Standard name
Human Ortholog
Description Cyclin; interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation; PCL8 has a paralog, PCL10, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.88 0.91 0.89 0.59 0.66 0.61 0.56 0.52 0.52 0.46 0.34 0.41 0.98 0.98 0.97 0.81 0.86 0.86 0.8 0.76 0.77 0.89 0.91 0.83
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.12 0 0.16 0.41 0.24 0.41 0.62 0.59 0.57 0.59 0.72 0.67 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0.05 0.08 0.05 0.09 0.08 0.09 0.05 0.1 0 0 0 0 0 0.05 0.09 0.08 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.08 0.09 0 0.07 0.22 0.05 0.06 0 0.06 0.09 0.1 0 0 0 0 0.22 0.21 0.13 0.05 0.07 0.1 0 0 0.05
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 1 0 3 8
Bud 0 1 4 1 1 0 0 8 1 3 2 4 0 1 0 0 0 0 1 1 0 0 1 15
Bud Neck 0 0 0 0 0 0 0 1 0 0 1 0 0 0 0 0 0 0 0 0 0 1 1 1
Bud Site 0 0 0 0 0 0 0 0 1 4 0 1 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 2 0 2 0 1 3 0 1 0 0 0 0 0 0
Cytoplasm 147 123 81 26 61 83 94 135 68 63 37 61 350 472 457 219 167 161 153 120 78 209 331 402
Endoplasmic Reticulum 1 2 1 1 0 1 0 1 0 0 0 0 1 5 1 11 6 5 0 0 1 0 2 4
Endosome 0 0 0 0 0 0 1 0 0 0 0 0 0 0 2 6 3 2 0 3 0 1 3 6
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 2 0 1 1 0 0 0 0
Mitochondria 20 3 15 18 22 56 104 155 75 81 79 99 3 2 2 6 0 2 2 2 2 4 2 5
Nucleus 2 1 1 1 5 11 8 23 11 12 5 14 1 1 1 5 3 10 16 11 3 4 1 2
Nuclear Periphery 0 0 0 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Nucleolus 0 0 0 0 0 0 1 0 0 1 0 0 0 0 0 1 0 0 1 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 1 1 1 0 0 3 4
Vac/Vac Membrane 14 12 4 3 20 7 10 11 8 12 11 5 5 10 11 60 41 25 8 11 9 9 8 22
Unique Cell Count 168 135 91 44 92 136 168 261 131 137 110 147 356 484 469 270 194 188 192 159 101 235 364 486
Labelled Cell Count 184 142 106 50 109 158 219 336 164 176 137 184 362 492 476 312 222 207 192 159 101 235 364 486


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.4 5.3 3.9 3.9 4.1 3.5 3.1 3.4 3.6 3.3 3.3 3.1 5.4 5.4 5.6 7.2 8.1 7.9 4.5 4.8 5.7
Std Deviation (1e-4) 0.5 0.8 1.3 1.8 1.4 1.2 0.9 1.2 1.4 0.9 1.5 0.7 1.1 1.0 1.2 1.6 1.6 1.5 1.0 1.1 1.3
Intensity Change (Log2) – – – -0.01 0.04 -0.16 -0.35 -0.23 -0.13 -0.27 -0.27 -0.36 0.45 0.46 0.52 0.86 1.04 1.0 0.21 0.29 0.53

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70002468WT3HU80HU120HU16002468WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302468WT1AF100AF140AF18002468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm -4.0 -3.7 -4.6 -5.4 -6.3 -5.8 -6.6 -7.9 -7.3 4.3 3.9 3.8 -1.7 -0.7 -0.8
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0 0 -5.0 0 -5.0
Nucleus 0 0 0 0 2.5 0 2.4 0 2.6 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 3.5 0 0 0 0 1.3 1.5 0 0 0 0 3.9 3.6 2.3

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.2961 2.1037 1.8428 1.7281 1.9018 1.9794 2.2268 1.7289 2.2813 1.4237 1.9407 2.0352 3.3096 2.6556 2.9121 2.7707 2.5665 3.0838
Actin 0.0735 0.0003 0.0067 0.0144 0.0183 0.0152 0.0749 0.0045 0.0004 0.0002 0.0048 0.003 0.0516 0.0137 0.0373 0.0004 0.0227 0.0004
Bud 0.0009 0.0002 0.0031 0.0008 0.0006 0.0003 0.0018 0.0013 0.0001 0 0.0004 0.0003 0.0016 0.0014 0.0004 0.0001 0.0124 0.0001
Bud Neck 0.0044 0.0004 0.0008 0.0139 0.0019 0.0049 0.0049 0.0003 0.0001 0.0001 0.0002 0.0165 0.0012 0.0005 0.0005 0.0003 0.0009 0.0019
Bud Periphery 0.001 0.0001 0.008 0.0015 0.0011 0.0004 0.003 0.0014 0 0 0.0005 0.0003 0.0035 0.0011 0.0003 0 0.0367 0.0001
Bud Site 0.0082 0.0051 0.0052 0.0215 0.0003 0.0004 0.0227 0.0048 0.0004 0.0001 0.0002 0.0014 0.0051 0.0098 0.0027 0.0001 0.0178 0.0001
Cell Periphery 0.0006 0.0002 0.0006 0.0012 0.0002 0.0001 0.001 0.0002 0 0 0.0001 0.0001 0.0004 0.0001 0.0001 0 0.001 0
Cytoplasm 0.3841 0.6093 0.4889 0.5983 0.4887 0.5679 0.2454 0.4305 0.1957 0.4731 0.3134 0.501 0.3264 0.537 0.4897 0.3918 0.4505 0.4568
Cytoplasmic Foci 0.0296 0.0086 0.0095 0.0068 0.0068 0.0076 0.0327 0.0114 0.0137 0.0025 0.0055 0.0154 0.0225 0.0052 0.0122 0.0049 0.0185 0.0066
Eisosomes 0.0005 0 0.0002 0.0009 0.0001 0.0001 0.0007 0.0001 0.0001 0 0.0001 0 0.0005 0.0001 0.0003 0.0001 0.0002 0
Endoplasmic Reticulum 0.0073 0.0036 0.0054 0.0046 0.0079 0.0061 0.0106 0.0065 0.0018 0.005 0.0015 0.0042 0.0153 0.0036 0.004 0.0029 0.0054 0.003
Endosome 0.0175 0.0015 0.0106 0.0053 0.0154 0.0115 0.0587 0.0089 0.0133 0.0016 0.0035 0.0144 0.0258 0.0023 0.0078 0.0024 0.0371 0.003
Golgi 0.0144 0.0001 0.0026 0.0005 0.011 0.0044 0.0231 0.0024 0.0022 0.0001 0.0031 0.0023 0.0068 0.0021 0.0023 0.0001 0.0058 0.0001
Lipid Particles 0.033 0.0003 0.0027 0.0003 0.0013 0.0032 0.0239 0.0006 0.0055 0.0001 0.0019 0.0023 0.0233 0.0001 0.0035 0.0003 0.0036 0.0001
Mitochondria 0.0165 0.0002 0.0114 0.0011 0.0045 0.007 0.0436 0.0014 0.0003 0.0002 0.0795 0.0007 0.0221 0.0025 0.0013 0.0004 0.0045 0.0003
None 0.2582 0.2949 0.3824 0.2542 0.1929 0.1878 0.3483 0.4865 0.7216 0.513 0.5737 0.3753 0.4017 0.3461 0.3306 0.5393 0.2847 0.3733
Nuclear Periphery 0.0122 0.0025 0.0072 0.0071 0.0145 0.0097 0.0153 0.0083 0.0032 0.0011 0.0011 0.0044 0.0268 0.0041 0.0067 0.0019 0.0237 0.0052
Nucleolus 0.0015 0.0003 0.0006 0.0005 0.0005 0.0012 0.0013 0.0003 0.0004 0 0.0001 0.0005 0.0009 0.0005 0.0006 0.0002 0.0024 0.0004
Nucleus 0.092 0.0672 0.0402 0.0528 0.2247 0.1552 0.0276 0.0242 0.0182 0.0018 0.0036 0.0471 0.0334 0.0634 0.0855 0.0515 0.0402 0.1407
Peroxisomes 0.0229 0.0001 0.0024 0.0006 0.0002 0.0017 0.0196 0.0011 0.0035 0 0.0049 0.001 0.0131 0.0004 0.0041 0.0001 0.0043 0.0001
Punctate Nuclear 0.015 0.0032 0.0079 0.0113 0.006 0.0131 0.0142 0.0026 0.0182 0.0004 0.0012 0.0076 0.0124 0.0047 0.0085 0.0022 0.0234 0.0065
Vacuole 0.0047 0.0016 0.0029 0.002 0.0021 0.0015 0.0235 0.0021 0.0011 0.0006 0.0006 0.0018 0.0038 0.001 0.0013 0.0008 0.0026 0.001
Vacuole Periphery 0.002 0.0001 0.0009 0.0004 0.0011 0.0007 0.003 0.0006 0.0002 0.0001 0.0002 0.0003 0.0016 0.0002 0.0003 0.0001 0.0013 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 4.8493 2.0008 4.9488 7.2388 8.2219 7.4563 7.9233 8.1922 11.047 8.7657
Translational Efficiency 1.5988 2.7929 1.0476 0.9359 0.8326 1.6279 0.8639 0.9518 0.9712 1.1595

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1375 539 1667 1481 400 1248 123 1690 1775 1787 1790 3171

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 679.82 765.57 875.62 915.55 796.87 768.84 1064.70 871.16 706.20 767.85 888.61 891.89
Standard Deviation 107.54 117.86 101.96 116.64 90.32 101.39 124.11 133.20 114.84 106.63 114.14 127.68
Intensity Change Log 2 — 0.171381 0.365152 0.429486 — -0.051661 0.418031 0.128593 — 0.055317 0.393928 0.274938

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000076 0.000525 0.000125 0.003753 0.000100 0.000319 0.000845 0.000837 0.000081 0.000381 0.000175 0.002199
Bud Neck 0.006287 0.008737 0.002608 0.014001 0.001059 0.014545 0.002526 0.010759 0.005108 0.012793 0.002603 0.012273
Bud Site 0.006341 0.006348 0.004226 0.040366 0.000886 0.010650 0.012832 0.048288 0.005111 0.009352 0.004817 0.044588
Cell Periphery 0.000144 0.000166 0.000083 0.000154 0.000201 0.000131 0.000230 0.001466 0.000157 0.000141 0.000093 0.000853
Cytoplasm 0.462145 0.447507 0.444857 0.423945 0.412733 0.413201 0.310181 0.477932 0.451010 0.423549 0.435603 0.452718
Cytoplasmic Foci 0.063563 0.093725 0.008012 0.012471 0.102146 0.102385 0.009846 0.023025 0.072258 0.099773 0.008138 0.018096
Eisosomes 0.000057 0.000066 0.000023 0.000039 0.000084 0.000071 0.000077 0.000047 0.000063 0.000069 0.000027 0.000043
Endoplasmic Reticulum 0.000576 0.003164 0.001806 0.002802 0.001577 0.001071 0.007832 0.001490 0.000801 0.001702 0.002220 0.002103
Endosome 0.002320 0.008018 0.001885 0.005716 0.004738 0.011005 0.004655 0.008354 0.002865 0.010104 0.002075 0.007122
Golgi 0.000689 0.002023 0.000133 0.013215 0.000186 0.002801 0.000124 0.005555 0.000576 0.002566 0.000133 0.009133
Lipid Particles 0.002828 0.003687 0.000842 0.000977 0.004345 0.005148 0.002280 0.001046 0.003170 0.004708 0.000940 0.001014
Mitochondria 0.001943 0.002623 0.000553 0.005693 0.000409 0.007261 0.000418 0.006698 0.001597 0.005862 0.000544 0.006228
Mitotic Spindle 0.002219 0.009341 0.003648 0.058336 0.000186 0.015363 0.030805 0.049410 0.001761 0.013546 0.005515 0.053579
None 0.015413 0.008372 0.007191 0.006404 0.003520 0.006741 0.002330 0.010288 0.012733 0.007233 0.006857 0.008474
Nuclear Periphery 0.000559 0.001015 0.001588 0.002086 0.000715 0.001222 0.002085 0.002186 0.000594 0.001160 0.001622 0.002139
Nuclear Periphery Foci 0.000394 0.001615 0.000635 0.001924 0.001589 0.000693 0.004446 0.001239 0.000664 0.000971 0.000897 0.001559
Nucleolus 0.001767 0.002091 0.000601 0.000519 0.001143 0.003043 0.000280 0.001593 0.001626 0.002756 0.000579 0.001092
Nucleus 0.414452 0.339386 0.479774 0.327599 0.430161 0.347195 0.391041 0.241599 0.417992 0.344839 0.473677 0.281765
Peroxisomes 0.001291 0.006441 0.000162 0.001484 0.000855 0.006816 0.000237 0.002712 0.001193 0.006703 0.000167 0.002139
Vacuole 0.016663 0.053648 0.040900 0.075477 0.033079 0.048478 0.216760 0.101638 0.020362 0.050038 0.052984 0.089420
Vacuole Periphery 0.000272 0.001502 0.000347 0.003038 0.000288 0.001861 0.000170 0.003837 0.000276 0.001752 0.000335 0.003464

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -6.01 -5.13 -2.62 -1.29 -2.35 -3.21 -3.97 -5.56 -2.40 1.17 -5.85 -6.57 -3.94 -2.17 -3.17
Bud Neck -1.62 3.35 -2.50 -0.16 -6.55 -8.93 -5.24 -9.13 3.82 -6.11 -5.86 2.59 -4.04 3.29 -8.23
Bud Site -0.33 1.47 -4.77 -4.99 -6.72 -5.96 -1.80 -11.98 -6.39 -3.07 -2.69 0.53 -9.71 -7.32 -11.18
Cell Periphery -1.01 2.65 1.03 3.21 -4.38 4.84 -0.38 -1.99 -2.30 -1.93 0.81 3.62 -2.04 -2.17 -2.55
Cytoplasm 2.05 8.12 14.95 8.31 6.82 0.35 7.85 1.41 1.36 -7.73 3.90 8.81 11.79 6.91 1.65
Cytoplasmic Foci -4.06 18.84 18.82 14.44 0.02 -0.22 15.58 15.15 21.34 -2.23 -6.27 23.99 22.77 26.15 -4.07
Eisosomes -2.07 5.26 1.67 4.56 -8.86 2.11 -1.32 6.78 5.45 6.18 -1.72 6.77 3.50 7.08 -7.61
Endoplasmic Reticulum -8.04 -15.06 -18.15 -0.45 -4.19 2.56 -6.96 -3.58 -8.46 6.28 -7.45 -14.90 -18.53 -7.13 1.33
Endosome -5.14 1.41 0.63 5.44 -0.77 -5.32 -0.19 1.25 6.20 1.32 -8.78 2.63 -0.46 8.45 -2.98
Golgi -1.33 1.62 -1.88 -0.60 -2.56 -3.55 1.91 -2.94 0.55 -3.02 -3.07 1.68 -2.84 0.08 -3.89
Lipid Particles -1.80 4.53 3.80 7.35 -3.78 -1.17 3.36 8.07 7.56 6.06 -3.19 6.31 6.15 9.09 -1.13
Mitochondria -0.54 3.26 -0.11 0.42 -2.66 -6.15 0.60 -3.27 2.79 -3.35 -4.80 3.15 -1.76 3.19 -3.98
Mitotic Spindle -2.80 -2.08 -8.05 -3.37 -7.05 -6.08 -1.16 -10.97 -4.64 -2.92 -5.86 -2.74 -12.78 -5.60 -10.44
None 3.10 4.99 4.53 0.59 -1.65 -3.26 4.16 -4.92 -0.54 -7.97 3.42 4.75 3.73 -0.05 -2.68
Nuclear Periphery -5.68 -19.32 -19.83 -14.70 -7.36 -2.92 -8.86 -4.86 -3.39 -0.54 -4.81 -21.19 -10.37 -7.00 -3.19
Nuclear Periphery Foci -6.35 -4.75 -5.00 0.50 -3.18 3.43 -5.40 2.08 -1.54 6.34 -3.26 -4.57 -3.98 -1.52 -0.68
Nucleolus -0.62 4.81 5.19 4.72 1.05 -4.23 6.46 0.75 4.25 -2.35 -3.11 5.41 3.93 5.66 -1.13
Nucleus 5.10 -9.67 2.79 -3.17 13.09 4.98 2.83 7.92 3.94 1.33 7.53 -8.90 9.02 0.29 19.09
Peroxisomes -3.07 5.90 4.14 3.65 -2.64 -7.57 6.14 -0.71 6.49 -2.34 -7.35 6.82 1.52 7.73 -3.01
Vacuole -9.90 -14.92 -28.87 -17.74 -19.00 -4.00 -12.10 -22.81 -20.66 6.28 -12.71 -16.51 -38.59 -28.15 -18.19
Vacuole Periphery -2.05 -0.26 -1.57 1.08 -1.50 -5.80 2.93 -3.29 0.42 -3.61 -5.76 -0.04 -3.66 1.40 -3.60
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Cyclin; interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation; PCL8 has a paralog, PCL10, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (28%), nucleus (7%), mixed (52%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Pcl8

Pcl8


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Pcl8-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available