Standard name | |
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Human Ortholog | |
Description | Mitochondrial inner membrane half-type ABC transporter; required for respiratory growth at high temperature; localizes to vacuole membrane in response to H2O2; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis |
ensLOC | DeepLoc | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 1 | 2 | 1 | 2 | 0 | 0 | 0 | 0 | – | 0 | 0 | 1 | 2 | 2 | 1 | 0 | – | – | 5 | 10 | 7 | 4 | 11 | 11 |
Bud | 3 | 4 | 7 | 5 | 4 | 9 | 11 | 16 | – | 15 | 11 | 13 | 0 | 0 | 0 | 0 | – | – | 0 | 2 | 0 | 2 | 1 | 3 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | 0 | 1 | 0 | 1 | 1 | 3 |
Bud Site | 0 | 2 | 0 | 0 | 1 | 5 | 5 | 5 | – | 12 | 9 | 10 | 0 | 0 | 0 | 0 | – | – | – | – | – | – | – | – |
Cell Periphery | 12 | 13 | 7 | 4 | 2 | 1 | 4 | 1 | – | 2 | 1 | 2 | 1 | 1 | 1 | 1 | – | – | 0 | 0 | 0 | 0 | 1 | 0 |
Cytoplasm | 2 | 3 | 9 | 4 | 6 | 5 | 5 | 10 | – | 2 | 3 | 4 | 7 | 7 | 4 | 8 | – | – | 0 | 0 | 0 | 1 | 0 | 0 |
Endoplasmic Reticulum | 0 | 4 | 0 | 1 | 0 | 2 | 0 | 3 | – | 4 | 6 | 4 | 6 | 9 | 1 | 3 | – | – | 0 | 0 | 1 | 1 | 1 | 1 |
Endosome | 13 | 3 | 7 | 1 | 10 | 8 | 6 | 6 | – | 0 | 1 | 0 | 9 | 11 | 3 | 0 | – | – | 10 | 22 | 15 | 12 | 12 | 10 |
Golgi | 19 | 9 | 4 | 3 | 5 | 0 | 0 | 2 | – | 0 | 2 | 0 | 45 | 47 | 53 | 4 | – | – | 21 | 41 | 17 | 7 | 24 | 20 |
Mitochondria | 272 | 364 | 383 | 212 | 272 | 403 | 508 | 509 | – | 520 | 440 | 505 | 73 | 73 | 33 | 0 | – | – | 272 | 283 | 311 | 123 | 176 | 147 |
Nucleus | 0 | 1 | 0 | 0 | 0 | 4 | 4 | 3 | – | 2 | 1 | 1 | 0 | 0 | 0 | 1 | – | – | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 19 | 12 | 22 | 10 | 24 | 42 | 41 | 26 | – | 45 | 44 | 67 | 4 | 3 | 1 | 2 | – | – | 3 | 2 | 4 | 4 | 4 | 3 |
Nucleolus | 17 | 12 | 19 | 3 | 25 | 50 | 69 | 54 | – | 65 | 34 | 68 | 3 | 3 | 2 | 0 | – | – | 1 | 1 | 0 | 1 | 1 | 1 |
Peroxisomes | 11 | 2 | 25 | 14 | 4 | 2 | 9 | 10 | – | 8 | 8 | 11 | 4 | 4 | 0 | 0 | – | – | 22 | 12 | 50 | 22 | 36 | 23 |
SpindlePole | 2 | 2 | 8 | 1 | 1 | 5 | 10 | 12 | – | 10 | 7 | 7 | 2 | 2 | 1 | 2 | – | – | 1 | 0 | 1 | 2 | 0 | 1 |
Vac/Vac Membrane | 52 | 31 | 14 | 9 | 33 | 14 | 23 | 13 | – | 11 | 19 | 9 | 30 | 30 | 24 | 7 | – | – | 2 | 15 | 1 | 2 | 6 | 11 |
Unique Cell Count | 321 | 389 | 414 | 225 | 318 | 429 | 559 | 554 | 550 | 464 | 541 | 128 | 132 | 95 | 26 | 343 | 398 | 417 | 190 | 282 | 241 | |||
Labelled Cell Count | 423 | 464 | 506 | 269 | 387 | 550 | 695 | 670 | 696 | 586 | 702 | 186 | 192 | 124 | 28 | 343 | 398 | 417 | 190 | 282 | 241 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 8.9 | 8.0 | 7.2 | 7.1 | 7.3 | 6.1 | 6.1 | 6.5 | – | 5.8 | 6.0 | 6.2 | 8.7 | 8.7 | 8.9 | 7.1 | – | – | 9.1 | 10.1 | 10.6 |
Std Deviation (1e-4) | 1.5 | 1.5 | 1.6 | 1.6 | 1.4 | 1.6 | 1.8 | 1.8 | – | 1.6 | 1.8 | 1.8 | 1.4 | 1.4 | 1.5 | 1.9 | – | – | 2.8 | 2.7 | 2.6 |
Intensity Change (Log2) | – | – | – | -0.04 | 0.01 | -0.24 | -0.26 | -0.16 | – | -0.31 | -0.28 | -0.22 | 0.27 | 0.27 | 0.31 | -0.03 | – | – | 0.33 | 0.48 | 0.56 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – |
Bud | 0 | 0 | 0.4 | 0.3 | 1.2 | – | 1.1 | 0.7 | 0.8 | 0 | 0 | 0 | 0 | – | – |
Bud Neck | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – |
Bud Site | 0 | 0 | 0 | 0 | 0 | – | 3.0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – |
Cytoplasm | 0 | -0.3 | -1.1 | -1.7 | -0.4 | – | 0 | -1.9 | -1.9 | 0 | 0 | 0 | 0 | – | – |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – |
Endosome | 0 | 1.3 | 0.2 | -0.8 | -0.8 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – |
Golgi | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 11.8 | 11.9 | 15.3 | 0 | – | – |
Mitochondria | 0.8 | -3.1 | 0.8 | -0.9 | -0.4 | – | 1.3 | 1.4 | 0.5 | -9.6 | -10.0 | -13.1 | -13.6 | – | – |
Nucleus | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – |
Nuclear Periphery | -0.5 | 1.2 | 2.5 | 1.3 | -0.4 | – | 1.7 | 2.3 | 3.7 | -1.0 | -1.5 | 0 | 0 | – | – |
Nucleolus | -2.2 | 1.8 | 3.7 | 4.2 | 3.0 | – | 3.9 | 1.7 | 4.2 | -1.1 | -1.2 | 0 | 0 | – | – |
Peroxisomes | 0.1 | -3.3 | -4.6 | -3.7 | -3.5 | – | -3.9 | -3.4 | -3.2 | -1.3 | -1.3 | 0 | 0 | – | – |
SpindlePole | 0 | 0 | -0.9 | -0.2 | 0.3 | – | -0.1 | -0.5 | -0.8 | 0 | 0 | 0 | 0 | – | – |
Vacuole | 0.4 | 3.8 | -0.1 | 0.6 | -1.0 | – | -1.3 | 0.6 | -1.7 | 7.3 | 7.1 | 7.3 | 0 | – | – |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Actin | 0.0378 | 0.019 | 0.0303 | 0.0158 | 0.0027 | 0.007 | 0.0684 | 0.0328 | 0.0405 | 0.0006 | 0.0015 | 0.0055 | – | – | – | – | – | – |
Bud | 0.0006 | 0.0025 | 0.0015 | 0.001 | 0.0006 | 0.0002 | 0.0008 | 0.0008 | 0.0004 | 0.0002 | 0.0012 | 0.0001 | – | – | – | – | – | – |
Bud Neck | 0.0009 | 0.0016 | 0.004 | 0.0026 | 0.0006 | 0.0003 | 0.0006 | 0.0004 | 0.0002 | 0.0001 | 0.0002 | 0.0001 | – | – | – | – | – | – |
Bud Periphery | 0.001 | 0.0043 | 0.0019 | 0.0023 | 0.0004 | 0.0004 | 0.0012 | 0.0011 | 0.0006 | 0.0008 | 0.0017 | 0.0001 | – | – | – | – | – | – |
Bud Site | 0.0053 | 0.0162 | 0.0046 | 0.0028 | 0.0107 | 0.0003 | 0.0021 | 0.0039 | 0.0007 | 0.0001 | 0.0043 | 0.0001 | – | – | – | – | – | – |
Cell Periphery | 0.0005 | 0.0013 | 0.0011 | 0.0017 | 0.0001 | 0.0001 | 0.0003 | 0.0008 | 0.0002 | 0.0001 | 0.0003 | 0.0001 | – | – | – | – | – | – |
Cytoplasm | 0.0101 | 0.0011 | 0.0012 | 0.0047 | 0.002 | 0.0002 | 0.006 | 0.002 | 0.0023 | 0.0001 | 0.0006 | 0 | – | – | – | – | – | – |
Cytoplasmic Foci | 0.0149 | 0.0131 | 0.0106 | 0.0073 | 0.0165 | 0.0034 | 0.0211 | 0.0122 | 0.0047 | 0.0047 | 0.0068 | 0.0038 | – | – | – | – | – | – |
Eisosomes | 0.0008 | 0.0007 | 0.0025 | 0.0003 | 0.0001 | 0.0002 | 0.0065 | 0.0005 | 0.0009 | 0.0001 | 0.0001 | 0.0002 | – | – | – | – | – | – |
Endoplasmic Reticulum | 0.005 | 0.0005 | 0.0012 | 0.0056 | 0.0003 | 0.0004 | 0.0047 | 0.003 | 0.0013 | 0.0001 | 0.0002 | 0 | – | – | – | – | – | – |
Endosome | 0.0236 | 0.0329 | 0.0273 | 0.0272 | 0.0701 | 0.0126 | 0.086 | 0.0385 | 0.0249 | 0.0279 | 0.0214 | 0.0038 | – | – | – | – | – | – |
Golgi | 0.0247 | 0.0455 | 0.023 | 0.0308 | 0.0201 | 0.0216 | 0.038 | 0.0664 | 0.0233 | 0.0759 | 0.0136 | 0.0198 | – | – | – | – | – | – |
Lipid Particles | 0.0338 | 0.0127 | 0.01 | 0.009 | 0.0048 | 0.0066 | 0.0258 | 0.0107 | 0.0093 | 0.0021 | 0.0059 | 0.0016 | – | – | – | – | – | – |
Mitochondria | 0.7795 | 0.7937 | 0.846 | 0.8279 | 0.8388 | 0.9292 | 0.6082 | 0.7755 | 0.8487 | 0.8786 | 0.921 | 0.9363 | – | – | – | – | – | – |
None | 0.0043 | 0.0002 | 0.0003 | 0.0022 | 0.0001 | 0.0001 | 0.0078 | 0.0002 | 0.0011 | 0.0001 | 0.0003 | 0 | – | – | – | – | – | – |
Nuclear Periphery | 0.0165 | 0.0004 | 0.0016 | 0.0118 | 0.0002 | 0.0008 | 0.0551 | 0.0019 | 0.0134 | 0.0001 | 0.0005 | 0 | – | – | – | – | – | – |
Nucleolus | 0.0013 | 0.0022 | 0.0003 | 0.0088 | 0.0002 | 0.0001 | 0.0015 | 0.0004 | 0.0002 | 0.0001 | 0.0014 | 0 | – | – | – | – | – | – |
Nucleus | 0.0056 | 0.0008 | 0.0005 | 0.0084 | 0.0002 | 0.0001 | 0.007 | 0.0003 | 0.0035 | 0.0001 | 0.0015 | 0 | – | – | – | – | – | – |
Peroxisomes | 0.0107 | 0.014 | 0.0154 | 0.0046 | 0.0166 | 0.0076 | 0.0138 | 0.0368 | 0.0062 | 0.0012 | 0.005 | 0.0273 | – | – | – | – | – | – |
Punctate Nuclear | 0.009 | 0.0004 | 0.0004 | 0.0026 | 0.0005 | 0.0002 | 0.0309 | 0.0001 | 0.0012 | 0 | 0.0005 | 0 | – | – | – | – | – | – |
Vacuole | 0.0047 | 0.0226 | 0.0084 | 0.0174 | 0.0075 | 0.0032 | 0.0059 | 0.0056 | 0.0035 | 0.0031 | 0.0093 | 0.0002 | – | – | – | – | – | – |
Vacuole Periphery | 0.0092 | 0.0141 | 0.0079 | 0.0051 | 0.0068 | 0.0053 | 0.0084 | 0.0064 | 0.0132 | 0.004 | 0.0029 | 0.0008 | – | – | – | – | – | – |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 27.7989 | 16.9918 | 19.8587 | 29.6924 | 32.0378 | 34.6701 | 33.2871 | 37.106 | 36.7709 | 34.864 |
Translational Efficiency | 0.4725 | 0.6016 | 0.6348 | 0.419 | 0.3477 | 0.4888 | 0.3939 | 0.3579 | 0.4154 | 0.3816 |
Dataset | Hit |
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Protein Concentration | – |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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