Standard name
Human Ortholog
Description Phosphoinositide binding protein; required for vesicle formation in the cytoplasm-to-vacuole targeting (CVT) pathway, autophagy, micronucleophagy and mitophagy; binds to several phosphoinositides including: PtdIns(3,5)P2, PI3P and PI4P; involved in PI3P-dependent recruitment and organization of both the Atg12-Atg5-Atg16 complex and Atg8p at the pre-autophagosomal structure; necessary for oxidant-induced cell death; WD-40 repeat containing PROPPIN family member
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0.06 0 0 0.06 0 0.07 0.08 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0.09 0.09 0.15 0.14 0.19 0.21 0.2 0.14 0.22 0.21 0 0 0.05 0.22 0.17 0.1 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0.24 0.51 0.46 0.51 0.45 0.38 0.29 0.26 0.16 0.11 0.08 0.08 0.75 0.82 0.8 0.58 0.57 0.62 0.74 0.76 0.75 0.83 0.82 0.78
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.63 0.11 0.32 0.28 0.32 0.44 0.59 0.53 0.59 0.75 0.67 0.68 0 0 0 0.1 0.08 0.06 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.2 0.07 0.24 0.15 0 0 0 0 0 0.05 0 0 0.18 0.22 0.13 0 0.08 0.08 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0.07 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0.1 0.05 0.18 0.18 0.07 0.13 0.06 0.08 0.05 0.09 0.06 0.07 0.15 0.19 0.13 0.13 0.17 0.25 0 0 0.06 0.07 0 0
Vac/Vac Membrane 0.38 0.55 0.15 0.3 0.19 0.12 0.11 0.16 0.1 0.08 0.08 0.11 0.45 0.38 0.4 0.43 0.38 0.39 0.14 0.11 0.06 0 0.06 0.1
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 1 3 0 0 0 0 1 0 1 1 0 1 0 0 0 2 1 1 1 0 0 1 0
Bud 4 1 3 0 4 10 3 8 11 6 10 12 0 0 0 1 0 1 0 1 0 0 2 4
Bud Neck 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 1 0 2 1 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 4 8 10 8 18 21 31 47 34 25 32 31 16 9 21 22 24 11 0 2 2 0 3 3
Endoplasmic Reticulum 0 5 2 0 1 0 1 3 7 8 5 1 1 0 1 2 6 5 0 0 1 0 0 1
Endosome 63 120 52 45 55 59 48 59 28 19 11 12 277 249 339 59 82 70 201 199 95 168 234 247
Golgi 0 1 0 0 3 0 1 0 0 0 0 0 0 0 0 1 4 2 3 3 0 0 2 3
Mitochondria 163 25 36 25 39 68 98 120 103 133 97 103 16 7 8 10 11 7 10 7 2 2 5 9
Nucleus 2 2 1 1 0 1 0 1 1 0 2 1 3 2 1 7 4 0 0 0 0 0 0 0
Nuclear Periphery 1 7 3 1 0 1 1 0 0 1 0 0 5 6 3 3 1 2 2 3 2 2 2 1
Nucleolus 53 17 27 13 5 5 6 4 2 8 2 6 66 67 55 4 12 9 0 0 0 0 1 0
Peroxisomes 0 1 1 2 0 11 6 7 5 4 1 4 11 6 9 0 1 0 2 1 1 2 1 2
SpindlePole 26 11 20 16 9 20 10 19 9 16 9 11 54 58 56 13 24 28 9 8 7 14 10 5
Vac/Vac Membrane 99 129 17 27 23 18 19 36 17 14 12 17 168 114 172 43 55 44 37 27 7 8 18 32
Unique Cell Count 259 234 113 89 121 154 167 228 174 177 144 151 371 302 426 101 143 113 272 263 127 204 285 317
Labelled Cell Count 415 328 175 138 157 214 225 305 217 236 182 201 619 518 665 165 226 180 272 263 127 204 285 317


Ambiguous, Endosome

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.0 6.2 5.3 5.6 5.6 4.9 4.5 5.0 4.8 4.5 4.8 4.7 6.4 6.4 6.5 7.1 7.9 7.9 5.3 5.5 6.2
Std Deviation (1e-4) 0.6 1.1 1.1 1.5 1.8 1.2 1.4 1.4 1.1 1.3 1.4 1.4 1.2 1.1 2.0 2.0 1.5 1.4 1.3 1.2 1.3
Intensity Change (Log2) – – – 0.08 0.08 -0.1 -0.23 -0.09 -0.14 -0.23 -0.14 -0.17 0.28 0.27 0.3 0.43 0.57 0.57 0.01 0.04 0.24

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70002468WT3HU80HU120HU16002468WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302468WT1AF100AF140AF18002468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 1.4 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 1.4 1.2 2.3 2.7 2.5 1.3 2.9 2.6 -1.9 -2.5 -1.6 2.6 1.9 0.2
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0.6 -0.1 -1.3 0 -3.7 0 0 0 0 5.7 7.4 7.1 1.8 1.8 2.4
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria -0.6 0.1 2.0 0 3.6 0 0 0 0 -8.3 -8.8 -10.3 -3.9 -5.0 -4.9
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus -1.6 -4.4 -5.1 0 -6.7 0 0 0 0 -1.4 -0.4 -2.9 -4.1 -3.4 -3.3
Peroxisomes 0 0 2.4 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0.1 -2.4 -1.1 0 -2.6 0 0 0 0 -0.8 0.3 -1.2 -1.0 -0.2 1.3
Vacuole 2.6 0.8 -0.8 -0.9 0.2 -1.4 -1.9 -1.7 -0.9 5.8 4.4 5.0 4.5 4.1 4.0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.8174 3.2673 2.8224 2.311 2.3838 2.8223 3.3476 3.9143 3.957 3.3878 3.1371 3.9398 4.528 5.6473 5.2962 5.2875 4.6449 5.2825
Actin 0.0275 0 0.0248 0.0575 0.0451 0.0018 0.0424 0.0005 0.0433 0.0269 0 0.004 0.0004 0 0.0003 0 0 0.0011
Bud 0.0002 0.0001 0.0003 0.0004 0.0004 0.0002 0.0003 0.0004 0.0006 0.0003 0 0.0001 0.0001 0.0001 0.0001 0 0 0.0001
Bud Neck 0.0006 0.0004 0.0011 0.0009 0.0003 0.0007 0.0008 0.0004 0.0008 0.0004 0.0001 0.0003 0.0004 0.0007 0.0005 0.0001 0.0001 0.0006
Bud Periphery 0.0002 0.0001 0.0005 0.0006 0.0008 0.0004 0.0004 0.0002 0.0008 0.0004 0 0.0001 0.0001 0.0001 0.0002 0 0 0.0001
Bud Site 0.0048 0.0007 0.0021 0.0022 0.0009 0.0005 0.0023 0.0021 0.0244 0.0009 0.0001 0.0002 0.0003 0.0004 0.0007 0.0001 0.0001 0.0003
Cell Periphery 0.0001 0.0001 0.0001 0.0002 0.0002 0.0002 0.0002 0.0002 0.0006 0.0004 0 0.0001 0.0001 0.0001 0.0002 0 0 0.0001
Cytoplasm 0.0213 0.0071 0.0017 0.0011 0.0012 0.0043 0.0068 0.0028 0.0064 0.0016 0.0018 0.0009 0.0105 0.0017 0.0034 0.0013 0.001 0.0015
Cytoplasmic Foci 0.1295 0.1132 0.1297 0.0955 0.0954 0.0927 0.1104 0.1425 0.1596 0.132 0.0753 0.0929 0.1269 0.1035 0.1403 0.1168 0.1003 0.0881
Eisosomes 0.0001 0 0.0002 0.0005 0.0005 0 0.0003 0 0.0004 0.0002 0 0 0 0 0 0 0 0.0001
Endoplasmic Reticulum 0.0012 0.0005 0.0005 0.0014 0.0016 0.0011 0.0007 0.0004 0.0034 0.0018 0.0006 0.0004 0.0014 0.0013 0.0006 0.0001 0.0003 0.0005
Endosome 0.4255 0.512 0.5289 0.615 0.3948 0.4421 0.4704 0.4892 0.3503 0.5108 0.7177 0.5198 0.4944 0.5182 0.5125 0.6985 0.6762 0.4946
Golgi 0.0408 0.0418 0.0693 0.0706 0.0524 0.0549 0.0583 0.0508 0.0608 0.1267 0.0772 0.0629 0.0403 0.0429 0.0706 0.0688 0.0753 0.0623
Lipid Particles 0.2369 0.1973 0.1441 0.0997 0.2898 0.2911 0.1976 0.2165 0.1986 0.0809 0.052 0.2116 0.229 0.2172 0.1679 0.0544 0.1097 0.2594
Mitochondria 0.0018 0.0014 0.0041 0.0045 0.0152 0.0075 0.016 0.0026 0.0288 0.0213 0.0016 0.0023 0.002 0.0019 0.0107 0.0005 0.0009 0.0025
None 0.0017 0.0003 0.0118 0.0071 0.0039 0.0003 0.0236 0.0005 0.0017 0.0003 0.0001 0.0002 0.0043 0.0005 0.0009 0.0001 0.0001 0.0077
Nuclear Periphery 0.0027 0.0023 0.0013 0.0028 0.0276 0.0032 0.001 0.0012 0.0015 0.0009 0.0009 0.0014 0.0031 0.0019 0.001 0.0002 0.0005 0.0025
Nucleolus 0.0014 0.0014 0.0026 0.0007 0.0014 0.0025 0.0006 0.0019 0.0009 0.0003 0.0001 0.0008 0.0015 0.0018 0.0011 0.0001 0.0001 0.0012
Nucleus 0.0027 0.0006 0.0007 0.0005 0.0014 0.0037 0.0021 0.0003 0.0005 0.0003 0.0001 0.0007 0.0019 0.0004 0.0005 0.0001 0.0001 0.0007
Peroxisomes 0.0324 0.0254 0.0292 0.0252 0.0372 0.0217 0.0487 0.0297 0.0681 0.0283 0.0128 0.0399 0.0349 0.0219 0.0283 0.0272 0.0146 0.0366
Punctate Nuclear 0.047 0.0048 0.0033 0.0027 0.0032 0.0057 0.0051 0.0024 0.0024 0.0006 0.0002 0.0008 0.009 0.0009 0.0011 0.0004 0.0013 0.003
Vacuole 0.0154 0.0709 0.0352 0.0072 0.02 0.0499 0.0085 0.0366 0.0343 0.0489 0.0288 0.0453 0.0292 0.0549 0.0423 0.0258 0.0131 0.0281
Vacuole Periphery 0.0062 0.0195 0.0084 0.0037 0.0068 0.0154 0.0035 0.0185 0.0117 0.0157 0.0304 0.0156 0.0102 0.0297 0.0168 0.0053 0.0061 0.0089

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 9.9906 4.6309 11.2907 9.8067 9.595 8.136 8.0268 10.6093 11.1938 13.1804
Translational Efficiency 0.862 1.706 0.6568 1.1449 1.0178 1.4559 1.4865 1.029 1.1751 0.7648

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
77 1576 1974 1290 2180 1687 133 186 2257 3263 2107 1476

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 730.70 774.53 896.77 963.64 770.27 802.18 1137.78 1085.38 768.92 788.83 911.98 978.98
Standard Deviation 68.45 110.61 114.59 149.55 90.94 100.92 127.27 161.96 90.55 106.61 129.46 156.47
Intensity Change Log 2 — 0.084042 0.295459 0.399215 — 0.058562 0.562785 0.494764 — 0.071022 0.438815 0.449039

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000120 0.000243 0.000216 0.000798 0.000042 0.000078 0.000621 0.002474 0.000044 0.000158 0.000241 0.001009
Bud Neck 0.017246 0.004225 0.011161 0.003936 0.002460 0.002903 0.009265 0.005148 0.002965 0.003541 0.011041 0.004089
Bud Site 0.004303 0.007016 0.004514 0.019840 0.001881 0.002412 0.006739 0.013831 0.001964 0.004636 0.004655 0.019083
Cell Periphery 0.000330 0.000044 0.000118 0.000080 0.000027 0.000044 0.000090 0.000071 0.000038 0.000044 0.000116 0.000079
Cytoplasm 0.027779 0.010043 0.003027 0.016071 0.002123 0.002190 0.002690 0.012982 0.002998 0.005983 0.003006 0.015682
Cytoplasmic Foci 0.121921 0.126748 0.040521 0.079009 0.076538 0.081497 0.063782 0.097931 0.078086 0.103353 0.041989 0.081393
Eisosomes 0.000128 0.000018 0.000061 0.000016 0.000012 0.000020 0.000041 0.000017 0.000016 0.000019 0.000060 0.000016
Endoplasmic Reticulum 0.000599 0.000231 0.002635 0.000973 0.000277 0.000380 0.003775 0.001658 0.000288 0.000308 0.002707 0.001059
Endosome 0.511799 0.664005 0.456986 0.373808 0.785552 0.701002 0.396173 0.405324 0.776212 0.683133 0.453147 0.377780
Golgi 0.036676 0.057289 0.028024 0.060318 0.055558 0.058354 0.024884 0.042482 0.054913 0.057840 0.027826 0.058070
Lipid Particles 0.047693 0.004401 0.014226 0.002351 0.009381 0.009854 0.005430 0.003492 0.010688 0.007220 0.013671 0.002495
Mitochondria 0.013833 0.011028 0.027742 0.009726 0.011024 0.020543 0.001657 0.003615 0.011120 0.015947 0.026095 0.008956
Mitotic Spindle 0.002453 0.012625 0.023411 0.018560 0.002244 0.008376 0.059211 0.019883 0.002251 0.010428 0.025671 0.018726
None 0.000269 0.000273 0.000641 0.000443 0.000141 0.000364 0.000066 0.003880 0.000146 0.000320 0.000604 0.000876
Nuclear Periphery 0.000568 0.000234 0.004851 0.001075 0.000139 0.000656 0.006511 0.002044 0.000153 0.000452 0.004956 0.001197
Nuclear Periphery Foci 0.005165 0.001482 0.021353 0.005678 0.001677 0.003172 0.027031 0.007394 0.001796 0.002356 0.021711 0.005894
Nucleolus 0.009072 0.001181 0.024069 0.001051 0.000511 0.001645 0.010422 0.001363 0.000803 0.001421 0.023207 0.001091
Nucleus 0.034075 0.001260 0.018123 0.001447 0.000451 0.001299 0.011389 0.001939 0.001598 0.001280 0.017698 0.001509
Peroxisomes 0.034016 0.012600 0.013540 0.006077 0.013734 0.011054 0.028723 0.009390 0.014426 0.011801 0.014499 0.006494
Vacuole 0.101052 0.065670 0.232388 0.343798 0.027993 0.068161 0.254712 0.318492 0.030486 0.066958 0.233797 0.340609
Vacuole Periphery 0.030901 0.019386 0.072395 0.054944 0.008234 0.025995 0.086785 0.046593 0.009007 0.022803 0.073303 0.053892

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -0.97 -2.57 -1.63 -1.28 -1.36 -1.71 -2.38 -1.03 -1.02 -0.70 -1.90 -6.81 -2.06 -1.80 -1.57
Bud Neck 1.76 0.79 1.79 0.18 8.08 -0.59 -4.25 -2.12 -1.70 2.24 -0.87 -8.94 -2.12 -1.20 8.22
Bud Site -1.27 -0.17 -6.26 -7.03 -9.36 -1.16 -4.50 -3.28 -3.14 -1.63 -4.69 -6.35 -11.45 -9.40 -9.52
Cell Periphery 1.49 1.10 1.31 -4.60 4.23 -2.05 -3.07 -2.82 -1.61 1.34 -0.76 -7.77 -4.62 -5.12 4.51
Cytoplasm 2.13 3.01 1.25 -3.08 -7.14 -0.02 -1.04 -2.56 -2.57 -2.30 -3.73 -0.22 -7.52 -5.76 -7.49
Cytoplasmic Foci -0.28 5.54 2.95 10.87 -11.88 -1.36 1.76 -2.08 -1.59 -2.83 -7.89 13.24 -0.71 6.42 -12.46
Eisosomes 3.69 2.19 3.76 1.00 16.81 -3.72 -4.18 -1.11 0.89 3.34 -1.36 -16.17 0.21 1.77 17.14
Endoplasmic Reticulum 3.04 -10.88 -2.43 -6.61 9.02 -0.72 -2.50 -2.27 -2.14 1.62 -0.18 -11.31 -4.36 -6.01 8.02
Endosome -3.90 1.40 3.56 29.85 8.56 10.41 15.93 18.37 14.11 -0.36 13.60 39.57 46.60 37.27 8.14
Golgi -2.38 1.02 -2.48 -0.44 -8.75 -0.86 6.82 1.97 2.33 -2.22 -1.07 11.17 -0.49 0.31 -8.93
Lipid Particles 3.44 2.65 3.60 3.86 9.59 -0.19 2.56 4.55 4.36 1.55 2.82 -1.91 7.24 6.57 9.61
Mitochondria 0.72 -3.40 1.07 0.83 8.11 -4.99 9.56 3.62 6.80 -0.97 -3.58 -8.14 1.50 4.38 8.40
Mitotic Spindle -4.33 -8.03 -6.39 -2.65 1.42 -6.06 -3.97 -3.06 -2.11 2.44 -8.25 -11.00 -8.72 -4.35 2.14
None -0.04 -2.77 -0.49 -0.48 0.61 -0.83 0.81 -1.06 -0.99 -1.08 -1.12 -4.71 -1.36 -0.98 -0.46
Nuclear Periphery 1.81 -10.70 -2.23 -4.92 9.33 -2.10 -3.32 -2.76 -1.94 2.09 -2.29 -13.38 -6.05 -3.59 9.25
Nuclear Periphery Foci 0.87 -3.66 -0.17 -3.90 7.53 -1.72 -3.85 -2.73 -2.01 2.80 -0.95 -11.34 -3.97 -3.48 7.98
Nucleolus 1.40 -2.60 1.43 0.42 13.46 -2.34 -3.37 -1.85 0.34 3.04 -1.66 -13.87 -0.85 0.91 13.71
Nucleus 2.24 1.05 2.24 -0.33 11.82 -1.75 -2.55 -2.24 -1.00 2.22 0.40 -11.27 -0.01 -0.70 11.98
Peroxisomes 3.12 3.01 4.14 5.24 6.99 1.94 -2.59 2.01 0.86 3.24 2.03 -0.12 6.46 5.67 7.51
Vacuole 1.95 -7.17 -12.80 -33.85 -12.72 -12.05 -11.69 -14.14 -12.10 -2.37 -13.61 -41.24 -42.18 -36.70 -12.88
Vacuole Periphery 1.10 -3.91 -2.22 -13.16 5.39 -10.69 -6.77 -7.71 -3.92 3.13 -11.38 -26.13 -19.92 -12.91 6.24
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Phosphoinositide binding protein; required for vesicle formation in the cytoplasm-to-vacuole targeting (CVT) pathway, autophagy, micronucleophagy and mitophagy; binds to several phosphoinositides including: PtdIns(3,5)P2, PI3P and PI4P; involved in PI3P-dependent recruitment and organization of both the Atg12-Atg5-Atg16 complex and Atg8p at the pre-autophagosomal structure; necessary for oxidant-induced cell death; WD-40 repeat containing PROPPIN family member
Localization
Cell Percentages endosome (78%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Atg21

Atg21


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Atg21-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available