Standard name
Human Ortholog
Description Protein of unknown function; mutant phenotype suggests a potential role in vacuolar function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; relocalizes from bud neck to cytoplasm upon DNA replication stress; SVL3 has a paralog, PAM1, that arose from the whole genome duplication

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.32 0.29 0.29 0.24 0.3 0.25 0.11 0.1 0.12 0.1 0.11 0.24 0.13 0.08 0.25 0.31 0.3 0.16 0.14 0.15 0.19 0.28 0.27
Bud 0.17 0.21 0.05 0.14 0.13 0.18 0.1 0.16 0.12 0.12 0.1 0.08 0 0 0.21 0.14 0.26 0.38 0.38 0.27 0.29 0.23 0.15
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.13 0.15 0.16 0.21 0.15 0.12
Bud Site 0.07 0.05 0.12 0.05 0.2 0.1 0 0.05 0 0 0.05 0 0 0 0 0 0
Cell Periphery 0.12 0.09 0.05 0.09 0.07 0.08 0.12 0.14 0.15 0.14 0.09 0.16 0.37 0.35 0.1 0.15 0.06 0.05 0 0 0.05 0.13 0.12
Cytoplasm 0.2 0.27 0.31 0.43 0.37 0.44 0.53 0.43 0.42 0.41 0.46 0.39 0.35 0.46 0.37 0.34 0.41 0 0.09 0.19 0.1 0.1 0.18
Endoplasmic Reticulum 0.18 0.15 0.07 0.1 0.07 0.07 0.11 0.06 0 0 0.05 0.3 0.4 0.26 0 0.05 0 0.09 0.05 0 0.06 0.05 0.08
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.08 0 0 0 0.15 0.21 0.09 0.3 0.29 0.4 0.27 0 0 0 0.06 0 0 0 0 0.05 0 0 0
Nucleus 0.08 0 0.05 0.07 0 0 0.06 0.07 0 0.05 0.08 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0.05 0 0 0 0 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0 0 0 0 0 0
Vac/Vac Membrane 0.11 0.19 0.21 0 0 0 0.1 0.08 0.08 0.08 0.07 0 0 0.1 0.2 0.16 0.2 0.06 0.06 0.05 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 54 60 12 14 14 29 17 15 22 12 14 37 35 20 25 23 21 36 38 13 36 65 84
Bud 29 43 2 8 6 21 15 25 21 15 13 12 6 7 21 10 18 83 103 25 54 53 47
Bud Neck 1 1 1 0 0 0 4 2 1 1 0 0 0 0 2 2 0 28 40 15 39 36 36
Bud Site 12 11 5 3 9 12 3 7 2 2 6 3 1 1 2 1 0
Cell Periphery 21 19 2 5 3 9 19 21 26 17 11 24 97 87 10 11 4 10 10 2 9 31 38
Cytoplasm 33 56 13 25 17 52 81 66 75 50 59 59 92 114 37 25 29 9 23 17 18 23 55
Endoplasmic Reticulum 30 31 3 6 3 8 17 9 7 5 6 46 106 65 1 4 1 20 15 2 12 12 25
Endosome 1 6 0 0 1 1 0 0 1 2 1 1 1 2 4 0 2 1 5 0 2 1 1
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 2 0 0 1 0 0 0 0
Mitochondria 14 3 0 2 7 25 14 46 51 49 34 0 1 1 6 0 1 5 4 4 4 2 5
Nucleus 13 6 2 4 2 5 10 11 7 6 10 6 2 9 1 2 1 5 3 1 0 0 0
Nuclear Periphery 0 0 0 0 0 0 1 1 4 1 0 0 0 2 0 0 0 2 2 1 0 0 0
Nucleolus 3 5 2 2 2 1 0 4 11 4 5 0 0 0 1 0 0 1 0 0 0 0 0
Peroxisomes 1 0 0 1 0 0 1 0 1 0 1 1 1 2 0 0 0 0 0 0 0 0 0
SpindlePole 5 2 2 1 0 2 4 0 5 3 1 0 1 1 1 5 0 1 6 2 0 0 0
Vac/Vac Membrane 18 40 9 0 1 1 16 13 15 10 9 1 11 25 20 12 14 13 17 4 3 5 5
Unique Cell Count 169 207 42 58 46 117 154 153 177 121 128 152 263 250 99 74 70 221 274 94 188 235 310
Labelled Cell Count 235 283 53 71 65 166 202 220 249 177 170 190 354 336 132 97 91 221 274 94 188 235 310


Ambiguous, Bud, Bud Neck, Cell Periphery, Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 9.5 9.5 8.4 8.4 6.3 7.0 7.6 6.3 6.3 6.1 6.2 9.6 9.5 9.2 12.3 12.8 11.6 9.0 8.4 8.4
Std Deviation (1e-4) 2.9 2.7 1.9 1.9 1.2 1.6 1.9 1.9 1.7 1.5 1.5 1.9 1.5 1.6 3.6 3.6 3.1 1.7 1.2 1.4
Intensity Change (Log2) 0.01 -0.42 -0.26 -0.14 -0.4 -0.4 -0.47 -0.44 0.21 0.19 0.14 0.56 0.62 0.47 0.1 -0.0 0.01

WT3RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP700051015WT3HU80HU120HU160051015WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3051015WT1AF100AF140AF180051015
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -0.5 0.2 -0.5 -2.8 -3.1 -2.6 -2.9 -2.8 -0.6 -2.5 0 -0.4 0.3 0.2
Bud 0 0 2.1 0 1.9 0 0 0 0 0 0 2.4 0 2.8
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 1.0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 1.7 0 0 1.9 4.1 3.9 0 0 0
Cytoplasm 1.2 0.6 1.5 2.5 1.4 1.4 1.2 1.7 0.9 0.5 1.8 0.7 0.3 1.1
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 3.1 4.2 2.7 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 3.3 0 4.1 4.0 4.9 3.7 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 -1.9 0 0 0 0 0 0 0 -0.2 -0.7 -0.2

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 8.4512 7.4362 8.1643 8.3679 7.0856 9.1246 7.4433 6.6224 6.9732 8.9765 7.2048 7.9815 6.913 6.4205 6.1773 7.2118 6.1406 7.2727
Actin 0.0943 0.014 0.0599 0.0127 0.1032 0.0449 0.1101 0.0325 0.014 0.0066 0.016 0.0667 0.1157 0.0428 0.0161 0.0294 0.0891 0.0431
Bud 0.0469 0.0454 0.3164 0.1374 0.1077 0.0132 0.0369 0.0785 0.2706 0.113 0.1212 0.0188 0.0221 0.0328 0.3123 0.1764 0.1127 0.0244
Bud Neck 0.0667 0.0339 0.0064 0.0027 0.0692 0.6344 0.066 0.0181 0.0083 0.0047 0.0137 0.5588 0.0976 0.0235 0.0136 0.0044 0.001 0.568
Bud Periphery 0.1375 0.1051 0.4377 0.7202 0.6293 0.0741 0.1387 0.1152 0.5016 0.7383 0.6648 0.1132 0.0623 0.0674 0.4587 0.5669 0.6547 0.1392
Bud Site 0.2049 0.5414 0.0958 0.0177 0.0112 0.0132 0.1618 0.5409 0.123 0.0076 0.0168 0.0153 0.2103 0.5346 0.086 0.0378 0.0134 0.0221
Cell Periphery 0.1648 0.0467 0.0124 0.0237 0.0193 0.0532 0.1616 0.029 0.0105 0.0602 0.0533 0.0607 0.1534 0.0316 0.0164 0.0192 0.0168 0.0479
Cytoplasm 0.1517 0.1486 0.0127 0.0049 0.0013 0.1245 0.1757 0.0868 0.0107 0.0103 0.007 0.0991 0.1463 0.1845 0.032 0.0239 0.0015 0.1046
Cytoplasmic Foci 0.0128 0.0009 0.0056 0.0171 0.0066 0.0021 0.0265 0.002 0.0025 0.0002 0.0023 0.0031 0.0232 0.0042 0.0015 0.0352 0.0008 0.0071
Eisosomes 0.0022 0.0005 0.0021 0.0003 0.0005 0.0002 0.002 0.0002 0.0003 0 0.0003 0.0004 0.0024 0.0006 0.0001 0.0001 0.0005 0.0003
Endoplasmic Reticulum 0.0213 0.0044 0.0054 0.0079 0.0014 0.0083 0.0216 0.0056 0.0028 0.0034 0.0024 0.0098 0.0281 0.0059 0.0055 0.0041 0.0018 0.0099
Endosome 0.0165 0.0005 0.0067 0.0014 0.0056 0.0025 0.0239 0.0008 0.0082 0.0007 0.0148 0.0068 0.0341 0.0012 0.0022 0.0053 0.0057 0.0012
Golgi 0.006 0.0003 0.0056 0.0013 0.0104 0.0012 0.0132 0.0007 0.0061 0.0001 0.0074 0.0051 0.0227 0.0006 0.0025 0.0013 0.002 0.001
Lipid Particles 0.0089 0.0003 0.006 0.0098 0.0097 0.0015 0.0147 0.0003 0.0014 0.0001 0.003 0.0036 0.0115 0.0014 0.009 0.0009 0.0007 0.0016
Mitochondria 0.0028 0.0004 0.0062 0.0064 0.0012 0.0006 0.0047 0.0075 0.0104 0.0005 0.0128 0.0054 0.0047 0.0009 0.0124 0.0014 0.078 0.0004
None 0.0092 0.0011 0.0044 0.0011 0.0006 0.0009 0.0024 0.0013 0.0006 0.0001 0.0003 0.001 0.0166 0.0127 0.0004 0.0002 0.0018 0.0098
Nuclear Periphery 0.013 0.0027 0.0023 0.0024 0.0014 0.0053 0.0058 0.0042 0.0071 0.0023 0.0014 0.0058 0.0088 0.0036 0.0017 0.0042 0.0049 0.0032
Nucleolus 0.0044 0.0024 0.0007 0.0003 0.0002 0.0006 0.0038 0.0018 0.0009 0.0013 0.002 0.0061 0.0049 0.0009 0.0009 0.0005 0.0012 0.0006
Nucleus 0.0089 0.0395 0.0034 0.004 0.0005 0.0112 0.0034 0.0595 0.0115 0.0152 0.0529 0.0066 0.0064 0.0404 0.0228 0.0432 0.0058 0.0055
Peroxisomes 0.0032 0.0001 0.0041 0.0187 0.0141 0.0004 0.0097 0.0003 0.0008 0 0.0009 0.0008 0.0036 0.0007 0.001 0.0134 0.0014 0.0007
Punctate Nuclear 0.0148 0.0018 0.0019 0.0016 0.0037 0.0016 0.0075 0.0091 0.0017 0.0001 0.0003 0.002 0.0121 0.0047 0.0005 0.003 0.0006 0.0045
Vacuole 0.0085 0.0094 0.0037 0.0064 0.0024 0.0055 0.0089 0.0053 0.0053 0.0328 0.0054 0.0099 0.0117 0.0045 0.0043 0.0247 0.0031 0.0046
Vacuole Periphery 0.0008 0.0005 0.0007 0.0023 0.0004 0.0006 0.001 0.0003 0.0016 0.0025 0.0009 0.0007 0.0013 0.0004 0.0004 0.0046 0.0023 0.0003

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 63.2298 58.9119 23.6298 30.1234 58.3099 49.3987 55.038 41.2894 23.1834 62.5686
Translational Efficiency 1.1634 1.2137 0.9865 0.574 0.8545 1.1558 0.8444 0.7048 0.9221 0.779

Hit Data

Dataset Hit
Protein Concentration
Protein Localization
Gene Expression
Translational Efficiency

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
833 1528 691 1127 1204 1784 1621 2724 2037 3312 2312 3851

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 877.66 966.49 1370.16 1251.16 872.83 1020.19 1243.77 1347.73 874.81 995.42 1281.54 1319.47
Standard Deviation 125.17 183.91 203.59 203.71 171.61 162.12 217.36 232.78 154.34 174.58 221.05 228.92
Intensity Change Log 2 0.139093 0.642610 0.511532 0.225065 0.510947 0.626759 0.182601 0.578462 0.570137

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.016063 0.015315 0.024982 0.021035 0.016165 0.012953 0.008237 0.007495 0.016123 0.014042 0.013242 0.011458
Bud Neck 0.169225 0.122147 0.195906 0.134382 0.128163 0.174688 0.139031 0.160886 0.144955 0.150448 0.156030 0.153130
Bud Site 0.562819 0.595013 0.626889 0.584636 0.524946 0.613774 0.547786 0.477809 0.540434 0.605118 0.571428 0.509072
Cell Periphery 0.048160 0.026974 0.042838 0.030913 0.072402 0.084302 0.029159 0.046081 0.062489 0.057854 0.033247 0.041642
Cytoplasm 0.112433 0.107151 0.012247 0.073363 0.109477 0.054389 0.098571 0.140927 0.110686 0.078731 0.072771 0.121154
Cytoplasmic Foci 0.013734 0.016184 0.001374 0.003667 0.026198 0.006370 0.006178 0.000986 0.021101 0.010898 0.004742 0.001771
Eisosomes 0.001925 0.000965 0.003274 0.001854 0.002716 0.001702 0.001148 0.001177 0.002392 0.001362 0.001784 0.001375
Endoplasmic Reticulum 0.009362 0.016260 0.019019 0.014577 0.019665 0.005971 0.012455 0.005132 0.015452 0.010718 0.014417 0.007896
Endosome 0.002187 0.005067 0.000966 0.001200 0.005668 0.002067 0.001468 0.000600 0.004244 0.003451 0.001318 0.000776
Golgi 0.001574 0.002265 0.000254 0.000869 0.002652 0.001218 0.000325 0.000123 0.002211 0.001701 0.000304 0.000341
Lipid Particles 0.002268 0.001986 0.000820 0.000860 0.003854 0.000608 0.001517 0.000346 0.003205 0.001244 0.001308 0.000497
Mitochondria 0.003889 0.004844 0.001880 0.002523 0.003908 0.002711 0.003391 0.005485 0.003900 0.003695 0.002940 0.004618
Mitotic Spindle 0.000751 0.001320 0.000907 0.003248 0.001086 0.001245 0.002624 0.006909 0.000949 0.001280 0.002111 0.005837
None 0.000496 0.001132 0.000126 0.000527 0.003595 0.000534 0.002563 0.001759 0.002328 0.000810 0.001834 0.001398
Nuclear Periphery 0.000105 0.000083 0.000149 0.000195 0.000122 0.000043 0.000275 0.000225 0.000115 0.000062 0.000237 0.000216
Nuclear Periphery Foci 0.000693 0.000932 0.000339 0.000877 0.001760 0.000234 0.000585 0.000052 0.001324 0.000556 0.000512 0.000293
Nucleolus 0.000365 0.000467 0.000113 0.000077 0.000541 0.000283 0.000475 0.000225 0.000469 0.000368 0.000367 0.000182
Nucleus 0.026718 0.044582 0.039429 0.060871 0.046711 0.019181 0.090252 0.094054 0.038535 0.030900 0.075062 0.084343
Peroxisomes 0.002308 0.002622 0.000257 0.000347 0.002679 0.001249 0.000564 0.000381 0.002528 0.001882 0.000472 0.000371
Vacuole 0.024532 0.033383 0.027913 0.063707 0.026824 0.016128 0.052942 0.049015 0.025887 0.024089 0.045462 0.053315
Vacuole Periphery 0.000393 0.001310 0.000317 0.000270 0.000868 0.000350 0.000452 0.000331 0.000674 0.000793 0.000412 0.000313

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 0.30 -2.66 -0.37 -0.82 2.63 1.74 5.15 6.16 4.88 2.14 1.37 2.19 4.58 3.90 3.40
Bud Neck 4.75 -1.28 6.08 1.86 8.52 -5.48 0.24 -1.44 5.17 -2.06 -0.82 0.24 2.55 4.09 2.73
Bud Site -1.83 -1.06 8.17 11.42 9.53 -7.26 2.65 11.28 22.60 9.05 -6.65 2.31 14.57 25.20 12.62
Cell Periphery 4.38 1.69 5.47 1.81 3.98 -2.00 9.27 7.22 10.82 -3.54 1.13 8.82 8.49 9.07 -0.75
Cytoplasm 0.46 13.79 1.68 1.46 -13.98 8.51 0.66 -7.66 -19.41 -9.05 6.04 5.89 -6.06 -14.01 -13.23
Cytoplasmic Foci -1.24 6.79 4.95 7.97 -3.64 8.19 8.40 10.83 6.44 7.10 5.99 10.11 12.16 11.24 4.78
Eisosomes 3.53 -1.58 1.91 -2.07 2.55 2.58 4.86 5.29 3.27 0.96 4.07 2.66 5.80 1.90 2.73
Endoplasmic Reticulum -3.19 -4.18 -2.94 0.52 2.17 6.79 2.30 7.16 0.53 8.89 3.02 -0.70 4.94 2.63 7.77
Endosome -4.41 2.86 2.04 6.05 -0.78 4.61 5.78 7.23 3.71 4.86 1.47 6.24 7.69 7.50 3.98
Golgi -1.23 3.79 1.99 2.95 -0.93 2.65 5.64 6.37 2.96 1.43 1.29 6.67 6.66 4.74 0.24
Lipid Particles 0.29 1.09 0.44 0.29 -2.14 5.03 3.09 5.09 -0.04 3.80 3.82 2.99 4.51 1.50 2.91
Mitochondria -0.64 1.34 1.31 2.63 0.19 1.25 0.61 -1.29 -3.71 -2.50 0.25 1.14 -0.48 -1.01 -2.33
Mitotic Spindle -1.55 -1.28 -3.97 -3.46 -3.58 -0.34 -3.21 -5.63 -5.41 -2.47 -1.13 -3.45 -6.89 -6.40 -3.67
None -3.07 2.89 -2.27 1.53 -5.90 2.59 0.92 1.42 -4.08 0.77 2.16 0.72 1.02 -3.60 0.31
Nuclear Periphery 0.33 -3.59 -7.65 -11.33 -4.90 4.57 -9.96 -9.93 -12.00 -2.51 2.21 -9.28 -11.86 -15.33 -4.36
Nuclear Periphery Foci -1.24 1.20 -2.18 -1.30 -3.64 5.02 3.30 5.48 2.90 7.44 3.76 3.33 4.32 1.23 2.31
Nucleolus -0.49 0.98 1.06 2.67 0.63 0.88 0.53 2.43 0.27 0.82 0.45 0.69 2.20 1.18 0.85
Nucleus -4.71 -6.82 -15.50 -11.94 -5.85 6.56 -11.96 -19.07 -28.90 -4.90 2.15 -14.52 -25.25 -29.12 -7.12
Peroxisomes -0.50 5.12 4.92 4.37 -1.60 3.59 6.26 6.75 3.44 1.18 1.77 7.89 8.25 5.42 0.91
Vacuole -3.18 -5.35 -18.43 -17.08 -14.15 4.61 -13.17 -16.26 -22.22 0.45 0.63 -14.32 -24.32 -25.76 -7.71
Vacuole Periphery -3.62 0.37 1.44 4.57 1.82 4.31 3.41 4.71 0.79 1.27 -0.89 2.93 4.56 4.38 1.72
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Componentsactinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein of unknown function; mutant phenotype suggests a potential role in vacuolar function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; relocalizes from bud neck to cytoplasm upon DNA replication stress; SVL3 has a paralog, PAM1, that arose from the whole genome duplication
Localization
Cell Percentages cell periphery (16%)
Cell Cycle Regulation No
Subcompartmental Group cell periphery-3

Svl3

Svl3


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)

Molecular Function (Gene Ontology)

Cellular Component (Gene Ontology)


Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Svl3-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available