Standard name
Human Ortholog
Description Pyruvate kinase; appears to be modulated by phosphorylation; transcription repressed by glucose, and Pyk2p may be active under low glycolytic flux; PYK2 has a paralog, CDC19, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.99 0.99 0.99 0.96 0.98 0.95 0.84 0.79 0.72 0.68 0.64 0.64 1.0 1.0 0.99 0.97 0.97 0.95 0.96 0.95 0.96 0.97 0.97 0.91
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.11 0.23 0.21 0.36 0.38 0.47 0.43 0 0 0 0 0 0.05 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0.06 0 0.06 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 1 1 0 0 1 0 0 0 0 0 0 0 0 0 0 0 2
Bud 2 2 1 0 1 0 1 2 3 1 0 3 1 1 0 0 0 0 0 1 0 0 0 2
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 7 2 0 5 3 13 8 8 8 12 10 8 4 3 2 5 0 0 0 0 0 0 0
Cytoplasm 218 289 216 131 241 223 322 245 191 208 156 206 249 444 354 142 114 19 217 274 201 125 226 197
Endoplasmic Reticulum 0 1 0 0 1 2 5 3 5 6 8 10 0 0 3 7 5 0 0 0 0 0 0 2
Endosome 0 0 0 1 1 0 2 1 0 1 0 0 0 0 0 1 0 0 2 1 0 0 1 1
Golgi 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 2
Mitochondria 5 0 2 6 3 25 87 64 96 117 114 138 0 2 0 6 2 1 0 2 0 0 0 2
Nucleus 0 0 1 0 0 1 1 2 1 1 0 0 1 1 1 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 1 1 2 3 2 1 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 1 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 2 0 2 1 0 9 19 8 17 7 15 0 0 1 4 0 0 0 3 4 0 0 1
Unique Cell Count 221 292 218 136 245 234 384 309 266 306 244 321 249 446 359 146 117 20 226 288 210 130 232 217
Labelled Cell Count 225 302 222 141 253 254 441 346 315 362 299 384 259 453 362 162 126 20 226 288 210 130 232 217


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.2 7.5 7.5 7.2 7.6 6.7 6.2 6.7 6.0 6.0 5.9 5.9 8.2 8.6 8.7 5.4 5.8 7.5 6.5 7.3 9.0
Std Deviation (1e-4) 0.8 1.2 1.4 1.4 1.2 1.1 1.6 1.4 1.2 1.4 1.4 1.3 1.5 1.3 1.3 1.4 1.4 1.5 1.2 1.5 1.8
Intensity Change (Log2) – – – -0.06 0.01 -0.16 -0.28 -0.18 -0.32 -0.32 -0.34 -0.35 0.12 0.2 0.21 -0.47 -0.36 -0.01 -0.21 -0.03 0.25


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 1.9 0 0 0 2.5 0 0 0 0 0 0 0
Cytoplasm -1.8 -0.7 -2.4 -5.8 -6.8 -8.2 -8.9 -9.5 -9.6 1.5 0.7 -0.5 -1.3 -1.2 -1.6
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 4.4 7.2 6.8 9.6 10.1 11.3 10.9 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 3.7 0 3.5 0 3.2 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 4.1638 5.316 5.0212 4.3743 4.6322 4.9094 4.7484 5.6603 5.5041 4.226 4.9821 5.4758 4.9979 6.3117 5.4445 5.719 5.4159 5.7291
Actin 0.0155 0.0003 0.014 0.0004 0.0003 0.0018 0.027 0.0004 0.0134 0.0129 0.0139 0.0009 0.0063 0.0012 0.0104 0.0004 0.0002 0.0007
Bud 0.0002 0.0002 0.0006 0.0005 0.0003 0.0001 0.0001 0.0001 0.0003 0.0002 0.0001 0.0001 0.0017 0.0004 0.0004 0.0002 0.0001 0.0001
Bud Neck 0.002 0.0002 0.0009 0.0005 0.0007 0.0013 0.0006 0.0001 0.0008 0.0004 0.0003 0.0005 0.0024 0.0094 0.0117 0.0003 0.0003 0.0006
Bud Periphery 0.0003 0.0001 0.0003 0.0002 0.0001 0.0001 0.0001 0 0.0003 0.0001 0.0001 0 0.0016 0.0003 0.0005 0.0001 0 0.0001
Bud Site 0.0043 0.0006 0.0061 0.0004 0.0003 0.0001 0.0007 0.0012 0.0019 0.0005 0.0008 0 0.0079 0.0099 0.0032 0.0002 0 0.0001
Cell Periphery 0.0007 0.0002 0.0002 0.0001 0.0001 0.0001 0.0002 0.0002 0.0001 0.0001 0 0 0.0003 0.0003 0.0002 0 0 0
Cytoplasm 0.8435 0.9828 0.9017 0.9798 0.9826 0.9559 0.8411 0.9743 0.887 0.9107 0.8461 0.9415 0.7399 0.9473 0.8423 0.9259 0.9902 0.953
Cytoplasmic Foci 0.0143 0.0022 0.0141 0.003 0.0033 0.0059 0.0156 0.0043 0.0088 0.0173 0.0237 0.0054 0.051 0.0107 0.0073 0.0078 0.0025 0.0052
Eisosomes 0.0004 0 0.0002 0 0 0 0.0002 0 0.0001 0 0.0001 0 0.0001 0 0.0001 0 0 0
Endoplasmic Reticulum 0.0101 0.0019 0.0033 0.0024 0.0025 0.0075 0.0078 0.0025 0.003 0.0019 0.0034 0.0044 0.0047 0.0013 0.0039 0.002 0.0006 0.0016
Endosome 0.019 0.0022 0.0054 0.0026 0.0043 0.0047 0.0087 0.0033 0.0077 0.0046 0.0151 0.0046 0.0537 0.0023 0.0146 0.0039 0.0005 0.0093
Golgi 0.0037 0.0001 0.0017 0.0002 0.0003 0.0011 0.0023 0.0003 0.006 0.0051 0.0063 0.0007 0.0147 0.0024 0.01 0.0004 0 0.0029
Lipid Particles 0.0086 0 0.003 0.0001 0 0.004 0.0022 0.0001 0.008 0.0041 0.0129 0 0.0146 0.0005 0.0031 0.0001 0 0.0008
Mitochondria 0.0042 0.0001 0.0011 0.0001 0.0001 0.0005 0.0009 0.0001 0.0058 0.0009 0.0016 0.0008 0.0042 0.0004 0.0187 0.0003 0 0.0046
None 0.0349 0.0062 0.0309 0.0048 0.0015 0.0101 0.0756 0.0108 0.0375 0.008 0.0561 0.0388 0.0706 0.0098 0.0587 0.0555 0.0041 0.019
Nuclear Periphery 0.014 0.0004 0.0016 0.0008 0.0005 0.0014 0.0025 0.0004 0.001 0.0004 0.0008 0.0003 0.0033 0.0002 0.0013 0.0005 0.0002 0.0002
Nucleolus 0.0008 0 0.0003 0 0 0 0.0001 0 0.0002 0 0.0001 0 0.0005 0.0001 0.001 0 0 0
Nucleus 0.005 0.0009 0.0024 0.0016 0.0013 0.0018 0.0025 0.0007 0.001 0.0008 0.0008 0.0009 0.0032 0.0006 0.0013 0.0012 0.0007 0.0006
Peroxisomes 0.0048 0 0.0078 0 0 0.0018 0.0056 0 0.0076 0.0307 0.0154 0.0001 0.0039 0.0022 0.009 0.0001 0 0.0002
Punctate Nuclear 0.009 0.0001 0.0027 0.0001 0.0001 0.0003 0.0042 0.0002 0.0077 0.0003 0.0009 0.0002 0.0108 0.0001 0.0007 0.0003 0.0001 0.0001
Vacuole 0.0034 0.0014 0.0013 0.0021 0.0014 0.0013 0.0015 0.0007 0.0012 0.0007 0.0012 0.0004 0.0035 0.0005 0.001 0.0008 0.0002 0.0005
Vacuole Periphery 0.0012 0.0001 0.0002 0.0003 0.0002 0.0003 0.0003 0.0001 0.0005 0.0001 0.0003 0.0001 0.0009 0 0.0006 0.0002 0 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 18.1362 7.7821 10.1056 21.1167 18.8115 26.8267 15.7369 24.7831 41.0043 28.4635
Translational Efficiency 0.8807 0.8908 1.0643 1.1743 0.6571 1.1687 1.012 0.8777 0.931 0.9245

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1764 411 1880 1585 1168 459 321 1605 2932 870 2201 3190

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 844.57 896.17 1139.37 1089.26 823.87 921.97 1304.60 1078.10 836.32 909.78 1163.47 1083.65
Standard Deviation 98.60 144.79 141.18 164.03 96.36 132.21 146.92 157.23 98.24 138.89 153.54 160.74
Intensity Change Log 2 — 0.085555 0.431947 0.367059 — 0.162303 0.663119 0.388002 — 0.123963 0.550727 0.377439

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000089 0.000333 0.000098 0.002098 0.000140 0.000416 0.000332 0.000482 0.000109 0.000377 0.000133 0.001285
Bud Neck 0.008649 0.004934 0.001636 0.006775 0.003539 0.007706 0.001048 0.004511 0.006613 0.006396 0.001550 0.005636
Bud Site 0.008940 0.022787 0.006414 0.035665 0.006146 0.024181 0.008813 0.030875 0.007827 0.023523 0.006764 0.033255
Cell Periphery 0.000120 0.000100 0.000048 0.000151 0.000123 0.000122 0.000112 0.000090 0.000121 0.000111 0.000057 0.000120
Cytoplasm 0.743104* 0.634230* 0.773582* 0.582596* 0.684726* 0.585674* 0.716501* 0.660711* 0.719848* 0.608612* 0.765257* 0.621898*
Cytoplasmic Foci 0.069423 0.175279 0.023144 0.035346 0.162731 0.211227* 0.030152 0.032404 0.106594 0.194245* 0.024166 0.033866
Eisosomes 0.000041 0.000038 0.000009 0.000021 0.000063 0.000064 0.000018 0.000016 0.000050 0.000051 0.000011 0.000018
Endoplasmic Reticulum 0.000345 0.000552 0.001049 0.001459 0.001157 0.001159 0.001202 0.000742 0.000669 0.000872 0.001072 0.001099
Endosome 0.002783 0.027445 0.002677 0.014866 0.008888 0.024441 0.004318 0.013739 0.005215 0.025860 0.002916 0.014299
Golgi 0.002022 0.004429 0.000156 0.014890 0.002202 0.003610 0.000285 0.006285 0.002094 0.003997 0.000174 0.010561
Lipid Particles 0.001358 0.001463 0.000700 0.001256 0.002356 0.004248 0.001456 0.000488 0.001756 0.002932 0.000810 0.000869
Mitochondria 0.001388 0.002322 0.000115 0.004329 0.001007 0.001816 0.000067 0.009184 0.001236 0.002055 0.000108 0.006772
Mitotic Spindle 0.000398 0.005326 0.004855 0.118691* 0.002295 0.002190 0.001550 0.058448 0.001154 0.003671 0.004373 0.088381
None 0.015133 0.001762 0.003271 0.003205 0.003605 0.000799 0.002830 0.003486 0.010540 0.001254 0.003207 0.003346
Nuclear Periphery 0.000072 0.000072 0.000468 0.000841 0.000235 0.000108 0.000358 0.000627 0.000137 0.000091 0.000452 0.000733
Nuclear Periphery Foci 0.000277 0.001940 0.001894 0.002806 0.001047 0.002126 0.010437 0.001958 0.000584 0.002038 0.003140 0.002379
Nucleolus 0.000709 0.000321 0.000206 0.000634 0.000373 0.000563 0.000083 0.000239 0.000575 0.000448 0.000188 0.000435
Nucleus 0.090377 0.017728 0.068737 0.039768 0.056831 0.016491 0.053653 0.036693 0.077014 0.017076 0.066537 0.038221
Peroxisomes 0.001231 0.004286 0.000147 0.002926 0.000886 0.003845 0.000155 0.002261 0.001094 0.004053 0.000148 0.002591
Vacuole 0.052784 0.092972 0.110460 0.123850 0.060487 0.106892 0.166427 0.128272 0.055853 0.100316 0.118623 0.126075
Vacuole Periphery 0.000756 0.001681 0.000333 0.007827 0.001161 0.002324 0.000204 0.008490 0.000917 0.002020 0.000314 0.008160

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -5.04 -2.80 -2.97 -1.66 -2.82 -4.43 -5.75 -2.97 1.94 2.01 -6.93 -3.13 -3.66 -0.96 -3.20
Bud Neck 3.97 8.74 5.46 1.13 -3.71 -3.71 6.67 1.64 4.40 -3.70 0.48 9.37 6.01 4.24 -3.98
Bud Site -5.73 2.59 -5.10 1.87 -6.79 -7.55 -1.60 -5.00 3.50 -3.17 -9.19 1.61 -6.84 3.82 -7.56
Cell Periphery 1.65 12.75 1.89 0.17 -4.03 0.21 0.92 9.25 6.01 7.05 1.25 13.25 6.37 3.54 -2.69
Cytoplasm 7.71 1.66 24.19 6.12 20.82 7.06 4.21 8.69 -1.13 0.89 11.25 0.80 23.70 3.49 19.48
Cytoplasmic Foci -12.02 18.22 14.29 16.99 -3.06 -5.03 25.77 27.92 21.55 0.67 -13.40 31.18 29.32 27.24 -2.88
Eisosomes 0.76 15.84 11.10 5.34 -7.58 -0.07 11.89 14.06 7.96 3.04 -0.41 21.24 17.92 9.49 -7.70
Endoplasmic Reticulum -2.41 -3.11 -1.24 -0.19 1.15 0.02 0.25 2.62 1.35 3.86 -0.73 -1.49 0.82 1.16 2.13
Endosome -6.87 0.98 -3.08 6.18 -3.58 -6.44 6.85 3.80 7.79 -1.45 -9.79 8.08 0.18 9.65 -4.63
Golgi -1.94 14.61 -1.42 0.61 -3.43 -1.97 5.48 0.45 2.08 -3.16 -2.78 12.01 -0.97 1.52 -4.61
Lipid Particles -0.34 2.67 -0.26 0.19 -5.54 -1.02 2.89 8.93 1.88 5.12 -1.18 5.33 4.50 1.88 -2.12
Mitochondria -0.50 6.81 0.49 0.63 -2.12 -0.69 2.32 -1.71 -0.72 -2.85 -0.77 5.70 -1.27 0.02 -3.45
Mitotic Spindle -1.75 -6.00 -12.84 -10.00 -11.10 0.10 -0.02 -7.92 -7.92 -8.22 -1.65 -4.94 -15.16 -12.75 -12.79
None 11.07 11.63 12.31 -1.31 0.15 4.55 2.32 1.68 -3.99 -1.14 12.49 10.97 12.01 -3.43 -0.10
Nuclear Periphery -0.45 -9.63 -14.31 -14.19 -4.43 1.25 -3.21 -3.79 -9.60 -1.13 1.07 -7.37 -11.66 -16.80 -3.58
Nuclear Periphery Foci -3.80 -9.95 -10.30 -0.20 -0.54 -1.58 -9.03 -3.73 0.66 8.29 -3.54 -11.92 -10.95 0.42 5.02
Nucleolus 8.71 16.66 3.31 -0.84 -2.00 -0.69 8.82 4.13 1.16 -5.90 0.68 16.45 5.27 0.87 -2.38
Nucleus 30.27 5.11 10.10 -17.93 4.84 16.22 -0.69 0.96 -16.96 1.38 34.07 1.49 9.47 -24.69 6.79
Peroxisomes -3.30 5.72 -0.39 3.14 -5.14 -6.65 10.14 -0.42 5.11 -2.64 -5.93 8.04 -0.40 5.44 -5.12
Vacuole -6.92 -17.81 -31.48 -19.38 -15.52 -7.47 -13.58 -27.99 -16.32 0.59 -10.48 -21.33 -42.44 -25.16 -15.44
Vacuole Periphery -3.67 6.79 -2.28 -0.33 -3.25 -1.25 2.74 -1.95 -0.29 -3.81 -2.27 4.14 -3.06 -0.37 -4.86
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Pyruvate kinase; appears to be modulated by phosphorylation; transcription repressed by glucose, and Pyk2p may be active under low glycolytic flux; PYK2 has a paralog, CDC19, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (99%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Pyk2

Pyk2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Pyk2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available