Standard name
Human Ortholog
Description Mitochondrial protein; required for normal mitochondrial morphology and inheritance; component of the mitochondria-ER-cortex-ancor (MECA); interacts with Num1p to link the ER and mitochondria at the cell cortex; proposed involvement in the formation of Dnm1p and Num1p-containing cortical anchor complexes that promote mitochondrial fission
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.14 0.3 0.16 0.2 0.13 0 0.08 – 0.14 0.05 0 0 0.1 0.07 0.07 0.42 0.35 0.3 0.18 0.2 0.14 0.08 0.14 0.16
Bud 0.07 0.06 0 0.13 0 0 0 – 0.07 0.06 0 0 0 0 0 0.06 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0.05 0.08 0 0.05 0.05 0.05
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0.12 0.27 0.2 0 0.09 0 0 – 0 0 0 0 0.21 0.18 0.15 0.3 0.26 0.36 0.23 0.26 0.23 0.21 0.31 0.28
Cytoplasm 0.63 0.55 0.63 0.73 0.77 0.83 0.71 – 0.37 0.58 0.35 0.5 0.82 0.86 0.91 0.3 0.31 0.35 0.14 0.13 0.13 0.3 0.22 0.24
Endoplasmic Reticulum 0 0.07 0.05 0 0 0.05 0.09 – 0.05 0.11 0.05 0.06 0 0 0 0.08 0.07 0.07 0.16 0.13 0.1 0.05 0.07 0.09
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.13 0 0 0.16 0 0.09 0.14 – 0.65 0.35 0.71 0.63 0 0 0 0.06 0 0 0.15 0.12 0.31 0.2 0.13 0.11
Nucleus 0 0 0 0.07 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.07 0 0 0 0 0 0 0
SpindlePole 0.05 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0.07 0.1 0.08 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 41 86 12 11 11 1 14 – 6 7 2 3 29 46 48 119 102 92 73 79 18 14 38 51
Bud 21 16 0 7 2 3 7 – 3 9 5 3 7 3 2 17 8 7 4 3 0 0 2 3
Bud Neck 1 0 1 0 1 1 2 – 0 1 0 0 0 2 2 0 2 0 21 30 3 9 12 15
Bud Site 1 0 0 0 0 0 0 – 0 0 0 0 1 0 0 1 2 0 – – – – – –
Cell Periphery 35 78 15 2 7 4 4 – 0 4 1 0 61 111 111 86 75 110 93 101 29 38 84 91
Cytoplasm 188 159 48 40 63 99 124 – 16 87 40 42 243 546 664 87 89 105 58 50 16 55 60 77
Endoplasmic Reticulum 7 20 4 1 3 6 16 – 2 16 6 5 7 7 5 24 21 22 64 51 12 9 19 27
Endosome 4 2 0 0 0 1 1 – 0 2 0 0 1 5 3 2 6 1 3 5 2 2 1 1
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 3 7 3 1 3 0 0 0 0
Mitochondria 40 6 0 9 1 11 24 – 28 53 81 53 0 0 1 16 12 8 61 47 39 36 35 36
Nucleus 4 2 0 4 0 1 1 – 0 2 0 1 0 2 4 3 1 1 0 0 0 1 0 0
Nuclear Periphery 0 1 0 1 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0
Peroxisomes 7 1 0 0 0 0 0 – 0 0 0 0 0 7 2 4 21 3 2 1 0 0 0 0
SpindlePole 14 3 1 0 3 3 4 – 1 2 2 1 7 18 18 20 28 23 0 0 0 2 1 1
Vac/Vac Membrane 1 2 0 0 1 2 0 – 0 1 0 0 2 0 2 3 11 6 12 14 2 7 9 12
Unique Cell Count 299 289 76 55 82 119 174 43 150 114 84 295 632 731 286 289 302 403 393 130 182 272 325
Labelled Cell Count 364 376 81 75 92 132 197 56 184 137 108 358 748 862 385 385 381 403 393 130 182 272 325


Ambiguous

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.8 6.0 6.0 5.2 6.2 5.0 4.9 – 4.0 4.6 4.1 4.4 6.4 6.3 6.2 7.5 7.8 7.2 6.0 6.1 6.2
Std Deviation (1e-4) 0.8 0.7 0.7 1.0 1.3 1.6 0.9 – 0.8 1.0 1.2 0.8 1.2 1.2 1.1 1.1 1.4 1.1 1.3 1.3 1.1
Intensity Change (Log2) – – – -0.22 0.04 -0.26 -0.3 – -0.6 -0.38 -0.56 -0.47 0.09 0.05 0.02 0.31 0.36 0.25 -0.02 0.01 0.04

WT3RAP60RAP140RAP220RAP300RAP460RAP540RAP620RAP70002468WT3HU80HU120HU16002468WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302468WT1AF100AF140AF18002468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0.6 -0.4 -4.1 -1.8 – 0 0 0 0 -1.5 -2.6 -2.9 4.2 3.3 2.6
Bud 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery -2.7 -2.0 -3.8 -4.8 – 0 0 0 0 0.2 -0.5 -1.0 1.8 1.1 2.8
Cytoplasm 1.2 1.9 3.2 1.3 – -2.7 -0.7 -3.8 -1.7 3.6 5.2 7.1 -5.2 -5.2 -4.5
Endoplasmic Reticulum 0 0 0 1.1 – 0 0 0 0 0 0 0 0.9 0.6 0.6
Endosome 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 3.4 – 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 2.4 0
Vacuole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.7353 0.9176 0.8628 0.4102 0.6817 0.7612 1.227 1.1859 1.3621 0.9971 1.0141 1.0666 1.7622 1.9038 1.8354 1.9232 1.857 1.8056
Actin 0.0989 0.0587 0.0988 0.1124 0.1401 0.0562 0.0829 0.0983 0.0528 0.0792 0.0773 0.0612 0.103 0.0453 0.0774 0.1001 0.012 0.0669
Bud 0.006 0.0034 0.0056 0.0038 0.0086 0.0042 0.0031 0.0033 0.0038 0.0028 0.0126 0.0044 0.004 0.0052 0.0066 0.0032 0.0155 0.0059
Bud Neck 0.0334 0.0069 0.0257 0.0213 0.0575 0.0338 0.023 0.0098 0.0192 0.0244 0.0306 0.0227 0.0242 0.0051 0.0342 0.0222 0.0054 0.03
Bud Periphery 0.0289 0.0077 0.0168 0.0261 0.0347 0.0315 0.0119 0.0126 0.021 0.023 0.0341 0.037 0.0165 0.0062 0.0167 0.011 0.0472 0.0313
Bud Site 0.063 0.144 0.0518 0.0227 0.0189 0.0134 0.0282 0.1838 0.0621 0.0219 0.0375 0.0082 0.0354 0.168 0.0744 0.0713 0.0212 0.0147
Cell Periphery 0.0866 0.035 0.056 0.0196 0.0406 0.0563 0.0843 0.0656 0.074 0.103 0.0557 0.0808 0.0588 0.05 0.0513 0.0477 0.0153 0.0732
Cytoplasm 0.2882 0.4155 0.3364 0.3113 0.258 0.4446 0.3814 0.3744 0.4863 0.4491 0.3436 0.4851 0.4198 0.5092 0.4857 0.4572 0.4344 0.533
Cytoplasmic Foci 0.0359 0.0378 0.0354 0.106 0.0602 0.0461 0.0305 0.0222 0.022 0.014 0.0517 0.0312 0.048 0.0318 0.0417 0.044 0.1187 0.0344
Eisosomes 0.0186 0.01 0.0102 0.0048 0.0059 0.0036 0.0164 0.0136 0.009 0.0193 0.0065 0.0121 0.0165 0.0058 0.0109 0.0049 0.0012 0.0099
Endoplasmic Reticulum 0.0105 0.0102 0.0099 0.0056 0.0098 0.0062 0.0135 0.0045 0.006 0.0227 0.0049 0.0081 0.0067 0.0073 0.0089 0.0126 0.0036 0.005
Endosome 0.0228 0.0304 0.0204 0.0355 0.0257 0.016 0.0189 0.005 0.007 0.0062 0.0391 0.008 0.0167 0.0102 0.0094 0.018 0.032 0.0068
Golgi 0.0141 0.0225 0.0146 0.0311 0.0274 0.01 0.0104 0.0115 0.0075 0.0116 0.0175 0.0074 0.0138 0.0134 0.009 0.008 0.0059 0.0085
Lipid Particles 0.0123 0.0031 0.0055 0.0077 0.0199 0.0053 0.0068 0.0017 0.0029 0.0192 0.0283 0.0031 0.0081 0.0017 0.0052 0.0031 0.0331 0.0102
Mitochondria 0.0104 0.0069 0.014 0.0047 0.0407 0.0108 0.0074 0.0098 0.0103 0.0185 0.0153 0.0086 0.0101 0.0075 0.0177 0.0018 0.0081 0.0114
None 0.2139 0.197 0.2691 0.2654 0.1794 0.2456 0.2511 0.174 0.197 0.1635 0.1821 0.2056 0.1774 0.1242 0.1164 0.1378 0.1573 0.1363
Nuclear Periphery 0.0037 0.0007 0.0021 0.0006 0.0146 0.0004 0.0036 0.0003 0.0012 0.0005 0.0037 0.0023 0.0095 0.0003 0.0008 0.0014 0.0023 0.0006
Nucleolus 0.0098 0.0009 0.0017 0.0006 0.0057 0.0007 0.0031 0.0006 0.001 0.002 0.0041 0.0007 0.0038 0.0004 0.0047 0.0024 0.0085 0.001
Nucleus 0.0061 0.0016 0.0025 0.0011 0.0081 0.0011 0.0052 0.001 0.0016 0.0015 0.006 0.0027 0.009 0.0008 0.0029 0.0364 0.0047 0.002
Peroxisomes 0.0166 0.0019 0.0139 0.0148 0.0178 0.0065 0.0049 0.0047 0.0027 0.0127 0.0174 0.0036 0.0068 0.0043 0.0097 0.006 0.0094 0.0147
Punctate Nuclear 0.0095 0.0011 0.0035 0.0013 0.0182 0.0012 0.0071 0.0005 0.0034 0.0005 0.0219 0.0033 0.002 0.0004 0.0037 0.0057 0.0318 0.0019
Vacuole 0.0097 0.0041 0.005 0.0028 0.0055 0.0056 0.0055 0.0026 0.0085 0.004 0.009 0.0033 0.008 0.0026 0.0116 0.0049 0.0282 0.0019
Vacuole Periphery 0.0012 0.0005 0.0012 0.0005 0.0026 0.0006 0.0008 0.0002 0.0005 0.0005 0.0012 0.0004 0.0018 0.0002 0.0011 0.0003 0.0041 0.0004

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 9.8292 5.6688 4.6272 6.153 5.7553 5.7041 7.0214 7.5437 5.3513 7.1811
Translational Efficiency 0.3476 0.6576 0.6573 0.5574 0.4729 0.945 0.6509 0.5873 0.6688 0.6652

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1609 1187 166 151 2077 1795 771 98 3686 2982 937 249

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 638.28 754.59 917.44 908.79 713.62 736.56 869.53 892.30 680.73 743.74 878.02 902.30
Standard Deviation 68.25 110.78 108.73 115.72 89.09 95.79 91.89 109.85 88.89 102.40 96.83 113.73
Intensity Change Log 2 — 0.241504 0.523424 0.509758 — 0.045647 0.285080 0.322373 — 0.141437 0.402527 0.413882

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.009066 0.043558 0.019385 0.109502 0.021613 0.011261 0.006171 0.074855 0.016136 0.024117 0.008512 0.095866
Bud Neck 0.043482 0.081542 0.007901 0.022531 0.059823 0.135289 0.005894 0.016925 0.052690 0.113895 0.006250 0.020324
Bud Site 0.021489 0.099053 0.034372 0.157865 0.035172 0.074067 0.015045 0.053841 0.029199 0.084013 0.018469 0.116924
Cell Periphery 0.006203 0.008763 0.005947 0.021317 0.006584 0.007721 0.002693 0.009193 0.006418 0.008136 0.003269 0.016545
Cytoplasm 0.471291 0.238516 0.283261 0.230584 0.396265 0.268743 0.440857 0.251003 0.429015 0.256711 0.412937 0.238620
Cytoplasmic Foci 0.185983 0.188839 0.161142 0.121662 0.165956 0.124028 0.147681 0.193973 0.174698 0.149826 0.150066 0.150122
Eisosomes 0.030213 0.012321 0.002837 0.014803 0.028227 0.011317 0.002673 0.007217 0.029094 0.011717 0.002702 0.011817
Endoplasmic Reticulum 0.006230 0.017670 0.059068 0.023460 0.014415 0.014634 0.006599 0.011938 0.010842 0.015842 0.015894 0.018925
Endosome 0.009846 0.046877 0.016331 0.007468 0.017172 0.052527 0.009246 0.011542 0.013974 0.050278 0.010501 0.009072
Golgi 0.035518 0.046261 0.004003 0.004901 0.039566 0.025299 0.001616 0.002820 0.037799 0.033643 0.002039 0.004082
Lipid Particles 0.032810 0.023905 0.031552 0.011374 0.040736 0.029613 0.014494 0.012900 0.037276 0.027341 0.017516 0.011975
Mitochondria 0.016672 0.045291 0.000913 0.000513 0.024394 0.047344 0.000272 0.003236 0.021023 0.046527 0.000385 0.001584
Mitotic Spindle 0.000173 0.000678 0.000742 0.001514 0.000300 0.001509 0.000417 0.004272 0.000244 0.001178 0.000474 0.002600
None 0.006895 0.001165 0.000532 0.001285 0.002611 0.001376 0.002189 0.001319 0.004481 0.001292 0.001895 0.001298
Nuclear Periphery 0.000141 0.000212 0.001156 0.000150 0.000169 0.000256 0.000789 0.000289 0.000157 0.000238 0.000854 0.000204
Nuclear Periphery Foci 0.000307 0.000590 0.017393 0.005098 0.000417 0.000423 0.004255 0.005822 0.000369 0.000489 0.006583 0.005383
Nucleolus 0.000479 0.000363 0.000479 0.000095 0.000389 0.000943 0.000503 0.000177 0.000428 0.000712 0.000499 0.000127
Nucleus 0.068907 0.024628 0.194568 0.081104 0.074986 0.039837 0.226973 0.051715 0.072332 0.033783 0.221233 0.069537
Peroxisomes 0.030585 0.047378 0.006957 0.015190 0.040244 0.030765 0.005092 0.021769 0.036028 0.037378 0.005422 0.017779
Vacuole 0.022636 0.065647 0.150949 0.169017 0.029251 0.115898 0.106345 0.264536 0.026363 0.095895 0.114247 0.206611
Vacuole Periphery 0.001074 0.006746 0.000511 0.000567 0.001709 0.007150 0.000197 0.000658 0.001432 0.006989 0.000252 0.000603

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -10.09 -2.18 -6.10 -3.80 -5.25 5.50 8.12 -2.51 -3.17 -3.51 -4.49 5.05 -6.24 -5.51 -6.93
Bud Neck -8.33 15.97 5.07 10.91 -3.97 -14.86 21.68 10.99 21.78 -2.58 -17.13 27.34 10.98 23.30 -5.09
Bud Site -15.92 -2.64 -7.97 -3.22 -7.05 -10.46 7.86 -1.64 2.93 -4.14 -18.51 5.20 -7.53 -2.55 -8.50
Cell Periphery -2.62 0.56 -4.36 -3.45 -4.43 -1.35 7.58 -0.44 0.06 -2.22 -2.71 8.24 -4.05 -3.19 -5.58
Cytoplasm 28.27 11.81 14.55 0.84 2.21 17.37 -3.18 6.71 1.31 7.72 31.18 3.19 14.44 1.96 11.06
Cytoplasmic Foci -0.43 2.26 5.35 5.41 2.29 8.54 2.82 -0.63 -2.69 -1.52 6.19 4.45 2.83 0.57 0.47
Eisosomes 8.90 14.89 5.35 -0.56 -4.28 10.63 17.70 10.39 2.80 -1.94 13.84 22.59 9.21 0.53 -4.67
Endoplasmic Reticulum -6.41 -8.04 -5.93 -1.78 4.96 -0.11 6.15 1.06 1.10 -1.98 -4.11 -3.34 -3.81 -1.36 -1.16
Endosome -14.25 -3.16 1.21 12.81 3.37 -14.31 5.82 3.01 14.24 -0.64 -20.12 3.22 3.53 19.46 1.21
Golgi -3.71 18.04 16.62 16.22 -0.63 7.34 26.43 21.33 13.77 -0.70 2.54 32.98 26.77 20.83 -2.30
Lipid Particles 4.18 0.42 9.39 5.27 5.18 4.97 12.33 10.39 6.65 1.08 6.30 11.80 14.35 8.92 3.19
Mitochondria -8.82 11.85 12.45 15.04 1.08 -8.26 17.34 8.05 13.38 -0.96 -12.11 21.30 14.77 21.72 -0.98
Mitotic Spindle -2.31 -2.34 -1.82 -0.98 -1.02 -3.47 -0.33 -1.04 -0.64 -1.01 -4.20 -1.17 -1.60 -0.83 -1.42
None 6.76 8.95 3.83 -0.23 -0.75 2.76 0.62 2.05 0.43 1.14 7.18 3.94 3.63 -0.03 0.56
Nuclear Periphery -1.84 -10.64 -0.63 1.47 10.47 -3.83 -11.31 -3.21 -1.61 6.01 -3.92 -14.44 -2.84 0.27 11.85
Nuclear Periphery Foci -3.90 -7.49 -6.59 -6.18 5.09 0.05 -10.46 -4.30 -4.30 -1.24 -2.36 -11.91 -7.51 -7.35 1.34
Nucleolus 2.14 -0.15 9.85 5.95 6.29 -6.40 -1.77 5.05 9.24 4.62 -4.99 -1.49 10.58 11.18 6.25
Nucleus 16.00 -8.86 -1.17 -5.97 6.87 11.76 -18.83 3.09 -1.28 16.22 18.42 -21.21 0.64 -5.28 16.42
Peroxisomes -6.13 13.88 5.28 9.35 -2.81 4.06 20.34 3.35 1.93 -1.94 -0.75 24.62 6.27 6.48 -3.43
Vacuole -12.56 -11.62 -9.43 -6.90 -1.17 -20.15 -15.96 -10.28 -7.21 -7.05 -23.52 -19.73 -13.42 -8.99 -6.87
Vacuole Periphery -8.76 2.78 1.42 8.36 -0.08 -11.03 10.35 2.98 11.05 -0.90 -14.17 12.11 3.18 13.82 -1.03
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Mitochondrial protein; required for normal mitochondrial morphology and inheritance; component of the mitochondria-ER-cortex-ancor (MECA); interacts with Num1p to link the ER and mitochondria at the cell cortex; proposed involvement in the formation of Dnm1p and Num1p-containing cortical anchor complexes that promote mitochondrial fission
Localization
Cell Percentages ER (15%), cell periphery (11%), mixed (41%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Mdm36

Mdm36


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Mdm36-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available