Standard name
Human Ortholog
Description DNA damage checkpoint protein; part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate; forms nuclear foci upon DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.05 0 0.12 0.13 0.12 0.15 0.13 0.18 0.11 0.12 0.1 0.13 0.18 0.19 0.27 0.1 0.12 0.08 0 0 0 0 0.05 0.06
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.25 0 0 0.06 0 0.23 0.25 0.25 0.41 0.32 0.65 0.42 0 0 0 0.07 0 0 0 0 0 0 0 0
Nucleus 0.77 0.85 0.84 0.84 0.78 0.68 0.71 0.64 0.67 0.66 0.55 0.63 0.79 0.66 0.65 0.81 0.81 0.82 0.75 0.79 0.64 0.6 0.62 0.6
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.06 0.18 0.05 0 0.09 0.07 0.07 0 0.05 0.08 0.05 0.08 0.06 0.09 0.06 0.08 0.08 0.11 0.15 0.11 0.22 0.19 0.18 0.16
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 1 0 0 1
Bud 0 0 0 0 0 1 5 1 0 7 5 5 0 0 0 2 0 0 3 4 3 1 2 1
Bud Neck 2 0 1 0 1 1 1 5 1 1 0 0 1 0 0 0 0 0 0 0 0 0 0 0
Bud Site 2 0 0 0 0 2 5 3 8 2 10 13 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0
Cytoplasm 15 7 17 25 35 45 49 64 36 47 42 49 14 17 27 38 42 28 7 4 5 1 4 8
Endoplasmic Reticulum 2 1 0 0 2 0 0 1 0 0 1 0 0 1 1 17 12 8 0 0 1 1 0 1
Endosome 1 0 0 1 4 2 3 3 2 4 0 2 0 2 1 11 2 3 4 4 2 1 2 3
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 1 1 1 0 0 0 0
Mitochondria 75 10 0 11 8 70 90 88 131 122 261 164 1 2 1 27 9 7 4 3 3 0 1 3
Nucleus 231 210 121 167 233 206 257 223 212 252 219 243 61 59 65 321 291 276 266 218 121 32 60 78
Nuclear Periphery 5 0 0 1 0 1 2 0 0 0 1 1 0 0 0 1 0 0 1 2 1 0 0 0
Nucleolus 4 0 0 0 0 0 0 0 0 0 1 1 1 1 1 0 0 0 1 0 1 0 1 2
Peroxisomes 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 1 0 2 4 11 5 8 7 4 12 3 8 2 3 2 3 3 2 5 3 4 0 2 2
Vac/Vac Membrane 17 45 7 7 28 22 24 14 17 29 20 32 5 8 6 33 29 37 54 29 41 10 17 20
Unique Cell Count 299 246 144 199 297 301 364 349 318 382 401 387 77 89 100 395 359 337 357 277 191 54 97 131
Labelled Cell Count 356 273 148 216 322 355 445 409 412 477 563 518 85 93 104 455 389 362 357 277 191 54 97 131


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.0 5.2 5.7 5.1 5.8 4.7 4.9 4.9 4.2 4.5 3.8 4.6 5.8 6.1 6.3 6.8 6.9 6.5 – 5.6 6.3
Std Deviation (1e-4) 0.7 0.9 1.1 1.1 1.4 1.4 1.3 1.4 0.9 1.0 1.2 1.8 1.5 1.6 2.0 1.3 1.5 1.2 – 1.7 1.8
Intensity Change (Log2) – – – -0.15 0.03 -0.26 -0.21 -0.19 -0.44 -0.32 -0.56 -0.3 0.04 0.1 0.16 0.27 0.28 0.21 – -0.0 0.16

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70002468WT3HU80HU120HU16002468WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302468WT1AF140AF18002468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.2 0 0.9 0.5 1.8 -0.2 0.2 -0.4 0.3 1.3 1.5 3.0 -0.7 0 -1.2
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 6.6 0 0 0 0 0 0 0 3.2 0 0
Nucleus 0 -1.4 -3.5 -3.1 -4.4 -3.9 -4.1 -6.3 -4.7 -0.9 -3.1 -3.4 -0.7 -0.8 -0.6
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole -0.6 1.7 1.0 0.7 -0.4 0.2 1.1 0.1 1.3 0 1.2 0.4 1.4 1.3 2.1

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.5338 2.8838 2.8144 2.5344 2.2312 2.8685 3.1562 2.4074 1.9007 1.3695 1.285 1.5798 3.1689 2.7843 2.7556 3.2456 2.5601 2.7061
Actin 0.011 0 0.0008 0.0004 0.0002 0.0005 0.0373 0.0016 0.0198 0.001 0.0003 0.0002 0.0218 0.0002 0.0205 0.0036 0.0001 0.0002
Bud 0.0008 0 0.0001 0.0002 0.0001 0.0001 0.0019 0.0001 0.0008 0.0001 0.0002 0.0001 0.0019 0.0001 0.0003 0.0013 0 0.0031
Bud Neck 0.0007 0.0002 0.0002 0.0008 0.0014 0.0024 0.0119 0.0003 0.0036 0.0009 0.0007 0.0015 0.0033 0.0004 0.0025 0.0005 0.0014 0.0051
Bud Periphery 0.0027 0 0.0003 0.0002 0.0001 0.0003 0.0052 0.0001 0.0006 0.0001 0.0002 0.0001 0.003 0 0.0007 0.0015 0 0.0008
Bud Site 0.0006 0.0004 0.0002 0.0001 0.0002 0.0002 0.0049 0.0005 0.008 0.0003 0.0003 0.0002 0.003 0.0007 0.0033 0.0021 0.0005 0.0004
Cell Periphery 0.0002 0 0 0 0 0 0.0008 0.0001 0.0002 0 0 0 0.0002 0.0001 0.0005 0.0001 0.0001 0
Cytoplasm 0.0152 0.0088 0.0235 0.0214 0.0434 0.0149 0.017 0.051 0.0764 0.052 0.1107 0.0224 0.0497 0.0802 0.0288 0.0857 0.03 0.019
Cytoplasmic Foci 0.0072 0.0001 0.0005 0.0027 0.0005 0.0006 0.0238 0.0065 0.0167 0.0011 0.0012 0.0074 0.0127 0.0036 0.0038 0.0096 0.001 0.0021
Eisosomes 0.0004 0 0 0 0 0.0001 0.0023 0.0001 0.0001 0 0 0 0.0001 0.0001 0.0002 0.0001 0 0
Endoplasmic Reticulum 0.0044 0.0005 0.0037 0.0045 0.004 0.0007 0.0088 0.0019 0.0018 0.0017 0.0013 0.0005 0.0042 0.0016 0.004 0.0021 0.0016 0.0008
Endosome 0.0232 0.0003 0.0015 0.0165 0.0034 0.0011 0.0377 0.0109 0.0218 0.0032 0.0009 0.0051 0.0196 0.0028 0.0062 0.0115 0.0009 0.0052
Golgi 0.0032 0 0.0002 0.0005 0 0.0001 0.027 0.0226 0.0134 0.0001 0 0.0013 0.0059 0.0002 0.0052 0.0083 0 0.0005
Lipid Particles 0.0048 0 0.0001 0.0079 0.0001 0.0003 0.0141 0.0038 0.0013 0.0002 0 0.0069 0.0053 0.0005 0.0092 0.0027 0.0003 0.0002
Mitochondria 0.0116 0.0002 0.0019 0.0011 0.0006 0.0014 0.0226 0.0021 0.027 0.0011 0.0011 0.0011 0.0054 0.0004 0.0102 0.0058 0.0005 0.0003
None 0.1821 0.0113 0.0866 0.0567 0.0093 0.0667 0.1567 0.1595 0.0391 0.0317 0.2469 0.0723 0.0666 0.0965 0.0617 0.1753 0.0761 0.0231
Nuclear Periphery 0.0497 0.0087 0.0232 0.0353 0.0365 0.0145 0.123 0.0407 0.0173 0.0803 0.0046 0.0102 0.0325 0.0133 0.0146 0.018 0.0037 0.0052
Nucleolus 0.0071 0.006 0.0069 0.0059 0.0105 0.0127 0.0103 0.0052 0.0057 0.0095 0.0055 0.0131 0.0087 0.0065 0.0041 0.0046 0.0098 0.0083
Nucleus 0.612 0.9556 0.8275 0.791 0.8587 0.8604 0.3771 0.6695 0.6974 0.7166 0.6173 0.8322 0.6858 0.7688 0.801 0.6499 0.8559 0.9117
Peroxisomes 0.0019 0 0 0.0004 0 0.0001 0.0149 0.0012 0.032 0.0001 0.0001 0.0032 0.0059 0.0001 0.003 0.0028 0 0.0002
Punctate Nuclear 0.0446 0.0073 0.02 0.0476 0.0263 0.0216 0.0887 0.0184 0.0109 0.0975 0.0074 0.021 0.0585 0.0219 0.0179 0.0116 0.017 0.013
Vacuole 0.0081 0.0005 0.001 0.0045 0.0038 0.0006 0.006 0.0018 0.005 0.0016 0.0009 0.001 0.0044 0.0019 0.0015 0.0021 0.0008 0.0007
Vacuole Periphery 0.0084 0.0001 0.0018 0.0022 0.0008 0.0008 0.0081 0.0021 0.0007 0.0009 0.0003 0.0003 0.0013 0.0003 0.0006 0.0009 0.0001 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 7.5 1.0727 3.9801 7.7893 8.5572 2.9984 5.4232 8.7847 6.7828 9.0275
Translational Efficiency – – – – – – – – – –

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency –

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2544 880 202 316 1592 1854 1832 584 4136 2734 2034 900

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 698.87 666.00 940.95 899.57 657.76 705.41 819.60 1113.86 683.05 692.72 831.65 1038.62
Standard Deviation 72.32 87.58 96.96 113.59 81.87 97.01 96.11 181.00 78.72 95.87 102.81 190.40
Intensity Change Log 2 — -0.069502 0.429094 0.364211 — 0.100901 0.317359 0.759935 — 0.015633 0.375999 0.569628

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000025 0.000217 0.005477 0.000491 0.000071 0.000198 0.000198 0.000307 0.000043 0.000204 0.000722 0.000371
Bud Neck 0.004308 0.008703 0.007906 0.005173 0.001902 0.012780 0.003662 0.030032 0.003382 0.011468 0.004084 0.021304
Bud Site 0.000630 0.003468 0.001746 0.002850 0.001155 0.004669 0.001551 0.018979 0.000832 0.004282 0.001570 0.013316
Cell Periphery 0.000125 0.000147 0.002166 0.000116 0.000145 0.000173 0.000150 0.000156 0.000132 0.000165 0.000351 0.000142
Cytoplasm 0.240250 0.103459 0.002057 0.104754 0.093928 0.112132 0.056447 0.212420 0.183929 0.109340 0.051046 0.174617
Cytoplasmic Foci 0.016860 0.028250 0.000229 0.001644 0.008643 0.017584 0.002064 0.001081 0.013697 0.021017 0.001882 0.001279
Eisosomes 0.000020 0.000048 0.000618 0.000034 0.000020 0.000034 0.000024 0.000013 0.000020 0.000038 0.000083 0.000020
Endoplasmic Reticulum 0.000526 0.002550 0.013346 0.005202 0.001048 0.002622 0.002674 0.001157 0.000727 0.002599 0.003734 0.002577
Endosome 0.000958 0.002473 0.000565 0.003310 0.000608 0.003029 0.000707 0.000880 0.000823 0.002850 0.000693 0.001733
Golgi 0.000519 0.000640 0.000097 0.000173 0.000178 0.001083 0.000167 0.000124 0.000388 0.000941 0.000160 0.000141
Lipid Particles 0.001912 0.004030 0.000661 0.000690 0.001440 0.003433 0.000677 0.000166 0.001730 0.003625 0.000675 0.000350
Mitochondria 0.001555 0.008994 0.000741 0.001037 0.000708 0.008514 0.000923 0.004153 0.001229 0.008668 0.000905 0.003059
Mitotic Spindle 0.000327 0.003606 0.000070 0.013987 0.001579 0.011409 0.002762 0.029006 0.000809 0.008898 0.002495 0.023732
None 0.009230 0.019472 0.000881 0.014189 0.014487 0.008994 0.009993 0.013866 0.011253 0.012366 0.009088 0.013979
Nuclear Periphery 0.001053 0.001682 0.000835 0.001691 0.001084 0.003342 0.001089 0.001155 0.001065 0.002808 0.001064 0.001344
Nuclear Periphery Foci 0.000397 0.001324 0.000191 0.000749 0.000601 0.000751 0.000200 0.000092 0.000476 0.000936 0.000199 0.000323
Nucleolus 0.002116 0.009295 0.002247 0.001446 0.003965 0.006485 0.002745 0.000981 0.002828 0.007390 0.002696 0.001144
Nucleus 0.714813 0.787812 0.948731 0.820878 0.865836 0.785449 0.907898 0.670926 0.772944 0.786210 0.911953 0.723576
Peroxisomes 0.000826 0.005552 0.000253 0.000195 0.000681 0.004316 0.000337 0.000317 0.000771 0.004714 0.000328 0.000274
Vacuole 0.003310 0.006898 0.011054 0.021213 0.001742 0.011867 0.005490 0.013738 0.002707 0.010268 0.006042 0.016362
Vacuole Periphery 0.000238 0.001379 0.000130 0.000177 0.000180 0.001137 0.000241 0.000454 0.000216 0.001215 0.000230 0.000357

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -8.78 -1.46 -10.50 -7.79 1.14 -4.06 -9.51 -6.45 -2.20 -0.98 -7.70 -2.22 -12.47 -6.94 0.47
Bud Neck -3.37 -2.03 -5.32 -0.69 -0.63 -8.95 -4.83 -10.21 -5.52 -9.16 -8.45 -2.62 -10.52 -5.35 -9.59
Bud Site -4.18 -3.12 -6.87 -1.37 -3.92 -3.88 -0.76 -4.56 -2.99 -4.37 -5.98 -1.94 -5.67 -3.18 -4.95
Cell Periphery -0.86 -0.97 -0.17 1.49 0.97 -0.84 0.43 2.33 2.86 2.84 -1.28 -0.99 1.12 3.11 1.18
Cytoplasm 18.60 50.32 21.28 4.42 -9.33 -3.24 7.95 -6.12 -4.05 -11.15 15.51 31.19 9.47 -1.43 -11.00
Cytoplasmic Foci -4.44 15.34 13.00 10.03 -3.88 -4.96 6.45 5.71 10.20 0.56 -5.28 14.51 12.77 14.28 0.26
Eisosomes -8.44 -1.12 -7.35 -2.69 0.97 -5.60 -3.37 3.82 10.56 9.02 -10.47 -1.34 -5.07 1.67 0.92
Endoplasmic Reticulum -11.44 -12.48 -11.52 -9.25 2.50 -6.78 -11.12 -3.69 3.64 7.15 -11.17 -16.43 -11.45 -5.92 -0.78
Endosome -3.58 0.66 -1.95 0.29 -2.23 -6.36 -0.93 0.68 6.47 1.43 -6.57 0.50 -1.20 4.59 -1.62
Golgi -0.61 1.74 1.50 4.07 -1.50 -2.94 0.67 1.23 3.23 0.32 -2.25 1.61 1.73 3.96 0.08
Lipid Particles -3.56 3.15 2.00 5.47 -1.80 -4.80 4.11 7.97 8.27 3.63 -5.06 4.34 5.15 9.79 0.98
Mitochondria -5.26 1.72 0.67 5.67 -3.40 -8.06 -1.12 -7.17 4.30 -6.17 -9.02 0.97 -4.64 6.74 -6.04
Mitotic Spindle -2.62 1.75 -3.15 -2.30 -3.19 -4.82 -2.40 -4.98 -2.75 -4.22 -6.06 -3.64 -6.05 -3.47 -4.80
None -4.51 10.62 0.36 3.99 -4.60 3.05 3.38 0.54 -3.56 -4.10 -0.91 3.15 -0.48 0.46 -3.52
Nuclear Periphery -1.89 -0.18 -8.01 -4.76 -8.24 -4.75 -2.59 -5.54 1.47 -4.32 -5.10 -2.85 -8.99 -0.47 -7.52
Nuclear Periphery Foci -1.76 1.05 -2.24 -0.75 -2.61 -0.74 1.81 1.41 1.96 0.06 -1.93 1.53 -1.37 0.28 -2.31
Nucleolus -5.88 0.70 1.41 6.48 0.81 -2.73 2.22 1.35 4.15 -0.61 -6.56 1.54 1.22 7.14 -0.07
Nucleus -5.94 -23.51 -5.39 -0.79 9.41 9.74 -5.58 10.27 3.34 14.03 -1.22 -24.19 1.58 2.28 15.84
Peroxisomes -5.13 2.96 3.25 5.85 0.65 -4.79 1.97 2.89 5.73 0.65 -6.73 2.78 4.40 7.91 0.59
Vacuole -4.13 -3.41 -8.00 -7.54 -5.81 -7.96 -7.37 -6.54 -2.33 -3.22 -8.41 -7.50 -9.81 -7.37 -7.28
Vacuole Periphery -3.35 0.87 0.79 3.77 -0.32 -6.16 -0.24 -0.98 5.76 -0.53 -6.33 0.18 -0.04 6.78 -0.26
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description DNA damage checkpoint protein; part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate; forms nuclear foci upon DNA replication stress
Localization
Cell Percentages nucleus (63%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-3

Ddc1

Ddc1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ddc1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available