Standard name
Human Ortholog
Description High-affinity copper transporter of plasma membrane; mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels; protein increases in abundance and relocalizes from nucleus to plasma membrane upon DNA replication stress; human homolog SLC31A1 can complement a yeast ctr1 ctr3 double deletion
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.12 0.08 0.16 0.06 0.07 0 0 0 0 0 0 0 0.06 0.1 0.07 0 0 0 0.22 0.18 0.25 0.14 0.13 0.14
Bud 0 0.05 0.11 0.05 0.07 0.07 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.06 0 0.05 0.05 0.05
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0.17 0.12 0.17 0.13 0.08 0 0 0 0 0 0 0 0.18 0.17 0.21 0 0 0.05 0.19 0.24 0.32 0.2 0.15 0.24
Cytoplasm 0.81 0.82 0.72 0.84 0.85 0.87 0.84 0.77 0.85 0.81 0.82 0.78 0.87 0.79 0.81 0.93 0.91 0.97 0.36 0.38 0.23 0.41 0.42 0.38
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0.05 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0.05 0.1 0.19 0.27 0.36 0.31 0.33 0.39 0.4 0 0 0 0 0 0 0.05 0 0.06 0.11 0.08 0.05
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 28 50 63 18 34 24 8 6 6 1 1 1 18 21 30 6 2 1 59 113 101 29 40 43
Bud 7 33 41 17 34 46 30 23 28 20 22 26 6 9 3 2 2 0 7 24 9 5 8 11
Bud Neck 0 2 1 0 2 5 5 2 1 2 0 1 2 1 1 0 0 1 12 38 14 9 14 16
Bud Site 0 1 1 0 0 2 1 1 2 0 1 5 0 3 0 0 0 0 – – – – – –
Cell Periphery 42 71 65 40 40 29 25 7 10 1 4 6 52 37 87 10 6 11 52 148 129 41 46 75
Cytoplasm 197 494 277 259 424 579 643 663 468 499 511 547 253 170 330 297 122 225 98 237 93 83 130 120
Endoplasmic Reticulum 2 12 4 1 1 0 3 1 0 0 1 0 1 3 5 19 6 11 11 12 9 3 12 7
Endosome 0 3 4 1 2 2 3 0 1 2 1 0 0 0 9 5 1 0 4 8 5 2 6 3
Golgi 1 2 0 0 0 0 0 0 0 0 0 0 0 1 1 2 1 1 6 1 2 0 1 1
Mitochondria 8 9 12 16 48 127 205 312 173 205 243 277 0 2 0 9 2 4 12 23 25 21 25 15
Nucleus 1 0 2 0 0 1 3 8 3 2 1 5 0 0 0 0 2 0 0 0 0 0 0 0
Nuclear Periphery 0 1 0 0 1 0 1 8 1 1 0 0 0 0 0 0 1 0 0 0 1 0 0 1
Nucleolus 0 1 0 0 1 1 0 3 0 2 0 3 0 0 1 0 0 0 1 0 0 0 0 0
Peroxisomes 0 0 13 4 3 0 1 2 1 0 1 0 1 2 9 0 0 1 1 0 1 0 1 0
SpindlePole 2 5 11 4 1 6 4 3 2 8 3 7 5 2 4 5 1 0 0 5 1 0 3 1
Vac/Vac Membrane 0 3 2 2 4 1 3 7 6 9 5 2 1 3 3 1 2 2 2 4 1 4 8 9
Unique Cell Count 243 606 387 310 498 668 767 861 552 618 624 699 291 214 408 320 134 233 274 630 404 206 309 314
Labelled Cell Count 288 687 496 362 595 823 935 1046 702 752 794 880 339 254 483 356 148 257 274 630 404 206 309 314


Bud, Cell Periphery

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.8 5.4 4.8 4.7 4.2 3.8 3.4 3.5 3.3 3.2 3.1 3.1 6.3 6.4 6.6 6.0 5.6 5.6 6.5 6.5 6.5
Std Deviation (1e-4) 1.5 1.3 1.5 2.0 1.5 1.4 1.3 1.3 1.2 1.1 1.2 1.1 1.2 2.0 1.9 1.6 1.3 1.5 1.6 1.6 1.4
Intensity Change (Log2) – – – -0.02 -0.2 -0.32 -0.47 -0.47 -0.52 -0.59 -0.6 -0.6 0.39 0.43 0.47 0.34 0.22 0.24 0.44 0.44 0.44


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 -4.0 -2.2 -3.9 -6.4 -4.5 -6.3
Bud 0 0 0 0 0 0 0 0 0 -4.3 -2.7 -6.1 -5.5 -3.3 -5.1
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0.4 0.2 1.6 -5.9 -3.6 -4.4
Cytoplasm 3.7 4.9 6.0 4.9 2.1 4.9 3.4 3.8 2.5 4.8 2.1 3.1 7.2 4.6 7.7
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 3.7 0 2.9
Endosome 0 0 0 0 0 0 0 0 0 0 0 1.3 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 -3.0 0 -3.6 -0.2 0 -1.1
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 -2.7 -1.8 -1.0 -3.3 0 -2.4
SpindlePole 0 0 0 0 0 0 0 0 0 -1.0 0 -1.9 -1.1 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.398 0.5477 0.3373 0.6489 0.3331 0.2304 2.637 2.8971 2.8663 2.7725 2.435 3.1278 0.2098 1.2983 0.9715 0.8424 1.1362 1.0923
Actin 0.0334 0.0046 0.0105 0.0437 0.0164 0.0066 0.0462 0.0224 0.0247 0.0362 0.0682 0.051 0.0186 0.0304 0.0357 0.0188 0.053 0.0209
Bud 0.0019 0.0041 0.0025 0.0004 0.0138 0.0061 0.0041 0.0063 0.0049 0.0212 0.0091 0.0034 0.0004 0.002 0.0013 0.0003 0.0014 0.0004
Bud Neck 0.0058 0.0007 0.001 0.0009 0.0191 0.0018 0.0086 0.0045 0.0172 0.0484 0.0044 0.0181 0.0051 0.0025 0.0082 0.0015 0.0008 0.0051
Bud Periphery 0.0044 0.0082 0.0085 0.0006 0.037 0.0047 0.0195 0.0239 0.0274 0.0165 0.023 0.0367 0.0017 0.0069 0.0032 0.0005 0.0389 0.0025
Bud Site 0.0129 0.0179 0.0047 0.0021 0.0033 0.0049 0.0258 0.0364 0.0498 0.0125 0.0105 0.0047 0.01 0.0294 0.0121 0.0013 0.0007 0.0007
Cell Periphery 0.0013 0.0021 0.0009 0.0001 0.0009 0.0003 0.0583 0.0271 0.0713 0.0274 0.017 0.0497 0.0254 0.0057 0.0185 0.0029 0.0117 0.0041
Cytoplasm 0.0879 0.1875 0.1384 0.0471 0.2029 0.1808 0.2174 0.4306 0.2652 0.3002 0.3275 0.3018 0.2322 0.3978 0.3728 0.2895 0.2916 0.4161
Cytoplasmic Foci 0.0303 0.0105 0.019 0.0572 0.0125 0.0239 0.0119 0.019 0.015 0.0166 0.023 0.017 0.0437 0.049 0.0361 0.0805 0.0412 0.0464
Eisosomes 0.0006 0.0002 0.0002 0.0003 0.0003 0.0001 0.0034 0.0023 0.0069 0.0017 0.0019 0.0035 0.0017 0.0002 0.0009 0.0005 0.0008 0.0008
Endoplasmic Reticulum 0.0052 0.0045 0.0015 0.001 0.001 0.0026 0.0036 0.0019 0.0022 0.0043 0.0023 0.0018 0.0039 0.0027 0.0028 0.0041 0.0035 0.0021
Endosome 0.0311 0.0181 0.0084 0.0466 0.0675 0.0104 0.0079 0.0012 0.0014 0.0184 0.0042 0.0037 0.0025 0.0031 0.003 0.0041 0.0128 0.0079
Golgi 0.0093 0.0008 0.0049 0.0174 0.0379 0.002 0.007 0.0011 0.0016 0.011 0.0024 0.002 0.0011 0.0012 0.001 0.0056 0.0092 0.0007
Lipid Particles 0.0106 0.0008 0.0041 0.0175 0.0069 0.0019 0.006 0.0003 0.0007 0.0073 0.0006 0.0015 0.0036 0.0007 0.0007 0.0024 0.011 0.0005
Mitochondria 0.0323 0.0013 0.0088 0.0095 0.0355 0.005 0.0069 0.0011 0.007 0.01 0.0024 0.0068 0.0005 0.0003 0.0003 0.0006 0.0043 0.0003
None 0.6954 0.7073 0.7704 0.6829 0.5307 0.7266 0.5593 0.4054 0.4899 0.4411 0.4926 0.4866 0.6359 0.4384 0.498 0.5667 0.4658 0.4818
Nuclear Periphery 0.0019 0.0032 0.0012 0.0046 0.0011 0.0047 0.0018 0.0004 0.0009 0.003 0.0011 0.001 0.0004 0.0003 0.0005 0.0005 0.0107 0.0003
Nucleolus 0.0043 0.0004 0.0008 0.0011 0.0005 0.0009 0.0004 0.0003 0.0005 0.005 0.0004 0.0006 0.0002 0.0001 0.0001 0.0001 0.0008 0.0001
Nucleus 0.0024 0.0038 0.0014 0.0029 0.001 0.0039 0.001 0.0017 0.0014 0.0048 0.0012 0.0008 0.0005 0.0007 0.001 0.001 0.0016 0.0009
Peroxisomes 0.0134 0.0007 0.0054 0.0502 0.0034 0.002 0.0061 0.0015 0.0053 0.0026 0.0044 0.0038 0.0108 0.0207 0.0024 0.0168 0.0263 0.0039
Punctate Nuclear 0.0055 0.0044 0.0024 0.0119 0.0012 0.0084 0.0016 0.0007 0.0058 0.0054 0.002 0.0012 0.0009 0.0006 0.0007 0.0016 0.0118 0.0006
Vacuole 0.0082 0.0176 0.0038 0.0013 0.0051 0.0015 0.0025 0.0116 0.0009 0.0052 0.0015 0.0038 0.0008 0.007 0.0006 0.0005 0.001 0.0038
Vacuole Periphery 0.0017 0.0012 0.0012 0.0006 0.0021 0.0009 0.0007 0.0003 0.0001 0.0011 0.0003 0.0004 0.0001 0.0002 0.0001 0.0001 0.001 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 18.0738 39.5843 67.1389 99.943 50.3819 62.32 159.6862 191.5737 174.82 167.4355
Translational Efficiency 1.1482 1.2863 1.2168 0.7704 0.7756 0.9593 1.1141 0.9624 1.2658 1.0155

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2233 1096 393 1452 2060 1699 1835 51 4293 2795 2228 1503

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 668.36 823.04 3773.41 1377.19 905.23 717.13 2227.88 1036.18 782.02 758.66 2500.50 1365.62
Standard Deviation 81.62 208.28 779.17 295.43 259.62 94.43 661.66 167.13 223.19 158.45 902.60 298.46
Intensity Change Log 2 — 0.300337 2.497172 1.043030 — -0.336050 1.299315 0.194918 — -0.030970 1.931213 0.616989

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.061515 0.063284 0.000900 0.025377 0.031759 0.019608 0.001753 0.108232* 0.047237 0.036734 0.001602 0.028188
Bud Neck 0.075092 0.044709 0.003623 0.010817 0.054595 0.058582 0.002589 0.027483 0.065256 0.053142 0.002772 0.011382
Bud Site 0.063508 0.197340* 0.005356 0.083482 0.165920* 0.043375 0.012804 0.097498 0.112651* 0.103749* 0.011490 0.083958
Cell Periphery 0.020365 0.288922* 0.927168* 0.829201* 0.555655* 0.007978 0.968457* 0.200663* 0.277224* 0.118144* 0.961174* 0.807873*
Cytoplasm 0.415024* 0.161569* 0.000038 0.016272 0.115385* 0.373835* 0.001761 0.180155* 0.271242* 0.290599* 0.001457 0.021833
Cytoplasmic Foci 0.134479 0.052714 0.000121 0.001318 0.011214 0.239807* 0.000160 0.074142 0.075331 0.166442 0.000154 0.003789
Eisosomes 0.029443 0.017130 0.040680 0.008566 0.030156 0.011739 0.004577 0.035460 0.029785 0.013853 0.010945 0.009479
Endoplasmic Reticulum 0.001708 0.030108 0.000710 0.007070 0.005538 0.002906 0.001825 0.038960 0.003546 0.013573 0.001628 0.008152
Endosome 0.005862 0.024009 0.000214 0.001624 0.001827 0.027746 0.000403 0.011638 0.003926 0.026280 0.000369 0.001964
Golgi 0.007717 0.029496 0.000604 0.002424 0.003363 0.017414 0.000623 0.005020 0.005628 0.022151 0.000620 0.002512
Lipid Particles 0.011349 0.025158 0.000017 0.001310 0.001899 0.016030 0.000173 0.031151 0.006814 0.019609 0.000145 0.002323
Mitochondria 0.007279 0.014831 0.001141 0.002102 0.004068 0.015358 0.000835 0.001648 0.005738 0.015151 0.000889 0.002087
Mitotic Spindle 0.000865 0.000302 0.001093 0.000800 0.000260 0.004858 0.000227 0.001531 0.000574 0.003072 0.000380 0.000825
None 0.002150 0.001645 0.000059 0.000051 0.000974 0.002656 0.000036 0.000059 0.001586 0.002259 0.000040 0.000051
Nuclear Periphery 0.000104 0.000110 0.000886 0.000264 0.000065 0.000180 0.000230 0.000319 0.000085 0.000153 0.000345 0.000266
Nuclear Periphery Foci 0.000170 0.000859 0.000075 0.000954 0.000151 0.000366 0.000056 0.003881 0.000161 0.000560 0.000059 0.001054
Nucleolus 0.000618 0.000185 0.000142 0.000025 0.000041 0.000669 0.000047 0.000077 0.000341 0.000479 0.000064 0.000027
Nucleus 0.096558 0.003140 0.000207 0.000561 0.004203 0.056678 0.000228 0.015120 0.052242 0.035685 0.000225 0.001055
Peroxisomes 0.032432 0.026748 0.000003 0.000682 0.007442 0.035471 0.000027 0.009647 0.020440 0.032050 0.000023 0.000986
Vacuole 0.033330 0.014251 0.015282 0.005871 0.005188 0.062777 0.002222 0.156921 0.019826 0.043749 0.004526 0.010996
Vacuole Periphery 0.000430 0.003489 0.001680 0.001228 0.000296 0.001969 0.000969 0.000395 0.000366 0.002565 0.001094 0.001199

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -0.39 18.56* 8.54 7.52 -9.50 4.54 14.87 -3.04 -3.56 -4.30 3.70 23.15* 5.65 2.43 -10.04
Bud Neck 7.51 23.91 20.78 11.71 -6.72 -1.00 21.56 3.86 4.27 -3.29 4.37 32.22 25.21 18.67 -8.71
Bud Site -16.45 16.17 -3.61 12.51 -14.95 20.22* 26.70* 2.84 -1.94 -3.14 1.87 29.14 4.80 3.12 -14.45
Cell Periphery -23.95* -143.50* -101.45* -39.97* 10.28 63.25* -46.40* 7.91 -3.89 17.03 20.47 -108.77 -52.39 -71.29* 18.41
Cytoplasm 31.39 76.01* 70.26* 23.66 -10.90 -32.43* 25.22 -1.96 5.85 -5.50 -2.87 63.54 53.26 49.78 -10.31
Cytoplasmic Foci 17.18 38.68 38.16 15.63 -3.75 -41.75* 9.44 -3.60 9.07 -4.25 -20.50 35.58 31.92 40.98 -4.86
Eisosomes 5.61 -2.48 11.39 5.85 7.44 8.56 13.39 -0.29 -2.04 -2.72 10.45 12.15 14.11 3.97 1.37
Endoplasmic Reticulum -11.01 3.52 -6.11 8.52 -7.59 2.57 4.31 -2.57 -2.78 -2.87 -8.49 4.10 -4.52 3.78 -6.89
Endosome -9.41 12.63 7.27 11.70 -4.04 -17.54 6.69 -1.99 3.33 -2.29 -18.89 13.51 4.17 19.92 -4.14
Golgi -9.29 13.58 5.97 11.28 -2.59 -12.53 5.25 -1.00 7.72 -3.14 -14.32 11.99 4.02 15.10 -2.63
Lipid Particles -5.58 13.10 10.34 10.11 -3.07 -12.15 5.95 -2.83 -1.37 -3.00 -10.37 13.93 6.20 13.67 -3.91
Mitochondria -6.31 9.71 7.07 10.66 -1.56 -8.36 8.99 1.85 7.40 -0.53 -9.87 14.33 6.20 12.73 -2.37
Mitotic Spindle 1.55 -0.56 0.11 -2.01 0.95 -4.05 2.04 -0.90 2.02 -0.93 -3.48 1.05 -0.84 3.04 -1.84
None 0.84 8.26 8.28 2.82 0.81 -1.94 2.70 2.62 3.22 -0.90 -1.19 7.28 7.23 4.10 -1.78
Nuclear Periphery -0.34 -12.21 -2.83 -2.55 7.34 -6.02 -12.23 -1.39 -0.73 -0.47 -4.60 -15.31 -3.31 -1.98 1.39
Nuclear Periphery Foci -2.18 4.87 -1.75 -0.23 -1.96 -3.54 5.52 -3.80 -3.56 -3.88 -3.12 6.37 -2.05 -1.11 -2.26
Nucleolus 1.81 2.03 2.50 2.82 7.31 -4.26 -1.40 -1.09 4.01 -0.92 -1.26 2.26 2.54 4.79 7.94
Nucleus 34.57* 36.09 35.93 6.34 -5.11 -23.99 11.48 -2.65 8.43 -3.57 7.77 33.22 32.45 24.31 -4.86
Peroxisomes 2.22 19.68 19.16 13.28 -3.93 -13.37 10.83 -0.56 7.20 -2.99 -6.82 21.78 20.31 21.51 -4.73
Vacuole 8.25 10.21 15.95 3.66 5.04 -20.85 4.10 -5.26 -3.56 -5.34 -12.03 17.77 3.71 12.12 -4.37
Vacuole Periphery -8.35 -8.68 -2.40 4.51 1.19 -10.40 -6.35 -0.28 5.08 2.07 -12.63 -8.30 -2.60 3.64 -0.37
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description High-affinity copper transporter of plasma membrane; mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels; protein increases in abundance and relocalizes from nucleus to plasma membrane upon DNA replication stress; human homolog SLC31A1 can complement a yeast ctr1 ctr3 double deletion
Localization
Cell Percentages cell periphery (43%), cytoplasm (10%), mixed (10%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Ctr1

Ctr1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ctr1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
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Images are not yet available