Standard name | |
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Human Ortholog | |
Description | B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome; CLB2 has a paralog, CLB1, that arose from the whole genome duplication |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 2 | 0 | 0 | 2 |
Bud | 0 | 1 | 1 | 1 | 0 | 0 | 3 | 3 | 2 | 5 | 1 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 5 | 39 | 8 | 3 | 0 | 1 |
Bud Neck | 0 | 1 | 1 | 0 | 0 | 0 | 2 | 4 | 2 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 2 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 2 | 1 | 2 | 2 | 0 | 2 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 2 | 0 | 1 | 2 | 1 | 2 | 0 | 5 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 5 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 15 | 159 | 101 | 46 | 90 | 106 | 116 | 173 | 123 | 122 | 76 | 92 | 29 | 83 | 67 | 125 | 156 | 94 | 32 | 97 | 55 | 56 | 122 | 103 |
Endoplasmic Reticulum | 1 | 3 | 0 | 1 | 1 | 0 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 0 | 0 | 7 | 24 | 12 | 0 | 0 | 0 | 0 | 1 | 1 |
Endosome | 0 | 4 | 1 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4 | 6 | 8 | 4 | 2 | 2 | 2 | 0 | 0 | 1 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 3 | 1 | 0 | 0 | 0 |
Mitochondria | 6 | 7 | 15 | 11 | 24 | 43 | 69 | 79 | 77 | 83 | 74 | 73 | 0 | 2 | 4 | 11 | 7 | 7 | 2 | 10 | 15 | 2 | 2 | 2 |
Nucleus | 3 | 88 | 35 | 18 | 13 | 16 | 35 | 46 | 27 | 22 | 22 | 15 | 15 | 35 | 30 | 44 | 54 | 33 | 12 | 95 | 39 | 3 | 0 | 0 |
Nuclear Periphery | 0 | 2 | 2 | 2 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 1 | 0 | 0 | 4 | 1 | 1 | 2 | 3 | 1 | 5 | 2 | 7 | 0 | 4 | 2 | 0 | 2 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 1 | 1 | 2 | 0 | 3 | 0 | 0 | 2 | 0 | 2 | 1 | 1 | 1 | 1 | 2 | 13 | 10 | 1 | 0 | 0 |
Vac/Vac Membrane | 1 | 23 | 3 | 0 | 3 | 4 | 5 | 3 | 2 | 0 | 0 | 0 | 1 | 8 | 10 | 16 | 35 | 18 | 0 | 19 | 7 | 2 | 0 | 4 |
Unique Cell Count | 22 | 278 | 148 | 71 | 125 | 141 | 192 | 256 | 185 | 187 | 134 | 145 | 45 | 132 | 116 | 189 | 256 | 156 | 61 | 293 | 153 | 73 | 132 | 124 |
Labelled Cell Count | 26 | 293 | 159 | 81 | 136 | 172 | 240 | 313 | 246 | 235 | 180 | 190 | 50 | 137 | 125 | 212 | 291 | 177 | 61 | 293 | 153 | 73 | 132 | 124 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 3.6 | 4.6 | 3.9 | 4.3 | 3.9 | 3.0 | 2.6 | 3.3 | 3.0 | 2.5 | 2.6 | 2.6 | 5.0 | 4.7 | 5.0 | 5.5 | 6.8 | 7.0 | 3.5 | 3.8 | 4.5 |
Std Deviation (1e-4) | 1.0 | 1.5 | 2.0 | 2.9 | 2.5 | 1.7 | 1.2 | 2.0 | 1.9 | 1.3 | 1.2 | 1.9 | 1.5 | 1.5 | 1.9 | 1.8 | 2.6 | 2.7 | 0.9 | 1.5 | 1.2 |
Intensity Change (Log2) | – | – | – | 0.12 | -0.03 | -0.38 | -0.58 | -0.25 | -0.41 | -0.64 | -0.59 | -0.58 | 0.36 | 0.25 | 0.35 | 0.49 | 0.79 | 0.83 | -0.15 | -0.05 | 0.18 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Actin | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Bud Neck | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Bud Site | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Cell Periphery | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Cyto | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Endoplasmic Reticulum | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Endosome | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Golgi | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Mitochondria | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Nuclear Periphery | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Nuc | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nucleolus | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Peroxisomes | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
SpindlePole | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Vac | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cortical Patches | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Cytoplasm | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Nucleus | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Vacuole | – | – | – | – | – | – | – | – | – | – | – | – | 2.5 | 3.9 | 3.3 |
R1 | R2 | R3 | ||||||||||||||||
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G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 4.0782 | 2.8308 | 3.6992 | 5.4379 | 6.2353 | 2.4901 | 2.6151 | 1.2706 | 2.0948 | 3.4238 | 3.8824 | 1.6598 | 2.2418 | 2.1748 | 2.1738 | 4.8904 | 4.8142 | 1.8373 |
Actin | 0.0602 | 0.0008 | 0.0196 | 0.0304 | 0.0081 | 0.0031 | 0.0568 | 0.0025 | 0.0105 | 0.0283 | 0.0205 | 0.0037 | 0.0367 | 0.005 | 0.0071 | 0.0281 | 0.0068 | 0.0006 |
Bud | 0.0073 | 0.0178 | 0.0021 | 0.0007 | 0.0013 | 0.0023 | 0.0124 | 0.0022 | 0.0036 | 0.0051 | 0.0009 | 0.0011 | 0.0021 | 0.0093 | 0.0053 | 0.0004 | 0.0008 | 0.0017 |
Bud Neck | 0.0068 | 0.0013 | 0.0064 | 0.0009 | 0.0037 | 0.0028 | 0.013 | 0.0012 | 0.0012 | 0.0059 | 0.0029 | 0.0028 | 0.024 | 0.0041 | 0.0008 | 0.0022 | 0.0011 | 0.0032 |
Bud Periphery | 0.0099 | 0.0156 | 0.0073 | 0.0017 | 0.0022 | 0.0024 | 0.0184 | 0.0026 | 0.0042 | 0.004 | 0.0019 | 0.0025 | 0.0043 | 0.005 | 0.0041 | 0.0007 | 0.0004 | 0.0035 |
Bud Site | 0.0217 | 0.0443 | 0.0114 | 0.0017 | 0.0027 | 0.0017 | 0.0264 | 0.0209 | 0.0094 | 0.0053 | 0.0016 | 0.0003 | 0.0234 | 0.0245 | 0.0072 | 0.0012 | 0.0004 | 0.0004 |
Cell Periphery | 0.0014 | 0.0014 | 0.0005 | 0.0001 | 0.0002 | 0.0001 | 0.0014 | 0.0005 | 0.0005 | 0.0004 | 0.0003 | 0.0001 | 0.0014 | 0.0011 | 0.0003 | 0.0001 | 0.0001 | 0.0003 |
Cytoplasm | 0.0491 | 0.0611 | 0.0452 | 0.0025 | 0.0091 | 0.0515 | 0.0355 | 0.0303 | 0.038 | 0.0171 | 0.009 | 0.0475 | 0.0427 | 0.0445 | 0.0635 | 0.0065 | 0.0128 | 0.0583 |
Cytoplasmic Foci | 0.0303 | 0.004 | 0.0057 | 0.0061 | 0.0035 | 0.01 | 0.0435 | 0.0135 | 0.0134 | 0.0163 | 0.0082 | 0.0076 | 0.0096 | 0.0044 | 0.0073 | 0.0093 | 0.0048 | 0.0059 |
Eisosomes | 0.0007 | 0.0002 | 0.0004 | 0.0001 | 0.0003 | 0.0001 | 0.0008 | 0.0003 | 0.0005 | 0.0001 | 0.0002 | 0.0001 | 0.0008 | 0.0005 | 0.0002 | 0.0003 | 0.0001 | 0.0001 |
Endoplasmic Reticulum | 0.0117 | 0.0016 | 0.0024 | 0.0002 | 0.0074 | 0.0013 | 0.0067 | 0.0009 | 0.0019 | 0.0041 | 0.0091 | 0.0016 | 0.0125 | 0.0024 | 0.004 | 0.0007 | 0.0006 | 0.001 |
Endosome | 0.0275 | 0.001 | 0.0036 | 0.0056 | 0.0158 | 0.007 | 0.0543 | 0.0005 | 0.0136 | 0.0252 | 0.0284 | 0.0077 | 0.0156 | 0.0013 | 0.0074 | 0.003 | 0.0051 | 0.001 |
Golgi | 0.0097 | 0.0001 | 0.0009 | 0.0019 | 0.005 | 0.0012 | 0.0126 | 0.0003 | 0.0107 | 0.0204 | 0.009 | 0.0096 | 0.0048 | 0.0004 | 0.0012 | 0.0026 | 0.0022 | 0.0001 |
Lipid Particles | 0.0134 | 0.0004 | 0.0046 | 0.0097 | 0.0129 | 0.0055 | 0.0345 | 0.0007 | 0.0065 | 0.0203 | 0.0266 | 0.0014 | 0.0088 | 0.0009 | 0.0074 | 0.0024 | 0.0065 | 0.0006 |
Mitochondria | 0.0091 | 0.0023 | 0.0013 | 0.0006 | 0.0151 | 0.001 | 0.0123 | 0.0007 | 0.0105 | 0.0042 | 0.0146 | 0.0054 | 0.0169 | 0.0011 | 0.0018 | 0.0159 | 0.0011 | 0.0017 |
None | 0.481 | 0.5333 | 0.3088 | 0.0046 | 0.0147 | 0.701 | 0.4074 | 0.7154 | 0.3876 | 0.0107 | 0.0334 | 0.6392 | 0.6501 | 0.5635 | 0.4018 | 0.0162 | 0.0472 | 0.6654 |
Nuclear Periphery | 0.0247 | 0.0052 | 0.0163 | 0.0032 | 0.0348 | 0.0044 | 0.0284 | 0.0044 | 0.0091 | 0.008 | 0.0417 | 0.0061 | 0.0437 | 0.0071 | 0.0201 | 0.0039 | 0.0291 | 0.0034 |
Nucleolus | 0.0116 | 0.0127 | 0.0064 | 0.0121 | 0.0358 | 0.0082 | 0.0147 | 0.0124 | 0.0065 | 0.0056 | 0.0291 | 0.0063 | 0.004 | 0.0098 | 0.0054 | 0.0159 | 0.0449 | 0.0137 |
Nucleus | 0.1666 | 0.2792 | 0.5239 | 0.9054 | 0.7911 | 0.1706 | 0.1377 | 0.1735 | 0.4312 | 0.8045 | 0.7226 | 0.2328 | 0.0642 | 0.2841 | 0.4324 | 0.8651 | 0.7858 | 0.2202 |
Peroxisomes | 0.0087 | 0.0004 | 0.0072 | 0.0041 | 0.0071 | 0.0078 | 0.0368 | 0.0018 | 0.0117 | 0.0079 | 0.014 | 0.0021 | 0.0038 | 0.0002 | 0.0012 | 0.0023 | 0.0016 | 0.0032 |
Punctate Nuclear | 0.0272 | 0.0123 | 0.0213 | 0.0077 | 0.0244 | 0.0159 | 0.022 | 0.0137 | 0.0261 | 0.0026 | 0.018 | 0.0198 | 0.0222 | 0.0268 | 0.019 | 0.0221 | 0.0474 | 0.0128 |
Vacuole | 0.016 | 0.0047 | 0.0042 | 0.0005 | 0.0028 | 0.0014 | 0.0205 | 0.0014 | 0.0026 | 0.0032 | 0.0058 | 0.0016 | 0.005 | 0.0035 | 0.0016 | 0.0006 | 0.0006 | 0.0023 |
Vacuole Periphery | 0.0053 | 0.0006 | 0.0007 | 0.0001 | 0.0021 | 0.0005 | 0.0042 | 0.0003 | 0.0008 | 0.0007 | 0.0023 | 0.0006 | 0.0033 | 0.0004 | 0.0007 | 0.0004 | 0.0007 | 0.0006 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 9.7183 | 67.4959 | 66.4493 | 57.3564 | 15.0234 | 10.4601 | 78.0426 | 92.3497 | 55.4664 | 22.2965 |
Translational Efficiency | 1.3031 | 1.2144 | 1.4306 | 1.1913 | 1.2543 | 0.7089 | 1.1159 | 1.1486 | 1.2301 | 1.0421 |
Dataset | Hit |
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Protein Concentration | ✔ |
Protein Localization | ✘ |
Gene Expression | ✔ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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