Standard name
Human Ortholog
Description Rho GTPase activating protein (RhoGAP); involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly
DOWNLOAD

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.18 0.18 0.11 0.07 0.07 0.05 0.05 0 0 0 0 0 0.05 0 0 0.14 0.11 0.14 0.13 0.1 0.09 0.12 0.1 0.09
Bud 0 0 0 0 0.07 0 0.05 0.05 0.05 0.06 0 0.06 0 0 0.05 0 0 0 0.1 0.07 0.05 0.16 0.06 0.05
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.16 0.16 0.12 0.1 0 0
Bud Site 0.07 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0.05 0 0 0 0 0 0.05 0.05 0 0 0.07 0.07 0.15 0.14 0.14 0.12 0 0 0 0 0 0
Cytoplasm 0.71 0.73 0.78 0.81 0.74 0.73 0.66 0.66 0.64 0.61 0.62 0.53 0.92 0.95 0.94 0.65 0.64 0.68 0.47 0.51 0.47 0.52 0.58 0.65
Endoplasmic Reticulum 0 0.07 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.08 0 0 0 0 0.07 0.05
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0.2 0.15 0.29 0.35 0.39 0.45 0.51 0.52 0.59 0 0 0 0 0 0.05 0 0 0.13 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0.1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0.07 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.08 0.07 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0.12 0.13 0 0 0.05 0 0 0.05 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 13 46 39 18 25 21 20 13 13 7 3 1 9 10 6 25 13 21 15 30 38 15 26 23
Bud 1 7 11 4 27 12 21 32 20 23 11 24 4 4 13 1 3 0 12 20 20 20 16 11
Bud Neck 0 0 5 1 3 1 3 2 2 2 3 2 0 0 0 2 3 2 19 48 50 13 9 6
Bud Site 5 7 15 2 11 5 10 11 6 8 2 7 0 0 0 4 2 6 – – – – – –
Cell Periphery 1 10 17 11 2 11 10 8 23 21 12 18 13 18 44 25 17 18 2 3 6 1 3 3
Cytoplasm 52 185 266 211 269 288 273 388 277 250 188 216 175 245 268 118 76 100 58 156 196 69 151 167
Endoplasmic Reticulum 0 18 9 6 4 14 7 5 9 8 1 2 5 2 5 8 4 12 1 4 13 2 18 13
Endosome 1 3 1 0 4 3 1 0 0 0 0 1 2 2 0 6 4 3 4 12 12 1 3 7
Golgi 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 1 2 0 2 0 3 0 2 1
Mitochondria 2 5 11 53 55 114 145 225 198 209 159 242 0 0 3 7 3 7 3 8 53 1 10 7
Nucleus 0 1 1 0 0 3 3 4 3 0 4 0 2 1 1 3 1 0 0 0 0 0 0 0
Nuclear Periphery 1 0 0 1 0 0 1 1 0 0 0 2 0 0 0 0 0 0 0 0 0 0 1 1
Nucleolus 0 1 0 0 5 2 2 0 1 0 2 3 0 0 0 0 0 0 0 0 0 0 0 1
Peroxisomes 7 8 5 0 11 1 4 3 2 0 1 4 0 1 0 4 3 2 0 0 0 0 0 0
SpindlePole 5 4 16 1 10 3 9 5 6 8 0 7 1 0 0 11 9 10 1 4 5 0 0 3
Vac/Vac Membrane 2 3 0 0 7 0 12 27 0 4 1 8 0 0 0 21 16 6 2 14 11 4 12 6
Unique Cell Count 73 254 342 261 362 396 412 584 436 412 305 409 191 257 286 182 119 146 125 310 419 132 259 258
Labelled Cell Count 90 298 398 308 433 478 521 724 560 540 387 537 211 283 340 236 156 187 125 310 419 132 259 258


Bud Neck, Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 7.4 6.4 4.9 4.4 4.9 4.4 4.3 4.2 3.7 3.7 3.8 3.6 6.9 6.8 5.9 8.2 9.2 9.2 7.3 7.6 7.5
Std Deviation (1e-4) 1.1 0.7 0.6 0.5 1.0 0.8 0.9 1.0 0.7 0.7 1.1 1.1 1.1 1.1 1.0 1.3 1.9 2.2 1.1 1.5 1.0
Intensity Change (Log2) – – – -0.14 0.0 -0.16 -0.19 -0.22 -0.39 -0.4 -0.36 -0.42 0.51 0.48 0.28 0.75 0.92 0.92 0.58 0.63 0.62

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 -2.1 0 0 0 0 0 0 0 -2.6 -3.3 -4.5 0.8 -0.1 0.9
Bud 0 2.5 0 0 0 0 0 0 0 -0.8 -1.3 0.9 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 -0.9 0 0 0 0 0 0 0 -2.9 -3.4 -3.6 -1.3 0 -0.1
Cell Periphery 0 -3.6 0 0 0 0 0 0 0 0.9 1.0 4.4 3.5 3.3 2.9
Cytoplasm 0.9 -1.1 -1.6 -3.5 -3.7 -4.3 -5.0 -4.5 -7.1 4.1 6.0 5.6 -3.2 -3.0 -2.2
Endoplasmic Reticulum 0 -1.5 0 0 0 0 0 0 0 0 0 -0.7 1.1 0 2.8
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 5.4 0 0 0 0 0 0 0 0 0 -1.8 0.4 0 0.8
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 1.4 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 -1.3 0 0 0 0 0 0 0 -2.6 -3.5 -3.7 0.7 1.2 1.0
Vacuole 0 0 0 3.2 4.0 0 0 0 0 0 0 0 6.4 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 3.2719 3.0495 2.7076 3.1808 2.0267 2.8846 5.7426 5.6257 5.6413 4.8344 6.3073 5.8822 5.6185 5.842 5.2749 6.079 5.4756 5.1232
Actin 0.1961 0.0204 0.0653 0.029 0.0333 0.0353 0.0537 0.0204 0.0512 0.0546 0.017 0.0413 0.0391 0.004 0.0335 0.0408 0.0242 0.0288
Bud 0.002 0.0033 0.0342 0.0106 0.0024 0.0014 0.0071 0.0252 0.0275 0.0381 0.0075 0.0071 0.0063 0.0134 0.0128 0.0089 0.0018 0.0021
Bud Neck 0.072 0.0026 0.0087 0.0897 0.0015 0.5346 0.0407 0.0079 0.009 0.0009 0.0041 0.426 0.0595 0.0065 0.0031 0.0023 0.0015 0.4238
Bud Periphery 0.0031 0.003 0.0515 0.0122 0.0018 0.0023 0.0126 0.0121 0.0453 0.0947 0.0149 0.0052 0.0105 0.0157 0.0111 0.0112 0.0024 0.0027
Bud Site 0.0805 0.192 0.0417 0.0541 0.0015 0.0027 0.0828 0.1165 0.0452 0.0113 0.01 0.0112 0.1113 0.2883 0.0482 0.0168 0.0016 0.0168
Cell Periphery 0.0049 0.005 0.0064 0.0024 0.0007 0.0022 0.0054 0.0037 0.0041 0.0009 0.0041 0.0014 0.0052 0.003 0.0018 0.0021 0.0006 0.0018
Cytoplasm 0.3941 0.7021 0.6857 0.6078 0.8723 0.3668 0.4958 0.6566 0.6445 0.5767 0.7243 0.3801 0.5262 0.5157 0.7362 0.7837 0.8728 0.4602
Cytoplasmic Foci 0.0539 0.0115 0.0141 0.0261 0.0447 0.0233 0.0485 0.0135 0.0305 0.0222 0.0888 0.0332 0.0325 0.0145 0.047 0.0263 0.0352 0.0273
Eisosomes 0.0026 0.0002 0.0004 0.0011 0 0.0001 0.0009 0.0004 0.0006 0.0002 0.0002 0.0005 0.0006 0.0004 0.0005 0.0002 0.0001 0.0001
Endoplasmic Reticulum 0.0126 0.0041 0.0089 0.0078 0.0043 0.0022 0.0213 0.0058 0.0089 0.0071 0.004 0.009 0.012 0.0034 0.0039 0.0055 0.0038 0.002
Endosome 0.0422 0.009 0.0168 0.0612 0.0079 0.0064 0.0384 0.0078 0.0261 0.0551 0.0231 0.0186 0.0305 0.01 0.0199 0.0282 0.0091 0.0087
Golgi 0.0201 0.0044 0.0083 0.005 0.0026 0.0028 0.0125 0.0027 0.0118 0.034 0.0054 0.0181 0.0095 0.0012 0.0112 0.007 0.0017 0.004
Lipid Particles 0.0118 0.0005 0.0049 0.005 0.0007 0.0002 0.0144 0.0011 0.0019 0.0015 0.0009 0.0021 0.0041 0.0003 0.0038 0.0007 0.0006 0.0001
Mitochondria 0.0053 0.0008 0.0058 0.04 0.0006 0.0005 0.0041 0.0018 0.0092 0.0175 0.0009 0.0038 0.011 0.0006 0.0091 0.0012 0.0005 0.0007
None 0.0301 0.0367 0.0287 0.0152 0.0178 0.0163 0.0961 0.115 0.0596 0.0607 0.089 0.0266 0.1124 0.1148 0.0453 0.0302 0.0339 0.018
Nuclear Periphery 0.0139 0.0004 0.0028 0.0045 0.0005 0.0001 0.0271 0.001 0.0053 0.0017 0.0003 0.005 0.0084 0.0008 0.0005 0.001 0.0008 0.0001
Nucleolus 0.001 0.0001 0.0003 0.0015 0 0.0001 0.0012 0.0003 0.0006 0.0003 0.0001 0.0011 0.0004 0.0007 0.0003 0.0005 0.0001 0.0001
Nucleus 0.0063 0.0009 0.0019 0.0036 0.0006 0.0005 0.0197 0.003 0.003 0.0018 0.0005 0.0018 0.0019 0.002 0.0009 0.0023 0.0008 0.0004
Peroxisomes 0.0193 0.0003 0.0049 0.0023 0.0017 0.0008 0.0047 0.0007 0.0053 0.0042 0.002 0.0037 0.0049 0.0005 0.0062 0.0009 0.0033 0.0008
Punctate Nuclear 0.0241 0.0004 0.0016 0.0014 0.0029 0.0003 0.0068 0.0015 0.0015 0.0009 0.0003 0.0018 0.0082 0.0012 0.0009 0.0006 0.0015 0.0002
Vacuole 0.0028 0.002 0.0061 0.0157 0.0017 0.0009 0.004 0.0027 0.007 0.0126 0.0024 0.0016 0.0043 0.0027 0.0031 0.028 0.0033 0.0011
Vacuole Periphery 0.0013 0.0002 0.0011 0.0038 0.0002 0.0001 0.002 0.0003 0.002 0.0031 0.0004 0.0007 0.0014 0.0003 0.0008 0.0016 0.0005 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 29.8085 11.0665 14.4788 23.6925 24.287 15.9542 19.8758 20.3707 20.5923 31.0373
Translational Efficiency 0.7533 1.1013 0.9036 0.5674 0.6955 1.3065 0.6419 0.6336 0.7012 0.6482

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
111 425 1747 1193 1760 909 581 222 1871 1334 2328 1415

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 749.54 901.89 1123.21 912.26 813.26 758.58 999.61 912.93 809.48 804.24 1092.36 912.37
Standard Deviation 85.94 1123.11 132.01 119.82 101.91 115.99 119.15 127.87 102.14 644.58 139.58 121.12
Intensity Change Log 2 — 0.266946 0.583550 0.283440 — -0.100415 0.297649 0.166788 — 0.087458 0.441849 0.223913

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.005885 0.010877 0.045395 0.010819 0.019155 0.009908 0.013920 0.002711 0.018368 0.010217 0.037539 0.009547
Bud Neck 0.101900 0.076128 0.025291 0.039984 0.135749 0.090051 0.085358 0.027742 0.133741 0.085615 0.040282 0.038064
Bud Site 0.248376 0.235500 0.391663 0.208424 0.285884 0.205656 0.267076 0.079173 0.283659 0.215164 0.360570 0.188145
Cell Periphery 0.006435 0.000688 0.000670 0.000370 0.003411 0.000753 0.000509 0.000487 0.003591 0.000732 0.000630 0.000388
Cytoplasm 0.422189 0.354427 0.447650 0.442019 0.362172 0.360147 0.328022 0.295998 0.365733 0.358324 0.417794 0.419110
Cytoplasmic Foci 0.116509 0.169443 0.042015 0.038517 0.103047 0.139466 0.061977 0.098076 0.103846 0.149017 0.046997 0.047862
Eisosomes 0.003320 0.000765 0.000165 0.000139 0.002461 0.000573 0.000214 0.000372 0.002512 0.000634 0.000178 0.000176
Endoplasmic Reticulum 0.001901 0.000466 0.000598 0.001379 0.002501 0.000906 0.001138 0.001146 0.002465 0.000766 0.000733 0.001342
Endosome 0.018361 0.033755 0.001758 0.009390 0.015100 0.039309 0.010989 0.015321 0.015293 0.037539 0.004062 0.010320
Golgi 0.011132 0.009733 0.001266 0.006964 0.013850 0.016771 0.001116 0.006848 0.013689 0.014529 0.001228 0.006946
Lipid Particles 0.003462 0.002586 0.000914 0.000787 0.003016 0.002897 0.002066 0.004527 0.003042 0.002798 0.001202 0.001374
Mitochondria 0.006416 0.002364 0.000193 0.006006 0.006778 0.011713 0.000172 0.003374 0.006756 0.008734 0.000188 0.005594
Mitotic Spindle 0.000419 0.001388 0.000832 0.028767 0.000390 0.008967 0.003401 0.022255 0.000392 0.006553 0.001473 0.027746
None 0.000089 0.000076 0.000440 0.000840 0.000401 0.000527 0.000546 0.000983 0.000383 0.000383 0.000466 0.000862
Nuclear Periphery 0.000037 0.000029 0.000016 0.000215 0.000024 0.000064 0.000224 0.000930 0.000025 0.000053 0.000068 0.000327
Nuclear Periphery Foci 0.000188 0.000353 0.001022 0.001124 0.000176 0.000275 0.002665 0.001562 0.000177 0.000300 0.001432 0.001193
Nucleolus 0.000056 0.000158 0.000040 0.000312 0.000100 0.000880 0.000155 0.001656 0.000097 0.000650 0.000068 0.000523
Nucleus 0.003980 0.004193 0.009921 0.032203 0.005931 0.007911 0.015705 0.134108 0.005815 0.006727 0.011364 0.048191
Peroxisomes 0.007610 0.020629 0.011606 0.008503 0.010662 0.019127 0.017730 0.008246 0.010481 0.019605 0.013135 0.008462
Vacuole 0.040313 0.074661 0.018408 0.160182 0.027340 0.080689 0.186722 0.288232 0.028110 0.078768 0.060414 0.180272
Vacuole Periphery 0.001422 0.001784 0.000138 0.003056 0.001851 0.003407 0.000295 0.006253 0.001825 0.002890 0.000177 0.003558

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.36 -10.61 0.01 1.64 12.64 4.19 2.80 9.34 5.19 4.71 3.92 -6.34 7.17 3.18 12.98
Bud Neck 1.46 4.61 4.83 7.69 1.62 5.87 8.35 17.35 10.49 6.75 7.08 17.64 20.54 13.65 5.69
Bud Site 0.51 -4.49 5.32 9.17 27.87 7.62 5.33 20.70 12.46 11.34 7.30 -5.45 22.57 13.62 28.51
Cell Periphery 2.23 2.24 2.41 2.44 9.94 5.08 5.75 6.04 4.26 2.56 5.55 5.87 6.57 5.35 10.35
Cytoplasm 2.18 -1.29 0.32 -3.65 3.96 0.15 1.89 4.15 3.83 2.36 0.71 -6.52 -2.60 -3.11 3.42
Cytoplasmic Foci -2.93 4.56 5.30 15.43 4.48 -5.52 7.34 5.14 8.71 -0.16 -7.72 14.09 17.06 22.08 4.55
Eisosomes 1.94 2.46 2.50 2.02 3.18 7.76 9.75 9.64 4.33 -0.58 7.31 10.14 10.36 4.38 3.24
Endoplasmic Reticulum 1.20 1.07 0.47 -3.61 -2.90 3.14 2.41 1.67 -2.88 -1.36 3.57 3.53 2.15 -2.84 -2.82
Endosome -3.66 6.18 4.99 8.88 -3.63 -8.36 3.62 2.71 8.99 0.37 -9.58 11.56 8.57 14.54 -1.88
Golgi 0.76 5.77 4.34 5.14 -1.69 -1.53 16.74 4.48 4.81 -0.87 -0.52 17.38 9.89 8.04 -1.93
Lipid Particles 0.52 1.94 1.80 1.37 -1.43 0.19 2.04 -0.36 -0.43 -1.81 0.41 6.05 5.41 2.54 -1.47
Mitochondria 1.26 1.95 1.18 -0.13 -2.40 -2.52 8.60 3.65 4.71 -1.11 -1.34 8.79 3.95 4.29 -2.60
Mitotic Spindle -2.23 -2.37 -6.36 -5.90 -6.20 -3.52 -2.31 -3.28 -1.75 -2.77 -3.69 -3.24 -7.17 -3.56 -6.66
None 0.59 -5.92 -10.08 -10.23 -5.95 -0.64 -0.54 -2.06 -1.18 -1.51 -0.11 -0.85 -6.31 -3.99 -5.87
Nuclear Periphery 0.30 0.73 -13.19 -17.08 -17.63 -2.39 -4.58 -5.62 -5.41 -4.36 -2.37 -3.98 -14.71 -13.59 -12.82
Nuclear Periphery Foci -1.80 -6.24 -10.01 -6.68 -0.04 -1.48 -7.75 -5.83 -5.45 1.26 -2.31 -9.76 -12.33 -9.77 1.39
Nucleolus -1.27 2.03 -1.99 -0.48 -2.17 -2.02 -3.25 -1.68 0.08 -1.57 -2.09 4.43 -2.24 1.22 -2.52
Nucleus -0.37 -8.52 -20.42 -20.75 -17.18 -1.74 -10.91 -7.83 -7.57 -6.41 -1.18 -11.92 -20.68 -19.48 -17.27
Peroxisomes -3.96 -1.73 1.75 5.97 6.10 -4.42 -2.06 3.88 6.44 4.10 -5.59 -1.62 6.74 9.52 7.37
Vacuole -3.43 1.84 -22.85 -24.06 -35.06 -11.92 -19.85 -19.47 -16.59 -8.08 -13.80 -13.20 -38.82 -30.27 -30.41
Vacuole Periphery -0.98 5.84 0.37 0.98 -2.26 -3.88 9.86 -0.61 0.35 -1.63 -3.48 11.63 0.70 2.56 -2.75
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Rho GTPase activating protein (RhoGAP); involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly
Localization
Cell Percentages cytoplasm (66%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-10

Bem3

Bem3


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Bem3-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available