Standard name
Human Ortholog
Description Component of yeast cortical actin cytoskeleton; binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.09 0.15 0.19 0.13 0.13 0.08 0 0.05 0.11 0.09 0.1 0.1 0.12 0.14 0.1 0.14 0.12 0.18 0.35 0.31 0.36 0.38 0.39 0.33
Bud 0.06 0.06 0.08 0.08 0.11 0.09 0.11 0.11 0.1 0.1 0.1 0.08 0 0 0.05 0 0 0.05 0 0.06 0 0.08 0.08 0.09
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0.05 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0.05 0.06 0 0 0 0 0 0 0 0 0 0 0.07 0.07 0.06 0 0 0 0 0 0
Cytoplasm 0.62 0.68 0.67 0.61 0.55 0.52 0.46 0.36 0.25 0.24 0.2 0.24 0.77 0.77 0.72 0.7 0.68 0.69 0.22 0.31 0.29 0.22 0.24 0.26
Endoplasmic Reticulum 0 0.12 0.08 0 0 0.06 0 0 0.06 0 0 0 0.06 0 0.05 0.06 0 0 0 0 0 0 0 0
Endosome 0.08 0 0 0.09 0.07 0.06 0.16 0.17 0.07 0.14 0.13 0.11 0.08 0.05 0.06 0.05 0.07 0 0.07 0.07 0 0.06 0.05 0.07
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.12 0 0 0 0 0.27 0.12 0.26 0.53 0.44 0.53 0.51 0 0 0 0 0 0 0.13 0.1 0.14 0.1 0.09 0.09
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0.06 0 0 0.06 0 0 0.1 0.1 0.06 0.09 0.05 0.07 0 0 0.06 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0.09 0.1 0.13 0.08 0.13 0.09 0 0.1 0.06 0.07 0 0 0 0.05 0.09 0.06 0 0 0 0.05 0 0
Vac/Vac Membrane 0 0 0 0 0.08 0 0.1 0.09 0 0.08 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 14 47 36 25 25 18 9 23 38 28 39 39 29 46 34 36 37 49 95 118 88 80 125 116
Bud 9 18 16 15 22 19 28 48 35 33 38 34 8 13 17 8 9 13 10 22 10 16 24 33
Bud Neck 0 0 1 1 1 0 1 1 2 0 1 0 0 0 0 1 3 0 12 26 7 11 14 12
Bud Site 1 4 3 1 2 4 3 6 5 8 3 7 1 1 0 1 2 1 – – – – – –
Cell Periphery 3 7 7 9 12 4 4 8 12 5 3 7 6 6 11 19 22 17 1 3 2 2 4 4
Cytoplasm 99 215 129 113 109 112 120 157 89 77 74 97 184 249 236 183 211 192 60 119 71 46 78 93
Endoplasmic Reticulum 5 37 16 2 3 12 3 3 21 5 13 9 15 13 16 15 13 12 8 5 3 2 5 7
Endosome 13 6 1 17 13 14 41 76 25 45 50 44 20 15 20 13 22 12 17 24 7 13 16 23
Golgi 0 0 1 0 0 0 0 0 2 1 4 2 1 0 5 7 6 2 4 4 1 1 3 6
Mitochondria 20 12 2 5 0 58 32 113 188 140 199 208 0 1 2 8 8 9 34 38 34 21 28 32
Nucleus 2 4 0 3 2 1 1 4 3 4 1 5 2 0 0 3 1 2 1 0 0 0 0 0
Nuclear Periphery 2 2 0 1 0 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 1 0 0 1
Nucleolus 1 0 0 0 1 2 1 6 0 3 0 4 1 0 0 0 0 0 0 0 0 0 0 1
Peroxisomes 9 1 1 11 8 8 26 43 20 27 20 27 4 6 18 2 4 1 7 0 2 0 3 4
SpindlePole 5 4 18 18 26 18 33 40 10 31 21 29 7 4 8 13 27 16 4 6 9 10 9 10
Vac/Vac Membrane 1 5 1 3 16 3 26 40 15 24 17 17 1 2 5 5 8 3 8 6 0 3 3 1
Unique Cell Count 160 314 192 186 198 217 262 440 356 315 373 408 238 324 326 260 309 278 272 382 245 213 322 355
Labelled Cell Count 184 362 232 224 240 273 329 568 466 431 483 529 279 356 372 314 373 329 272 382 245 213 322 355


Actin

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.9 6.2 6.5 6.4 7.6 5.2 6.1 6.1 5.4 5.7 5.3 5.6 6.5 6.3 6.8 7.7 7.1 6.9 5.6 5.7 6.0
Std Deviation (1e-4) 0.9 1.2 1.2 2.2 3.5 2.3 1.8 1.8 1.4 1.4 1.2 1.3 1.4 1.3 1.5 1.7 1.2 1.4 1.6 1.4 1.9
Intensity Change (Log2) – – – -0.02 0.22 -0.33 -0.09 -0.09 -0.27 -0.21 -0.3 -0.23 -0.0 -0.05 0.05 0.23 0.11 0.07 -0.22 -0.2 -0.14

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -1.4 -1.7 -3.1 -5.4 -5.4 -2.6 -3.2 -2.8 -3.2 -1.9 -1.4 -2.7 -1.4 -2.1 -0.3
Bud -0.1 0.9 0.2 0.8 1.0 0.6 0.8 0.7 0 -2.2 -2.1 -1.4 -2.5 -2.7 -1.6
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0.6 1.1 -1.1 0 0 -0.2 0 0 0 -0.7 0 -0.2 1.7 1.6 1.2
Cytoplasm -1.3 -2.5 -3.2 -4.5 -7.3 -9.6 -9.5 -11.1 -10.2 2.3 2.4 1.3 0.7 0.3 0.4
Endoplasmic Reticulum -3.3 -3.1 -1.1 -3.8 -5.2 -1.1 -3.7 -2.5 -3.5 -0.8 -2.1 -1.6 -1.1 -1.9 -1.8
Endosome 3.9 3.2 3.2 5.5 5.9 3.4 5.2 5.1 4.5 3.8 2.6 3.1 2.7 3.4 2.5
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 7.3 4.5 7.4 12.1 10.6 12.3 12.0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 3.0 0 0 4.2 4.2 3.0 3.8 2.9 3.3 0 0 2.9 0 0 0
SpindlePole 0.1 1.2 -0.4 1.1 -0.1 -3.3 0.2 -1.7 -1.0 -2.8 -4.4 -3.5 -1.8 -0.2 -1.5
Vacuole 0 3.7 0 4.2 4.0 2.4 3.6 2.6 2.4 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.7112 2.0417 1.8869 1.14 1.9658 1.9332 2.7722 2.917 2.8925 2.8023 2.532 3.1097 5.2607 5.5888 5.4271 5.537 5.5233 5.5737
Actin 0.2702 0.144 0.2671 0.1949 0.2439 0.1926 0.3251 0.1687 0.344 0.3585 0.4059 0.278 0.3524 0.1227 0.3254 0.3159 0.2496 0.2218
Bud 0.0033 0.01 0.0334 0.0121 0.0155 0.0025 0.0042 0.0128 0.039 0.0206 0.012 0.0015 0.0046 0.0025 0.058 0.015 0.0052 0.001
Bud Neck 0.0088 0.0048 0.0206 0.0024 0.0006 0.1612 0.0161 0.0049 0.0072 0.0014 0.0075 0.1294 0.0074 0.0032 0.0143 0.0032 0.0009 0.1196
Bud Periphery 0.0121 0.0124 0.0457 0.0163 0.0665 0.0031 0.0099 0.0134 0.0621 0.0422 0.0328 0.0018 0.0087 0.0027 0.0662 0.0215 0.0048 0.0011
Bud Site 0.0306 0.1182 0.0646 0.0055 0.0017 0.0039 0.0527 0.1107 0.0437 0.0055 0.0166 0.0027 0.0616 0.0621 0.0471 0.0029 0.0023 0.002
Cell Periphery 0.0015 0.0023 0.0017 0.0006 0.0008 0.0004 0.0015 0.0016 0.0013 0.0005 0.0014 0.0004 0.0009 0.0016 0.0011 0.0003 0.0003 0.0006
Cytoplasm 0.237 0.4102 0.2471 0.2918 0.2368 0.2637 0.1749 0.388 0.2533 0.1677 0.1797 0.2065 0.2293 0.4549 0.3162 0.322 0.3494 0.373
Cytoplasmic Foci 0.1773 0.1029 0.106 0.1194 0.0832 0.1843 0.1219 0.0991 0.0633 0.1096 0.0653 0.1258 0.0825 0.0655 0.0522 0.0433 0.0663 0.119
Eisosomes 0.0007 0.0004 0.0003 0.0006 0.0005 0.0002 0.0012 0.0002 0.0009 0.0002 0.0006 0.0003 0.0006 0.0005 0.0003 0.0003 0.0004 0.0002
Endoplasmic Reticulum 0.0109 0.0051 0.0069 0.0097 0.007 0.0026 0.0068 0.0038 0.0037 0.0087 0.0016 0.0027 0.0069 0.012 0.003 0.0021 0.0218 0.0057
Endosome 0.0425 0.0243 0.0447 0.0756 0.1093 0.0229 0.0475 0.0328 0.0178 0.0795 0.0177 0.037 0.0213 0.0374 0.0119 0.0501 0.0167 0.0377
Golgi 0.0399 0.0181 0.0177 0.0454 0.0625 0.02 0.0397 0.0225 0.0221 0.0375 0.021 0.0265 0.0427 0.0213 0.0195 0.0135 0.0122 0.0298
Lipid Particles 0.0124 0.0025 0.0024 0.0086 0.0085 0.003 0.0104 0.0019 0.0034 0.0064 0.0083 0.0096 0.0036 0.0032 0.001 0.0011 0.003 0.0056
Mitochondria 0.0037 0.0037 0.0072 0.0173 0.0103 0.0038 0.017 0.0075 0.0109 0.0053 0.061 0.0095 0.0059 0.0017 0.0069 0.0062 0.0019 0.0027
None 0.0958 0.0928 0.0816 0.1202 0.114 0.0782 0.083 0.0789 0.0774 0.0886 0.0457 0.0851 0.1093 0.1937 0.0467 0.1842 0.2085 0.0451
Nuclear Periphery 0.0014 0.0018 0.0021 0.0036 0.0016 0.0004 0.0117 0.0009 0.0019 0.0025 0.002 0.0008 0.0012 0.0011 0.0006 0.0004 0.0026 0.0004
Nucleolus 0.0003 0.0005 0.0003 0.0005 0.0001 0.0002 0.001 0.0002 0.0004 0.0002 0.0015 0.0001 0.0001 0.0003 0.0001 0.0001 0.0001 0
Nucleus 0.0012 0.0029 0.0016 0.0021 0.0009 0.0012 0.002 0.0014 0.0023 0.0087 0.0135 0.0006 0.0006 0.0008 0.0009 0.0005 0.0014 0.0004
Peroxisomes 0.042 0.0367 0.0441 0.0616 0.0301 0.0486 0.0642 0.0455 0.04 0.0507 0.0847 0.0792 0.0585 0.0096 0.0249 0.0139 0.0475 0.0323
Punctate Nuclear 0.0026 0.0028 0.0016 0.004 0.0015 0.005 0.0035 0.0022 0.0032 0.0019 0.0194 0.0015 0.001 0.0015 0.0006 0.0005 0.0042 0.0012
Vacuole 0.005 0.0031 0.0023 0.006 0.0038 0.0015 0.0038 0.0025 0.0014 0.0028 0.0014 0.0007 0.0006 0.0015 0.0023 0.0026 0.0006 0.0005
Vacuole Periphery 0.0006 0.0006 0.001 0.0019 0.001 0.0004 0.0018 0.0006 0.0006 0.001 0.0006 0.0004 0.0004 0.0003 0.0007 0.0004 0.0002 0.0003

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 25.618 24.5367 30.3455 38.3866 17.7937 25.6038 22.3281 29.0237 36.1272 30.3527
Translational Efficiency 1.699 1.3356 1.3127 1.3718 2.5584 1.5835 1.433 1.5825 1.4369 1.4686

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1871 1047 169 1175 1781 2733 2614 1551 3652 3780 2783 2726

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 679.69 771.76 1082.70 883.58 711.43 844.19 948.44 999.39 695.17 824.13 956.59 949.47
Standard Deviation 81.14 131.16 125.36 138.44 84.67 105.09 128.47 164.16 84.38 117.48 132.23 163.96
Intensity Change Log 2 — 0.183275 0.671685 0.378484 — 0.246846 0.414835 0.490326 — 0.216136 0.546043 0.436763

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.010116 0.021859 0.211020 0.218126 0.010739 0.031500 0.152883 0.205742 0.010420 0.028829 0.156413 0.211080
Bud Neck 0.054239 0.028274 0.018149 0.019705 0.043086 0.060616 0.038916 0.018091 0.048800 0.051657 0.037655 0.018786
Bud Site 0.037627 0.068476 0.210413 0.269952 0.035375 0.092790 0.278199 0.222627 0.036529 0.086055 0.274082 0.243026
Cell Periphery 0.000351 0.000498 0.001194 0.001141 0.000444 0.000469 0.000447 0.000913 0.000396 0.000477 0.000492 0.001011
Cytoplasm 0.270134 0.292988 0.109681 0.177443 0.346902 0.357044 0.246050 0.231677 0.307572 0.339301 0.237768 0.208300
Cytoplasmic Foci 0.348595 0.327028 0.102159 0.069226 0.330665 0.202255 0.053596 0.063955 0.339851 0.236815 0.056545 0.066227
Eisosomes 0.001687 0.001133 0.000656 0.001127 0.001775 0.001472 0.000418 0.001008 0.001730 0.001378 0.000432 0.001060
Endoplasmic Reticulum 0.001506 0.003016 0.014811 0.004467 0.001460 0.001397 0.001479 0.001873 0.001483 0.001846 0.002289 0.002991
Endosome 0.023163 0.043923 0.020708 0.008936 0.018049 0.016422 0.006531 0.016147 0.020669 0.024039 0.007392 0.013039
Golgi 0.033210 0.034037 0.005122 0.005250 0.020430 0.022982 0.005037 0.011212 0.026977 0.026044 0.005042 0.008642
Lipid Particles 0.025845 0.017482 0.031140 0.005442 0.020225 0.008650 0.003006 0.007224 0.023105 0.011096 0.004715 0.006456
Mitochondria 0.029046 0.014631 0.000292 0.001737 0.013416 0.019034 0.003810 0.003140 0.021424 0.017815 0.003596 0.002535
Mitotic Spindle 0.003432 0.004471 0.014519 0.010440 0.002402 0.008997 0.014887 0.021832 0.002930 0.007743 0.014864 0.016922
None 0.002709 0.003457 0.000113 0.002150 0.001541 0.001077 0.000392 0.000369 0.002139 0.001736 0.000375 0.001137
Nuclear Periphery 0.000139 0.000239 0.000281 0.000125 0.000151 0.000110 0.000110 0.000131 0.000145 0.000146 0.000121 0.000129
Nuclear Periphery Foci 0.000236 0.000921 0.007448 0.001192 0.000258 0.000148 0.000415 0.000638 0.000247 0.000362 0.000842 0.000877
Nucleolus 0.000636 0.001548 0.000114 0.000156 0.000700 0.000417 0.000132 0.000127 0.000668 0.000731 0.000131 0.000139
Nucleus 0.054426 0.030808 0.023319 0.028290 0.058725 0.041171 0.022007 0.023638 0.056523 0.038301 0.022087 0.025643
Peroxisomes 0.066925 0.053561 0.089555 0.086708 0.053766 0.091267 0.117988 0.082786 0.060508 0.080823 0.116262 0.084476
Vacuole 0.034271 0.049079 0.139011 0.087955 0.038933 0.040732 0.053508 0.084936 0.036544 0.043044 0.058701 0.086238
Vacuole Periphery 0.001706 0.002571 0.000295 0.000431 0.000958 0.001450 0.000189 0.001934 0.001341 0.001761 0.000195 0.001287

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -4.31 -8.46 -22.07 -20.00 -0.98 -9.11 -26.27 -21.48 -18.25 -3.68 -10.61 -28.13 -30.72 -26.60 -5.90
Bud Neck 7.81 11.19 11.82 3.59 -0.72 -5.61 2.20 10.24 18.00 10.71 -1.17 5.79 15.81 17.78 10.78
Bud Site -6.39 -8.54 -25.21 -19.90 -3.47 -15.06 -36.83 -22.48 -13.40 7.30 -16.64 -38.75 -33.45 -22.63 4.35
Cell Periphery -2.41 -7.59 -10.20 -6.93 0.57 -0.32 0.39 -3.95 -3.74 -5.50 -1.52 -1.95 -9.28 -7.00 -9.04
Cytoplasm -2.16 9.96 9.70 9.74 -4.32 -1.30 9.87 9.60 11.31 1.04 -5.11 7.63 12.49 16.61 4.34
Cytoplasmic Foci 2.44 26.57 44.58 32.57 3.21 19.40 48.20 43.78 29.00 -2.86 19.99 67.27 62.87 41.10 -3.36
Eisosomes 2.40 8.57 2.79 0.27 -1.98 1.54 7.83 4.28 3.96 -3.49 2.64 12.72 5.22 3.06 -4.48
Endoplasmic Reticulum -2.79 -7.45 -7.24 -2.58 5.87 0.20 -1.40 -1.54 -1.65 -0.48 -1.48 -5.41 -6.44 -4.17 -1.30
Endosome -6.80 1.29 9.62 12.09 4.87 1.37 11.17 2.79 1.88 -5.40 -2.72 14.79 8.07 9.96 -4.73
Golgi -0.08 17.02 16.39 12.23 -0.42 -1.45 11.74 6.48 8.44 -3.33 0.79 20.57 15.47 14.61 -2.99
Lipid Particles 3.46 -0.60 11.57 6.58 3.81 7.20 11.49 7.68 1.62 -3.43 9.26 15.32 13.39 5.30 -1.76
Mitochondria 5.97 16.59 15.75 7.30 -6.18 -3.43 7.78 7.70 12.94 1.26 2.60 16.21 16.78 15.62 2.44
Mitotic Spindle -0.91 -2.35 -3.24 -2.64 1.00 -4.90 -8.01 -7.71 -4.98 -2.51 -4.79 -8.44 -8.23 -5.12 -0.80
None -0.55 3.87 0.64 0.97 -1.77 1.35 3.35 3.34 3.91 0.06 0.83 4.56 1.81 1.12 -1.51
Nuclear Periphery -2.24 -4.69 -1.61 1.44 4.05 2.09 -2.15 -3.65 -6.05 -1.81 -0.28 -3.74 -3.90 -2.99 0.00
Nuclear Periphery Foci -4.95 -6.66 -6.74 -1.52 5.74 3.95 -3.47 -3.55 -4.22 -1.11 -2.85 -6.57 -6.84 -5.43 0.31
Nucleolus -1.48 3.13 2.92 2.21 -0.37 1.36 2.61 2.70 4.62 0.84 -0.45 3.91 3.98 3.08 0.52
Nucleus 7.33 1.14 5.60 -1.19 0.92 6.28 10.88 9.02 3.44 -0.51 8.48 11.61 10.29 2.43 -0.92
Peroxisomes 3.36 -0.69 -2.37 -4.97 -0.45 -8.92 -11.94 -3.76 4.04 6.82 -6.37 -11.43 -4.10 1.59 6.80
Vacuole -5.14 -8.57 -14.73 -11.05 3.40 -0.87 -13.07 -17.89 -17.71 -9.24 -4.12 -16.48 -23.29 -21.23 -8.69
Vacuole Periphery -3.02 9.87 8.20 8.40 -1.04 -3.97 11.89 -1.47 -0.18 -3.54 -3.20 14.55 1.32 2.96 -3.87
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Component of yeast cortical actin cytoskeleton; binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin
Localization
Cell Percentages cytoplasm (25%), actin (13%), mixed (19%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Scp1

Scp1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Scp1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available