 -1.99 3.02 6.71 4.96 -5.76 3.12 -1.59 4.32 -5.03 -3.53 2.23 -0.38 4.27 -4.12
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome
Localization
Cell Percentages ER (61%)
Cell Cycle Regulation No
Subcompartmental Group ER-3

Ypk9

Ypk9


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ypk9-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available