Standard name | |
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Human Ortholog | |
Description | Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase); cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis; human ACAT1 functionally complements the growth defect caused by repression of ERG10 expression |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 |
Bud Neck | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 0 | 3 | 18 | 13 | 37 | 19 | 49 | 70 | 57 | 55 | 53 | 35 | 13 | 17 | 25 | 11 | 6 | 12 | 0 | 0 | 0 | 0 | 0 | 1 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 4 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 2 | 1 | 3 | 5 | 9 | 36 | 105 | 92 | 102 | 185 | 160 | 159 | 0 | 0 | 3 | 40 | 31 | 12 | 0 | 1 | 1 | 0 | 0 | 0 |
Nucleus | 106 | 75 | 316 | 299 | 464 | 336 | 577 | 555 | 332 | 501 | 298 | 361 | 146 | 173 | 187 | 203 | 196 | 168 | 106 | 85 | 303 | 17 | 126 | 115 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 17 | 17 | 27 | 66 | 118 | 136 | 309 | 313 | 219 | 378 | 229 | 298 | 11 | 21 | 25 | 27 | 32 | 21 | 2 | 2 | 12 | 0 | 7 | 15 |
Peroxisomes | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 4 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vac/Vac Membrane | 0 | 0 | 0 | 3 | 2 | 1 | 3 | 14 | 0 | 12 | 6 | 3 | 0 | 2 | 4 | 2 | 7 | 5 | 0 | 3 | 10 | 0 | 17 | 47 |
Unique Cell Count | 109 | 81 | 332 | 332 | 553 | 416 | 776 | 809 | 493 | 788 | 496 | 599 | 159 | 204 | 226 | 237 | 232 | 203 | 110 | 94 | 331 | 19 | 155 | 184 |
Labelled Cell Count | 125 | 97 | 364 | 386 | 633 | 528 | 1046 | 1048 | 710 | 1131 | 748 | 858 | 170 | 217 | 246 | 284 | 273 | 222 | 110 | 94 | 331 | 19 | 155 | 184 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 50.1 | 50.5 | 51.3 | 47.0 | 49.2 | 46.9 | 48.2 | 51.8 | 52.3 | 49.8 | 52.4 | 49.1 | 54.8 | 58.3 | 56.0 | 70.0 | 68.0 | 65.7 | – | 54.9 | 62.8 |
Std Deviation (1e-4) | 12.5 | 20.0 | 20.3 | 18.2 | 22.2 | 20.6 | 21.7 | 25.0 | 24.4 | 21.1 | 27.2 | 21.5 | 24.2 | 29.0 | 28.8 | 29.9 | 29.7 | 25.9 | – | 24.0 | 26.2 |
Intensity Change (Log2) | – | – | – | -0.13 | -0.06 | -0.13 | -0.09 | 0.01 | 0.03 | -0.04 | 0.03 | -0.06 | 0.09 | 0.18 | 0.13 | 0.45 | 0.41 | 0.36 | – | 0.1 | 0.29 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | -0.9 | 0.8 | -0.5 | 0.6 | 1.9 | 3.0 | 1.0 | 2.7 | 0.3 | 1.2 | 1.3 | 2.5 | -0.4 | -1.6 | 0.2 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 4.7 | 6.5 | 5.8 | 8.4 | 9.2 | 11.1 | 9.9 | 0 | 0 | 0 | 7.1 | 6.1 | 3.4 |
Nucleus | -2.5 | -5.0 | -5.9 | -8.0 | -9.6 | -9.6 | -10.9 | -11.3 | -11.5 | -1.5 | -4.1 | -4.8 | -4.0 | -4.3 | -4.7 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 4.4 | 5.1 | 8.1 | 10.5 | 10.3 | 11.2 | 12.7 | 11.6 | 12.8 | -0.5 | 0.9 | 1.2 | 1.3 | 2.2 | 0.9 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 45.48 | 53.5859 | 49.2696 | 46.9392 | 47.1964 | 48.8132 | 51.4461 | 67.069 | 59.0461 | 49.6085 | 53.9703 | 57.0907 | 60.0738 | 69.2033 | 61.9535 | 56.2704 | 61.5762 | 61.0377 |
Actin | 0.006 | 0 | 0.0167 | 0 | 0.0015 | 0 | 0.001 | 0 | 0.0002 | 0.0007 | 0.0219 | 0.0031 | 0.0017 | 0 | 0.0101 | 0.0001 | 0 | 0.003 |
Bud | 0.0007 | 0 | 0.0003 | 0 | 0 | 0.0001 | 0.0009 | 0 | 0 | 0.0001 | 0.0002 | 0.0004 | 0.0002 | 0 | 0.0002 | 0 | 0 | 0.0001 |
Bud Neck | 0.0002 | 0 | 0.0022 | 0 | 0.0001 | 0.0001 | 0.0001 | 0 | 0 | 0 | 0.0001 | 0.0005 | 0.0001 | 0 | 0.0001 | 0 | 0 | 0.0001 |
Bud Periphery | 0.0008 | 0 | 0.0004 | 0 | 0 | 0.0001 | 0.0005 | 0 | 0 | 0.0001 | 0.0003 | 0.0009 | 0.0002 | 0 | 0.0002 | 0 | 0 | 0.0001 |
Bud Site | 0.0015 | 0 | 0.0028 | 0 | 0.0001 | 0.0001 | 0.0004 | 0 | 0 | 0.0001 | 0.0002 | 0.0002 | 0.0009 | 0 | 0.0005 | 0 | 0 | 0 |
Cell Periphery | 0.0011 | 0 | 0.0001 | 0 | 0.0001 | 0.0002 | 0.0003 | 0 | 0 | 0.0003 | 0.0002 | 0.0007 | 0.0006 | 0 | 0 | 0 | 0 | 0.0005 |
Cytoplasm | 0.0023 | 0 | 0.0014 | 0 | 0.0003 | 0.0001 | 0.0008 | 0 | 0.0004 | 0.0009 | 0.0011 | 0.0001 | 0.0012 | 0 | 0.0014 | 0.0008 | 0 | 0.0002 |
Cytoplasmic Foci | 0.0205 | 0 | 0.0014 | 0 | 0.0335 | 0.0005 | 0.0001 | 0 | 0 | 0.0025 | 0.0004 | 0.0009 | 0.0116 | 0 | 0.0008 | 0.0001 | 0 | 0.0004 |
Eisosomes | 0.0002 | 0 | 0.0001 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0001 | 0 | 0.0003 | 0 | 0 | 0 | 0 | 0 |
Endoplasmic Reticulum | 0.0017 | 0 | 0.0025 | 0 | 0.0002 | 0 | 0.0002 | 0 | 0.0002 | 0.0005 | 0.0006 | 0.0001 | 0.0008 | 0 | 0.0002 | 0.0002 | 0 | 0.0001 |
Endosome | 0.0075 | 0 | 0.0064 | 0 | 0.0115 | 0 | 0.0005 | 0 | 0.0004 | 0.0029 | 0.0033 | 0.0013 | 0.0056 | 0 | 0.0024 | 0.0007 | 0 | 0.0013 |
Golgi | 0.0022 | 0 | 0.002 | 0 | 0.0041 | 0 | 0 | 0 | 0 | 0.0001 | 0.0014 | 0.0024 | 0.0016 | 0 | 0.0004 | 0 | 0 | 0.0006 |
Lipid Particles | 0.0096 | 0 | 0.001 | 0 | 0.0338 | 0.0002 | 0 | 0 | 0 | 0.0004 | 0.0006 | 0.0029 | 0.0047 | 0 | 0.0002 | 0 | 0 | 0.0005 |
Mitochondria | 0.0112 | 0.0003 | 0.0014 | 0.0004 | 0.0023 | 0.0013 | 0.007 | 0.0006 | 0.0097 | 0.0147 | 0.0145 | 0.006 | 0.008 | 0.0003 | 0.0013 | 0.0004 | 0.0027 | 0.0009 |
None | 0.0054 | 0 | 0.0006 | 0 | 0.0005 | 0.0001 | 0.0005 | 0 | 0.0001 | 0.0007 | 0.0005 | 0.0001 | 0.0023 | 0 | 0.0003 | 0.0001 | 0 | 0.0001 |
Nuclear Periphery | 0.0172 | 0.0001 | 0.0093 | 0.0004 | 0.0006 | 0.0002 | 0.0138 | 0.0002 | 0.0054 | 0.0202 | 0.0225 | 0.0011 | 0.0253 | 0.0001 | 0.0024 | 0.0107 | 0.0001 | 0.0041 |
Nucleolus | 0.0924 | 0.0148 | 0.0168 | 0.011 | 0.3105 | 0.0982 | 0.0376 | 0.0111 | 0.0323 | 0.0676 | 0.1585 | 0.0714 | 0.0764 | 0.011 | 0.0146 | 0.0132 | 0.0875 | 0.0536 |
Nucleus | 0.7996 | 0.9846 | 0.932 | 0.9881 | 0.5758 | 0.884 | 0.9326 | 0.9879 | 0.9502 | 0.8836 | 0.7687 | 0.9049 | 0.8499 | 0.9885 | 0.9625 | 0.9712 | 0.9093 | 0.928 |
Peroxisomes | 0.0025 | 0 | 0.0003 | 0 | 0.0166 | 0 | 0.0001 | 0 | 0 | 0.0002 | 0.0004 | 0.0007 | 0.0013 | 0 | 0.0003 | 0 | 0 | 0.0004 |
Punctate Nuclear | 0.0115 | 0 | 0.001 | 0 | 0.0078 | 0.0142 | 0.0018 | 0 | 0.0002 | 0.0005 | 0.0016 | 0.0005 | 0.0041 | 0 | 0.0008 | 0.0021 | 0 | 0.0048 |
Vacuole | 0.0023 | 0 | 0.0007 | 0 | 0.0002 | 0.0003 | 0.0007 | 0 | 0.0002 | 0.001 | 0.0008 | 0.0008 | 0.0011 | 0 | 0.0007 | 0.0001 | 0 | 0.0006 |
Vacuole Periphery | 0.0036 | 0 | 0.0006 | 0 | 0.0004 | 0.0003 | 0.0011 | 0.0002 | 0.0005 | 0.0028 | 0.0022 | 0.0012 | 0.002 | 0.0001 | 0.0005 | 0.0002 | 0.0003 | 0.0005 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 377.0196 | 327.968 | 368.107 | 338.5118 | 359.7446 | 396.1581 | 320.5684 | 318.8494 | 371.7675 | 329.6273 |
Translational Efficiency | 1.6985 | 1.7838 | 1.5737 | 2.0939 | 1.6085 | 1.5942 | 1.6747 | 1.8864 | 1.6075 | 1.6735 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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