Standard name
Human Ortholog
Description Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs; protein abundance increases in response to DNA replication stress; DBP1 has a paralog, DED1, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0.06 0 0 0 0 0 0.11 0.11 0.09 0 0 0 0 0 0
Cytoplasm 0.97 0.98 0.99 0.99 0.95 0.9 0.85 – 0.68 0.72 0.5 0.63 1.0 0.99 0.99 0.92 0.92 0.94 0.89 0.86 0.79 0.88 0.9 0.86
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.11 0.12 – 0.3 0.23 0.6 0.37 0 0 0 0 0 0 0 0 0.12 0 0 0
Nucleus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 – 0.09 0.05 0 0.05 0 0 0 0.06 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 1 1 3 – 1 8 2 3 0 0 0 1 0 0 1 5 2 0 0 1
Bud 4 1 0 0 1 1 4 – 2 0 3 2 0 0 0 0 0 0 2 12 3 0 2 0
Bud Neck 0 0 2 0 1 0 0 – 0 1 0 0 0 0 0 0 0 0 1 4 1 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 4 8 6 2 6 6 4 – 6 19 4 5 1 6 6 40 40 29 0 1 1 0 0 0
Cytoplasm 311 564 246 139 218 219 303 – 179 229 122 160 101 174 216 348 348 296 299 504 206 62 121 154
Endoplasmic Reticulum 0 4 2 1 2 6 13 – 8 12 5 6 0 0 2 13 12 4 4 6 3 0 1 7
Endosome 0 3 0 0 0 1 1 – 2 2 0 0 0 0 0 1 0 0 3 5 1 0 2 2
Golgi 0 0 1 0 2 0 0 – 0 1 0 1 0 0 0 1 1 0 0 3 0 0 0 3
Mitochondria 5 3 0 2 6 27 42 – 79 72 146 93 0 1 1 4 2 0 12 18 32 2 1 3
Nucleus 4 1 1 0 0 0 3 – 3 6 0 3 0 0 0 2 5 1 0 2 1 0 0 0
Nuclear Periphery 2 0 0 0 0 0 0 – 0 2 0 1 0 0 0 0 0 0 0 1 0 0 0 0
Nucleolus 0 0 0 1 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
SpindlePole 0 0 0 0 1 0 0 – 0 0 0 0 0 0 0 0 0 0 1 3 0 0 1 0
Vac/Vac Membrane 0 3 0 0 2 3 9 – 24 15 6 13 0 1 1 23 13 14 2 10 4 0 1 1
Unique Cell Count 322 575 248 141 229 242 357 263 317 244 252 101 176 218 379 379 315 335 586 261 71 135 179
Labelled Cell Count 330 587 258 145 240 264 382 304 367 288 287 102 182 226 433 421 344 335 586 261 71 135 179


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.4 5.6 5.8 5.6 6.7 6.0 6.6 – 6.4 6.5 5.7 6.1 6.8 6.7 6.5 20.3 20.7 19.9 5.1 6.4 6.7
Std Deviation (1e-4) 0.8 1.2 0.9 1.5 1.4 1.1 1.4 – 1.5 1.6 1.9 1.7 1.6 1.0 1.2 5.2 4.9 4.8 0.9 1.4 1.5
Intensity Change (Log2) – – – -0.05 0.22 0.07 0.19 – 0.15 0.18 -0.01 0.08 0.24 0.21 0.18 1.82 1.85 1.78 -0.19 0.14 0.22

WT3RAP60RAP140RAP220RAP300RAP460RAP540RAP620RAP70001020WT3HU80HU120HU16001020WT3rpd3Δ_1rpd3Δ_2rpd3Δ_301020WT1AF100AF140AF18001020
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0.1 0 0 – -0.1 2.1 0 -0.3 0 0 0.2 3.8 3.8 3.3
Cytoplasm -0.6 -2.7 -4.4 -6.0 – -9.4 -8.7 -12.6 -10.2 0.9 -0.3 -0.1 -4.0 -4.0 -3.2
Endoplasmic Reticulum 0 0 0 2.2 – 0 2.3 0 0 0 0 0 2.1 2.0 0
Endosome 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 5.4 5.6 – 9.4 8.0 14.5 10.6 0 0 0 0 0 0
Nucleus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 – 4.9 3.5 0 3.6 0 0 0 4.0 2.9 3.4

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.6975 0.1122 -0.009 0.1385 0.366 -0.026 0.2461 0.6096 0.4905 0.6276 1.5597 0.6376 0.6652 0.6211 0.6491 0.2401 1.05 0.6823
Actin 0.0881 0.001 0.0077 0.0249 0.0228 0.0143 0.0111 0.003 0.0135 0.0366 0.0338 0.0055 0.0223 0.0013 0.0095 0.0004 0.031 0.0075
Bud 0.0044 0.0073 0.0027 0.0054 0.0034 0.005 0.0038 0.0071 0.002 0.0105 0.0017 0.0018 0.017 0.0185 0.0284 0.0067 0.027 0.0207
Bud Neck 0.0049 0.0001 0.0008 0.0026 0.0032 0.0007 0.0051 0.0003 0.0026 0.0173 0.0031 0.0006 0.0055 0.0004 0.001 0.0005 0.0079 0.0064
Bud Periphery 0.0094 0.0022 0.0007 0.0106 0.0045 0.0087 0.0112 0.0045 0.0035 0.0186 0.0032 0.007 0.0144 0.0097 0.0122 0.0023 0.0076 0.015
Bud Site 0.0225 0.0117 0.0162 0.022 0.0294 0.0017 0.0114 0.0191 0.0116 0.0356 0.0055 0.0006 0.0296 0.0241 0.019 0.0011 0.0297 0.0053
Cell Periphery 0.0013 0.0004 0.0006 0.0008 0.0013 0.0003 0.0006 0.0006 0.0005 0.0009 0.0004 0.0002 0.0011 0.0008 0.0012 0.0003 0.0011 0.0006
Cytoplasm 0.1108 0.2446 0.2416 0.2162 0.2613 0.2491 0.1631 0.2085 0.1691 0.0887 0.1856 0.2181 0.273 0.4075 0.2751 0.4269 0.2057 0.4156
Cytoplasmic Foci 0.0406 0.0074 0.0224 0.0177 0.0722 0.0318 0.0238 0.0115 0.0092 0.0201 0.049 0.0101 0.0159 0.0099 0.0168 0.0164 0.0407 0.0183
Eisosomes 0.0012 0.0001 0.0004 0.0006 0.0002 0.0001 0.0004 0.0002 0.0002 0.0003 0.0009 0.0001 0.0003 0.0001 0.0002 0.0001 0.0005 0.0001
Endoplasmic Reticulum 0.0105 0.0016 0.0033 0.0046 0.0036 0.0023 0.0026 0.0013 0.0021 0.0007 0.0049 0.0023 0.0044 0.003 0.0024 0.0023 0.0046 0.0018
Endosome 0.0456 0.0079 0.0166 0.0202 0.0603 0.0197 0.0038 0.0031 0.0031 0.0071 0.0328 0.004 0.0083 0.0038 0.0066 0.0079 0.0412 0.0037
Golgi 0.0141 0.0003 0.0016 0.0232 0.035 0.0087 0.001 0.0005 0.001 0.0052 0.0115 0.0008 0.002 0.0009 0.0009 0.0006 0.0095 0.0005
Lipid Particles 0.0247 0.0005 0.0029 0.0237 0.0215 0.0053 0.0023 0.0005 0.002 0.005 0.0118 0.0014 0.001 0.0002 0.0011 0.0002 0.0105 0.0003
Mitochondria 0.0207 0.0004 0.0139 0.0113 0.014 0.0085 0.0018 0.001 0.0047 0.0276 0.0082 0.003 0.0017 0.0026 0.0023 0.0007 0.006 0.002
None 0.5395 0.7098 0.647 0.5922 0.4341 0.6268 0.7316 0.7285 0.7589 0.7028 0.5356 0.7311 0.5716 0.5076 0.5905 0.521 0.3887 0.4785
Nuclear Periphery 0.024 0.0005 0.0015 0.0017 0.0075 0.0043 0.0074 0.0008 0.0019 0.0005 0.0409 0.0038 0.0063 0.0008 0.0016 0.0018 0.0115 0.0022
Nucleolus 0.002 0.0002 0.0014 0.0003 0.0009 0.0004 0.0006 0.0004 0.0008 0.0007 0.0098 0.0003 0.0012 0.001 0.0026 0.0003 0.0064 0.0022
Nucleus 0.0041 0.0009 0.0028 0.0011 0.0024 0.0015 0.0041 0.0022 0.005 0.0014 0.0271 0.0012 0.0066 0.0033 0.0106 0.0041 0.0375 0.0078
Peroxisomes 0.0179 0.0001 0.0011 0.0151 0.0038 0.0041 0.0091 0.0041 0.0027 0.0164 0.0087 0.0045 0.0007 0.0003 0.0042 0.0005 0.0068 0.0005
Punctate Nuclear 0.0048 0.0004 0.0094 0.0017 0.0071 0.0025 0.0035 0.0013 0.0035 0.0015 0.0186 0.0023 0.0141 0.0018 0.0101 0.002 0.1207 0.0088
Vacuole 0.0057 0.0023 0.0047 0.0033 0.009 0.0028 0.0014 0.0014 0.0016 0.0022 0.0042 0.0009 0.0024 0.002 0.0032 0.0034 0.0039 0.0019
Vacuole Periphery 0.0033 0.0002 0.0007 0.0007 0.0028 0.0012 0.0005 0.0002 0.0003 0.0005 0.0026 0.0003 0.0006 0.0003 0.0006 0.0006 0.0017 0.0005

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 4.166 1.5961 4.3426 3.4487 4.244 4.7585 2.6897 5.9906 6.0646 4.8727
Translational Efficiency – – – – – – – – – –

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency –

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1958 1702 408 765 1788 1645 1736 570 3746 3347 2144 1335

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 636.31 762.51 1012.31 874.44 678.42 720.15 864.90 813.32 656.41 741.69 892.95 848.34
Standard Deviation 93.26 101.33 117.09 183.57 78.28 102.10 117.68 118.71 88.96 103.89 131.03 161.99
Intensity Change Log 2 — 0.261026 0.669849 0.458630 — 0.086119 0.350355 0.261644 — 0.173421 0.513824 0.360343

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000122 0.000217 0.000481 0.000203 0.000110 0.000357 0.000123 0.000415 0.000116 0.000286 0.000191 0.000293
Bud Neck 0.014360 0.014170 0.001660 0.006328 0.010277 0.035880 0.002796 0.007143 0.012411 0.024840 0.002580 0.006676
Bud Site 0.007742 0.015989 0.015378 0.016016 0.004088 0.034622 0.007263 0.018901 0.005998 0.025147 0.008807 0.017247
Cell Periphery 0.000210 0.000079 0.000169 0.003691 0.000144 0.000137 0.000073 0.000134 0.000178 0.000107 0.000092 0.002172
Cytoplasm 0.558665 0.594180 0.618143 0.609242 0.558754 0.395299 0.750812 0.511516 0.558708 0.496433 0.725565 0.567516
Cytoplasmic Foci 0.182944 0.179495 0.053052 0.035201 0.218645 0.283065 0.029973 0.067259 0.199985 0.230398 0.034365 0.048889
Eisosomes 0.000210 0.000055 0.000049 0.007584 0.000131 0.000142 0.000020 0.000063 0.000172 0.000098 0.000025 0.004373
Endoplasmic Reticulum 0.000944 0.000823 0.003025 0.002680 0.000925 0.001165 0.000789 0.000907 0.000935 0.000991 0.001215 0.001923
Endosome 0.008470 0.014615 0.010200 0.004552 0.011116 0.050616 0.002964 0.012488 0.009733 0.032309 0.004341 0.007940
Golgi 0.001971 0.003196 0.000294 0.003758 0.001915 0.016633 0.000527 0.001322 0.001945 0.009800 0.000482 0.002718
Lipid Particles 0.007694 0.002625 0.002498 0.009162 0.005535 0.004990 0.000759 0.005479 0.006664 0.003787 0.001090 0.007589
Mitochondria 0.002858 0.003093 0.000124 0.000728 0.004141 0.017494 0.000260 0.009698 0.003470 0.010171 0.000234 0.004558
Mitotic Spindle 0.000657 0.003706 0.001907 0.006670 0.001994 0.008153 0.002884 0.010302 0.001295 0.005892 0.002698 0.008221
None 0.009017 0.002929 0.001647 0.085798 0.002845 0.002311 0.002465 0.002827 0.006071 0.002626 0.002309 0.050373
Nuclear Periphery 0.000298 0.000269 0.000889 0.000468 0.000332 0.000266 0.000442 0.001084 0.000314 0.000267 0.000527 0.000731
Nuclear Periphery Foci 0.000474 0.000407 0.009504 0.008642 0.000447 0.000256 0.001785 0.003043 0.000461 0.000333 0.003254 0.006251
Nucleolus 0.001235 0.000800 0.000219 0.000874 0.000958 0.000861 0.000135 0.000477 0.001103 0.000830 0.000151 0.000705
Nucleus 0.138932 0.073391 0.101828 0.053787 0.121319 0.024721 0.103487 0.061305 0.130526 0.049470 0.103171 0.056997
Peroxisomes 0.001968 0.004469 0.000352 0.006254 0.003758 0.011001 0.000181 0.002044 0.002822 0.007679 0.000214 0.004457
Vacuole 0.060234 0.083620 0.178231 0.137558 0.051199 0.106701 0.092143 0.278104 0.055922 0.094964 0.108525 0.197567
Vacuole Periphery 0.000994 0.001873 0.000351 0.000803 0.001367 0.005328 0.000120 0.005487 0.001172 0.003571 0.000164 0.002803

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.61 -6.66 -2.65 0.22 5.12 -6.46 -1.32 -2.10 0.37 -1.83 -6.41 -4.80 -3.01 0.62 -0.94
Bud Neck 0.24 15.15 10.18 8.59 -2.79 -12.31 8.82 3.91 13.48 -2.02 -10.05 14.09 9.95 16.07 -2.53
Bud Site -4.55 -1.49 -1.40 2.21 0.62 -13.38 -2.05 -4.27 6.12 -3.29 -13.13 -1.25 -4.03 6.43 -2.80
Cell Periphery 7.80 1.78 -3.69 -4.11 -3.80 0.17 1.70 1.06 3.54 -2.90 3.14 3.91 -3.56 -3.98 -4.07
Cytoplasm -3.89 -0.40 0.31 2.99 0.55 17.27 -14.20 5.97 -5.45 14.79 9.47 -14.51 4.14 -2.57 13.97
Cytoplasmic Foci 0.71 27.78 33.41 27.89 3.83 -8.71 37.56 28.03 36.25 -7.34 -6.13 50.51 43.27 45.20 -4.59
Eisosomes 16.62 16.11 -2.82 -2.98 -2.98 -0.41 4.62 3.38 10.57 -7.89 5.91 11.81 -2.75 -2.89 -3.02
Endoplasmic Reticulum 0.73 -8.30 -1.31 -1.69 5.16 -0.62 -0.49 0.72 1.28 2.20 -0.25 -3.94 -0.78 -0.50 2.05
Endosome -6.01 -1.20 7.37 11.53 6.93 -17.90 10.54 1.81 17.50 -4.75 -18.20 10.91 5.75 20.70 -2.24
Golgi -2.45 11.54 0.87 2.25 -1.86 -12.57 5.23 3.81 13.44 -1.25 -12.31 6.97 2.13 11.89 -1.93
Lipid Particles 7.27 7.27 3.21 -1.45 -1.42 0.76 14.19 1.48 1.12 -1.99 6.14 14.17 3.29 0.06 -3.31
Mitochondria -0.28 7.14 6.01 4.83 -1.52 -6.84 4.59 -0.64 4.19 -2.47 -6.54 7.18 0.81 5.71 -2.56
Mitotic Spindle -2.70 -2.47 -3.90 -1.73 -2.99 -4.05 -1.05 -2.51 0.01 -2.09 -4.89 -2.37 -4.41 -1.01 -3.13
None 4.97 6.39 -4.18 -5.37 -5.63 0.83 1.53 1.16 0.36 0.18 4.84 6.18 -4.14 -5.28 -5.48
Nuclear Periphery 0.53 -11.20 -9.37 -9.09 5.47 0.86 -8.43 -1.70 -1.87 -0.69 1.00 -13.73 -3.36 -3.57 -0.25
Nuclear Periphery Foci 0.73 -12.74 -4.90 -4.99 4.75 1.17 -6.67 -1.98 -2.27 -0.30 1.39 -14.29 -5.11 -5.39 -0.23
Nucleolus 2.82 7.66 4.99 2.77 -3.43 0.45 3.97 2.90 4.02 -4.85 1.91 7.81 5.19 4.67 -6.06
Nucleus 15.81 3.17 16.68 1.98 7.31 28.84 -0.15 11.74 -7.90 11.56 29.95 2.50 20.07 -4.73 14.90
Peroxisomes -5.11 8.76 -0.35 1.52 -1.67 -7.97 7.08 4.45 13.28 -4.23 -9.52 9.89 1.31 6.87 -2.43
Vacuole -7.02 -15.33 -20.90 -17.87 -3.10 -14.17 -19.53 -24.25 -19.17 -15.75 -14.97 -23.64 -31.57 -25.69 -16.22
Vacuole Periphery -4.27 6.37 2.51 5.16 -0.19 -9.34 5.33 -1.47 1.60 -2.51 -10.26 8.20 -0.74 3.36 -2.63
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs; protein abundance increases in response to DNA replication stress; DBP1 has a paralog, DED1, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (45%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Dbp1

Dbp1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Dbp1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available