Standard name
Human Ortholog
Description Aurora kinase of chromosomal passenger complex; mediates release of mono-oriented kinetochores from microtubules in meiosis I, and kinetochore release from SPB clusters at meiotic exit; helps maintain condensed chromosomes during anaphase; required for SPB cohesion and prevention of multipolar spindle formation; promotes telomerase release at G2/M; Iocalizes to nuclear foci that diffuse upon DNA replication stress; required for inhibition of karyopherin Pse1p upon SAC arrest
DOWNLOAD

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0.07 0 0.05 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0.06 0.09 0.05 0 0.07 0.08 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.09 0.09 0 0.17 0.18 0.21 0.2 0.28 0.2 0.35 0.22 0.26 0.24 0.41 0.47 0.09 0.1 0.11 0 0 0 0.07 0.13 0.23
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0.21 0 0 0.05 0 0 0 0 0 0 0 0.06 0.09 0.21 0.25 0.26 0.2 0.09 0.13 0.09 0.11 0.09 0.07
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.59 0.2 0.17 0.08 0.08 0.31 0.46 0.32 0.62 0.52 0.76 0.59 0 0 0 0.19 0.11 0.14 0.05 0.06 0.05 0.08 0.1 0.08
Nucleus 0.1 0.12 0.22 0.08 0.15 0.19 0.13 0.15 0.12 0.1 0.14 0.11 0.17 0.2 0.18 0.16 0.17 0.22 0.06 0.05 0.07 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.11 0.16 0 0.05 0.06 0.07 0.07 0 0.06 0 0 0 0.07 0 0 0.33 0.35 0.45 0.05 0.09 0.09 0.07 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0.38 0.41 0.61 0.67 0.6 0.41 0.34 0.36 0.19 0.17 0.16 0.22 0.5 0.35 0.24 0.54 0.53 0.38 0.53 0.46 0.48 0.45 0.49 0.45
Vac/Vac Membrane 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0.06 0 0.06 0.05 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 1 1 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 0 1 3 3
Bud 2 1 1 4 3 6 10 16 8 13 4 9 0 1 0 0 0 0 0 0 0 1 4 6
Bud Neck 2 0 1 11 23 9 7 17 18 15 2 7 2 4 0 0 0 0 1 0 0 0 2 4
Bud Site 5 1 0 5 8 7 11 6 9 9 3 13 1 0 0 1 1 3 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 21 11 1 30 47 42 59 68 44 95 21 45 31 75 90 12 12 16 7 5 3 8 30 51
Endoplasmic Reticulum 5 1 1 0 0 0 0 0 0 0 0 0 0 0 0 2 1 0 2 0 0 0 1 1
Endosome 6 27 0 1 14 5 2 4 1 0 0 1 8 16 39 34 31 29 25 23 8 13 20 16
Golgi 0 1 0 1 0 0 0 0 0 0 0 0 0 1 2 0 2 3 2 1 0 0 1 0
Mitochondria 132 25 4 14 20 61 135 77 135 144 73 102 5 1 0 26 13 21 14 11 4 8 23 18
Nucleus 23 15 5 14 38 37 37 35 26 27 13 20 22 37 35 21 20 32 16 8 6 1 2 0
Nuclear Periphery 4 0 0 0 0 0 0 0 1 1 0 0 0 0 0 3 0 1 1 2 0 0 0 0
Nucleolus 25 20 1 8 15 13 20 9 13 12 3 5 9 6 3 45 41 65 13 16 8 8 7 1
Peroxisomes 1 2 0 0 0 0 1 1 0 0 0 1 0 0 2 2 3 4 0 0 0 0 1 0
SpindlePole 85 53 14 115 157 81 100 85 42 46 15 39 64 65 45 73 62 55 144 84 46 52 115 100
Vac/Vac Membrane 3 8 0 0 1 2 3 3 0 4 1 1 0 5 3 5 8 8 5 11 4 3 4 7
Unique Cell Count 223 128 23 172 262 199 292 239 218 275 96 174 127 184 190 135 117 145 274 186 97 118 235 224
Labelled Cell Count 314 166 29 204 327 263 385 321 297 366 135 243 142 211 219 224 194 237 274 186 97 118 235 224


Microtubule

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 3.2 4.4 4.1 4.5 4.8 3.9 3.5 4.2 3.1 3.4 2.9 3.4 4.5 5.2 5.3 6.5 6.7 6.5 4.5 4.8 5.2
Std Deviation (1e-4) 0.5 0.8 1.0 1.8 2.0 1.6 1.4 1.9 0.9 1.3 0.9 1.5 0.6 1.8 2.1 1.5 1.8 1.9 1.6 1.5 2.2
Intensity Change (Log2) – – – 0.12 0.24 -0.06 -0.23 0.04 -0.41 -0.29 -0.48 -0.26 0.13 0.34 0.36 0.66 0.71 0.67 0.14 0.24 0.35


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – – – –
Bud Neck – – – – – – – – – – – – – – –
Bud Site – – – – – – – – – – – – – – –
Cell Periphery – – – – – – – – – – – – – – –
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – – – –
Endosome – – – – – – – – – – – – – – –
Golgi – – – – – – – – – – – – – – –
Mitochondria – – – – – – – – – – – – – – –
Nuclear Periphery – – – – – – – – – – – – – – –
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – – – –
Peroxisomes – – – – – – – – – – – – – – –
SpindlePole – – – – – – – – – – – – – – –
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – – – –
Cytoplasm – – – – – – – – – – – – – – –
Nucleus – – – – – – – – – – – – – – –
Vacuole – – – – – – – – – – – – – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration -0.2667 0.6402 0.3112 0.2031 0.0504 0.253 -0.6142 0.0022 0.1116 0.0372 -0.0729 -0.0779 -0.9709 -0.636 -0.9695 -0.1758 -0.3766 -0.8763
Actin 0.005 0.0006 0.0002 0.0002 0.0043 0.0009 0.0215 0.0002 0.0022 0.0032 0.0043 0.0039 0.0289 0.0004 0.0026 0.0624 0.0171 0.0029
Bud 0.0002 0.0006 0 0.0001 0.0002 0.0004 0.0005 0.0002 0.0001 0.0005 0.0004 0.0002 0.0004 0.0025 0.0001 0.0007 0.0006 0.0001
Bud Neck 0.0027 0.0011 0.0018 0.001 0.0098 0.0096 0.002 0.0023 0.0012 0.0185 0.0064 0.0135 0.002 0.0013 0.001 0.0732 0.0045 0.0076
Bud Periphery 0.0005 0.0002 0 0 0.0012 0.0002 0.0008 0.0003 0.0001 0.0005 0.0005 0.0006 0.001 0.0005 0.0002 0.0013 0.0015 0.0005
Bud Site 0.0015 0.002 0.0003 0.0001 0.0008 0.0003 0.002 0.0026 0.0009 0.0186 0.0007 0.0007 0.0041 0.0048 0.0011 0.0053 0.0023 0.0005
Cell Periphery 0.0001 0.0001 0 0 0.0004 0.0001 0.0002 0.0001 0 0.0002 0.0001 0.0003 0.0002 0.0001 0 0.0003 0.0003 0.0002
Cytoplasm 0.0179 0.0059 0.0043 0.017 0.0073 0.0083 0.0317 0.017 0.0056 0.02 0.0163 0.0151 0.022 0.0136 0.0173 0.0102 0.0028 0.0066
Cytoplasmic Foci 0.0595 0.025 0.0048 0.0197 0.0052 0.0232 0.0769 0.027 0.0164 0.0242 0.0119 0.0208 0.0773 0.0401 0.016 0.0042 0.0233 0.0318
Eisosomes 0.0003 0.0001 0 0.0001 0.001 0.0001 0.0002 0.0001 0 0 0.0001 0.0002 0.0003 0 0 0.0004 0.0006 0.0001
Endoplasmic Reticulum 0.0011 0.0005 0.0001 0.0003 0.0013 0.0003 0.0031 0.0007 0.0009 0.0006 0.0024 0.0029 0.0033 0.0004 0.001 0.0015 0.0021 0.0005
Endosome 0.0088 0.0055 0.0008 0.0008 0.0054 0.0041 0.0328 0.0038 0.0054 0.0092 0.0317 0.011 0.0229 0.0034 0.0116 0.0103 0.033 0.0085
Golgi 0.0019 0.0008 0.0002 0.0001 0.0017 0.0014 0.0098 0.0008 0.0022 0.0037 0.0073 0.006 0.0058 0.0009 0.0013 0.0059 0.0092 0.0032
Lipid Particles 0.0274 0.013 0.0011 0.0021 0.0281 0.054 0.0416 0.0192 0.0109 0.013 0.0073 0.0394 0.0378 0.0056 0.0094 0.0081 0.0712 0.0717
Mitochondria 0.0063 0.0008 0.0003 0.0003 0.0283 0.0029 0.0058 0.0005 0.0014 0.0014 0.0044 0.0093 0.009 0.0003 0.0008 0.0039 0.0152 0.0144
None 0.152 0.0198 0.0565 0.0502 0.0472 0.0343 0.1075 0.1218 0.0226 0.0125 0.0718 0.0497 0.1149 0.0823 0.0505 0.0377 0.0624 0.0256
Nuclear Periphery 0.0153 0.0229 0.009 0.0105 0.1205 0.016 0.0249 0.0073 0.0075 0.0133 0.03 0.0108 0.0246 0.0073 0.0155 0.0096 0.0995 0.0185
Nucleolus 0.0382 0.0808 0.0446 0.0176 0.0752 0.0531 0.0237 0.0572 0.0512 0.0208 0.1128 0.0579 0.0118 0.0478 0.0302 0.0213 0.0855 0.0523
Nucleus 0.0848 0.2235 0.3824 0.4373 0.1503 0.0838 0.0638 0.2581 0.2883 0.3939 0.2559 0.1126 0.0605 0.2152 0.3571 0.392 0.0953 0.0806
Peroxisomes 0.0138 0.0132 0.0003 0.0005 0.004 0.0109 0.0102 0.0014 0.0138 0.0358 0.0014 0.0134 0.012 0.009 0.0078 0.0052 0.0236 0.0123
Punctate Nuclear 0.5604 0.5814 0.4929 0.4414 0.5021 0.6952 0.5353 0.4779 0.5685 0.4084 0.4303 0.6297 0.5545 0.5638 0.4735 0.3434 0.4395 0.66
Vacuole 0.0017 0.0017 0.0001 0.0005 0.0022 0.0006 0.0043 0.0013 0.0004 0.0013 0.0021 0.0014 0.0052 0.0007 0.0024 0.0022 0.0058 0.0013
Vacuole Periphery 0.0006 0.0006 0.0001 0.0001 0.0033 0.0005 0.0014 0.0002 0.0002 0.0002 0.0016 0.0006 0.0014 0.0001 0.0005 0.0007 0.0048 0.0009

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 11.9935 2.6804 2.6519 4.3998 7.7751 3.9956 7.227 2.7437 4.4557 7.7048
Translational Efficiency 1.1512 2.8725 1.2427 1.0432 1.2759 3.5506 0.8132 2.2102 1.2534 1.5017

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✔
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
51 917 421 191 894 1915 358 111 945 2832 779 302

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 752.35 751.51 859.57 939.08 656.40 749.77 928.20 935.82 661.58 750.33 891.11 937.88
Standard Deviation 162.17 97.06 99.37 118.88 76.67 91.16 96.31 116.84 86.32 93.12 103.78 118.14
Intensity Change Log 2 — -0.001612 0.192211 0.319844 — 0.191873 0.499860 0.511656 — 0.091777 0.343746 0.412398

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.002137 0.000708 0.000975 0.001325 0.000389 0.000654 0.001021 0.001071 0.000483 0.000672 0.000996 0.001232
Bud Neck 0.038688 0.006752 0.006096 0.010795 0.008908 0.009338 0.006850 0.003138 0.010515 0.008501 0.006442 0.007981
Bud Site 0.023134 0.003217 0.010704 0.017706 0.002041 0.006194 0.005380 0.002505 0.003180 0.005230 0.008257 0.012119
Cell Periphery 0.000500 0.000129 0.000122 0.000079 0.000211 0.000150 0.000131 0.000061 0.000227 0.000143 0.000126 0.000072
Cytoplasm 0.147279* 0.068386 0.021163 0.002640 0.163343* 0.071575 0.012099 0.002848 0.162476* 0.070543 0.016997 0.002716
Cytoplasmic Foci 0.144808 0.093628 0.003536 0.003139 0.169355 0.070727 0.005933 0.000807 0.168030 0.078142 0.004637 0.002282
Eisosomes 0.000275 0.000088 0.000069 0.000040 0.000130 0.000069 0.000086 0.000055 0.000138 0.000075 0.000077 0.000046
Endoplasmic Reticulum 0.020729 0.001851 0.003398 0.006682 0.001341 0.001419 0.005056 0.004084 0.002387 0.001559 0.004160 0.005727
Endosome 0.021232 0.012261 0.001845 0.003813 0.011835 0.012381 0.002907 0.001243 0.012342 0.012342 0.002333 0.002869
Golgi 0.013039 0.010102 0.000509 0.009218 0.003776 0.005752 0.000587 0.000335 0.004276 0.007161 0.000545 0.005953
Lipid Particles 0.058166 0.038778 0.002792 0.000963 0.071888 0.031525 0.003168 0.001435 0.071147 0.033873 0.002965 0.001137
Mitochondria 0.020958 0.017340 0.001653 0.001496 0.014091 0.015950 0.001769 0.000932 0.014461 0.016400 0.001706 0.001289
Mitotic Spindle 0.068903 0.489610* 0.519707* 0.751587* 0.132613* 0.442312* 0.425950* 0.688324* 0.129174* 0.457627* 0.476620* 0.728335*
None 0.015943 0.018892 0.010547 0.000635 0.033363 0.018629 0.004545 0.003219 0.032423 0.018714 0.007789 0.001585
Nuclear Periphery 0.004687 0.001899 0.001372 0.001509 0.003886 0.003547 0.001268 0.000893 0.003930 0.003014 0.001324 0.001282
Nuclear Periphery Foci 0.019516 0.023240 0.014555 0.010014 0.018489 0.025167 0.012508 0.008112 0.018545 0.024543 0.013614 0.009315
Nucleolus 0.082995 0.065143 0.083368 0.011994 0.070176 0.091058 0.068273 0.031950 0.070868 0.082667 0.076431 0.019329
Nucleus 0.215620* 0.122379 0.309714* 0.137357* 0.270280* 0.170845* 0.426638* 0.241189* 0.267330* 0.155152* 0.363448* 0.175521*
Peroxisomes 0.032354 0.020197 0.002219 0.001714 0.019030 0.015655 0.004437 0.001221 0.019749 0.017126 0.003238 0.001532
Vacuole 0.050807 0.004210 0.004839 0.025207 0.004077 0.005889 0.011081 0.006393 0.006599 0.005345 0.007708 0.018292
Vacuole Periphery 0.018229 0.001189 0.000819 0.002084 0.000779 0.001163 0.000314 0.000185 0.001721 0.001171 0.000587 0.001386

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 2.37 0.10 -2.20 -6.63 -3.36 -1.96 -8.94 -6.52 -5.95 -2.27 -2.53 -11.00 -9.85 -9.08 -4.07
Bud Neck 1.76 1.40 0.24 -6.35 -4.70 -1.08 -2.76 -2.73 -2.32 -0.55 0.47 -2.20 -5.60 -6.48 -4.52
Bud Site 2.74 1.21 -0.08 -3.71 -1.60 -3.99 -4.59 -5.32 -3.75 -1.86 -2.70 -4.61 -5.06 -4.48 -2.20
Cell Periphery 4.76 4.49 3.77 -2.45 -1.64 4.28 0.89 0.76 -1.87 -0.12 5.40 2.44 0.64 -3.31 -1.37
Cytoplasm 1.95 3.39 3.56 10.64 1.50 10.03 17.27 17.23 11.79 0.98 10.25 17.49 18.45 16.65 1.80
Cytoplasmic Foci 2.51 5.65 5.72 17.76 2.49 12.10 24.02 25.04 22.75 2.83 12.34 25.24 25.80 28.92 3.76
Eisosomes 5.96 5.73 5.44 0.04 0.18 8.72 -1.83 -0.73 -3.10 0.48 8.71 0.73 1.30 -2.42 0.71
Endoplasmic Reticulum 2.75 1.92 0.42 -6.68 -4.14 -2.96 -9.93 -6.94 -6.70 -1.87 0.73 -10.05 -8.69 -9.12 -4.40
Endosome 2.12 4.68 4.33 6.60 -0.86 0.08 5.38 4.31 4.33 -0.19 -0.26 8.14 6.11 7.20 -0.68
Golgi 0.57 2.53 1.89 2.62 -0.72 -1.54 7.23 6.67 7.79 0.11 -3.04 7.56 1.55 2.80 -0.72
Lipid Particles 2.02 4.47 4.56 10.75 1.37 8.33 14.56 14.20 10.85 0.13 8.19 15.25 15.42 16.22 1.20
Mitochondria 1.05 3.90 3.70 6.73 -2.05 0.41 9.53 9.53 8.81 0.70 0.17 10.27 9.70 10.73 -1.45
Mitotic Spindle -13.57* -12.70 -10.63 -1.36 -0.43 -18.89* -8.89 -7.79 -2.20 -2.57 -22.98 -15.90 -13.04 -3.12 -2.25
None -0.71 2.23 3.81 9.66 3.59 7.07 12.24 13.94 11.61 2.48 7.13 12.33 15.05 16.17 4.51
Nuclear Periphery 1.19 1.06 0.10 -3.84 -3.35 1.08 3.13 1.88 1.19 -0.88 1.98 3.31 0.64 -1.61 -3.38
Nuclear Periphery Foci -0.13 -0.03 0.83 2.00 1.63 -0.96 -0.99 0.03 0.45 0.66 -0.99 -0.83 1.24 1.96 1.77
Nucleolus 0.19 -0.85 2.05 3.87 5.01 -1.55 1.09 6.81 8.52 4.86 0.45 1.68 8.76 10.13 6.97
Nucleus 2.55 -2.00 -2.26 -6.60 -0.67 4.38 -7.93 -3.55 -4.89 1.13 5.73 -7.89 -4.94 -7.86 0.55
Peroxisomes 1.78 3.80 4.04 12.34 2.93 1.34 7.05 9.24 9.25 1.49 0.71 9.58 11.62 15.87 3.10
Vacuole 2.68 2.45 0.00 -4.64 -4.22 -1.87 -3.12 -2.47 -2.35 -1.50 0.73 -2.81 -5.05 -5.19 -4.21
Vacuole Periphery 2.17 2.22 2.15 -0.19 -0.72 -1.13 2.07 0.44 1.36 -1.26 1.40 1.98 0.91 -0.23 -0.93
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Aurora kinase of chromosomal passenger complex; mediates release of mono-oriented kinetochores from microtubules in meiosis I, and kinetochore release from SPB clusters at meiotic exit; helps maintain condensed chromosomes during anaphase; required for SPB cohesion and prevention of multipolar spindle formation; promotes telomerase release at G2/M; Iocalizes to nuclear foci that diffuse upon DNA replication stress; required for inhibition of karyopherin Pse1p upon SAC arrest
Localization
Cell Percentages nucleus (27%), nucleolus (15%), mixed (28%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Ipl1

Ipl1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ipl1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available