Standard name
Human Ortholog
Description RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with exosome to mediate 3'-end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; required for termination of non-poly(A) transcripts and efficient splicing; Nrd1-Nab3 pathway appears to have a role in rapid suppression of some genes when cells are shifted to poor growth conditions, indicating role for Nrd1-Nab3 in regulating cellular response to nutrient availability
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0.05 0 0 0 0 – 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.9 0.98 0.99 0.99 0.99 0.96 0.96 0.96 0.86 – 0.82 0.87 1.0 0.99 1.0 0.93 0.92 0.95 0.77 0.81 0.69 0.6 0.68 0.68
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0.07 0 0.07 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.15 0 0 0 0 0.06 0.07 0 0.19 – 0.32 0.17 0.11 0 0 0 0 0 0.12 0.08 0.14 0.2 0.16 0.1
Nucleus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0.07 0.08 0.06 0 0 0 0.06 0.06 0.05
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 1 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 1 5 1 4 6
Bud 1 2 0 0 0 0 0 1 9 – 4 3 0 1 0 0 0 0 0 1 0 0 3 4
Bud Neck 2 1 6 2 15 14 13 19 9 – 6 15 0 0 0 3 3 3 0 2 1 2 3 2
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 2 1 0 0 3 3 2 0 – 0 2 0 0 0 8 3 1 0 3 4 1 1 2
Cytoplasm 77 301 322 167 294 344 387 519 320 – 211 283 66 241 250 772 534 506 64 253 188 58 149 136
Endoplasmic Reticulum 0 2 0 0 0 0 0 0 1 – 0 0 0 0 0 59 21 40 1 0 0 1 1 3
Endosome 0 0 1 0 0 0 0 0 2 – 0 0 0 0 0 4 5 1 1 2 2 1 3 2
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 1 0 0 0 0
Mitochondria 13 6 0 5 1 20 28 11 70 – 83 55 7 1 0 18 15 6 9 25 37 19 34 19
Nucleus 0 1 1 1 2 1 1 6 6 – 5 1 0 0 0 18 8 3 0 0 3 0 0 0
Nuclear Periphery 0 0 0 0 0 1 0 0 0 – 0 0 0 1 0 1 0 0 0 0 0 0 0 0
Nucleolus 0 1 0 0 0 0 1 0 1 – 0 0 0 1 0 1 1 0 0 0 0 0 0 0
Peroxisomes 0 0 1 0 0 0 0 0 1 – 0 0 0 0 1 0 0 0 0 0 1 0 0 0
SpindlePole 0 0 0 1 1 6 8 16 4 – 6 10 0 0 1 1 1 0 1 2 2 1 0 4
Vac/Vac Membrane 0 1 0 0 0 1 1 0 3 – 0 3 0 0 0 62 44 34 2 10 8 6 14 9
Unique Cell Count 86 308 325 168 297 358 403 540 374 258 325 66 243 251 831 579 534 84 312 271 97 222 202
Labelled Cell Count 93 318 332 176 313 390 442 574 426 315 372 73 245 252 947 635 594 84 312 271 97 222 202


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 3.2 3.6 4.3 4.1 4.8 3.6 3.8 4.2 3.3 – 3.1 3.7 3.7 3.9 3.9 5.5 5.4 5.3 3.4 3.6 4.2
Std Deviation (1e-4) 0.4 0.7 1.1 1.4 1.8 1.7 1.6 1.7 1.4 – 1.5 1.6 0.7 1.0 1.5 0.9 0.9 0.9 1.1 1.1 1.8
Intensity Change (Log2) – – – -0.06 0.16 -0.24 -0.17 -0.02 -0.37 – -0.45 -0.21 -0.22 -0.13 -0.13 0.36 0.34 0.31 -0.34 -0.25 -0.03


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 0 0
Bud Neck – – – – – – – – – – – – 0 0 0
Bud Site – – – – – – – – – – – – 0 0 0
Cell Periphery – – – – – – – – – – – – 0 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 0 0
Endosome – – – – – – – – – – – – 0 0 0
Golgi – – – – – – – – – – – – 0 0 0
Mitochondria – – – – – – – – – – – – 0 0 0
Nuclear Periphery – – – – – – – – – – – – 0 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 0 0
Peroxisomes – – – – – – – – – – – – 0 0 0
SpindlePole – – – – – – – – – – – – 0 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 0 0
Cytoplasm – – – – – – – – – – – – 0 0 0
Nucleus – – – – – – – – – – – – 0 0 0
Vacuole – – – – – – – – – – – – 5.1 5.1 4.6

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.8352 1.3591 1.4362 1.0929 0.7913 1.2753 -0.1106 0.3025 -0.2267 0.3591 0.0168 -0.1377 0.2418 -0.0784 0.039 0.2791 -0.197 -0.1083
Actin 0.0199 0.0001 0.0058 0.0015 0.0025 0.0119 0.0277 0.0005 0.0062 0.0081 0.0395 0.0038 0.0337 0.0004 0.0166 0.0606 0.0291 0.002
Bud 0.0003 0.0012 0.0003 0.0006 0.001 0.0104 0.0023 0.002 0.003 0.0018 0.007 0.0008 0.0012 0.0025 0.0004 0.0035 0.0032 0.0001
Bud Neck 0.0027 0.0001 0.0004 0.0003 0.0003 0.0008 0.0014 0.0002 0.001 0.0004 0.0025 0.0009 0.0034 0.0001 0.0002 0.0014 0.0002 0.0004
Bud Periphery 0.0008 0.0008 0.0005 0.0005 0.0034 0.0047 0.0049 0.0033 0.0031 0.003 0.0075 0.0017 0.0047 0.0043 0.0006 0.005 0.0043 0.0002
Bud Site 0.0015 0.0041 0.0015 0.0002 0.0041 0.0024 0.0149 0.0038 0.0141 0.0009 0.0012 0.0004 0.0097 0.0036 0.0012 0.0064 0.0047 0.0004
Cell Periphery 0.0007 0.0003 0.0002 0.0003 0.0009 0.0002 0.0007 0.0005 0.0008 0.0001 0.0005 0.0001 0.0006 0.0003 0.0002 0.0004 0.0001 0.0001
Cytoplasm 0.1224 0.1469 0.1669 0.1325 0.0745 0.1332 0.2168 0.2496 0.191 0.3628 0.2098 0.2186 0.3455 0.3313 0.3498 0.1355 0.4036 0.3834
Cytoplasmic Foci 0.0165 0.0019 0.0203 0.0109 0.0116 0.0249 0.0318 0.0075 0.0228 0.0186 0.0341 0.0222 0.0249 0.0099 0.01 0.0159 0.0152 0.0132
Eisosomes 0.0017 0.0002 0.0012 0.0004 0.0004 0.0002 0.0005 0.0001 0.0002 0.0001 0.0007 0.0001 0.0005 0.0001 0.0003 0.0007 0.0001 0.0001
Endoplasmic Reticulum 0.0022 0.0009 0.0019 0.0051 0.0034 0.0019 0.0056 0.002 0.0018 0.0021 0.002 0.0024 0.0131 0.0007 0.0088 0.0023 0.0018 0.0023
Endosome 0.009 0.0009 0.0103 0.0124 0.0387 0.0118 0.0283 0.006 0.0219 0.0221 0.026 0.0195 0.0336 0.0033 0.0226 0.0427 0.0308 0.0172
Golgi 0.0058 0.0001 0.0048 0.0021 0.0138 0.0062 0.0061 0.0009 0.0064 0.007 0.0084 0.0017 0.0085 0.0004 0.0032 0.0218 0.002 0.0011
Lipid Particles 0.0056 0.0002 0.0064 0.0271 0.022 0.0067 0.0167 0.0002 0.004 0.0029 0.0067 0.0011 0.0145 0.0005 0.0011 0.02 0.0004 0.001
Mitochondria 0.0028 0.0004 0.0134 0.0016 0.0202 0.0147 0.0104 0.0009 0.0081 0.0028 0.0052 0.0024 0.0129 0.0004 0.0015 0.0815 0.0015 0.0007
None 0.7827 0.8332 0.7486 0.7868 0.7673 0.7494 0.6023 0.7051 0.6968 0.5444 0.6135 0.7087 0.4666 0.6371 0.5697 0.5842 0.4912 0.5696
Nuclear Periphery 0.0011 0.0002 0.0004 0.0011 0.0037 0.0012 0.0038 0.0016 0.0012 0.0007 0.0012 0.0065 0.0071 0.0003 0.0034 0.0018 0.0006 0.0029
Nucleolus 0.0006 0.0005 0.0004 0.0008 0.0019 0.0006 0.0007 0.0002 0.0011 0.0002 0.0004 0.0003 0.0003 0.0007 0.0002 0.0005 0.0001 0.0003
Nucleus 0.0007 0.0046 0.0007 0.0033 0.0061 0.0024 0.0023 0.0122 0.0023 0.0011 0.0025 0.0012 0.0022 0.0008 0.001 0.0013 0.0005 0.0013
Peroxisomes 0.0194 0.0001 0.0099 0.0015 0.0075 0.0073 0.0134 0.0001 0.0071 0.0155 0.0234 0.0014 0.0069 0.0005 0.0005 0.0072 0.0049 0.0004
Punctate Nuclear 0.0015 0.0013 0.0028 0.0086 0.0008 0.0075 0.0033 0.0004 0.0035 0.001 0.0039 0.0039 0.0036 0.0007 0.0004 0.0007 0.0007 0.0014
Vacuole 0.0015 0.0018 0.0029 0.0017 0.0117 0.0011 0.0047 0.0025 0.0028 0.0036 0.003 0.0014 0.0055 0.0019 0.0068 0.0042 0.0038 0.0015
Vacuole Periphery 0.0004 0.0002 0.0005 0.0006 0.0042 0.0005 0.0014 0.0004 0.0009 0.0009 0.001 0.0009 0.0012 0.0003 0.0016 0.0025 0.0013 0.0005

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 51.2998 61.4182 54.3861 50.1828 43.9457 51.2714 58.5809 62.311 53.3832 48.9219
Translational Efficiency 2.5922 2.489 2.1455 2.3202 2.2731 2.3071 1.9194 1.7493 1.8781 1.9436

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1393 1648 100 1693 1657 2032 159 1961 3050 3680 259 3654

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 647.87 859.19 1212.48 1208.29 815.61 877.03 1142.50 1127.96 739.00 869.04 1169.52 1165.18
Standard Deviation 110.83 152.50 148.09 149.31 128.89 129.04 125.52 177.01 147.03 140.31 138.92 169.56
Intensity Change Log 2 — 0.407273 0.904185 0.899190 — 0.104747 0.486243 0.467765 — 0.246547 0.686312 0.674792

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000222 0.000319 0.009545 0.000803 0.000259 0.000629 0.002739 0.001376 0.000242 0.000490 0.005367 0.001110
Bud Neck 0.011582 0.010079 0.008491 0.002234 0.004960 0.012789 0.006402 0.002756 0.007984 0.011576 0.007209 0.002514
Bud Site 0.013020 0.027492 0.073356 0.037686 0.013082 0.026502 0.042425 0.039971 0.013054 0.026946 0.054367 0.038912
Cell Periphery 0.000170 0.000119 0.000441 0.000191 0.000142 0.000126 0.000125 0.000129 0.000155 0.000123 0.000247 0.000157
Cytoplasm 0.486263* 0.559635* 0.326413* 0.668839* 0.547534* 0.435512* 0.231618* 0.627188* 0.519550* 0.491098* 0.268218* 0.646486*
Cytoplasmic Foci 0.242788* 0.241403* 0.186236* 0.100558 0.281305* 0.248463* 0.220977* 0.121060 0.263714* 0.245301* 0.207564* 0.111561
Eisosomes 0.000109 0.000049 0.000079 0.000008 0.000083 0.000075 0.000056 0.000012 0.000095 0.000063 0.000065 0.000010
Endoplasmic Reticulum 0.002046 0.000981 0.004801 0.000343 0.002327 0.002059 0.002197 0.000387 0.002199 0.001576 0.003202 0.000367
Endosome 0.036387 0.019108 0.044102 0.023934 0.022474 0.047796 0.121496 0.027749 0.028828 0.034949 0.091614 0.025981
Golgi 0.012822 0.013856 0.006518 0.008544 0.014889 0.020232 0.012400 0.016895 0.013945 0.017376 0.010129 0.013026
Lipid Particles 0.007325 0.002152 0.009328 0.002942 0.004537 0.004768 0.006260 0.002583 0.005811 0.003596 0.007444 0.002749
Mitochondria 0.005880 0.005242 0.000153 0.000679 0.001661 0.007609 0.000152 0.001400 0.003588 0.006549 0.000152 0.001066
Mitotic Spindle 0.001493 0.002741 0.090118 0.004319 0.000862 0.003266 0.032302 0.010301 0.001150 0.003031 0.054625 0.007529
None 0.012931 0.001294 0.000267 0.000100 0.002298 0.001307 0.000721 0.000328 0.007154 0.001301 0.000546 0.000222
Nuclear Periphery 0.000360 0.000104 0.000682 0.000112 0.000161 0.000242 0.001098 0.000112 0.000252 0.000180 0.000937 0.000112
Nuclear Periphery Foci 0.000708 0.000290 0.020192 0.000671 0.000630 0.000264 0.011744 0.000626 0.000665 0.000276 0.015006 0.000647
Nucleolus 0.001642 0.000414 0.000167 0.000201 0.000481 0.000647 0.001088 0.000233 0.001012 0.000543 0.000732 0.000218
Nucleus 0.086351 0.043625 0.039235 0.003275 0.032162 0.028612 0.010733 0.009947 0.056912 0.035335 0.021738 0.006855
Peroxisomes 0.003889 0.004914 0.009853 0.003644 0.002276 0.004622 0.015571 0.004724 0.003013 0.004752 0.013363 0.004223
Vacuole 0.067656 0.061594 0.169030 0.135933 0.063497 0.145789 0.276211* 0.125896 0.065396 0.108084 0.234828* 0.130546
Vacuole Periphery 0.006356 0.004590 0.000993 0.004986 0.004380 0.008690 0.003686 0.006329 0.005282 0.006854 0.002646 0.005707

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.50 -3.90 -5.02 -4.11 3.66 -1.95 -2.76 -4.08 -2.11 1.57 -2.34 -4.71 -5.53 -3.09 3.91
Bud Neck 1.23 1.25 10.65 9.78 5.12 -8.74 -1.24 5.61 11.38 3.31 -4.99 0.48 11.95 14.99 5.87
Bud Site -8.50 -6.01 -11.60 -3.36 3.55 -7.85 -5.02 -14.06 -4.86 0.58 -11.45 -7.72 -18.19 -5.87 2.96
Cell Periphery 4.61 -6.26 -0.27 -3.01 5.90 1.22 0.33 1.40 0.20 0.78 3.64 -4.88 0.64 -1.94 4.87
Cytoplasm -7.14 6.53 -17.15 -10.65 -13.34 12.21 13.55 -7.67 -19.55 -16.74 4.07 14.43 -17.18 -21.68 -21.49
Cytoplasmic Foci 0.18 5.78 21.72 22.55 3.93 4.70 4.92 25.77 22.61 5.49 3.53 6.90 33.63 31.97 6.82
Eisosomes 4.82 1.53 8.35 14.96 8.39 1.22 2.75 12.72 17.74 7.20 4.70 3.04 13.41 22.94 10.93
Endoplasmic Reticulum 3.00 -4.96 5.01 6.45 8.25 0.72 -0.12 7.17 6.09 5.70 2.36 -3.60 8.56 7.69 9.59
Endosome 7.32 0.37 5.48 -1.99 1.77 -11.99 -6.97 -2.30 9.50 6.64 -3.80 -6.11 2.87 6.98 6.65
Golgi -0.90 4.71 4.31 5.64 -1.86 -4.02 1.22 -0.14 3.26 -1.24 -3.78 2.42 2.50 5.78 -1.46
Lipid Particles 7.45 -2.22 6.22 -2.70 6.32 -0.42 -2.52 4.83 4.01 4.56 4.93 -3.05 7.84 2.60 7.36
Mitochondria 0.58 7.09 6.17 5.81 -1.21 -6.55 7.91 0.89 6.58 -3.20 -4.22 8.97 5.80 8.73 -3.31
Mitotic Spindle -1.62 -4.23 -3.08 -1.60 4.03 -3.47 -3.22 -6.35 -4.42 2.28 -3.66 -5.24 -7.03 -4.58 4.49
None 6.89 7.46 7.61 9.64 3.71 1.70 2.58 4.19 2.98 1.16 6.98 7.73 8.48 5.68 1.66
Nuclear Periphery 4.65 -4.15 2.91 -0.52 5.60 -1.38 -2.40 0.52 2.67 2.47 1.76 -3.22 2.65 1.32 3.67
Nuclear Periphery Foci 5.29 -5.01 -0.38 -4.02 5.00 3.33 -3.48 -0.54 -4.02 3.46 5.59 -5.37 -0.66 -5.68 5.35
Nucleolus 7.59 9.46 9.23 3.93 -1.33 -0.74 -1.56 2.19 2.33 2.04 3.72 0.37 8.46 3.26 1.99
Nucleus 7.82 2.21 17.41 12.89 4.86 1.14 4.16 6.28 5.80 0.08 7.12 4.43 17.58 13.34 4.37
Peroxisomes -1.66 -2.21 1.11 2.63 2.50 -6.01 -4.04 -5.58 0.46 3.34 -4.76 -4.49 -3.14 2.28 4.04
Vacuole 1.32 -7.35 -14.07 -15.52 3.59 -16.56 -10.25 -14.51 1.15 6.74 -12.86 -12.50 -20.23 -7.98 7.53
Vacuole Periphery 2.20 7.51 2.11 0.11 -7.98 -7.00 1.28 -1.82 3.69 -2.38 -3.17 4.44 0.15 3.32 -4.29
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with exosome to mediate 3'-end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; required for termination of non-poly(A) transcripts and efficient splicing; Nrd1-Nab3 pathway appears to have a role in rapid suppression of some genes when cells are shifted to poor growth conditions, indicating role for Nrd1-Nab3 in regulating cellular response to nutrient availability
Localization
Cell Percentages cytoplasm (82%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-4

Nab3

Nab3


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Nab3-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available