Standard name
Human Ortholog
Description Heme A:farnesyltransferase; catalyzes first step in conversion of protoheme to heme A prosthetic group required for cytochrome c oxidase activity; human ortholog COX10 can complement yeast cox10 null mutant; human ortholog COX10 is associated with mitochondrial disorders
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 – 0 0.05 0.06 0 0 0 – – 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – 0 0 0 0 0 0 0
Cytoplasm 0.88 0.66 0.76 0.82 0.62 0.5 0.44 0.38 – 0.31 0.3 0.19 0.97 0.97 0.98 – – 0.55 0.44 0.46 0.32 0.46 0.43 0.54
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – 0.09 0 0 0 0 0 0
Endosome 0 0 0 0 0.09 0 0 0 – 0 0 0 0 0 0 – – 0 0 0 0.05 0 0 0
Golgi 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – 0 0 0 0 0 0 0
Mitochondria 0.08 0.42 0.18 0.23 0.29 0.55 0.61 0.6 – 0.75 0.79 0.85 0 0 0 – – 0.16 0.36 0.35 0.45 0.37 0.37 0.25
Nucleus 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – 0 0 0 0 0 0 0
SpindlePole 0 0 0.05 0 0 0.05 0.06 0.09 – 0.06 0.05 0.08 0 0 0 – – 0.11 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0.07 0 0 0 – 0 0 0 0 0 0 – – 0.07 0 0.07 0 0.05 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 1 1 0 0 0 0 0 0 – 0 0 0 0 0 0 – – 0 2 1 9 4 6 7
Bud 0 1 0 5 9 4 8 16 – 12 18 27 0 0 0 – – 3 0 0 0 1 3 10
Bud Neck 1 0 0 0 0 0 3 3 – 2 4 2 0 1 0 – – 2 0 0 4 0 5 12
Bud Site 0 0 0 2 2 0 7 5 – 9 5 9 0 0 0 – – 0 – – – – – –
Cell Periphery 0 0 3 0 1 3 1 0 – 2 2 1 5 2 2 – – 2 1 0 3 0 2 2
Cytoplasm 107 83 168 211 171 169 205 211 – 151 98 83 172 170 215 – – 41 63 62 88 86 132 190
Endoplasmic Reticulum 2 1 3 0 0 0 0 0 – 0 0 0 4 2 0 – – 7 1 0 4 0 3 4
Endosome 4 0 3 5 25 9 11 12 – 1 0 0 1 0 1 – – 2 5 5 14 5 9 4
Golgi 1 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – 0 1 0 0 0 0 1
Mitochondria 10 52 40 60 80 188 285 332 – 364 263 382 1 0 0 – – 12 51 48 123 70 113 87
Nucleus 0 0 0 0 2 4 4 13 – 7 5 2 0 1 1 – – 1 0 1 0 0 0 1
Nuclear Periphery 0 0 0 0 1 0 1 0 – 2 1 2 0 0 0 – – 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 1 1 – 2 4 0 0 0 0 – – 1 0 0 0 0 0 0
Peroxisomes 0 0 4 4 4 4 9 5 – 3 0 7 1 0 0 – – 3 0 0 2 0 2 0
SpindlePole 0 0 10 5 9 17 26 48 – 31 16 34 1 0 0 – – 8 4 1 6 2 9 9
Vac/Vac Membrane 1 2 8 4 19 12 15 10 – 4 4 9 0 2 5 – – 5 4 9 6 9 10 10
Unique Cell Count 122 125 222 258 277 341 464 550 485 332 447 178 175 219 75 144 137 277 190 306 351
Labelled Cell Count 127 140 239 296 323 410 576 656 590 420 558 185 178 224 87 144 137 277 190 306 351


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 3.8 3.5 3.4 3.7 3.7 3.2 3.0 3.3 – 2.6 2.7 2.9 4.8 5.1 5.2 3.8 4.1 5.0 4.9 5.1 5.4
Std Deviation (1e-4) 0.8 0.7 0.9 1.7 1.8 1.7 1.4 1.4 – 0.9 1.1 0.8 0.8 1.0 0.9 1.1 1.3 2.1 1.1 1.6 1.9
Intensity Change (Log2) – – – 0.12 0.14 -0.07 -0.18 -0.03 – -0.4 -0.31 -0.23 0.49 0.6 0.61 0.15 0.29 0.57 0.54 0.59 0.67

WT3RAP60RAP140RAP220RAP300RAP380RAP540RAP620RAP7000246WT3HU80HU120HU1600246WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30246WT1AF100AF140AF1800246
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – – – –
Bud Neck – – – – – – – – – – – – – – –
Bud Site – – – – – – – – – – – – – – –
Cell Periphery – – – – – – – – – – – – – – –
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – – – –
Endosome – – – – – – – – – – – – – – –
Golgi – – – – – – – – – – – – – – –
Mitochondria – – – – – – – – – – – – – – –
Nuclear Periphery – – – – – – – – – – – – – – –
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – – – –
Peroxisomes – – – – – – – – – – – – – – –
SpindlePole – – – – – – – – – – – – – – –
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – – – –
Cytoplasm – – – – – – – – – – – – – – –
Nucleus – – – – – – – – – – – – – – –
Vacuole – – – – – – – – – – – – – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.3865 0.3548 1.0066 0.4029 -0.012 0.5452 0.9738 1.2954 1.2874 1.1678 1.1362 1.1092 0.7209 2.1742 1.3599 1.4562 0.7895 1.2426
Actin 0.0369 0.0093 0.0339 0.001 0.0093 0.0197 0.0118 0.0173 0.0223 0.0354 0.0328 0.0092 0.0063 0.0112 0.0204 0.0084 0.0051 0.0068
Bud 0.0014 0.0019 0.0006 0.0008 0.0005 0.001 0.0018 0.0083 0.0012 0.0011 0.0013 0.0009 0.0013 0.001 0.0021 0.0049 0.0016 0.0017
Bud Neck 0.0043 0.0012 0.0056 0.001 0.0005 0.0009 0.0022 0.0018 0.003 0.001 0.0015 0.0094 0.0008 0.0016 0.0135 0.001 0.0007 0.0079
Bud Periphery 0.0032 0.0037 0.0015 0.0023 0.0024 0.004 0.0039 0.0186 0.0031 0.0084 0.0045 0.0028 0.0035 0.0025 0.0047 0.0255 0.0043 0.0092
Bud Site 0.0071 0.0173 0.0032 0.0014 0.0008 0.0007 0.016 0.0115 0.005 0.0043 0.0029 0.001 0.0038 0.0193 0.0072 0.0018 0.0026 0.001
Cell Periphery 0.0062 0.0016 0.0011 0.0054 0.0007 0.0007 0.0014 0.0013 0.0017 0.0012 0.0024 0.0013 0.0015 0.0027 0.0019 0.0017 0.0008 0.0016
Cytoplasm 0.0485 0.101 0.0857 0.1093 0.0999 0.0781 0.0704 0.1276 0.1022 0.0584 0.0779 0.1311 0.128 0.17 0.1435 0.1436 0.1079 0.1836
Cytoplasmic Foci 0.0747 0.0367 0.0367 0.0759 0.0533 0.0547 0.1107 0.1068 0.0929 0.1015 0.099 0.0962 0.1065 0.115 0.0679 0.0631 0.1465 0.0816
Eisosomes 0.0014 0.0007 0.0014 0.0005 0.0008 0.0004 0.0008 0.0004 0.001 0.0007 0.0006 0.0004 0.0008 0.0009 0.0012 0.0006 0.0003 0.0004
Endoplasmic Reticulum 0.0058 0.0026 0.0143 0.0059 0.0125 0.0061 0.0044 0.0023 0.0051 0.003 0.0023 0.0025 0.0121 0.0055 0.0067 0.0103 0.0022 0.0054
Endosome 0.0491 0.0191 0.0313 0.0917 0.1046 0.0272 0.071 0.0599 0.0602 0.0671 0.059 0.0567 0.1009 0.0488 0.0814 0.0855 0.1406 0.0714
Golgi 0.0181 0.0076 0.009 0.0307 0.0363 0.013 0.0242 0.0221 0.0255 0.0111 0.0472 0.0141 0.0456 0.0276 0.0243 0.0243 0.0405 0.0304
Lipid Particles 0.0113 0.0111 0.0133 0.0281 0.0307 0.0098 0.0287 0.011 0.0148 0.0205 0.019 0.0102 0.0298 0.0122 0.0084 0.0046 0.0176 0.0117
Mitochondria 0.06 0.0284 0.0417 0.0444 0.155 0.0722 0.1001 0.0782 0.1162 0.185 0.1904 0.0762 0.1161 0.0969 0.1356 0.1918 0.1232 0.1675
None 0.5511 0.7425 0.6889 0.5055 0.4696 0.6776 0.4927 0.4893 0.5013 0.4383 0.408 0.5578 0.4021 0.4448 0.4526 0.405 0.3448 0.3986
Nuclear Periphery 0.0269 0.0006 0.0076 0.0059 0.0013 0.0011 0.003 0.0009 0.0014 0.0017 0.0096 0.0005 0.0024 0.001 0.0023 0.0014 0.0005 0.0006
Nucleolus 0.0026 0.001 0.0015 0.0027 0.0003 0.0009 0.0013 0.0007 0.0006 0.0008 0.0006 0.0003 0.0007 0.0016 0.0006 0.0005 0.0003 0.0003
Nucleus 0.038 0.0014 0.0061 0.0523 0.0009 0.0014 0.003 0.0012 0.001 0.0012 0.0012 0.0006 0.0011 0.0012 0.001 0.0013 0.0007 0.0007
Peroxisomes 0.0101 0.0057 0.0046 0.0103 0.0113 0.0179 0.0352 0.0307 0.0303 0.0451 0.0241 0.023 0.0237 0.027 0.013 0.0067 0.047 0.012
Punctate Nuclear 0.0218 0.001 0.0033 0.0021 0.0008 0.0058 0.0094 0.0016 0.0022 0.004 0.0099 0.0014 0.0022 0.0012 0.0007 0.0005 0.0011 0.0006
Vacuole 0.0165 0.0047 0.0071 0.0193 0.0052 0.005 0.006 0.007 0.0067 0.007 0.0035 0.0034 0.008 0.0066 0.0082 0.0141 0.0078 0.0052
Vacuole Periphery 0.0051 0.0007 0.0016 0.0036 0.0031 0.0017 0.0021 0.0013 0.0023 0.0031 0.0024 0.0012 0.0027 0.0013 0.0031 0.0033 0.0039 0.0019

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 13.5046 7.8115 7.9043 12.6323 8.7546 7.1455 12.7448 15.9922 12.7747 16.9779
Translational Efficiency 0.4775 0.4787 0.6254 0.5793 0.7051 1.2979 0.6334 0.5871 0.7721 0.4638

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
144 985 301 1622 177 1446 1718 1505 321 2431 2019 3127

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 850.68 689.93 854.96 825.30 612.50 713.62 750.47 805.72 719.35 704.02 766.05 815.88
Standard Deviation 114.99 103.59 84.36 116.79 70.13 84.83 89.46 95.09 150.59 93.61 96.21 107.34
Intensity Change Log 2 — -0.302167 0.007240 -0.043698 — 0.220446 0.293085 0.395569 — -0.060027 0.133853 0.156667

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.003322 0.000455 0.000691 0.003319 0.000224 0.000557 0.000290 0.002955 0.001614 0.000516 0.000350 0.003143
Bud Neck 0.018885 0.040963 0.004490 0.017093 0.058996 0.055024 0.006362 0.015784 0.041002 0.049327 0.006083 0.016463
Bud Site 0.031146 0.014448 0.005451 0.050714 0.007643 0.012614 0.008284 0.042920 0.018186 0.013357 0.007861 0.046963
Cell Periphery 0.004373 0.000173 0.000223 0.000252 0.000313 0.000368 0.000114 0.000247 0.002134 0.000289 0.000130 0.000250
Cytoplasm 0.206409 0.353270 0.259522 0.379006 0.247464 0.323026 0.416909 0.381960 0.229047 0.335280 0.393446 0.380428
Cytoplasmic Foci 0.108084 0.262901 0.026905 0.057024 0.387573 0.311825 0.020290 0.077879 0.262195 0.292002 0.021276 0.067061
Eisosomes 0.001081 0.000169 0.000081 0.000121 0.000574 0.000279 0.000036 0.000129 0.000801 0.000235 0.000043 0.000125
Endoplasmic Reticulum 0.011535 0.000935 0.008289 0.004186 0.000491 0.000588 0.002397 0.001796 0.005445 0.000728 0.003275 0.003036
Endosome 0.031336 0.035386 0.005546 0.012148 0.031749 0.034754 0.002501 0.008086 0.031564 0.035010 0.002955 0.010193
Golgi 0.013811 0.006941 0.000159 0.008107 0.010987 0.012615 0.000328 0.004975 0.012254 0.010316 0.000303 0.006600
Lipid Particles 0.004443 0.014193 0.003900 0.002840 0.033394 0.012865 0.001522 0.002858 0.020407 0.013403 0.001876 0.002848
Mitochondria 0.007182 0.025133 0.001601 0.007906 0.046805 0.034024 0.000850 0.006678 0.029030 0.030422 0.000962 0.007315
Mitotic Spindle 0.016987 0.003805 0.000960 0.036642 0.000153 0.003362 0.004621 0.016463 0.007704 0.003541 0.004075 0.026930
None 0.000664 0.004033 0.003344 0.002139 0.000786 0.001495 0.004526 0.002198 0.000731 0.002523 0.004350 0.002167
Nuclear Periphery 0.000965 0.000692 0.002189 0.001525 0.000438 0.000281 0.001404 0.001041 0.000674 0.000448 0.001521 0.001292
Nuclear Periphery Foci 0.001223 0.000564 0.002523 0.001303 0.000215 0.000159 0.001001 0.000571 0.000667 0.000323 0.001228 0.000951
Nucleolus 0.001068 0.003418 0.001079 0.000883 0.002310 0.001704 0.000479 0.000588 0.001753 0.002398 0.000568 0.000741
Nucleus 0.211085 0.137181 0.598917 0.242083 0.088935 0.097023 0.484780 0.295683 0.143731 0.113294 0.501796 0.267880
Peroxisomes 0.024024 0.025831 0.000952 0.021000 0.038481 0.033507 0.001567 0.034909 0.031995 0.030397 0.001475 0.027694
Vacuole 0.293766 0.065796 0.072688 0.148795 0.039758 0.061280 0.041526 0.101466 0.153706 0.063110 0.046172 0.126016
Vacuole Periphery 0.008611 0.003712 0.000489 0.002917 0.002710 0.002650 0.000215 0.000816 0.005358 0.003080 0.000256 0.001906

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 2.10 1.76 0.60 -4.61 -3.50 -1.97 -1.67 -5.13 -3.93 -4.90 1.66 1.94 -1.38 -5.87 -6.78
Bud Neck -5.03 3.15 0.82 7.80 -4.18 0.41 5.61 4.88 12.44 -4.97 -1.51 6.13 4.79 14.64 -6.98
Bud Site 2.27 3.79 -0.86 -5.97 -8.66 -1.59 0.13 -6.31 -6.79 -8.61 0.98 2.97 -4.58 -9.10 -11.74
Cell Periphery 1.26 1.23 1.25 -1.16 1.67 -0.45 4.66 2.38 1.51 -3.48 1.22 1.36 1.31 1.42 -4.27
Cytoplasm -7.65 -1.89 -7.25 1.30 -6.54 -4.29 -6.81 -6.06 -3.13 1.32 -8.23 -9.06 -9.22 -1.44 0.36
Cytoplasmic Foci -14.27 6.77 5.15 29.99 -4.70 4.24 21.83 18.91 36.06 -13.48 -2.62 17.93 15.32 47.72 -15.16
Eisosomes 1.00 1.12 1.11 6.06 -0.67 4.63 8.60 7.35 8.11 -7.16 1.56 2.20 2.00 10.00 -9.39
Endoplasmic Reticulum 2.22 -0.05 1.43 -5.20 5.54 -0.56 -14.63 -11.86 -9.65 4.74 2.18 0.15 0.78 -7.78 3.07
Endosome -1.80 3.92 3.60 9.63 -1.64 -0.51 5.53 4.78 14.73 -6.49 -1.53 7.09 5.96 17.08 -7.92
Golgi 0.57 1.81 1.07 2.44 -4.60 -0.40 2.92 2.08 6.57 -3.57 0.08 3.26 2.15 6.85 -5.72
Lipid Particles -6.32 0.24 2.74 8.03 3.50 3.34 5.24 5.05 9.17 -4.93 1.97 5.33 5.12 12.22 -3.92
Mitochondria -4.97 1.44 0.31 6.87 -2.78 1.14 4.17 3.82 9.11 -4.10 -0.28 4.33 3.75 11.37 -5.44
Mitotic Spindle 1.63 1.95 -0.73 -7.22 -8.71 -4.35 -5.16 -6.92 -4.85 -3.69 1.15 0.85 -2.63 -8.78 -7.69
None -5.90 -5.40 -7.90 3.22 1.54 -2.42 -10.46 -4.83 -2.33 6.33 -6.23 -13.06 -8.22 1.28 7.18
Nuclear Periphery 2.54 -6.08 -6.15 -12.00 1.20 1.37 -11.16 -8.82 -19.41 3.45 3.02 -10.55 -10.52 -21.03 0.12
Nuclear Periphery Foci 2.70 -3.80 0.28 -5.32 5.08 0.81 -4.42 -6.02 -9.79 2.08 2.91 -3.17 -2.02 -10.03 2.20
Nucleolus -3.87 0.09 0.58 6.15 0.92 0.41 1.26 1.23 4.48 -0.61 -0.85 1.41 1.32 7.41 -0.85
Nucleus 3.15 -12.76 -2.47 -16.30 17.42 -0.87 -38.27 -20.45 -27.31 19.37 2.53 -27.43 -11.52 -31.71 28.24
Peroxisomes -1.28 3.35 1.23 5.03 -6.18 0.68 5.23 1.91 2.79 -8.31 -0.17 6.15 2.45 5.81 -10.21
Vacuole 11.06 9.26 4.46 -22.64 -12.32 -3.69 -3.75 -15.15 -15.76 -15.41 7.72 7.38 -1.18 -27.63 -24.99
Vacuole Periphery 0.54 1.22 0.99 3.37 -3.28 0.09 3.14 2.63 6.73 -4.16 0.57 1.88 1.48 6.03 -4.90
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Heme A:farnesyltransferase; catalyzes first step in conversion of protoheme to heme A prosthetic group required for cytochrome c oxidase activity; human ortholog COX10 can complement yeast cox10 null mutant; human ortholog COX10 is associated with mitochondrial disorders
Localization
Cell Percentages mitochondrion (17%)
Cell Cycle Regulation No
Subcompartmental Group mito-1

Cox10

Cox10


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Cox10-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available