Standard name
Human Ortholog
Description Protein of unknown function; required for selective and nonselective autophagy, and mitophagy; regulates the rate of autophagosome formation; interacts with Atg9p, and has a similar peri-mitochondrial localization; elevated Gcn4p-dependent expression under autophagy-inducing conditions; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate; ATG41 has a paralog, ICY1, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0.06 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.69 0.76 0.73 0.94 0.96 0.92 – 0.82 0.81 0.79 0.73 0.62 0.75 0.84 0.85 0.72 0.83 0.88 0.2 0.26 0.24 0.28 0.16 0.13
Endoplasmic Reticulum 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.05 0.06 0.05 0 0 0 0 0 0
Endosome 0 0.09 0 0 0 0 – 0 0 0 0 0 0.16 0.1 0.08 0.07 0.07 0.06 0.2 0.22 0.21 0.16 0.3 0.31
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0.17 0.13 0 0.22 – 0.32 0.37 0.43 0.48 0.64 0 0 0 0 0 0 0 0 0.07 0.06 0 0
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0.05
Vac/Vac Membrane 0.26 0.19 0.16 0 0 0 – 0 0 0 0 0 0.14 0.14 0.13 0.22 0.15 0.1 0.51 0.42 0.38 0.39 0.37 0.38
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 1 0 0 0 0 0 – 0 0 0 0 0 1 0 0 1 0 0 0 1 1 1 3 7
Bud 0 6 10 0 6 5 – 20 7 8 11 4 8 2 4 0 2 0 4 3 2 2 9 14
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 3 2 0 0 0 2
Bud Site 0 0 0 0 0 0 – 1 0 1 0 2 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 2 1 – 0 1 3 2 1 0 0 1 0 0 3 0 0 0 0 0 0
Cytoplasm 141 243 116 179 238 312 – 444 277 256 186 226 241 278 300 87 108 68 45 94 46 39 55 49
Endoplasmic Reticulum 8 0 0 3 0 1 – 0 0 0 0 1 3 0 1 6 8 4 0 3 4 0 1 1
Endosome 6 30 6 4 5 4 – 6 0 3 0 1 52 33 29 8 9 5 48 77 40 21 105 121
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 1 0 0 1 0 0 1 2 0 0 0 2
Mitochondria 8 3 27 25 6 76 – 171 127 139 123 231 0 0 3 2 4 2 3 9 13 7 14 6
Nucleus 0 1 1 1 0 0 – 3 1 1 0 1 0 0 0 2 0 0 2 1 0 3 2 2
Nuclear Periphery 0 2 0 0 0 0 – 0 2 0 0 0 0 0 0 0 0 0 0 3 3 0 1 3
Nucleolus 0 2 0 0 0 2 – 2 0 0 4 0 2 0 1 0 0 0 0 0 0 0 3 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 3 0 2 0 0 0 0 0 0 0 0 0
SpindlePole 1 2 3 0 1 0 – 8 3 3 1 2 16 3 8 2 1 0 3 3 2 1 14 19
Vac/Vac Membrane 54 61 26 1 6 8 – 9 8 3 5 3 44 48 45 27 20 8 119 150 72 53 129 146
Unique Cell Count 204 319 159 191 247 338 539 342 325 254 363 320 332 355 121 130 77 235 359 191 138 350 388
Labelled Cell Count 219 350 189 213 264 409 664 426 417 332 472 371 364 394 136 152 90 235 359 191 138 350 388


Ambiguous

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.3 5.1 4.4 4.8 5.0 3.9 – 3.8 3.5 3.6 4.0 3.2 6.6 6.6 6.6 7.4 7.8 8.4 5.6 6.4 6.5
Std Deviation (1e-4) 0.7 0.9 1.5 1.8 1.8 1.7 – 1.7 2.0 1.5 2.8 1.2 2.0 2.1 1.8 1.4 2.2 3.1 2.1 2.2 2.2
Intensity Change (Log2) – – – 0.14 0.2 -0.15 – -0.18 -0.31 -0.28 -0.13 -0.43 0.59 0.61 0.6 0.76 0.84 0.94 0.35 0.56 0.58


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud 0 -2.0 0 – 0 0 0 0 0 -2.1 0 0 0 -2.0 0
Bud Neck 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 5.3 6.9 5.8 – 2.6 2.0 1.4 0.1 -2.4 0.6 2.8 3.1 -0.2 2.1 2.7
Endoplasmic Reticulum 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 – 0 0 0 0 0 3.9 2.4 1.8 1.1 1.2 0
Golgi 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 -5.2 0 – 0 0 0 0 0 -7.6 -7.7 -7.2 -4.2 -3.8 -3.2
Nucleus 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 – 0 0 0 0 0 1.6 0 0 0 0 0
Vacuole -5.5 -5.1 -5.8 – -7.5 -5.8 -6.7 -5.4 -7.1 -0.8 -0.5 -1.1 1.3 -0.2 -1.2

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.2103 3.2377 2.6748 2.5168 2.07 2.6532 2.6556 3.2947 3.0777 2.7777 2.5646 2.9974 4.3211 4.6233 4.4436 4.1888 4.1052 4.1497
Actin 0.0138 0 0.0114 0.0167 0.0063 0.0043 0.0114 0.0001 0.0084 0.0027 0.0037 0.0018 0.0104 0.0001 0.0019 0.0001 0.0669 0.0067
Bud 0.0008 0.0003 0.0024 0.0208 0.0028 0.001 0.0007 0.0003 0.001 0.0065 0.0008 0.0004 0.0006 0.0002 0.0015 0.0003 0.0027 0.0004
Bud Neck 0.0054 0.0006 0.0059 0.0026 0.0006 0.0011 0.002 0.0005 0.0009 0.0008 0.0004 0.0011 0.0017 0.0001 0.0003 0.0008 0.0014 0.0009
Bud Periphery 0.0008 0.0001 0.0018 0.0303 0.0048 0.0006 0.0006 0.0002 0.0006 0.0048 0.0006 0.0003 0.0007 0 0.0009 0.0001 0.0022 0.0002
Bud Site 0.0061 0.0007 0.014 0.0161 0.002 0.0006 0.0075 0.0013 0.0057 0.004 0.0009 0.0004 0.0011 0.0006 0.002 0.0003 0.0144 0.0003
Cell Periphery 0.0003 0.0001 0.0002 0.0007 0.0002 0.0001 0.0003 0.0001 0.0002 0.0006 0.0001 0 0.0001 0 0.0001 0 0.0002 0
Cytoplasm 0.5004 0.7682 0.6184 0.5539 0.4894 0.645 0.6236 0.7998 0.6879 0.5947 0.5499 0.7288 0.5921 0.8187 0.7302 0.535 0.4472 0.6894
Cytoplasmic Foci 0.064 0.0331 0.0538 0.0511 0.1013 0.0765 0.0511 0.0651 0.0728 0.0801 0.0776 0.0662 0.0702 0.0355 0.0589 0.156 0.0624 0.0766
Eisosomes 0.0001 0 0.0001 0.0001 0.0001 0 0.0001 0 0.0003 0.0006 0.0001 0 0.0001 0 0 0 0.0004 0.0001
Endoplasmic Reticulum 0.0082 0.0036 0.0066 0.0035 0.0025 0.0042 0.0104 0.0056 0.0056 0.0029 0.0048 0.0049 0.012 0.0036 0.0063 0.0013 0.0022 0.004
Endosome 0.2078 0.1085 0.1284 0.1092 0.1789 0.1595 0.1524 0.0411 0.1479 0.1565 0.1969 0.1195 0.1672 0.0506 0.1144 0.1904 0.2314 0.1365
Golgi 0.0159 0.0011 0.0079 0.0049 0.0318 0.005 0.0069 0.0012 0.0053 0.0114 0.0115 0.0033 0.0052 0.0008 0.0026 0.004 0.0261 0.0046
Lipid Particles 0.016 0.0002 0.0053 0.0003 0.0231 0.0088 0.0111 0.0005 0.0024 0.0107 0.0282 0.0016 0.0055 0.0002 0.0007 0.0012 0.0029 0.0017
Mitochondria 0.011 0.0003 0.0222 0.0017 0.0698 0.0059 0.0029 0.0008 0.0024 0.0441 0.0108 0.0029 0.0022 0.0002 0.0009 0.0006 0.0124 0.0016
None 0.0404 0.0284 0.0263 0.1369 0.0251 0.034 0.0438 0.0429 0.0139 0.0303 0.0397 0.0171 0.0627 0.0545 0.0458 0.0108 0.0715 0.0311
Nuclear Periphery 0.01 0.0027 0.0087 0.0024 0.0028 0.0047 0.0126 0.0039 0.0043 0.0039 0.0055 0.004 0.0124 0.0029 0.0044 0.0017 0.0018 0.0066
Nucleolus 0.0008 0.0001 0.0004 0.0003 0.0007 0.0003 0.0004 0.0003 0.0005 0.0004 0.0003 0.0001 0.0005 0.0001 0.0002 0.0001 0.0002 0.0002
Nucleus 0.0053 0.0027 0.0049 0.0041 0.0032 0.0054 0.0111 0.0054 0.0038 0.0049 0.004 0.0049 0.0058 0.004 0.0043 0.0023 0.0022 0.0053
Peroxisomes 0.0098 0.0001 0.0213 0.0013 0.0122 0.0058 0.0044 0.0031 0.0061 0.0109 0.0121 0.008 0.0019 0.0001 0.001 0.0136 0.0072 0.0042
Punctate Nuclear 0.006 0.0004 0.0039 0.0009 0.0026 0.003 0.0021 0.0014 0.0018 0.0027 0.0052 0.0012 0.0033 0.0015 0.0022 0.001 0.0014 0.0021
Vacuole 0.0647 0.0428 0.0442 0.0329 0.0302 0.0276 0.0394 0.0233 0.0241 0.0204 0.0378 0.0263 0.039 0.0204 0.017 0.0677 0.0334 0.0216
Vacuole Periphery 0.0123 0.0059 0.012 0.0094 0.0096 0.0066 0.005 0.0029 0.0041 0.0057 0.0091 0.0072 0.0052 0.0058 0.0044 0.0126 0.0094 0.0062

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 45.6396 33.5992 33.8364 37.8676 48.7313 64.3967 92.8166 97.4477 73.0945 70.5092
Translational Efficiency 1.6345 2.2743 1.5969 1.4492 1.1345 2.6834 1.6701 1.7148 2.0614 1.756

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✔
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1103 1118 66 1743 351 2000 855 1531 1454 3118 921 3274

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 693.43 800.61 990.89 884.94 668.68 785.25 878.54 829.70 687.46 790.76 886.59 859.11
Standard Deviation 116.80 116.24 128.41 118.09 84.82 101.89 104.61 117.31 110.45 107.51 110.36 120.91
Intensity Change Log 2 — 0.207349 0.514975 0.351829 — 0.231836 0.393792 0.311274 — 0.219422 0.456755 0.332062

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000066 0.000175 0.000870 0.000455 0.000165 0.000130 0.000147 0.000424 0.000090 0.000146 0.000199 0.000440
Bud Neck 0.016466 0.012488 0.002359 0.008365 0.017823 0.015544 0.005252 0.011051 0.016794 0.014449 0.005044 0.009621
Bud Site 0.009510 0.014617 0.004711 0.031952 0.012355 0.011265 0.006825 0.025288 0.010197 0.012467 0.006674 0.028836
Cell Periphery 0.000281 0.000081 0.000302 0.000139 0.000378 0.000086 0.000122 0.000124 0.000305 0.000084 0.000135 0.000132
Cytoplasm 0.244197* 0.178885* 0.303336* 0.473427* 0.266852* 0.147796* 0.432731* 0.534300* 0.249666* 0.158943* 0.423459* 0.501893*
Cytoplasmic Foci 0.194608* 0.250657* 0.076603 0.025770 0.369902* 0.234384* 0.027995 0.038033 0.236925* 0.240219* 0.031478 0.031504
Eisosomes 0.000297 0.000061 0.000148 0.000037 0.000434 0.000086 0.000050 0.000045 0.000330 0.000077 0.000057 0.000040
Endoplasmic Reticulum 0.003904 0.003014 0.009597 0.002300 0.004754 0.003264 0.001974 0.001025 0.004109 0.003175 0.002520 0.001704
Endosome 0.150219 0.182252 0.021616 0.009707 0.077504 0.223984* 0.005878 0.010638 0.132665 0.209020* 0.007006 0.010142
Golgi 0.003409 0.008844 0.000341 0.005537 0.014985 0.011897 0.001655 0.002402 0.006203 0.010802 0.001561 0.004071
Lipid Particles 0.016506 0.009082 0.011355 0.001414 0.014696 0.015999 0.002201 0.001512 0.016069 0.013519 0.002857 0.001460
Mitochondria 0.005282 0.006937 0.000294 0.004384 0.029855 0.013692 0.001369 0.003863 0.011214 0.011269 0.001292 0.004140
Mitotic Spindle 0.000372 0.007256 0.000473 0.048145 0.000148 0.007543 0.006118 0.011301 0.000318 0.007440 0.005714 0.030916
None 0.007363 0.000596 0.001032 0.003404 0.001087 0.000532 0.003671 0.004083 0.005848 0.000555 0.003482 0.003722
Nuclear Periphery 0.000609 0.000518 0.002119 0.001802 0.000352 0.000706 0.001945 0.000818 0.000547 0.000638 0.001957 0.001342
Nuclear Periphery Foci 0.000691 0.000797 0.011948 0.001497 0.000134 0.000618 0.001439 0.001049 0.000557 0.000682 0.002192 0.001288
Nucleolus 0.001464 0.001115 0.001309 0.000471 0.000445 0.001327 0.000702 0.000681 0.001218 0.001251 0.000745 0.000569
Nucleus 0.029550 0.014451 0.236662* 0.134399* 0.038603 0.013764 0.372755* 0.127755 0.031735 0.014011 0.363002* 0.131292*
Peroxisomes 0.003879 0.006139 0.001381 0.000779 0.005444 0.007498 0.000486 0.004110 0.004257 0.007010 0.000550 0.002336
Vacuole 0.296172* 0.281450* 0.312479* 0.239485* 0.114309 0.266367* 0.126200 0.219008* 0.252270* 0.271775* 0.139549 0.229909*
Vacuole Periphery 0.015156 0.020585 0.001065 0.006530 0.029776 0.023518 0.000485 0.002491 0.018685 0.022466 0.000526 0.004641

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -5.15 -5.68 -5.77 -3.27 3.67 1.25 -1.61 -2.52 -2.90 -1.84 -3.87 -5.64 -5.52 -4.35 -1.68
Bud Neck 2.30 10.26 7.08 4.92 -5.27 0.94 5.25 3.94 5.25 -2.17 1.73 8.08 7.58 7.87 -2.01
Bud Site -2.80 2.90 -3.47 -1.07 -6.26 0.49 3.03 -1.40 -2.18 -4.66 -1.68 2.94 -3.83 -2.63 -6.45
Cell Periphery 3.81 -0.54 3.69 -0.56 8.26 5.00 4.64 4.83 -0.73 1.02 5.22 4.30 5.06 -0.78 3.25
Cytoplasm 6.67 -1.01 -16.03 -23.79 -4.08 9.92 -8.19 -15.20 -37.33 -7.62 12.79 -12.00 -23.36 -44.26 -5.95
Cytoplasmic Foci -7.20 11.98 34.22 38.66 4.40 11.17 30.81 29.98 44.37 -4.71 -0.63 39.98 41.21 59.73 -0.15
Eisosomes 4.90 2.80 5.36 5.64 8.42 5.64 6.18 6.31 9.27 2.75 6.42 6.85 7.32 11.25 6.51
Endoplasmic Reticulum 1.87 -3.93 4.04 1.92 4.91 1.36 1.34 3.21 5.44 8.52 2.11 0.53 5.77 4.98 7.74
Endosome -4.14 22.60 27.54* 32.12* 6.04 -20.00 13.30 12.90 43.52* -2.10 -13.44 29.48 29.56 53.83* 0.06
Golgi -5.57 11.03 2.29 6.28 -2.86 1.31 6.07 6.25 11.29 -0.26 -5.23 5.73 6.81 12.42 -0.87
Lipid Particles 5.42 3.03 12.53 11.49 5.77 -0.88 9.06 9.58 17.34 2.01 2.19 13.35 15.04 20.46 4.31
Mitochondria -1.07 4.80 2.89 4.22 -4.23 3.83 6.99 6.70 10.03 -1.55 -0.02 7.58 6.83 11.07 -2.14
Mitotic Spindle -4.84 -1.48 -9.92 -6.67 -9.74 -5.86 -4.12 -5.55 -0.72 -0.67 -7.44 -4.04 -11.25 -6.18 -5.38
None 3.57 3.40 2.28 -6.50 -5.91 0.78 -3.51 -2.70 -6.47 1.00 3.67 1.58 1.88 -9.54 1.07
Nuclear Periphery 0.83 -6.85 -16.80 -17.42 -3.13 -2.25 -11.64 -8.04 -4.81 6.60 -0.90 -11.92 -17.14 -14.09 3.08
Nuclear Periphery Foci -1.24 -6.87 -8.11 -6.67 6.24 -6.66 -9.59 -6.96 -3.86 2.40 -1.97 -9.17 -8.89 -7.45 4.63
Nucleolus 0.94 1.01 3.27 2.51 2.31 -4.49 -1.97 -1.77 3.55 0.32 -0.33 2.21 2.89 4.53 1.21
Nucleus 6.08 -6.55 -29.64 -34.29 1.91 4.44 -31.14 -15.68 -30.96 22.19 8.20 -36.29 -35.08 -46.59 21.65
Peroxisomes -2.53 3.53 4.54 10.96 3.57 -2.61 8.49 3.71 6.14 -2.68 -3.91 6.38 4.52 11.17 -2.45
Vacuole 1.48 -1.90 -3.58 -5.13 0.86 -15.52 -5.64 -16.60 -3.09 -11.11 -2.49 6.27 -7.74 -6.50 -13.49
Vacuole Periphery -3.04 13.06 10.23 12.26 -2.36 1.70 8.22 7.94 19.79 -2.50 -2.50 15.20 13.39 22.47 -3.94
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein of unknown function; required for selective and nonselective autophagy, and mitophagy; regulates the rate of autophagosome formation; interacts with Atg9p, and has a similar peri-mitochondrial localization; elevated Gcn4p-dependent expression under autophagy-inducing conditions; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate; ATG41 has a paralog, ICY1, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (19%), vacuole (11%), mixed (31%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Atg41

Atg41


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Atg41-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available