Standard name
Human Ortholog
Description Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; regulates cell proliferation and colony development via the Rho1-Tor1 pathway; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.34 0.18 0.25 0.21 0.16 0.11 – 0.09 0.13 0.09 0.09 0.13 0 0 0 0.06 0.09 0.12 0.23 0.16 0.23 0.16 0.15 0.11
Bud 0.11 0.13 0.08 0.11 0.09 0.06 – 0.11 0.13 0.11 0.15 0.1 0 0 0 0 0.05 0 0.08 0.06 0.07 0.09 0.07 0.06
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0.05 0 0.21 0.17 0.16 0.21 0.12 0.1
Bud Site 0.06 0 0.05 0.05 0 0 – 0 0 0 0.05 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0.22 0.16 0.25 0.32 0.15 0.17 – 0.12 0.16 0.14 0.15 0.15 0.21 0.29 0.23 0.18 0.19 0.23 0.17 0.09 0.24 0.19 0.15 0.16
Cytoplasm 0.5 0.76 0.51 0.6 0.6 0.57 – 0.49 0.41 0.44 0.36 0.31 0.95 0.86 0.92 0.83 0.8 0.74 0.24 0.45 0.16 0.26 0.42 0.47
Endoplasmic Reticulum 0.05 0 0 0 0.05 0 – 0 0 0 0 0.05 0 0 0 0.05 0.05 0.05 0 0 0.06 0 0 0
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0.06 0.22 – 0.3 0.43 0.45 0.57 0.53 0 0 0 0.07 0.05 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0.06 0 0 0.08 – 0.06 0.07 0.06 0.05 0.07 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0.09 0 0.12 0.1 0.08 0 – 0.06 0 0 0 0.05 0 0 0 0 0.05 0.07 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 94 26 60 39 56 44 – 59 69 48 45 65 4 9 7 41 52 54 77 27 65 44 52 42
Bud 31 19 19 20 32 25 – 69 71 59 72 53 6 8 4 16 28 17 25 9 19 23 23 22
Bud Neck 1 0 2 1 2 1 – 4 1 3 1 3 2 2 4 15 27 5 71 29 44 56 42 38
Bud Site 16 2 13 9 12 13 – 17 21 13 26 14 0 2 0 8 5 6 – – – – – –
Cell Periphery 59 23 60 61 55 67 – 76 89 72 73 79 30 66 46 123 107 102 59 16 66 52 53 61
Cytoplasm 138 112 123 114 216 222 – 311 224 227 177 160 134 192 186 555 456 320 81 77 46 69 147 186
Endoplasmic Reticulum 15 1 5 7 19 15 – 13 24 10 17 24 1 6 2 35 31 23 9 2 17 8 9 17
Endosome 1 0 1 2 14 17 – 23 12 7 2 5 0 0 0 9 2 7 6 0 3 4 1 3
Golgi 0 1 3 0 1 0 – 0 0 0 0 0 0 0 0 2 1 3 0 1 2 1 2 2
Mitochondria 0 3 6 8 22 88 – 190 233 231 276 271 0 0 0 44 29 14 4 2 7 6 8 9
Nucleus 0 0 0 2 3 2 – 6 3 3 3 3 1 2 1 3 5 1 0 0 0 0 0 0
Nuclear Periphery 0 0 1 0 1 0 – 1 2 4 0 0 0 0 0 0 0 0 0 0 1 0 0 1
Nucleolus 0 0 1 0 1 3 – 5 2 4 3 1 0 0 0 0 0 1 0 0 0 0 0 1
Peroxisomes 6 0 15 7 10 31 – 36 39 32 24 34 0 0 0 0 1 3 0 0 0 0 0 0
SpindlePole 25 0 29 18 29 16 – 38 24 19 17 24 1 4 0 27 30 31 1 0 0 0 0 2
Vac/Vac Membrane 0 0 0 3 9 8 – 15 17 4 7 4 1 0 1 5 2 4 0 2 3 2 1 3
Unique Cell Count 274 147 239 189 359 392 636 547 516 486 513 141 224 203 672 567 435 339 173 282 273 351 398
Labelled Cell Count 386 187 338 291 482 552 863 831 736 743 740 180 291 251 883 776 591 339 173 282 273 351 398


Bud, Cell Periphery, Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 7.3 6.2 6.8 6.9 6.3 5.4 – 5.5 5.0 4.8 4.8 4.8 6.7 7.1 7.3 5.5 6.1 7.5 7.9 7.8 8.0
Std Deviation (1e-4) 1.1 0.8 1.9 2.1 2.1 1.7 – 1.4 1.1 1.2 1.2 1.1 0.9 0.8 1.0 1.0 1.0 1.8 1.5 1.3 1.4
Intensity Change (Log2) – – – 0.02 -0.11 -0.33 – -0.3 -0.43 -0.49 -0.49 -0.48 -0.01 0.07 0.12 -0.29 -0.15 0.15 0.22 0.2 0.24

WT3RAP60RAP140RAP220RAP380RAP460RAP540RAP620RAP70002468WT3HU80HU120HU16002468WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302468WT1AF100AF140AF18002468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -1.1 -2.9 -4.6 – -6.1 -4.3 0 0 0 -5.6 -6.4 -6.3 -8.0 -6.0 -4.2
Bud 0.9 0.4 -0.8 – 1.3 2.0 0 0 0 -1.4 -2.0 -2.8 -3.8 -1.7 -2.2
Bud Neck 0 0 0 – 0 0 0 0 0 0 0 0 0 2.7 0
Bud Site -0.3 -1.3 -1.3 – -2.0 -1.0 0 0 0 0 -2.8 -3.4 -3.8 -4.0 -3.0
Cell Periphery 1.6 -3.0 -2.4 – -4.8 -2.9 0 0 0 -0.8 1.1 -0.6 -2.3 -2.0 -0.5
Cytoplasm 1.8 2.1 1.3 – -0.7 -2.7 -1.9 -3.9 -5.3 8.8 7.9 9.2 9.5 8.3 5.8
Endoplasmic Reticulum 1.0 2.0 1.2 – 0 1.6 0 0 0 0 0.4 0 2.0 2.1 2.0
Endosome 0 2.7 2.9 – 2.6 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 1.0 2.1 6.8 – 8.7 11.2 0 0 0 0 0 0 2.4 1.7 0.5
Nucleus 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes -1.2 -2.1 0.8 – -0.3 0.4 0 0 0 -3.0 -3.8 -3.6 0 0 -4.3
SpindlePole -0.9 -1.6 -3.8 – -3.1 -4.0 0 0 0 -4.0 -4.3 -5.1 -4.5 -3.4 -2.2
Vacuole 0 0 0 – 0 2.8 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.2321 3.0965 2.1167 2.7818 1.718 2.5488 5.0083 3.5137 3.8924 3.4998 2.9761 4.0017 3.1273 3.6628 3.2078 3.4506 2.4308 3.4742
Actin 0.0903 0.0519 0.0652 0.0467 0.1731 0.0762 0.1225 0.0567 0.0581 0.096 0.2401 0.0499 0.0969 0.0028 0.0927 0.0905 0.1914 0.0702
Bud 0.0063 0.013 0.0487 0.0222 0.0372 0.0032 0.0007 0.0081 0.0401 0.0216 0.0118 0.0012 0.002 0.0104 0.0511 0.021 0.0181 0.0007
Bud Neck 0.0727 0.0066 0.0119 0.0252 0.0457 0.4429 0.0828 0.0076 0.0103 0.0013 0.0078 0.5321 0.0781 0.0025 0.0164 0.023 0.1316 0.4052
Bud Periphery 0.0384 0.0298 0.1581 0.0911 0.1556 0.0174 0.0026 0.0354 0.2687 0.1915 0.0749 0.0082 0.0074 0.0235 0.1793 0.134 0.2922 0.0047
Bud Site 0.0691 0.2627 0.0874 0.0135 0.0235 0.0216 0.0787 0.2844 0.0491 0.0042 0.0405 0.0081 0.0859 0.241 0.0397 0.047 0.0168 0.0148
Cell Periphery 0.072 0.0281 0.031 0.0201 0.0245 0.0325 0.0423 0.0343 0.0507 0.0407 0.1005 0.0282 0.0973 0.0224 0.0474 0.0655 0.0755 0.0302
Cytoplasm 0.5323 0.5144 0.4811 0.5631 0.4764 0.3208 0.4019 0.452 0.3191 0.3951 0.49 0.2681 0.3754 0.5765 0.462 0.5386 0.2276 0.4465
Cytoplasmic Foci 0.0105 0.0067 0.0067 0.0045 0.0069 0.011 0.005 0.0043 0.0106 0.0038 0.0035 0.0069 0.0101 0.0016 0.0101 0.0022 0.0162 0.0053
Eisosomes 0.0017 0.0012 0.0011 0.0004 0.0017 0.0008 0.0021 0.0038 0.0014 0.0022 0.0012 0.0003 0.0013 0.0001 0.0005 0.0003 0.0057 0.0006
Endoplasmic Reticulum 0.0118 0.0054 0.0041 0.0126 0.0041 0.0035 0.0083 0.0052 0.0064 0.0048 0.0052 0.0018 0.0233 0.0021 0.007 0.0017 0.0031 0.0015
Endosome 0.0065 0.0012 0.0027 0.0096 0.0021 0.004 0.0017 0.0011 0.0058 0.0013 0.0026 0.0008 0.0914 0.0003 0.0169 0.0002 0.002 0.0002
Golgi 0.0051 0.0022 0.0029 0.0073 0.005 0.0034 0.0008 0.001 0.0075 0.002 0.0048 0.0011 0.011 0.0003 0.0071 0.0006 0.008 0.0006
Lipid Particles 0.0031 0.0015 0.001 0.0019 0.001 0.0016 0.0019 0.0013 0.0182 0.0027 0.0024 0.0015 0.0034 0.0003 0.0012 0.0003 0.001 0.0002
Mitochondria 0.0012 0.0006 0.0012 0.0013 0.0007 0.0048 0.0001 0.0002 0.0045 0.0009 0.001 0.0001 0.0033 0.0001 0.0023 0.0001 0.0006 0
None 0.0646 0.0693 0.0905 0.1697 0.0378 0.0506 0.2449 0.0981 0.1373 0.2281 0.0061 0.0898 0.076 0.1137 0.0498 0.0726 0.0073 0.0181
Nuclear Periphery 0.0047 0.0004 0.0007 0.0036 0.0007 0.0008 0.0005 0.0003 0.0006 0.0003 0.0003 0.0001 0.0201 0.0002 0.0049 0.0002 0.0003 0.0001
Nucleolus 0.0003 0.0005 0.0004 0.0006 0.0001 0.0002 0.0003 0.0003 0.0003 0.0002 0.0003 0.0001 0.0003 0.0001 0.0007 0.0001 0.0001 0
Nucleus 0.0028 0.0009 0.0009 0.0013 0.0008 0.0006 0.0005 0.0007 0.0006 0.0003 0.0005 0.0002 0.0037 0.0004 0.0017 0.0004 0.0003 0.0002
Peroxisomes 0.0017 0.0003 0.0009 0.0001 0.0006 0.0017 0.0001 0.0001 0.0066 0.0002 0.0005 0.0003 0.0008 0 0.0013 0.0002 0.0012 0.0003
Punctate Nuclear 0.0014 0.0004 0.001 0.0008 0.0004 0.0007 0.0004 0.0003 0.0005 0.0001 0.0001 0.0003 0.001 0.0001 0.0029 0.0002 0.0003 0.0001
Vacuole 0.003 0.0029 0.0021 0.0037 0.0017 0.0014 0.0019 0.0047 0.0032 0.0024 0.0056 0.0008 0.008 0.0016 0.0034 0.0014 0.0007 0.0004
Vacuole Periphery 0.0004 0.0001 0.0002 0.0005 0.0002 0.0002 0.0001 0.0001 0.0004 0.0002 0.0002 0 0.0033 0.0001 0.0019 0.0001 0.0001 0

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 14.584 13.9912 12.9775 18.6151 8.532 11.7318 15.111 16.3833 15.8013 15.0533
Translational Efficiency 0.5592 0.8157 0.9965 0.6755 0.8761 0.7464 0.9129 0.6391 0.7666 0.5946

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
171 933 1094 121 1277 1667 581 2599 1448 2600 1675 2720

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1039.39 814.20 1114.65 1284.14 655.40 874.59 1104.67 1117.63 700.75 852.92 1111.19 1125.04
Standard Deviation 128.39 134.38 138.43 174.80 90.98 109.07 125.85 156.32 156.85 122.25 134.28 160.89
Intensity Change Log 2 — -0.352282 0.100854 0.305065 — 0.416231 0.753168 0.769995 — -0.005117 0.389011 0.502991

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.083273 0.033736 0.038449 0.170685 0.003699 0.029641 0.061349 0.053076 0.013096 0.031111 0.046392 0.058308
Bud Neck 0.049434 0.107233 0.033950 0.038179 0.110332 0.196427 0.086248 0.054220 0.103140 0.164420 0.052091 0.053507
Bud Site 0.414523 0.320042 0.288404 0.521027 0.115338 0.318996 0.500068 0.387382 0.150670 0.319371 0.361823 0.393327
Cell Periphery 0.015283 0.008918 0.004196 0.058240 0.022673 0.016505 0.008065 0.013547 0.021800 0.013782 0.005538 0.015535
Cytoplasm 0.179377 0.309914 0.448195 0.123013 0.567013 0.304164 0.263329 0.466033 0.521235 0.306227 0.384072 0.450774
Cytoplasmic Foci 0.035187 0.102275 0.062548 0.008038 0.064832 0.040684 0.015794 0.003679 0.061331 0.062786 0.046331 0.003873
Eisosomes 0.002856 0.002894 0.000850 0.012736 0.010073 0.008185 0.001546 0.001310 0.009220 0.006286 0.001091 0.001818
Endoplasmic Reticulum 0.001887 0.001228 0.002093 0.001871 0.006294 0.000959 0.000948 0.000206 0.005774 0.001056 0.001695 0.000280
Endosome 0.028148 0.021353 0.003895 0.000766 0.006945 0.010186 0.000858 0.000545 0.009449 0.014193 0.002841 0.000555
Golgi 0.015989 0.012029 0.000899 0.000340 0.012350 0.008571 0.000286 0.000415 0.012780 0.009812 0.000687 0.000411
Lipid Particles 0.002852 0.006636 0.002697 0.001901 0.006202 0.002548 0.000804 0.000381 0.005806 0.004015 0.002040 0.000448
Mitochondria 0.007852 0.002283 0.000082 0.000018 0.018476 0.005076 0.000049 0.000368 0.017221 0.004074 0.000070 0.000353
Mitotic Spindle 0.012185 0.000515 0.000188 0.000039 0.000303 0.000665 0.000050 0.000529 0.001706 0.000611 0.000140 0.000507
None 0.000024 0.002310 0.000349 0.000014 0.001487 0.000125 0.000035 0.000126 0.001314 0.000909 0.000240 0.000121
Nuclear Periphery 0.000210 0.000234 0.000042 0.000015 0.000082 0.000024 0.000014 0.000006 0.000097 0.000099 0.000032 0.000006
Nuclear Periphery Foci 0.001277 0.000469 0.004815 0.000754 0.000197 0.000149 0.000937 0.000107 0.000324 0.000264 0.003470 0.000136
Nucleolus 0.000080 0.000161 0.000045 0.000004 0.000438 0.000236 0.000012 0.000015 0.000396 0.000209 0.000034 0.000014
Nucleus 0.002599 0.005949 0.013630 0.001714 0.022605 0.006087 0.005130 0.002683 0.020242 0.006038 0.010682 0.002640
Peroxisomes 0.008855 0.015703 0.002541 0.001194 0.005567 0.008189 0.002779 0.001258 0.005955 0.010886 0.002624 0.001256
Vacuole 0.132138 0.045269 0.091998 0.059426 0.021917 0.041731 0.051662 0.013998 0.034934 0.043001 0.078007 0.016019
Vacuole Periphery 0.005971 0.000850 0.000134 0.000023 0.003178 0.000850 0.000039 0.000117 0.003508 0.000850 0.000101 0.000113

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 3.28 3.17 -3.24 -5.96 -5.89 -11.40 -9.72 -19.17 -6.81 1.04 -7.04 -8.82 -14.08 -8.21 -3.57
Bud Neck -5.95 2.07 1.04 7.21 -0.72 -10.73 3.44 10.37 21.27 3.88 -9.42 10.17 9.96 21.42 -1.21
Bud Site 3.04 5.01 -2.52 -5.86 -7.64 -23.76 -26.83 -37.72 -7.12 6.82 -20.76 -20.63 -30.73 -8.72 -5.26
Cell Periphery 1.12 2.22 -3.69 -4.61 -5.20 2.56 7.10 4.22 1.79 -4.54 3.72 8.90 3.08 -0.98 -9.03
Cytoplasm -6.73 -14.41 2.26 9.36 16.90 26.77 22.14 10.48 -17.95 -15.34 23.57 12.62 7.16 -17.99 -6.59
Cytoplasmic Foci -8.71 -4.90 4.54 16.29 16.11 6.78 13.83 22.48 15.85 7.30 -0.44 3.70 22.98 23.59 22.48
Eisosomes -0.15 3.81 -3.25 -3.24 -4.01 1.97 12.80 14.16 9.03 0.62 3.97 14.77 13.02 8.36 -3.38
Endoplasmic Reticulum 1.27 -0.52 0.04 -1.21 0.56 5.81 5.65 6.70 4.93 3.68 5.81 4.94 6.83 5.80 9.81
Endosome 0.78 3.21 3.63 10.12 7.35 -3.31 13.29 14.03 11.22 1.83 -3.63 6.73 9.17 14.84 9.35
Golgi 0.54 2.44 2.53 9.07 4.77 3.41 20.76 19.80 8.49 -0.77 2.53 13.96 14.02 12.06 1.40
Lipid Particles -2.31 0.11 0.88 3.16 1.44 6.25 10.09 11.37 7.12 3.49 2.59 7.54 11.52 6.63 9.08
Mitochondria 1.03 1.47 1.48 6.33 3.31 8.23 13.54 13.29 5.25 -5.76 8.94 12.74 12.52 6.29 -5.26
Mitotic Spindle 1.94 2.00 2.03 4.75 6.36 -0.64 1.22 -0.26 0.38 -1.71 1.52 2.19 1.60 0.36 -1.37
None -2.16 -3.60 1.57 2.17 3.75 5.99 6.40 5.92 -0.06 -2.49 0.96 5.22 5.86 2.06 1.63
Nuclear Periphery -0.17 1.66 2.01 1.66 8.84 2.67 3.00 3.55 4.50 5.20 -0.04 2.65 4.11 1.97 16.04
Nuclear Periphery Foci 1.99 -7.05 0.91 -2.22 10.82 1.49 -4.74 2.48 2.02 5.27 1.02 -13.72 3.07 3.52 14.83
Nucleolus -1.68 0.76 1.68 6.84 13.98 1.07 3.31 3.29 1.32 -1.31 1.31 3.19 3.36 1.82 9.83
Nucleus -4.43 -14.77 1.39 5.75 16.31 6.88 6.79 8.34 7.23 5.60 6.70 3.78 8.32 8.58 16.80
Peroxisomes -2.10 2.13 2.52 10.32 3.27 -3.00 2.87 10.09 8.92 1.54 -5.69 5.71 9.07 13.53 3.29
Vacuole 5.47 1.97 2.75 -2.22 1.78 -8.57 -8.01 4.90 12.21 9.29 -2.34 -13.42 6.66 12.75 21.00
Vacuole Periphery 1.43 1.64 1.67 8.77 11.77 7.67 11.46 11.09 5.41 -2.21 5.52 7.22 7.17 7.64 -0.43
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; regulates cell proliferation and colony development via the Rho1-Tor1 pathway; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (50%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-10

Sro7

Sro7


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Sro7-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available