Standard name
Human Ortholog
Description Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0 0
Bud 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – 0 – – – – – –
Cell Periphery 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0 0
Cytoplasm 0.87 0.95 1.0 0.94 0.77 – 0.75 0.61 0.6 0.59 0.29 0.56 0.99 0.98 0.99 – – 0.64 0.59 0.75 0.47 0.8 0.75 0.7
Endoplasmic Reticulum 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – 0.07 0 0 0 0 0 0
Endosome 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – 0.05 0 0 0.05 0 0 0
Golgi 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0 0
Mitochondria 0.24 0.07 0 0.06 0.31 – 0.48 0.52 0.45 0.52 0.72 0.6 0 0 0 – – 0.07 0.24 0.12 0.21 0.07 0.12 0.1
Nucleus 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 – 0 0.06 0 0 0 0 0 0 0 – – 0.13 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0.06 0 – 0 0 0 0 0 0 0 0 0 – – 0 0 0 0.06 0 0 0.07
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – 4 2 2 1 2 2 3
Bud 0 0 0 0 0 – 1 0 1 1 2 2 0 0 0 – – 1 0 0 0 1 4 6
Bud Neck 0 1 0 0 1 – 0 0 0 0 1 1 1 0 0 – – 3 3 3 1 1 2 2
Bud Site 1 0 0 0 0 – 0 1 0 0 1 0 0 0 0 – – 4 – – – – – –
Cell Periphery 0 2 0 0 0 – 0 0 1 0 0 2 0 0 1 – – 3 1 2 0 1 2 4
Cytoplasm 217 200 28 15 57 – 49 58 49 43 23 63 360 521 442 – – 78 158 167 21 163 209 203
Endoplasmic Reticulum 3 0 0 0 1 – 0 0 0 1 1 0 0 4 1 – – 9 5 1 0 0 0 1
Endosome 0 0 0 0 0 – 0 1 0 0 0 0 0 2 0 – – 6 7 4 2 2 2 4
Golgi 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – 1 1 0 0 0 3 0
Mitochondria 60 15 0 1 23 – 31 49 37 38 56 68 4 4 2 – – 9 64 27 9 15 32 29
Nucleus 1 0 0 0 0 – 1 1 0 0 0 0 2 1 0 – – 2 0 0 0 0 0 1
Nuclear Periphery 1 1 0 0 0 – 0 0 0 0 1 1 0 0 1 – – 0 0 0 0 0 0 1
Nucleolus 1 0 0 0 1 – 1 0 0 1 2 0 0 1 0 – – 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0 0
SpindlePole 2 0 0 0 0 – 0 6 3 2 2 1 0 2 1 – – 16 4 2 0 5 4 5
Vac/Vac Membrane 1 0 0 1 0 – 0 2 0 1 2 0 2 1 3 – – 3 9 5 2 2 7 19
Unique Cell Count 249 210 28 16 74 65 95 82 73 78 113 364 530 448 121 270 224 46 204 280 293
Labelled Cell Count 287 219 28 17 83 83 118 91 87 91 138 369 536 451 139 270 224 46 204 280 293


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 3.0 3.2 3.6 3.0 3.7 – 3.1 3.1 2.9 2.7 3.3 2.5 3.8 3.8 3.8 4.0 4.6 4.9 3.6 4.0 4.4
Std Deviation (1e-4) 0.4 0.7 2.0 1.1 2.3 – 2.1 1.5 1.8 1.6 2.3 1.3 1.0 1.5 1.3 1.3 1.6 1.3 1.4 1.9 1.7
Intensity Change (Log2) – – – -0.28 0.05 – -0.21 -0.23 -0.32 -0.43 -0.13 -0.56 0.07 0.06 0.05 0.13 0.33 0.43 -0.01 0.14 0.27


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – – – –
Bud Neck – – – – – – – – – – – – – – –
Bud Site – – – – – – – – – – – – – – –
Cell Periphery – – – – – – – – – – – – – – –
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – – – –
Endosome – – – – – – – – – – – – – – –
Golgi – – – – – – – – – – – – – – –
Mitochondria – – – – – – – – – – – – – – –
Nuclear Periphery – – – – – – – – – – – – – – –
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – – – –
Peroxisomes – – – – – – – – – – – – – – –
SpindlePole – – – – – – – – – – – – – – –
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – – – –
Cytoplasm – – – – – – – – – – – – – – –
Nucleus – – – – – – – – – – – – – – –
Vacuole – – – – – – – – – – – – – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.0982 0.1453 0.1552 -0.2883 0.3552 0.2932 0.0849 -0.1235 -0.1951 -0.3848 -0.5368 -0.1913 0.2548 0.9571 0.2653 0.4475 0.2794 0.6562
Actin 0.0327 0.0032 0.0094 0.0008 0.0115 0.0099 0.0339 0.0005 0.0061 0.0017 0.0033 0.0107 0.0113 0.005 0.0155 0.0083 0.0049 0.0036
Bud 0.0007 0.0093 0.0036 0.0111 0.0033 0.0022 0.002 0.0002 0.0014 0.0016 0.0001 0.0009 0.0012 0.0011 0.0011 0.0001 0.0002 0.0006
Bud Neck 0.0046 0.0021 0.0046 0.0128 0.0038 0.0044 0.001 0.0001 0.001 0.0004 0.0001 0.0053 0.001 0.0008 0.0064 0.0012 0.0007 0.0027
Bud Periphery 0.0023 0.0092 0.0058 0.024 0.0091 0.0052 0.0099 0.0006 0.0029 0.0041 0.0004 0.0034 0.0031 0.0027 0.0056 0.0002 0.0005 0.0016
Bud Site 0.0063 0.0224 0.0062 0.0079 0.0031 0.0006 0.0028 0.001 0.0052 0.0014 0.0002 0.0005 0.0013 0.0151 0.0032 0.0003 0.0005 0.0004
Cell Periphery 0.001 0.0012 0.0008 0.0005 0.0007 0.0002 0.0025 0.0005 0.0012 0.0002 0.0002 0.0009 0.0003 0.002 0.0012 0.0002 0.0003 0.0004
Cytoplasm 0.0612 0.0874 0.0647 0.0917 0.0723 0.1421 0.0315 0.035 0.0438 0.0717 0.0415 0.0416 0.0715 0.1067 0.0835 0.0604 0.1134 0.121
Cytoplasmic Foci 0.039 0.0208 0.0387 0.0463 0.0153 0.0363 0.0339 0.0243 0.0354 0.0262 0.0165 0.0426 0.0334 0.0324 0.0343 0.0751 0.0357 0.049
Eisosomes 0.0007 0.0003 0.0007 0.0001 0.0004 0.0002 0.0011 0.0004 0.0015 0.0001 0.0004 0.0003 0.0004 0.0004 0.0007 0.0007 0.0009 0.0002
Endoplasmic Reticulum 0.0034 0.002 0.002 0.0022 0.0034 0.0011 0.0045 0.0008 0.0033 0.0005 0.0007 0.001 0.0023 0.0025 0.0015 0.0009 0.0008 0.0019
Endosome 0.0152 0.0138 0.0113 0.0135 0.0098 0.0098 0.0376 0.0023 0.0236 0.0344 0.0079 0.0134 0.0196 0.0165 0.0043 0.0153 0.0327 0.0155
Golgi 0.0065 0.0014 0.0037 0.0018 0.0038 0.0024 0.0181 0.0013 0.0062 0.0093 0.0083 0.003 0.0036 0.0029 0.0021 0.0022 0.0046 0.0052
Lipid Particles 0.0079 0.0039 0.0051 0.0032 0.0018 0.0036 0.039 0.0064 0.0056 0.0108 0.0222 0.0042 0.0071 0.0034 0.003 0.0042 0.0329 0.0038
Mitochondria 0.0102 0.0176 0.0091 0.006 0.0322 0.0037 0.0249 0.0153 0.0102 0.0051 0.0028 0.0203 0.0263 0.0151 0.0025 0.0016 0.0108 0.0306
None 0.7799 0.784 0.8043 0.7414 0.8015 0.7592 0.6932 0.9014 0.8371 0.7671 0.8852 0.8396 0.7904 0.7774 0.8185 0.8045 0.7426 0.7475
Nuclear Periphery 0.0032 0.0013 0.0012 0.0022 0.0053 0.0006 0.0032 0.0002 0.0009 0.0002 0.0004 0.0019 0.0049 0.001 0.0006 0.0004 0.0003 0.0003
Nucleolus 0.0009 0.002 0.0014 0.0063 0.0011 0.0004 0.0006 0.0004 0.002 0.0002 0.0002 0.0003 0.0012 0.0006 0.0004 0.0003 0.0006 0.0002
Nucleus 0.0014 0.0033 0.0019 0.0063 0.0078 0.001 0.0011 0.0004 0.0013 0.0004 0.0007 0.0008 0.0105 0.0008 0.0017 0.0004 0.0004 0.0005
Peroxisomes 0.0096 0.003 0.0144 0.0056 0.0037 0.0099 0.0511 0.0065 0.003 0.0606 0.0069 0.0045 0.0031 0.0067 0.0111 0.0217 0.0135 0.0093
Punctate Nuclear 0.0077 0.0038 0.0077 0.0067 0.0006 0.0052 0.0035 0.001 0.0014 0.0007 0.0012 0.0019 0.0048 0.0009 0.0014 0.0012 0.0005 0.0014
Vacuole 0.0047 0.0069 0.0027 0.0081 0.0069 0.0015 0.0032 0.0014 0.0059 0.0025 0.0008 0.0019 0.0019 0.005 0.0013 0.0007 0.0024 0.003
Vacuole Periphery 0.0009 0.001 0.0006 0.0014 0.0027 0.0005 0.0012 0.0001 0.0009 0.0009 0.0003 0.0009 0.0006 0.001 0.0002 0.0002 0.0009 0.0012

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 1.5105 2.7006 1.002 2.1034 1.4688 2.2645 3.2425 3.4555 4.329 2.9311
Translational Efficiency – – – – – – – – – –

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency –

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1839 1266 174 1379 1112 1553 222 1163 2951 2819 396 2542

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 663.97 619.43 880.97 832.83 643.26 634.15 922.02 772.66 656.17 627.54 903.98 805.30
Standard Deviation 69.73 110.84 99.32 121.18 70.73 92.15 116.67 111.04 70.82 101.23 111.27 120.44
Intensity Change Log 2 — -0.100177 0.407975 0.326904 — -0.020578 0.519396 0.264432 — -0.060459 0.463878 0.296501

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000063 0.000276 0.000635 0.014794 0.000034 0.000374 0.000344 0.000888 0.000052 0.000330 0.000472 0.008432
Bud Neck 0.023210 0.034942 0.003452 0.027159 0.009222 0.066054 0.006208 0.026541 0.017939 0.052081 0.004997 0.026877
Bud Site 0.004871 0.008160 0.011595 0.112395* 0.001327 0.018701 0.007433 0.027736 0.003536 0.013967 0.009262 0.073662
Cell Periphery 0.000214 0.000238 0.000292 0.000247 0.000132 0.000180 0.000203 0.000344 0.000183 0.000206 0.000242 0.000291
Cytoplasm 0.526172* 0.333212* 0.224850* 0.259164* 0.515215* 0.293898* 0.268881* 0.328918* 0.522043* 0.311554* 0.249534* 0.291078*
Cytoplasmic Foci 0.110882 0.243775* 0.027192 0.090471 0.182191* 0.313579* 0.050291 0.086160 0.137753 0.282231* 0.040141 0.088499
Eisosomes 0.000150 0.000308 0.000117 0.000123 0.000112 0.000213 0.000107 0.000141 0.000136 0.000255 0.000111 0.000132
Endoplasmic Reticulum 0.000668 0.001187 0.008017 0.003187 0.000583 0.000437 0.003605 0.002548 0.000636 0.000774 0.005543 0.002894
Endosome 0.005485 0.022223 0.007294 0.022559 0.005293 0.042555 0.010770 0.044311 0.005413 0.033424 0.009242 0.032511
Golgi 0.000779 0.006191 0.000254 0.027737 0.000788 0.012184 0.000695 0.008583 0.000783 0.009492 0.000502 0.018974
Lipid Particles 0.005665 0.014998 0.005466 0.003283 0.006691 0.012394 0.003279 0.009358 0.006052 0.013563 0.004240 0.006062
Mitochondria 0.003061 0.023833 0.000592 0.035699 0.001585 0.037475 0.000439 0.027778 0.002505 0.031348 0.000506 0.032075
Mitotic Spindle 0.002816 0.003309 0.001245 0.095084 0.000084 0.005929 0.041893 0.036425 0.001787 0.004753 0.024032 0.068247
None 0.003883 0.022927 0.003727 0.001694 0.005235 0.004329 0.003673 0.009358 0.004393 0.012681 0.003697 0.005200
Nuclear Periphery 0.000596 0.000955 0.002644 0.000942 0.000561 0.000351 0.001800 0.002542 0.000583 0.000622 0.002171 0.001674
Nuclear Periphery Foci 0.000175 0.000578 0.002956 0.001107 0.000233 0.000221 0.001580 0.002214 0.000197 0.000381 0.002184 0.001613
Nucleolus 0.001250 0.005426 0.001626 0.000799 0.001062 0.002404 0.001353 0.004445 0.001179 0.003761 0.001473 0.002467
Nucleus 0.268180* 0.210631* 0.602688* 0.111465 0.241804* 0.084281 0.449330* 0.193647* 0.258241* 0.141024* 0.516715* 0.149064*
Peroxisomes 0.002518 0.020289 0.001061 0.064134 0.002268 0.034327 0.003225 0.013479 0.002424 0.028023 0.002275 0.040959
Vacuole 0.038757 0.043475 0.093816 0.121846 0.024846 0.066957 0.144518 0.164221 0.033515 0.056411 0.122240 0.141233
Vacuole Periphery 0.000603 0.003067 0.000480 0.006110 0.000735 0.003156 0.000374 0.010364 0.000653 0.003116 0.000421 0.008056

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -8.61 -7.29 -8.50 -8.32 -7.93 -6.35 -7.27 -3.35 -1.77 -1.04 -8.82 -10.15 -8.80 -8.40 -7.95
Bud Neck -3.98 12.37 -0.92 3.21 -12.50 -17.16 1.08 -6.37 11.69 -6.56 -14.61 9.27 -3.90 11.39 -12.27
Bud Site -3.56 -0.83 -18.01 -17.28 -12.09 -11.93 -4.32 -9.49 -1.91 -5.98 -10.99 -2.02 -19.65 -15.34 -14.28
Cell Periphery -0.72 -2.08 0.20 1.37 2.61 -2.28 -4.33 -5.25 -3.20 -2.49 -1.00 -2.78 -2.96 -2.23 -0.02
Cytoplasm 20.37 19.68 27.31 5.46 -4.56 21.17 16.54 15.93 -3.18 -5.80 30.53 25.58 30.66 1.58 -6.96
Cytoplasmic Foci -18.40 17.29 7.63 23.50 -10.38 -16.12 20.34 15.44 34.29 -7.48 -27.14 25.01 15.66 41.26 -12.00
Eisosomes -3.19 1.13 3.34 3.91 1.41 -7.98 -0.23 -1.75 6.14 -1.35 -5.13 1.46 1.81 5.78 0.05
Endoplasmic Reticulum -3.70 -9.80 -9.83 -7.78 6.45 0.86 -8.43 -6.10 -7.67 5.36 -1.42 -12.79 -11.55 -11.22 8.05
Endosome -10.66 -2.33 -7.99 2.98 -5.41 -18.00 -2.30 -10.98 1.95 -8.20 -20.62 -3.02 -13.36 4.15 -9.32
Golgi -8.08 4.79 -8.46 -5.52 -8.73 -11.75 1.35 -5.44 3.83 -5.68 -14.15 2.94 -9.91 -2.42 -10.23
Lipid Particles -8.06 -0.14 4.02 10.31 3.31 -4.90 5.01 -1.17 3.24 -4.61 -9.21 3.23 0.94 9.28 -1.78
Mitochondria -8.85 6.60 -7.99 -0.25 -9.01 -13.68 7.03 -6.69 3.97 -7.05 -16.03 8.19 -10.33 3.02 -11.39
Mitotic Spindle -0.51 1.61 -13.71 -13.62 -14.15 -5.47 -3.63 -8.41 -6.66 0.68 -3.35 -3.37 -15.84 -14.85 -4.54
None -6.21 1.18 3.86 6.96 2.20 0.67 1.64 -1.40 -1.88 -2.60 -5.40 1.84 -0.17 4.99 -1.60
Nuclear Periphery -2.35 -11.30 -6.95 -3.90 7.40 3.56 -9.65 -4.99 -5.56 0.70 -0.47 -14.09 -7.16 -7.06 4.16
Nuclear Periphery Foci -5.62 -5.31 -5.93 -3.60 3.33 0.13 -8.45 -3.26 -3.28 0.78 -4.79 -8.52 -5.46 -4.67 3.17
Nucleolus -5.77 -0.96 1.62 6.40 3.06 -4.42 -0.02 -3.81 -2.09 -3.72 -6.89 -0.47 -3.05 2.90 -2.80
Nucleus 6.43 -15.16 15.80 7.43 20.55 20.83 -8.29 3.73 -15.59 9.89 20.74 -15.07 13.89 -5.47 20.14
Peroxisomes -11.11 3.72 -12.76 -6.87 -13.26 -17.65 0.06 -8.07 10.75 -6.51 -20.56 1.38 -14.23 -0.91 -14.26
Vacuole -1.95 -7.39 -22.98 -21.90 -4.36 -13.49 -11.78 -25.07 -17.81 1.54 -10.46 -13.33 -33.44 -27.50 -0.77
Vacuole Periphery -7.18 1.69 -3.83 -1.07 -4.00 -8.20 1.81 -6.02 -4.04 -6.46 -11.89 2.73 -7.08 -3.68 -7.49
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate
Localization
Cell Percentages cytoplasm (31%), nucleus (4%), mixed (41%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Cit3

Cit3


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Cit3-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available