Standard name
Human Ortholog
Description 2-methylisocitrate lyase of the mitochondrial matrix; functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0.05 0 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0.09 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.22 0.44 0.64 0.57 0.5 0.28 0.26 – 0.15 0.19 0.09 0.11 0.78 0.71 0.71 0.36 0.36 0.32 0.08 0.13 0.08 0.2 0.18 0.14
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0.06 0.07 0.06 0 0 0 0 0 0
Endosome 0 0.13 0 0.06 0.09 0.07 0.07 – 0 0 0 0 0 0.09 0.12 0.12 0.17 0.2 0.11 0.11 0.07 0.08 0.06 0.11
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.74 0.25 0 0.15 0.16 0.53 0.54 – 0.79 0.71 0.89 0.83 0 0 0 0.1 0.06 0.07 0.6 0.49 0.57 0.53 0.4 0.44
Nucleus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0.06 0 0 0 0 0 – 0 0 0 0 0 0 0.08 0 0 0.09 0 0 0 0 0 0
SpindlePole 0.06 0.07 0.18 0.15 0.19 0.08 0.16 – 0.11 0.13 0.06 0.11 0.11 0.17 0.11 0.31 0.32 0.3 0.06 0.08 0.08 0.05 0.14 0.12
Vac/Vac Membrane 0.07 0.1 0.09 0 0.09 0.07 0.07 – 0 0 0 0 0 0 0 0.11 0.1 0.13 0.05 0.05 0.05 0.06 0.06 0.06
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 2 4 1 1 0 1 – 0 2 0 2 2 2 2 5 4 1 0 10 8 1 2 2
Bud 1 8 4 5 4 11 11 – 16 12 16 31 0 1 1 6 9 4 0 6 3 0 1 2
Bud Neck 0 0 20 5 2 3 5 – 1 9 4 7 0 1 3 3 6 5 1 5 5 0 2 1
Bud Site 0 0 0 1 0 1 1 – 2 1 11 11 0 0 0 6 1 2 – – – – – –
Cell Periphery 0 2 7 2 3 1 3 – 2 1 3 6 0 1 1 4 8 10 0 1 3 0 0 0
Cytoplasm 15 117 151 119 136 95 103 – 51 59 53 60 35 100 92 74 81 88 6 45 28 10 14 13
Endoplasmic Reticulum 1 10 2 5 3 2 2 – 0 2 3 6 0 2 2 12 15 17 0 3 3 0 0 0
Endosome 2 34 6 13 25 22 28 – 6 4 3 4 1 13 16 24 37 56 9 39 27 4 4 10
Golgi 0 1 0 2 1 0 0 – 0 0 0 0 0 0 0 4 1 4 0 6 2 0 0 1
Mitochondria 50 66 2 31 43 178 211 – 273 219 503 455 1 2 0 20 13 20 53 173 205 28 32 41
Nucleus 1 0 1 2 4 13 7 – 6 10 15 16 0 1 1 1 5 2 0 1 0 0 0 0
Nuclear Periphery 0 0 0 0 0 2 1 – 1 3 4 6 0 0 0 1 1 0 0 0 4 0 0 0
Nucleolus 1 0 0 0 1 0 1 – 0 0 3 3 0 0 0 0 2 2 0 1 1 0 0 0
Peroxisomes 0 15 2 6 6 3 6 – 1 1 0 2 1 6 10 6 5 24 3 6 9 0 1 0
SpindlePole 4 19 42 32 52 28 63 – 38 41 33 61 5 24 14 64 72 85 4 27 29 2 11 10
Vac/Vac Membrane 5 27 21 6 24 22 29 – 15 13 21 16 2 1 2 22 22 36 4 17 18 3 4 5
Unique Cell Count 68 263 235 208 272 338 390 347 309 563 550 45 140 129 208 223 279 89 354 361 53 81 95
Labelled Cell Count 80 301 262 230 305 381 472 412 377 672 686 47 154 144 252 282 356 89 354 361 53 81 95


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 3.7 4.7 5.3 5.1 5.5 4.7 4.8 – 4.1 4.3 3.8 4.0 5.4 5.5 5.1 6.2 6.3 6.0 4.4 5.7 5.5
Std Deviation (1e-4) 0.6 1.2 0.9 1.6 1.4 1.5 1.4 – 1.1 1.3 0.9 0.8 1.3 1.2 1.3 1.3 1.7 1.4 1.0 2.3 1.1
Intensity Change (Log2) – – – -0.07 0.04 -0.19 -0.16 – -0.37 -0.3 -0.5 -0.43 0.03 0.04 -0.08 0.21 0.24 0.17 -0.27 0.08 0.05

WT3RAP60RAP140RAP220RAP300RAP460RAP540RAP620RAP70002468WT3HU80HU120HU16002468WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302468WT1AF100AF140AF18002468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 0 0
Bud Neck – – – – – – – – – – – – 0 0 0
Bud Site – – – – – – – – – – – – 0 0 0
Cell Periphery – – – – – – – – – – – – 0 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 0 0
Endosome – – – – – – – – – – – – 0 0 0
Golgi – – – – – – – – – – – – 0 0 0
Mitochondria – – – – – – – – – – – – 0 0 0
Nuclear Periphery – – – – – – – – – – – – 0 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 0 0
Peroxisomes – – – – – – – – – – – – 0 0 0
SpindlePole – – – – – – – – – – – – 0 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 0 0
Cytoplasm – – – – – – – – – – – – 0 0 0
Nucleus – – – – – – – – – – – – 0 0 0
Vacuole – – – – – – – – – – – – 0.6 0.3 1.4

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration -0.406 -0.1152 -0.231 -0.5906 -0.539 -0.2652 0.027 -0.1076 -0.0809 -0.0846 0.1355 0.1088 0.284 -0.3631 -0.0138 0.3615 0.3782 -0.1726
Actin 0.0133 0.0084 0.008 0.0125 0.005 0.0054 0.0318 0.0061 0.023 0.013 0.019 0.0107 0.056 0.008 0.0429 0.0346 0.0509 0.0249
Bud 0.0019 0.0046 0.0028 0.0021 0.0048 0.0007 0.0046 0.0065 0.0027 0.0074 0.0025 0.0018 0.0016 0.0077 0.0067 0.0283 0.0172 0.0079
Bud Neck 0.0035 0.0026 0.0077 0.0005 0.0018 0.0033 0.0068 0.0023 0.0043 0.0023 0.0037 0.0067 0.0186 0.0038 0.0025 0.0008 0.0023 0.013
Bud Periphery 0.007 0.0099 0.0065 0.0094 0.0108 0.002 0.0177 0.0101 0.0105 0.0206 0.0073 0.0072 0.0032 0.0108 0.0168 0.0317 0.0328 0.0069
Bud Site 0.0072 0.0347 0.0126 0.0009 0.0021 0.0009 0.0116 0.027 0.0129 0.0136 0.0066 0.0022 0.0102 0.0388 0.0353 0.0116 0.0755 0.0024
Cell Periphery 0.0018 0.0016 0.0015 0.0007 0.0008 0.0007 0.0027 0.0023 0.0024 0.0029 0.0012 0.0009 0.0022 0.0014 0.0043 0.0013 0.0036 0.0013
Cytoplasm 0.0572 0.0671 0.0525 0.0787 0.0369 0.0642 0.0652 0.0801 0.0663 0.0735 0.046 0.0775 0.0855 0.1496 0.1308 0.1281 0.0505 0.1666
Cytoplasmic Foci 0.14 0.1053 0.1249 0.0765 0.1595 0.1473 0.1368 0.1221 0.1262 0.1461 0.1325 0.1343 0.1427 0.1494 0.1055 0.1041 0.0745 0.1499
Eisosomes 0.0013 0.0014 0.0008 0.0012 0.0008 0.0004 0.0014 0.0007 0.0016 0.0013 0.0011 0.0005 0.0007 0.0004 0.0016 0.0008 0.0002 0.0009
Endoplasmic Reticulum 0.0028 0.0038 0.0032 0.0057 0.0054 0.0018 0.0093 0.0043 0.0037 0.0035 0.0035 0.0026 0.0078 0.0043 0.0063 0.0066 0.0034 0.0073
Endosome 0.1097 0.115 0.1073 0.1016 0.0969 0.0929 0.1201 0.0868 0.0978 0.0734 0.1267 0.0713 0.1455 0.1474 0.1094 0.0726 0.2406 0.1176
Golgi 0.0241 0.022 0.0195 0.0211 0.0302 0.0201 0.0326 0.0335 0.0367 0.0405 0.0667 0.0287 0.0449 0.0461 0.0396 0.0644 0.0662 0.064
Lipid Particles 0.0416 0.0237 0.0264 0.005 0.0276 0.0316 0.0432 0.0135 0.0264 0.0331 0.0259 0.0314 0.071 0.0172 0.0147 0.0475 0.1236 0.0207
Mitochondria 0.2074 0.1704 0.1832 0.3548 0.1893 0.2333 0.1498 0.2342 0.2406 0.3029 0.2374 0.2303 0.1077 0.1135 0.1376 0.0506 0.1949 0.1608
None 0.3121 0.3273 0.3474 0.2872 0.279 0.3052 0.2999 0.2825 0.2695 0.1703 0.2326 0.2982 0.2307 0.2373 0.2592 0.318 0.0081 0.1598
Nuclear Periphery 0.0027 0.0031 0.0052 0.0027 0.0072 0.0016 0.0059 0.0018 0.0029 0.0047 0.0035 0.0016 0.0071 0.0015 0.0032 0.0037 0.0022 0.0021
Nucleolus 0.0031 0.0075 0.0022 0.0007 0.0087 0.0025 0.0018 0.0024 0.0017 0.0016 0.0017 0.0009 0.0014 0.0009 0.0035 0.0016 0.0005 0.004
Nucleus 0.0021 0.0065 0.0033 0.0021 0.0107 0.0028 0.0031 0.004 0.0018 0.0028 0.0019 0.0023 0.0026 0.0016 0.0041 0.0034 0.0013 0.0041
Peroxisomes 0.0442 0.0494 0.0644 0.0204 0.073 0.0651 0.035 0.0604 0.0537 0.0654 0.0532 0.0801 0.0372 0.0381 0.0256 0.0744 0.0306 0.0653
Punctate Nuclear 0.0036 0.0163 0.0056 0.0017 0.0349 0.0065 0.0045 0.0015 0.0029 0.0117 0.0086 0.0032 0.0069 0.0028 0.0164 0.0042 0.0011 0.0089
Vacuole 0.0103 0.015 0.0116 0.0088 0.0102 0.0086 0.0126 0.0141 0.0092 0.0067 0.0137 0.005 0.0109 0.0154 0.027 0.0088 0.0136 0.0083
Vacuole Periphery 0.0031 0.0043 0.0034 0.0057 0.0044 0.0028 0.0036 0.0036 0.0031 0.0027 0.0047 0.0025 0.0054 0.0043 0.0071 0.0032 0.0065 0.0032

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 10.536 12.558 6.7772 8.2322 10.3488 8.9347 9.6673 9.7385 11.2852 11.2708
Translational Efficiency 0.741 0.5938 1.0483 1.0397 0.7631 1.0043 0.8789 1.0128 0.9262 0.8176

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✔

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
239 1085 299 380 1466 1429 180 366 1705 2514 479 746

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 591.84 707.89 978.16 933.84 644.82 681.56 936.93 884.29 637.39 692.92 962.67 909.53
Standard Deviation 66.07 97.84 110.24 136.29 70.56 93.29 106.17 114.31 72.33 96.17 110.55 128.40
Intensity Change Log 2 — 0.258318 0.724863 0.657968 — 0.079944 0.539045 0.455623 — 0.168065 0.630963 0.556006

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000856 0.001452 0.005875 0.023783 0.000513 0.002977 0.012371 0.021313 0.000561 0.002319 0.008316 0.022571
Bud Neck 0.108921 0.039646 0.016678 0.014701 0.039432 0.042477 0.014590 0.015894 0.049173 0.041255 0.015894 0.015287
Bud Site 0.015724 0.038580 0.054758 0.129928 0.012766 0.030858 0.066364 0.126168 0.013181 0.034191 0.059120 0.128083
Cell Periphery 0.000638 0.000283 0.000259 0.000355 0.000277 0.000355 0.000318 0.000297 0.000328 0.000324 0.000281 0.000327
Cytoplasm 0.188400 0.100814 0.111772 0.045804 0.149222 0.091557 0.134717 0.067537 0.154714 0.095552 0.120395 0.056467
Cytoplasmic Foci 0.335821 0.256987 0.151236 0.146718 0.363982 0.252987 0.174579 0.140399 0.360035 0.254713 0.160008 0.143618
Eisosomes 0.000570 0.000193 0.000156 0.000148 0.000329 0.000250 0.000187 0.000132 0.000363 0.000225 0.000168 0.000140
Endoplasmic Reticulum 0.001155 0.000974 0.010752 0.001932 0.001946 0.000774 0.008234 0.001352 0.001835 0.000860 0.009806 0.001648
Endosome 0.042048 0.104681 0.083710 0.086148 0.056815 0.102685 0.082895 0.087887 0.054745 0.103546 0.083404 0.087001
Golgi 0.016733 0.061731 0.021684 0.093717 0.037944 0.070666 0.017023 0.082126 0.034971 0.066810 0.019932 0.088030
Lipid Particles 0.028806 0.010102 0.012679 0.004794 0.026628 0.016027 0.012483 0.003138 0.026933 0.013470 0.012606 0.003981
Mitochondria 0.084370 0.174539 0.008055 0.088615 0.150428 0.195602 0.006915 0.094213 0.141168 0.186512 0.007627 0.091362
Mitotic Spindle 0.003275 0.025014 0.098890 0.161981 0.004419 0.023590 0.094950 0.115733 0.004259 0.024204 0.097409 0.139291
None 0.002308 0.001325 0.000904 0.000221 0.001697 0.002228 0.000972 0.000201 0.001783 0.001838 0.000929 0.000211
Nuclear Periphery 0.000429 0.000293 0.002501 0.001104 0.000664 0.000416 0.003138 0.000293 0.000631 0.000363 0.002740 0.000706
Nuclear Periphery Foci 0.000245 0.000433 0.006804 0.001745 0.000296 0.000470 0.005278 0.000890 0.000289 0.000454 0.006231 0.001326
Nucleolus 0.001596 0.002447 0.004997 0.000378 0.002100 0.004189 0.003820 0.000794 0.002030 0.003437 0.004555 0.000582
Nucleus 0.072942 0.022870 0.106657 0.005906 0.043586 0.020491 0.100123 0.004445 0.047701 0.021518 0.104202 0.005189
Peroxisomes 0.064020 0.093010 0.059915 0.121493 0.059822 0.082255 0.070717 0.163351 0.060410 0.086897 0.063975 0.142029
Vacuole 0.027065 0.054509 0.231925 0.062968 0.039811 0.049317 0.184632 0.068295 0.038024 0.051558 0.214153 0.065581
Vacuole Periphery 0.004077 0.010116 0.009791 0.007560 0.007323 0.009828 0.005692 0.005543 0.006868 0.009953 0.008250 0.006571

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.14 -5.57 -6.20 -6.07 -4.67 -2.33 -4.36 -4.69 -3.98 -1.91 -2.87 -7.04 -7.67 -6.85 -4.66
Bud Neck 5.40 7.31 7.39 6.96 0.57 -0.89 8.67 7.14 7.82 -0.82 2.38 11.23 10.74 10.62 -0.06
Bud Site -6.28 -6.13 -11.47 -9.03 -6.97 -6.72 -4.91 -11.75 -9.59 -4.82 -10.08 -8.32 -16.72 -13.26 -8.60
Cell Periphery 2.22 2.25 1.90 -0.87 -0.97 -1.60 -0.66 -0.23 1.19 0.34 0.15 1.07 0.47 0.34 -0.55
Cytoplasm 5.92 4.30 8.90 5.55 5.73 8.42 0.36 7.49 1.68 3.96 9.78 2.86 12.50 4.91 6.57
Cytoplasmic Foci 4.83 12.26 11.61 11.41 -0.96 13.61 15.19 23.72 12.71 1.63 15.01 25.13 28.46 17.02 0.37
Eisosomes 4.70 5.10 5.33 1.98 1.26 2.24 5.78 9.19 3.45 3.08 5.10 8.87 10.65 3.93 3.01
Endoplasmic Reticulum 0.37 -9.13 -1.80 -3.26 8.58 2.82 -6.39 0.38 -3.14 6.78 2.68 -10.47 -0.31 -4.62 10.89
Endosome -8.96 -4.30 -4.42 3.21 -0.55 -10.32 -1.40 -3.36 2.89 -0.92 -13.14 -3.33 -4.80 4.33 -1.06
Golgi -10.04 -0.10 -8.55 -2.77 -8.58 -8.81 7.71 -4.90 -0.48 -8.15 -10.80 7.29 -8.12 -2.21 -11.68
Lipid Particles 3.95 3.24 4.92 3.14 3.66 5.22 6.49 14.97 8.90 5.23 8.05 7.68 14.35 8.34 6.00
Mitochondria -5.97 6.23 0.41 7.44 -7.12 -4.85 22.42 5.46 8.97 -7.69 -5.75 23.32 6.57 11.82 -10.45
Mitotic Spindle -6.19 -7.85 -11.82 -10.00 -3.92 -8.44 -5.51 -10.06 -8.22 -1.71 -10.87 -9.62 -15.54 -12.95 -3.96
None 0.95 1.38 2.24 6.33 4.27 -1.21 1.45 5.10 5.19 2.71 -0.34 2.36 5.52 6.91 4.91
Nuclear Periphery 0.93 -4.66 -1.17 -1.41 2.10 1.57 -2.95 1.91 0.70 3.38 2.04 -5.02 -0.31 -1.21 4.08
Nuclear Periphery Foci -2.51 -8.02 -2.65 -2.29 5.29 -2.05 -8.29 -3.22 -2.27 6.86 -2.79 -10.77 -3.58 -2.97 7.96
Nucleolus -2.34 -3.99 3.10 5.15 5.44 -2.67 -1.38 2.75 4.35 2.49 -2.91 -3.45 3.92 6.11 5.66
Nucleus 5.74 -3.94 7.46 4.53 10.61 7.22 -3.92 12.89 6.37 6.47 8.84 -7.67 14.21 7.35 12.38
Peroxisomes -3.09 1.26 -4.24 -2.24 -5.80 -4.53 -0.07 -7.40 -5.55 -6.00 -6.39 0.96 -9.04 -5.79 -8.56
Vacuole -6.10 -16.93 -7.23 -4.47 9.40 -3.06 -10.67 -5.93 -4.83 6.47 -5.35 -19.48 -8.77 -6.65 11.51
Vacuole Periphery -5.76 -3.30 -2.18 2.35 0.95 -2.71 2.21 2.36 4.60 -0.42 -4.10 -0.01 1.07 4.62 0.87
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description 2-methylisocitrate lyase of the mitochondrial matrix; functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol
Localization
Cell Percentages mitochondrion (56%)
Cell Cycle Regulation No
Subcompartmental Group mito-1

Icl2

Icl2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Icl2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available