Standard name
Human Ortholog
Description Essential 121 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in ER and Golgi inheritance in small buds; relocalizes away from bud neck upon DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches – 0.44 0.3 0.28 0.18 0.19 – 0.18 0.18 0.17 0.22 0.16 0.36 0.39 0.35 0.21 0.19 0.31 0.22 0.3 0.31 0.09 0.11 0.21
Bud – 0.21 0.2 0.22 0.24 0.2 – 0.19 0.23 0.17 0.21 0.2 0.11 0.11 0.17 0.18 0.11 0.12 0.39 0.3 0.33 0.45 0.53 0.42
Bud Neck – 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0.21 0.19 0.16 0.27 0.17 0.08
Bud Site – 0.18 0.15 0.15 0.07 0.09 – 0.06 0.06 0.06 0.06 0.08 0.06 0.07 0 0.09 0.11 0.06 – – – – – –
Cell Periphery – 0.08 0.08 0.11 0.06 0.11 – 0.11 0.11 0.12 0.1 0.1 0.18 0.18 0.23 0.05 0.06 0.11 0.06 0 0 0 0 0
Cytoplasm – 0.27 0.2 0.21 0.29 0.23 – 0.2 0.18 0.16 0.14 0.14 0.37 0.37 0.44 0.46 0.48 0.37 0 0.09 0 0.05 0.08 0.17
Endoplasmic Reticulum – 0.05 0 0 0 0 – 0 0.05 0 0 0 0.1 0.07 0 0.06 0 0.05 0 0 0 0 0 0
Endosome – 0 0.06 0.07 0.12 0.07 – 0.09 0.05 0 0 0 0 0 0 0 0.05 0.08 0 0 0 0 0 0
Golgi – 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria – 0.14 0 0.09 0.05 0.21 – 0.27 0.41 0.47 0.52 0.45 0 0 0 0.07 0.11 0.05 0 0 0 0 0 0
Nucleus – 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery – 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus – 0 0 0 0.05 0 – 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes – 0.06 0.3 0.28 0.25 0.2 – 0.17 0.12 0.15 0.12 0.18 0.05 0.05 0 0.08 0.11 0.08 0 0 0 0 0 0
SpindlePole – 0 0.15 0.16 0.15 0.07 – 0.09 0.06 0.06 0.05 0.07 0.08 0.08 0.09 0.12 0.13 0.15 0 0 0 0 0 0
Vac/Vac Membrane – 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches – 75 75 74 70 55 – 110 63 95 86 80 30 32 26 38 28 37 6 54 91 8 18 55
Bud – 36 50 59 91 60 – 119 81 93 82 98 9 9 13 32 17 14 11 53 94 42 94 109
Bud Neck – 0 2 8 9 11 – 16 8 7 12 11 0 0 0 1 5 1 6 35 45 25 30 21
Bud Site – 31 38 40 26 27 – 35 22 32 25 38 5 6 1 16 17 7 – – – – – –
Cell Periphery – 13 19 28 22 31 – 68 38 67 39 48 15 15 17 10 9 13 2 3 10 1 1 1
Cytoplasm – 46 51 55 109 67 – 125 65 89 57 69 31 31 33 83 72 44 0 15 10 4 13 44
Endoplasmic Reticulum – 9 4 4 8 13 – 18 18 14 16 12 8 6 3 11 2 6 0 1 3 0 3 4
Endosome – 4 16 18 45 22 – 53 16 24 9 17 0 0 0 7 7 9 0 3 5 2 3 2
Golgi – 0 0 0 0 0 – 1 0 1 0 0 0 0 2 1 1 2 0 0 3 0 1 3
Mitochondria – 23 4 24 18 62 – 167 146 264 204 218 0 0 1 13 17 6 0 2 6 1 2 2
Nucleus – 1 4 7 7 1 – 8 7 2 1 4 2 2 0 2 3 3 0 1 0 0 0 0
Nuclear Periphery – 0 0 0 0 0 – 2 0 4 1 2 0 0 0 0 0 0 0 0 1 0 1 0
Nucleolus – 2 4 6 18 5 – 32 13 25 12 15 0 0 0 0 0 3 0 0 0 0 0 0
Peroxisomes – 10 75 73 94 59 – 102 43 85 47 87 4 4 2 15 16 9 0 0 5 0 0 2
SpindlePole – 7 37 42 57 20 – 53 23 35 18 33 7 7 7 22 19 18 0 3 9 2 2 3
Vac/Vac Membrane – 4 2 6 7 3 – 10 6 15 4 9 1 1 1 0 3 4 0 3 0 3 1 2
Unique Cell Count 170 250 265 382 295 615 354 561 394 485 84 83 75 182 151 119 31 181 291 94 179 260
Labelled Cell Count 261 381 444 581 436 919 549 852 613 741 112 113 106 251 216 176 31 181 291 94 179 260


Ambiguous, Bud, Bud Neck, Cell Periphery, Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) – 7.6 8.2 7.7 7.6 6.3 – 6.4 6.1 5.8 5.7 5.7 8.3 8.3 8.5 6.3 6.7 8.7 8.7 9.1 9.0
Std Deviation (1e-4) – 1.6 2.1 2.0 2.2 1.7 – 1.6 1.6 1.5 1.3 1.4 1.2 1.2 1.5 1.8 1.5 2.4 1.4 1.5 1.6
Intensity Change (Log2) – – – -0.08 -0.1 -0.37 – -0.36 -0.43 -0.5 -0.51 -0.52 0.02 0.02 0.06 -0.38 -0.29 0.08 0.08 0.15 0.14


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -0.5 -3.4 -3.1 – -3.9 -3.5 -4.2 -2.3 -4.3 1.0 1.4 0.8 -2.1 -2.5 0.2
Bud 0.6 1.1 0.1 – -0.2 0.8 -1.2 0.2 0.1 -1.9 -1.9 -0.5 -0.6 -2.3 -2.0
Bud Neck 0 0 2.2 – 1.7 0 0 1.9 0 0 0 0 0 0 0
Bud Site 0 -3.4 -2.2 – -4.6 -3.6 -4.4 -3.7 -3.1 -2.2 -1.9 -3.2 -2.0 -1.1 -2.6
Cell Periphery 1.2 -0.9 1.2 – 1.5 1.3 1.9 1.0 1.0 2.7 2.7 3.6 -0.9 -0.6 1.1
Cytoplasm 0.1 2.3 0.7 – 0 -0.6 -1.6 -2.0 -2.1 3.0 3.1 4.1 5.6 5.7 3.4
Endoplasmic Reticulum 0 0 1.9 – 1.1 2.3 0.8 1.8 0.8 0 0 0 2.5 0 0
Endosome 0.2 2.2 0.5 – 1.1 -1.0 -1.3 -2.6 -1.8 0 0 0 -1.2 -0.7 0.4
Golgi 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 3.7 2.1 6.9 – 8.6 11.1 12.7 13.3 12.1 0 0 0 2.9 4.2 0
Nucleus 0.8 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 2.1 0 – 2.4 1.5 2.0 1.1 1.2 0 0 0 0 0 0
Peroxisomes -0.6 -1.5 -2.7 – -4.4 -5.5 -4.9 -5.7 -3.7 -4.7 -4.7 -4.9 -5.5 -4.5 -4.8
SpindlePole 0.3 0 -3.0 – -2.7 -3.4 -4.0 -4.5 -3.5 -1.5 -1.5 -1.2 -0.8 -0.6 0.1
Vacuole 0 0 0 – 0 0 1.7 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 3.6664 3.7498 3.8965 3.7823 3.5567 4.1111 5.4856 5.5874 5.5785 5.6484 5.6339 5.9378 4.7984 3.9916 5.3948 4.6058 4.9127 5.3088
Actin 0.2668 0.0471 0.1864 0.3026 0.6177 0.1713 0.3282 0.1031 0.1859 0.4239 0.581 0.1966 0.0787 0.0024 0.1558 0.384 0.6012 0.1245
Bud 0.0593 0.0912 0.294 0.1099 0.047 0.0115 0.0248 0.1116 0.2978 0.0701 0.0604 0.0117 0.0012 0.0044 0.2397 0.0512 0.0283 0.012
Bud Neck 0.0586 0.0123 0.0083 0.0158 0.0071 0.657 0.0727 0.0127 0.0028 0.0026 0.0125 0.5813 0.0201 0.0009 0.0031 0.0009 0.0016 0.5871
Bud Periphery 0.121 0.0831 0.3668 0.3928 0.1468 0.0268 0.0592 0.0747 0.3621 0.1829 0.1806 0.0294 0.0007 0.0022 0.2557 0.1923 0.1319 0.0111
Bud Site 0.2301 0.5341 0.0749 0.0511 0.0471 0.0189 0.2065 0.5704 0.0449 0.0529 0.0588 0.0264 0.3352 0.3261 0.0446 0.0138 0.0118 0.0178
Cell Periphery 0.0174 0.004 0.0031 0.01 0.0083 0.005 0.0233 0.0029 0.002 0.0047 0.0028 0.0105 0.0033 0.0008 0.0007 0.002 0.0029 0.0023
Cytoplasm 0.1442 0.178 0.0367 0.07 0.0591 0.0319 0.1243 0.048 0.0495 0.1157 0.0101 0.0354 0.2384 0.2097 0.0166 0.0668 0.0528 0.0824
Cytoplasmic Foci 0.0413 0.019 0.0106 0.0086 0.0344 0.0444 0.0296 0.0349 0.0079 0.0454 0.016 0.0528 0.2921 0.0115 0.0177 0.0168 0.0111 0.0421
Eisosomes 0.0009 0.0002 0.0002 0.001 0.0041 0.0006 0.0029 0.0004 0.0004 0.0003 0.0007 0.0008 0.0002 0 0.0003 0.0014 0.0003 0.0002
Endoplasmic Reticulum 0.0045 0.001 0.0011 0.0028 0.0015 0.0005 0.0045 0.0005 0.0025 0.0016 0.0006 0.001 0.0004 0.0082 0.0012 0.002 0.0007 0.0073
Endosome 0.0118 0.0013 0.0048 0.0056 0.0035 0.0049 0.0161 0.0097 0.0097 0.0151 0.0077 0.0056 0.0003 0.1552 0.0575 0.0658 0.0908 0.0451
Golgi 0.0102 0.0014 0.0041 0.0035 0.0077 0.0054 0.0083 0.0022 0.0031 0.0089 0.0148 0.0064 0.0018 0.0012 0.0175 0.0155 0.0024 0.0027
Lipid Particles 0.0048 0.0005 0.0008 0.0014 0.0009 0.0021 0.0041 0.0058 0.006 0.0062 0.01 0.0062 0.001 0.0055 0.0058 0.0037 0.0005 0.0021
Mitochondria 0.0013 0.0005 0.0015 0.0021 0.0033 0.0006 0.0147 0.0006 0.0024 0.0014 0.0114 0.0031 0.0003 0.0022 0.0061 0.0079 0.0015 0.0034
None 0.0126 0.0174 0.0024 0.0116 0.0011 0.0014 0.018 0.0042 0.0048 0.0305 0.0055 0.0038 0.0004 0.0468 0.128 0.1249 0.0049 0.0078
Nuclear Periphery 0.0005 0.0002 0.0002 0.0007 0.0004 0.0002 0.0089 0.0011 0.0067 0.0008 0.0002 0.0006 0 0.0103 0.0011 0.0008 0.0004 0.0016
Nucleolus 0.0014 0.0005 0.0003 0.001 0.0001 0.0005 0.0015 0.0009 0.0003 0.0003 0.0002 0.0008 0.0001 0.0005 0.0002 0.0002 0.0001 0.0009
Nucleus 0.0013 0.0011 0.0004 0.0018 0.0004 0.0011 0.0172 0.0031 0.0012 0.0005 0.0002 0.0008 0.0001 0.0032 0.0006 0.0007 0.0004 0.002
Peroxisomes 0.0033 0.003 0.0011 0.0013 0.0072 0.0112 0.0181 0.0077 0.0055 0.0055 0.0245 0.0211 0.0236 0.0002 0.0242 0.008 0.0012 0.0021
Punctate Nuclear 0.0015 0.0018 0.0006 0.0013 0.0006 0.0033 0.0122 0.0027 0.0025 0.0283 0.0014 0.0038 0.002 0.0006 0.0006 0.0006 0.0002 0.0009
Vacuole 0.0067 0.002 0.0014 0.0045 0.0012 0.0013 0.0039 0.0025 0.0012 0.002 0.0006 0.0016 0.0001 0.1632 0.0187 0.0327 0.0496 0.0259
Vacuole Periphery 0.0005 0.0001 0.0002 0.0007 0.0003 0.0002 0.0008 0.0002 0.0006 0.0004 0.0002 0.0003 0 0.0448 0.0041 0.008 0.0051 0.0186

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 16.0439 17.2724 9.8415 17.2038 16.3281 13.4487 18.9454 20.2064 16.3707 23.498
Translational Efficiency 0.6874 0.6769 0.8827 0.4967 0.5978 0.7042 0.6861 0.434 0.6089 0.4946

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✔
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
197 1720 90 459 1769 1761 242 2014 1966 3481 332 2473

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1014.99 969.30 1117.84 1000.96 705.51 926.00 1101.87 1043.79 736.52 947.40 1106.20 1035.84
Standard Deviation 135.24 142.71 119.55 177.76 99.48 116.47 110.54 158.56 139.19 131.89 113.28 163.14
Intensity Change Log 2 — -0.066450 0.139248 -0.020081 — 0.392346 0.643216 0.565093 — 0.139598 0.367543 0.249097

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.079027 0.095122 0.139685* 0.216055* 0.060529 0.057509 0.134415* 0.070284 0.062382 0.076094 0.135843* 0.097340
Bud Neck 0.043044 0.106995 0.067499 0.033305 0.147668 0.127950 0.080542 0.053909 0.137184 0.117596 0.077006 0.050085
Bud Site 0.673383* 0.649408* 0.632040* 0.545884* 0.529478* 0.619001* 0.664010* 0.685975* 0.543898* 0.634025* 0.655344* 0.659973*
Cell Periphery 0.012874 0.018965 0.006787 0.030508 0.033280 0.014509 0.009420 0.011661 0.031236 0.016711 0.008707 0.015159
Cytoplasm 0.127467* 0.074287 0.058282 0.098812 0.105726* 0.092371 0.043568 0.157180* 0.107905* 0.083435 0.047557 0.146347*
Cytoplasmic Foci 0.013992 0.020686 0.027008 0.015169 0.040265 0.026534 0.015912 0.004064 0.037633 0.023644 0.018920 0.006125
Eisosomes 0.003961 0.002102 0.001152 0.008165 0.005430 0.001495 0.002015 0.002021 0.005283 0.001795 0.001781 0.003161
Endoplasmic Reticulum 0.000887 0.000250 0.001468 0.002875 0.001272 0.000509 0.001906 0.000178 0.001234 0.000381 0.001787 0.000678
Endosome 0.002114 0.004541 0.005537 0.004253 0.010436 0.008601 0.002213 0.000691 0.009602 0.006595 0.003114 0.001352
Golgi 0.000937 0.004122 0.002680 0.003790 0.010931 0.008492 0.001143 0.000690 0.009930 0.006333 0.001559 0.001266
Lipid Particles 0.000676 0.000280 0.001638 0.001844 0.001822 0.001188 0.001175 0.000317 0.001707 0.000739 0.001300 0.000600
Mitochondria 0.001930 0.003195 0.000143 0.000679 0.023781 0.008752 0.000103 0.001210 0.021591 0.006006 0.000114 0.001112
Mitotic Spindle 0.004290 0.002013 0.000223 0.000636 0.000660 0.003447 0.000613 0.002043 0.001023 0.002739 0.000507 0.001782
None 0.000032 0.000208 0.000045 0.000080 0.001452 0.000402 0.000019 0.000095 0.001310 0.000306 0.000026 0.000092
Nuclear Periphery 0.000010 0.000005 0.000027 0.000017 0.000017 0.000023 0.000028 0.000007 0.000016 0.000014 0.000028 0.000009
Nuclear Periphery Foci 0.000178 0.000206 0.001745 0.000236 0.000317 0.000189 0.001152 0.000030 0.000303 0.000197 0.001313 0.000068
Nucleolus 0.000010 0.000169 0.000042 0.000028 0.000168 0.000281 0.000036 0.000020 0.000152 0.000226 0.000037 0.000021
Nucleus 0.000496 0.000443 0.002050 0.001936 0.002912 0.001711 0.002028 0.000890 0.002670 0.001085 0.002034 0.001084
Peroxisomes 0.004312 0.013869 0.024208 0.010839 0.018427 0.016680 0.006962 0.001919 0.017012 0.015291 0.011637 0.003574
Vacuole 0.030006 0.002857 0.027658 0.024752 0.004291 0.009032 0.032688 0.006688 0.006868 0.005981 0.031324 0.010040
Vacuole Periphery 0.000373 0.000275 0.000081 0.000137 0.001138 0.001324 0.000056 0.000128 0.001061 0.000806 0.000063 0.000130

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.20 -2.03 -6.20 -7.13 -2.16 0.56 -3.99 -1.46 -1.97 3.45 -2.81 -4.74 -5.40 -3.17 2.47
Bud Neck -7.45 -1.52 1.27 12.53 2.32 2.68 6.37 16.42 12.66 2.21 3.27 6.64 16.81 16.24 2.83
Bud Site 0.16 0.65 4.49 7.05 2.67 -8.00 -4.23 -14.37 -5.60 -1.95 -9.92 -4.28 -10.85 -1.70 -0.93
Cell Periphery -1.26 1.08 -2.19 -1.69 -3.96 6.93 7.06 8.12 1.63 -0.90 6.00 7.93 6.38 1.23 -2.61
Cytoplasm 4.25 3.89 1.44 -4.15 -3.28 2.23 5.66 -8.87 -10.64 -11.44 5.27 6.59 -7.59 -13.25 -11.85
Cytoplasmic Foci -1.33 -1.81 -0.46 1.34 1.72 4.44 5.13 14.91 10.99 3.87 5.54 4.46 13.83 11.90 4.55
Eisosomes 0.73 1.13 -1.24 -2.87 -3.39 5.89 4.57 4.86 -1.01 -0.13 5.56 5.18 3.01 -2.39 -2.24
Endoplasmic Reticulum 1.39 -1.21 -2.71 -4.38 -1.65 3.54 -0.99 5.91 2.85 2.56 4.69 -1.19 2.73 -2.21 2.25
Endosome -2.43 -2.03 -1.42 0.36 0.82 1.35 7.37 10.44 8.81 3.65 2.92 6.05 9.52 8.64 3.44
Golgi -5.70 -2.32 -1.64 0.40 -0.50 1.82 9.78 10.40 8.04 1.10 3.50 9.19 9.36 7.99 0.68
Lipid Particles 0.97 -1.30 -1.89 -3.72 -0.31 1.72 1.14 4.93 2.86 2.28 3.66 0.76 3.88 0.60 2.16
Mitochondria -0.94 1.36 0.95 3.67 -1.92 7.37 15.17 13.96 5.48 -2.56 9.75 15.14 14.03 6.01 -2.79
Mitotic Spindle 0.97 1.83 1.58 2.00 -2.03 -3.43 0.19 -2.52 1.43 -2.59 -2.94 1.67 -1.51 1.38 -2.92
None -2.21 -0.10 -1.98 1.56 -1.25 1.99 2.78 2.64 1.94 -6.99 2.15 2.77 2.63 2.42 -5.51
Nuclear Periphery 2.68 -1.31 -1.73 -5.03 0.66 -0.88 -2.52 1.21 1.85 3.11 0.38 -2.73 0.76 0.34 3.24
Nuclear Periphery Foci -0.44 -2.70 -2.16 -1.84 2.44 1.07 -2.48 3.66 2.97 3.12 1.16 -3.34 3.01 3.11 3.96
Nucleolus -1.90 -2.44 -1.80 1.71 0.86 -1.05 0.41 4.06 1.74 1.04 -1.16 0.63 3.99 2.29 1.09
Nucleus 1.74 -1.84 -4.12 -4.56 -0.92 1.23 -0.77 2.15 1.23 1.53 2.20 -0.82 1.36 -2.03 1.44
Peroxisomes -5.56 -2.28 -2.53 1.36 1.54 0.82 5.35 11.01 10.47 3.42 1.00 1.82 9.58 10.63 3.12
Vacuole 4.06 0.49 -0.72 -6.86 -1.26 -4.44 -4.99 -4.81 -0.55 4.46 1.48 -5.21 -5.04 -6.57 4.14
Vacuole Periphery 0.33 1.10 0.90 2.43 -1.19 -0.57 9.65 8.89 3.74 -1.82 1.30 9.61 8.87 4.11 -2.06
Standard name
Human Ortholog
Description Essential 121 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in ER and Golgi inheritance in small buds; relocalizes away from bud neck upon DNA replication stress
Localization
Cell Percentages bud neck (20%), actin (14%), mixed (20%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Sec8

Sec8


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Sec8-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available