Standard name
Human Ortholog
Description Ser/Thr kinase involved in late nuclear division; one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; DBF20 has a paralog, DBF2, that arose from the whole genome duplication

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.05 0 0.1 0.07 0.06 0.07 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0.08 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.07 0.06 0 0 0 0 0 0
Cytoplasm 0.91 0.9 0.86 0.88 0.87 0.86 0.88 0.89 0.78 0.83 0.66 0.76 0.95 0.99 0.97 0.84 0.83 0.82 0.82 0.81 0.66 0.76 0.86 0.82
Endoplasmic Reticulum 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0.08 0.08 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0.17 0.12 0.38 0.21 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0.06 0 0 0 0 0 0 0 0 0 0 0.07 0.05 0.09 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0.12 0 0.06
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 11 7 9 14 15 20 15 19 6 10 7 7 1 0 1 1 12 9 8 5 3 0 0 1
Bud 2 5 0 3 3 5 11 17 7 9 12 9 3 0 0 0 2 1 2 7 5 0 1 1
Bud Neck 0 1 1 0 2 3 5 5 1 3 3 5 0 0 1 0 0 0 11 8 11 1 1 1
Bud Site 0 0 2 4 2 8 5 6 2 1 6 3 0 0 0 0 1 2
Cell Periphery 4 11 1 5 2 1 3 2 5 7 5 6 1 5 6 10 13 12 0 0 0 0 0 0
Cytoplasm 188 199 81 174 206 249 375 400 165 208 186 245 113 247 269 133 157 177 177 188 92 43 102 121
Endoplasmic Reticulum 5 8 5 4 4 9 10 1 8 0 12 4 3 0 1 13 15 7 3 2 2 0 0 0
Endosome 1 1 0 1 1 5 1 2 2 0 0 2 0 2 1 3 7 14 5 4 4 0 1 2
Golgi 0 0 0 0 0 0 0 1 0 0 0 0 0 0 1 2 0 0 0 0 0 0 1 0
Mitochondria 5 2 0 0 0 7 19 17 35 31 108 68 1 0 0 6 1 3 2 2 4 0 2 4
Nucleus 0 2 1 1 0 0 4 5 1 0 4 2 3 0 3 2 3 1 0 0 1 0 0 1
Nuclear Periphery 0 0 0 0 0 0 0 0 1 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 1 0 1 0 0 3 1 3 0 0 0 0 3 4 0 0 0 0 0 0
Peroxisomes 1 0 0 1 2 4 2 2 0 1 1 0 0 0 0 1 1 0 0 0 0 0 0 1
SpindlePole 2 0 0 7 13 10 13 17 5 6 6 11 0 1 2 11 9 20 1 1 1 0 0 0
Vac/Vac Membrane 0 0 0 1 1 0 1 1 1 3 1 3 0 2 1 5 4 4 2 7 9 6 4 9
Unique Cell Count 207 220 94 197 236 290 424 450 212 250 283 323 119 250 276 159 190 215 217 232 139 58 120 148
Labelled Cell Count 219 236 100 215 252 321 465 495 239 282 352 369 125 257 286 187 228 254 217 232 139 58 120 148


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.7 6.7 7.0 6.8 7.0 5.7 5.5 5.9 4.9 5.0 4.3 4.7 6.7 7.2 6.9 8.3 8.1 7.7 7.0 7.4
Std Deviation (1e-4) 0.7 0.9 0.8 1.4 1.3 1.1 1.1 1.3 1.0 1.1 0.9 0.8 1.1 1.3 1.3 1.1 1.4 1.4 1.1 1.4
Intensity Change (Log2) -0.04 -0.01 -0.3 -0.37 -0.26 -0.53 -0.49 -0.73 -0.58 -0.07 0.04 -0.02 0.24 0.21 0.14 -0.0 0.08

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70002468WT3HU80HU120HU16002468WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302468WT1AF140AF18002468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -0.7 -1.0 -0.9 0 0 0 -2.0 0 0 0 0 0 0 -1.0 -1.9
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.5 0.3 -0.1 0.6 0.7 -1.7 -0.7 -3.8 -2.1 2.2 5.0 4.2 -0.5 -0.8 -0.8
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0.9 0.8 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 3.6 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3.1
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.8838 2.1184 1.8915 1.9854 1.606 1.896 0.7897 1.5385 1.2211 1.5321 1.3116 1.0685 0.9525 1.2489 0.7697 0.7704 0.5669 0.8777
Actin 0.0293 0.003 0.008 0.0018 0.0182 0.0125 0.025 0.0061 0.0142 0.0488 0.003 0.0114 0.0368 0.0035 0.038 0.0001 0.0001 0.0108
Bud 0.0018 0.0045 0.0044 0.002 0.0011 0.0016 0.0008 0.0006 0.0032 0.0005 0.0055 0.0003 0.003 0.0019 0.0028 0.0002 0 0.0007
Bud Neck 0.0181 0.002 0.0084 0.0006 0.0094 0.2871 0.0082 0.0011 0.0015 0.0016 0.0011 0.3266 0.0247 0.0034 0.0013 0.0001 0.0001 0.3619
Bud Periphery 0.0034 0.0029 0.0059 0.0026 0.0017 0.0015 0.0015 0.0005 0.0051 0.0004 0.0102 0.0005 0.0052 0.0013 0.0022 0.0001 0 0.0011
Bud Site 0.0289 0.0308 0.012 0.0012 0.0031 0.0014 0.0125 0.0225 0.0111 0.0021 0.0018 0.0009 0.0461 0.0195 0.0048 0.0001 0 0.005
Cell Periphery 0.0012 0.0009 0.0005 0.0002 0.0004 0.0003 0.0016 0.0009 0.0008 0.0002 0.0005 0.0004 0.0019 0.0013 0.0004 0 0 0.0009
Cytoplasm 0.5463 0.6477 0.6066 0.6915 0.6536 0.4282 0.5143 0.6657 0.5644 0.5499 0.5112 0.41 0.4163 0.7419 0.6708 0.8774 0.6168 0.4741
Cytoplasmic Foci 0.0392 0.0236 0.0196 0.0123 0.0406 0.0606 0.0388 0.0068 0.0191 0.0215 0.0259 0.0619 0.0523 0.0132 0.0159 0.008 0.0501 0.0439
Eisosomes 0.0004 0.0001 0.0002 0 0.0001 0.0001 0.0004 0.0001 0.0001 0.0002 0.0002 0.0001 0.0005 0.0002 0.0006 0 0.0001 0.0001
Endoplasmic Reticulum 0.0053 0.0024 0.004 0.0035 0.0019 0.0014 0.0095 0.0016 0.0038 0.0019 0.0037 0.0025 0.0089 0.0033 0.0028 0.0016 0.0051 0.0021
Endosome 0.0199 0.0093 0.0128 0.006 0.0303 0.0073 0.0235 0.0049 0.0183 0.0146 0.025 0.0127 0.0507 0.0056 0.0094 0.0041 0.0347 0.0063
Golgi 0.0051 0.0006 0.0011 0.0003 0.0072 0.0022 0.0058 0.0009 0.0084 0.0066 0.0073 0.0081 0.0101 0.0013 0.0077 0.0002 0.0007 0.0041
Lipid Particles 0.0053 0.0002 0.0008 0.0001 0.006 0.0056 0.0086 0.0004 0.0035 0.0422 0.0136 0.0047 0.0134 0.0007 0.0048 0 0.0009 0.0054
Mitochondria 0.0051 0.0005 0.002 0.0006 0.0024 0.0011 0.0041 0.0064 0.012 0.0041 0.0032 0.0096 0.0299 0.0113 0.0141 0.0001 0.0001 0.0136
None 0.2554 0.2643 0.2965 0.2685 0.2059 0.1742 0.304 0.277 0.3219 0.2591 0.3581 0.1411 0.2269 0.1874 0.207 0.1038 0.2873 0.0493
Nuclear Periphery 0.0032 0.0007 0.0013 0.0014 0.0017 0.0007 0.0102 0.0002 0.0024 0.0012 0.0008 0.0004 0.0203 0.0004 0.0007 0.0005 0.0008 0.0002
Nucleolus 0.0021 0.0002 0.0005 0.0001 0.0003 0.0005 0.0007 0.0001 0.0003 0.0005 0.0003 0.0001 0.002 0.0004 0.0004 0 0 0.0001
Nucleus 0.0052 0.0021 0.0039 0.0022 0.0013 0.0015 0.0031 0.0007 0.0013 0.0022 0.0008 0.0006 0.0107 0.0007 0.0013 0.0008 0.0004 0.0005
Peroxisomes 0.0126 0.0006 0.0044 0.0003 0.0096 0.0054 0.0139 0.002 0.0031 0.0317 0.0228 0.0048 0.0173 0.0007 0.0101 0 0.0001 0.0154
Punctate Nuclear 0.007 0.0009 0.0012 0.0011 0.003 0.0057 0.0075 0.0002 0.0025 0.0019 0.0006 0.0018 0.0118 0.0003 0.0027 0.0003 0.0007 0.0034
Vacuole 0.0042 0.0027 0.0053 0.003 0.0017 0.0009 0.0047 0.0012 0.0023 0.0077 0.0036 0.001 0.0087 0.0015 0.0018 0.0021 0.0016 0.001
Vacuole Periphery 0.0008 0.0003 0.0006 0.0005 0.0005 0.0002 0.001 0.0001 0.0007 0.0011 0.0009 0.0005 0.0024 0.0001 0.0003 0.0003 0.0002 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 6.1843 7.5651 6.0455 10.6149 10.9722 14.3135 11.1794 14.6936 11.4013 11.1441
Translational Efficiency 1.1129 0.9984 1.1625 0.6877 0.4927 0.4736 0.8881 0.6248 0.8254 0.6201

Hit Data

Dataset Hit
Protein Concentration
Protein Localization
Gene Expression
Translational Efficiency

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
454 209 983 1139 1908 1970 124 136 2362 2179 1107 1275

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 683.21 853.09 1018.64 946.54 804.13 804.32 1020.91 894.48 780.89 809.00 1018.89 940.99
Standard Deviation 79.22 97.79 125.16 121.96 94.23 104.46 108.98 113.91 103.20 104.83 123.46 122.19
Intensity Change Log 2 0.320369 0.576243 0.470334 0.000341 0.344355 0.153620 0.156196 0.455516 0.307771

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000442 0.000724 0.000601 0.004257 0.000533 0.000419 0.000462 0.000831 0.000516 0.000448 0.000585 0.003891
Bud Neck 0.059895 0.037534 0.040114 0.056794 0.083536 0.055162 0.050578 0.046704 0.078992 0.053471 0.041287 0.055717
Bud Site 0.029029 0.062747 0.089886 0.131388 0.055018 0.059693 0.054750 0.031894 0.050022 0.059986 0.085950 0.120775
Cell Periphery 0.000429 0.000099 0.000188 0.000263 0.000240 0.000102 0.000295 0.000209 0.000276 0.000102 0.000200 0.000257
Cytoplasm 0.507255 0.439844 0.593620 0.407721 0.482774 0.501644 0.359338 0.392970 0.487480 0.495717 0.567377 0.406147
Cytoplasmic Foci 0.248465 0.236053 0.046624 0.064212 0.223257 0.201426 0.094104 0.083936 0.228102 0.204747 0.051943 0.066316
Eisosomes 0.000449 0.000077 0.000045 0.000133 0.000245 0.000089 0.000161 0.000134 0.000284 0.000088 0.000058 0.000133
Endoplasmic Reticulum 0.001054 0.000258 0.001582 0.001104 0.001069 0.000513 0.001195 0.000575 0.001066 0.000488 0.001538 0.001047
Endosome 0.032294 0.050074 0.009626 0.009143 0.026476 0.032017 0.013445 0.017506 0.027594 0.033749 0.010053 0.010035
Golgi 0.006140 0.003089 0.000379 0.005396 0.006878 0.008163 0.000209 0.002161 0.006736 0.007676 0.000360 0.005051
Lipid Particles 0.006819 0.001458 0.001580 0.001414 0.004042 0.002253 0.002987 0.002095 0.004576 0.002177 0.001737 0.001487
Mitochondria 0.002053 0.001110 0.000175 0.001026 0.002253 0.003536 0.000058 0.001012 0.002215 0.003303 0.000162 0.001025
Mitotic Spindle 0.000173 0.004803 0.006131 0.031023 0.001066 0.009859 0.000951 0.008941 0.000895 0.009374 0.005551 0.028667
None 0.002505 0.000227 0.001508 0.001124 0.001075 0.000433 0.000512 0.001395 0.001350 0.000413 0.001397 0.001153
Nuclear Periphery 0.000138 0.000042 0.000424 0.000678 0.000136 0.000071 0.000563 0.000346 0.000136 0.000068 0.000439 0.000642
Nuclear Periphery Foci 0.000409 0.000483 0.006538 0.004317 0.000475 0.000272 0.006861 0.001345 0.000463 0.000292 0.006574 0.004000
Nucleolus 0.000414 0.000504 0.000262 0.000235 0.000277 0.000391 0.000289 0.000609 0.000304 0.000401 0.000265 0.000275
Nucleus 0.027096 0.007341 0.059727 0.029006 0.020431 0.011258 0.061987 0.064583 0.021712 0.010882 0.059981 0.032801
Peroxisomes 0.003405 0.011380 0.002476 0.009252 0.004851 0.008475 0.001142 0.014853 0.004573 0.008754 0.002327 0.009849
Vacuole 0.069904 0.140797 0.138211 0.238190 0.083954 0.101836 0.349931 0.323602 0.081253 0.105573 0.161926 0.247301
Vacuole Periphery 0.001633 0.001357 0.000303 0.003325 0.001414 0.002388 0.000183 0.004299 0.001456 0.002289 0.000289 0.003429

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -0.87 -0.79 -5.00 -3.94 -5.04 1.19 0.62 -0.75 -1.15 -1.01 0.75 -0.63 -5.20 -5.45 -5.11
Bud Neck 2.25 3.92 4.66 1.68 1.28 4.80 4.81 5.93 3.34 0.52 4.92 9.81 11.55 7.54 1.38
Bud Site -3.44 -5.02 -6.20 -0.56 -0.48 -0.93 1.85 4.87 5.50 1.12 -2.40 -1.71 -2.34 -0.43 -0.27
Cell Periphery 9.06 6.78 6.84 -5.94 0.17 9.07 0.17 3.59 -1.39 2.51 12.13 5.65 6.43 -6.27 0.95
Cytoplasm 2.85 -3.14 8.49 2.79 13.49 -2.05 6.79 4.30 5.03 -1.47 -1.02 -3.87 10.68 11.11 12.12
Cytoplasmic Foci 0.80 20.84 19.43 12.09 -3.03 3.33 12.15 17.23 14.91 1.66 3.87 35.58 33.36 28.01 -2.13
Eisosomes 10.28 11.29 9.59 -2.77 -8.25 6.42 3.71 5.22 -1.11 1.86 9.39 10.85 8.40 -2.42 -7.03
Endoplasmic Reticulum 3.09 -2.90 -0.20 -10.56 5.21 2.96 -2.16 2.09 -1.42 3.95 3.52 -4.35 0.01 -5.36 5.90
Endosome -2.12 6.61 7.65 6.39 3.41 -2.82 5.83 5.67 7.67 0.89 -3.10 12.22 15.37 18.71 3.53
Golgi 3.80 9.56 4.72 1.20 -2.40 -1.64 14.71 7.82 8.52 -1.37 -1.30 16.94 6.98 7.31 -2.53
Lipid Particles 6.75 6.88 7.17 -0.62 1.11 4.74 2.18 5.27 0.84 2.31 6.82 8.77 10.01 1.78 1.82
Mitochondria 0.97 3.65 3.06 0.75 -2.66 -1.36 3.30 2.31 4.10 -1.09 -1.32 3.78 3.19 4.84 -2.88
Mitotic Spindle -1.30 -4.52 -7.78 -4.00 -4.74 -5.30 -1.18 -2.17 -0.45 -1.06 -5.54 -4.14 -7.77 -3.99 -4.86
None 2.23 0.97 1.06 -6.06 0.49 2.59 1.84 -1.43 -3.28 -2.81 3.34 -0.26 -0.34 -6.22 -0.17
Nuclear Periphery 2.85 -12.11 -5.92 -6.97 -1.25 0.90 -6.15 -4.61 -5.96 0.02 1.15 -8.21 -5.83 -7.50 -1.23
Nuclear Periphery Foci -1.24 -12.53 -6.14 -5.03 5.21 2.75 -5.54 -4.15 -4.71 4.18 2.09 -13.53 -6.40 -6.70 5.94
Nucleolus -0.27 1.78 0.72 0.52 -0.89 -1.56 -0.22 -1.26 -0.84 -1.21 -1.41 1.12 -0.87 0.50 -1.35
Nucleus 10.32 -13.66 -6.70 -15.52 7.81 9.79 -5.32 -4.76 -6.06 0.61 12.60 -17.37 -11.17 -16.25 7.61
Peroxisomes -3.39 3.42 -3.22 1.94 -4.94 -4.17 6.71 -1.23 -0.39 -2.11 -5.26 6.23 -2.22 1.70 -5.35
Vacuole -6.22 -15.28 -31.26 -15.71 -15.72 -5.01 -12.98 -12.56 -11.83 0.36 -7.29 -18.56 -34.73 -31.11 -14.06
Vacuole Periphery 1.24 10.04 1.00 0.30 -1.81 -4.18 9.60 -0.24 0.32 -0.97 -3.99 10.88 0.52 2.12 -2.05
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Componentsactinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Ser/Thr kinase involved in late nuclear division; one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; DBF20 has a paralog, DBF2, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (85%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Dbf20

Dbf20


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)

Molecular Function (Gene Ontology)

Cellular Component (Gene Ontology)


Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Dbf20-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available