Standard name
Human Ortholog
Description Mitochondrial inner membrane protein; exposed to the mitochondrial matrix; associates with mitochondrial ribosomes; NOT required for respiratory growth; homolog of human Letm1, a protein implicated in Wolf-Hirschhorn syndrome
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.06 0 0 0 0 0 0 0
Cytoplasm 0 0.05 0.05 0.07 0.09 0 0 0.05 0 0.06 0.06 0.05 0 0.06 0 0.45 0.4 0.38 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0.35 0.54 0.59 0.2 0.11 0.19 0.06 0.09 0 0.16 0.14 0.12
Mitochondria 0.97 0.9 0.87 0.9 0.83 0.9 0.9 0.8 0.88 0.89 0.92 0.91 0.8 0.59 0.74 0.06 0.08 0.12 0.83 0.77 0.77 0.69 0.68 0.7
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0.11 0.1 0.09 0.13 0.09 0.08 0.08 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.07 0 0 0 0.08 0.14 0.14 0.14 0.1 0.11 0.09 0.08 0 0 0 0 0.1 0.11 0 0 0 0 0 0
Peroxisomes 0 0 0.08 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0 0 0.09 0 0 0.05
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.06 0.07 0 0 0 0 0 0 0 0 0 0 0.11 0.17 0.08 0.13 0.13 0.14 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 5 15 9 4 2 3 3 2 4 3 0 2 4 12 5 5 6 6 9 20 18 24 27
Bud 0 6 9 8 5 15 21 25 11 22 9 13 1 1 2 1 2 1 0 8 5 9 9 6
Bud Neck 0 1 0 0 1 0 0 0 1 0 0 0 0 0 0 0 1 0 0 0 0 0 1 0
Bud Site 0 1 0 0 0 2 5 0 1 6 3 3 0 0 0 0 4 1 – – – – – –
Cell Periphery 1 12 15 8 1 1 5 4 8 4 4 4 8 12 14 7 12 2 0 0 1 0 0 0
Cytoplasm 4 22 25 27 36 23 35 40 26 47 33 26 12 37 17 64 80 55 0 7 12 6 18 9
Endoplasmic Reticulum 1 2 2 2 2 0 4 1 6 4 1 2 1 1 5 6 7 9 0 0 0 0 3 0
Endosome 0 0 2 1 5 2 3 10 2 0 1 0 2 8 6 6 8 2 1 5 3 4 7 7
Golgi 1 16 16 15 7 0 0 0 0 3 0 3 140 307 328 28 21 28 9 42 16 81 76 71
Mitochondria 168 414 424 352 351 538 775 651 600 727 539 507 319 338 410 8 15 17 143 352 386 360 382 428
Nucleus 0 1 1 0 1 2 5 2 4 3 3 1 0 1 0 3 2 6 0 0 0 0 1 0
Nuclear Periphery 7 16 18 9 15 68 87 73 89 75 46 45 6 4 8 2 6 4 0 2 1 4 5 5
Nucleolus 13 14 11 9 32 85 124 110 65 94 55 44 11 11 6 6 20 16 2 0 2 2 4 3
Peroxisomes 1 9 41 18 11 9 5 33 19 8 3 9 3 7 8 2 14 4 5 9 45 11 9 31
SpindlePole 0 1 3 0 2 2 9 19 9 9 3 4 1 3 1 3 6 1 0 5 4 3 4 4
Vac/Vac Membrane 11 32 7 6 11 15 13 23 19 15 15 14 43 97 43 19 26 21 1 12 0 15 14 8
Unique Cell Count 174 460 487 391 421 598 863 809 682 818 589 556 397 572 552 143 199 145 172 460 505 522 563 610
Labelled Cell Count 207 552 589 464 484 764 1094 994 862 1021 718 675 549 831 860 160 229 173 172 460 505 522 563 610


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 15.8 14.7 16.2 14.6 13.6 12.4 11.6 11.7 11.6 10.8 10.2 10.9 18.7 18.2 16.8 17.1 15.4 16.9 20.2 18.9 21.6
Std Deviation (1e-4) 3.6 4.3 4.3 4.2 4.0 3.5 3.4 3.6 3.4 4.0 3.6 3.9 4.3 5.7 3.7 9.8 7.6 8.2 5.8 5.7 6.0
Intensity Change (Log2) – – – -0.15 -0.25 -0.38 -0.49 -0.46 -0.49 -0.59 -0.67 -0.58 0.21 0.17 0.05 0.07 -0.07 0.06 0.32 0.22 0.41

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70001020WT3HU80HU120HU16001020WT3rpd3Δ_1rpd3Δ_2rpd3Δ_301020WT1AF100AF140AF18001020
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -0.7 -2.2 -3.6 -4.2 -4.0 -3.9 -3.8 -3.3 -4.2 -2.8 -2.9 -0.9 0 -0.4 0
Bud 0.2 -0.8 0.7 0.7 1.4 -0.3 1.0 -0.4 0.5 0 0 -2.3 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery -1.0 -3.2 -4.0 -3.7 -3.8 -2.3 -3.8 -3.0 -2.8 -1.0 -1.0 -0.5 0 1.8 0
Cytoplasm 1.1 2.1 -1.0 -0.9 -0.2 -1.1 0.5 0.3 -0.3 -1.6 0.9 -1.7 12.0 11.6 10.4
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0.4 -1.6 -4.5 -5.4 -5.2 -4.8 -4.3 -4.4 -3.3 12.4 17.7 19.2 6.7 3.8 6.7
Mitochondria 1.4 -1.6 1.5 1.5 -3.1 0.5 1.0 2.4 2.1 -2.7 -10.1 -5.2 -18.5 -19.7 -17.3
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery -1.2 -0.1 4.7 4.2 3.6 5.5 3.7 2.8 3.0 -2.0 -3.4 -2.3 0 -0.4 -0.5
Nucleolus 0 3.8 6.9 7.1 6.8 5.0 5.9 4.8 4.1 0.5 -0.4 -1.5 0 4.5 4.6
Peroxisomes -2.2 -3.8 -5.4 -7.6 -3.3 -4.3 -6.8 -6.5 -5.1 -5.2 -5.6 -5.3 -2.9 -0.6 -2.3
SpindlePole 0 0 0 0 2.3 0 0 0 0 0 0 0 0 0 0
Vacuole 0.1 1.3 1.2 0.1 1.6 1.5 0.5 1.3 1.2 6.0 8.5 4.8 6.3 6.5 6.7

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 20.333 21.206 22.1182 19.6311 20.1894 20.5023 18.6336 22.7407 20.9145 18.2109 20.48 20.5402 20.4849 21.8847 21.7125 21.1313 19.9088 21.1026
Actin 0.0167 0.0083 0.008 0.0011 0.0004 0.0008 0.0079 0.0032 0.0121 0.0315 0.0075 0.0007 0.0076 0.0013 0.0011 0.0035 0.0033 0.0003
Bud 0.0002 0.0005 0.0001 0.0001 0 0 0.0007 0 0.0002 0.0002 0.0001 0 0.0001 0 0 0 0 0
Bud Neck 0 0.0001 0.0004 0 0 0 0.0004 0 0.0007 0.0005 0.0001 0 0.0001 0 0 0 0.0003 0
Bud Periphery 0.0008 0.0008 0.0002 0.0001 0 0.0001 0.0009 0.0001 0.0004 0.0004 0.0001 0 0.0001 0 0.0001 0 0 0
Bud Site 0.0003 0.0012 0.0039 0.0001 0 0 0.0025 0.0001 0.0054 0.001 0.0005 0 0.0005 0 0 0 0.0001 0
Cell Periphery 0.0006 0.0007 0.0004 0.0001 0 0 0.0005 0.0001 0.0002 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0 0
Cytoplasm 0.0001 0.0001 0.0002 0 0 0 0.0012 0 0.0005 0.0012 0.0055 0 0 0 0 0 0.0005 0
Cytoplasmic Foci 0.0012 0.0012 0.0011 0.0007 0.0002 0.0003 0.0088 0.0005 0.0029 0.0057 0.0045 0.0001 0.0003 0.0007 0 0.0001 0.0007 0
Eisosomes 0.0004 0.0011 0.0008 0.0001 0.0001 0.0001 0.0007 0.0003 0.0006 0.001 0.0003 0.0003 0.0006 0.0003 0.0004 0.0001 0.0002 0.0003
Endoplasmic Reticulum 0.0001 0.0001 0.0002 0 0 0 0.0012 0.0001 0.0012 0.0017 0.0034 0.0001 0 0 0 0 0.001 0
Endosome 0.0017 0.0092 0.0031 0.0021 0.0009 0.0024 0.0133 0.0027 0.0033 0.0056 0.0034 0.0012 0.0011 0.0026 0.0004 0.0008 0.005 0.0005
Golgi 0.0059 0.0353 0.0119 0.0034 0.0173 0.0066 0.0081 0.0163 0.01 0.0181 0.005 0.0048 0.0042 0.0197 0.0046 0.0011 0.0028 0.013
Lipid Particles 0.0191 0.0053 0.0008 0.0138 0.0005 0.0024 0.0164 0.0098 0.0046 0.008 0.0149 0.0071 0.0024 0.003 0.0027 0.0017 0.0013 0.0005
Mitochondria 0.9022 0.9011 0.9531 0.9585 0.9785 0.9737 0.8989 0.9522 0.952 0.9 0.9399 0.9661 0.9776 0.9673 0.9875 0.9838 0.9623 0.982
None 0.0002 0.0001 0.0001 0 0 0 0.0015 0 0.0006 0.0022 0.003 0 0.0001 0 0 0 0.001 0
Nuclear Periphery 0.0013 0.0001 0.0001 0 0 0.0001 0.0058 0 0.0003 0.004 0.0025 0.0092 0.0001 0 0.0001 0 0.0121 0
Nucleolus 0.0153 0.001 0.0001 0.0001 0 0 0.002 0.0001 0.0005 0.0006 0.0002 0.0001 0.0001 0.0001 0 0 0.0004 0
Nucleus 0.0037 0.0004 0.0001 0 0 0 0.0018 0 0.0001 0.0011 0.0007 0.0001 0 0 0 0 0.0022 0
Peroxisomes 0.0013 0.0029 0.0009 0.0031 0.0011 0.0011 0.0076 0.0031 0.0019 0.0119 0.0015 0.0004 0.0013 0.0028 0.0006 0.0018 0.0005 0.0003
Punctate Nuclear 0.0017 0 0 0 0 0 0.0046 0 0.0002 0.0032 0.0048 0.0001 0 0 0 0 0.0051 0
Vacuole 0.0047 0.0089 0.0031 0.0014 0.0001 0.0029 0.0032 0.0014 0.0004 0.0008 0.0005 0.0004 0.001 0.0004 0.0002 0.0011 0.0003 0.0002
Vacuole Periphery 0.0224 0.0217 0.0113 0.0153 0.0006 0.0094 0.0118 0.0097 0.0019 0.0014 0.0012 0.0093 0.0028 0.0016 0.0022 0.0057 0.001 0.003

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 38.801 21.6786 27.347 31.7728 31.442 33.9321 24.4764 22.191 29.3449 31.7594
Translational Efficiency 1.6136 2.1697 1.6818 1.5078 1.4106 1.7379 1.5913 1.512 1.5092 1.4247

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1670 323 2339 1291 2051 2023 1058 2419 3721 2346 3397 3710

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1285.86 1698.44 1627.00 1983.58 1390.93 1388.01 1480.90 2256.27 1343.77 1430.75 1581.50 2161.38
Standard Deviation 251.91 301.29 323.92 478.39 261.41 311.48 362.98 555.44 262.45 328.03 343.30 545.59
Intensity Change Log 2 — 0.401477 0.339481 0.625373 — -0.003032 0.090424 0.697890 — 0.205444 0.215436 0.663509

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.001697 0.005246 0.002181 0.009197 0.001439 0.005247 0.005782 0.003724 0.001555 0.005247 0.003303 0.005628
Bud Neck 0.000223 0.005401 0.000699 0.002357 0.000466 0.003544 0.009851 0.000989 0.000357 0.003800 0.003549 0.001465
Bud Site 0.000603 0.002009 0.000659 0.005021 0.000248 0.012817 0.023865 0.002526 0.000407 0.011329 0.007887 0.003394
Cell Periphery 0.000185 0.000118 0.000067 0.000784 0.000029 0.000852 0.001285 0.001091 0.000099 0.000751 0.000446 0.000984
Cytoplasm 0.000112 0.000355 0.000117 0.000427 0.000089 0.002430 0.002930 0.000576 0.000099 0.002144 0.000993 0.000524
Cytoplasmic Foci 0.003307 0.043653 0.004355 0.008344 0.010088 0.019399 0.024516 0.003108 0.007045 0.022738 0.010634 0.004930
Eisosomes 0.000558 0.001027 0.000414 0.001239 0.000353 0.000454 0.000350 0.000667 0.000445 0.000533 0.000394 0.000866
Endoplasmic Reticulum 0.000081 0.000272 0.000036 0.000589 0.000055 0.000362 0.000611 0.000468 0.000067 0.000350 0.000215 0.000510
Endosome 0.000573 0.007385 0.000964 0.003413 0.001085 0.015712 0.017635 0.001734 0.000856 0.014566 0.006156 0.002318
Golgi 0.006479 0.050535 0.008551 0.028192 0.013673 0.034207 0.025059 0.030878 0.010444 0.036455 0.013692 0.029943
Lipid Particles 0.001336 0.008915 0.001183 0.003572 0.003592 0.010893 0.012090 0.001939 0.002579 0.010621 0.004580 0.002508
Mitochondria 0.974406 0.831546 0.967738 0.891085 0.954320 0.853684 0.797128 0.917721 0.963335 0.850636 0.914601 0.908452
Mitotic Spindle 0.000066 0.006510 0.000478 0.003110 0.000668 0.001373 0.008012 0.000830 0.000398 0.002080 0.002825 0.001623
None 0.001619 0.002207 0.001382 0.002913 0.002126 0.002250 0.002397 0.002549 0.001898 0.002244 0.001698 0.002676
Nuclear Periphery 0.000081 0.000566 0.000218 0.000464 0.000288 0.000449 0.002977 0.000327 0.000195 0.000465 0.001077 0.000375
Nuclear Periphery Foci 0.000039 0.000695 0.000113 0.000251 0.000150 0.000626 0.002291 0.000163 0.000100 0.000636 0.000792 0.000193
Nucleolus 0.000100 0.001107 0.000168 0.000388 0.000201 0.001333 0.002708 0.000255 0.000156 0.001302 0.000959 0.000301
Nucleus 0.000039 0.000212 0.000021 0.000113 0.000029 0.000609 0.000652 0.000176 0.000034 0.000554 0.000217 0.000154
Peroxisomes 0.005994 0.018468 0.003758 0.003808 0.005124 0.011667 0.014782 0.000775 0.005514 0.012603 0.007191 0.001831
Vacuole 0.000598 0.008080 0.002397 0.009882 0.001787 0.011746 0.021840 0.009557 0.001254 0.011241 0.008453 0.009670
Vacuole Periphery 0.001907 0.005694 0.004501 0.024851 0.004190 0.010345 0.023238 0.019948 0.003165 0.009705 0.010337 0.021654

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.27 -0.76 -5.41 -1.96 -4.86 -4.49 -5.17 -3.55 1.67 2.31 -5.04 -3.45 -6.42 -0.44 -3.20
Bud Neck -3.18 -3.67 -6.35 1.78 -4.77 -6.89 -9.28 -3.11 5.47 8.68 -7.78 -9.49 -6.97 4.93 5.61
Bud Site -1.93 -0.15 -3.94 -2.51 -4.06 -7.79 -7.62 -4.26 5.99 6.76 -7.77 -7.47 -5.62 5.23 3.93
Cell Periphery 0.71 1.25 -2.17 -2.55 -2.74 -5.43 -4.96 -4.58 -0.86 0.57 -4.76 -3.83 -4.89 -1.06 -2.77
Cytoplasm -4.06 -0.13 -3.32 -0.84 -3.41 -4.51 -2.98 -1.28 2.86 2.31 -4.56 -3.00 -1.71 3.13 1.22
Cytoplasmic Foci -7.78 -1.77 -4.26 6.65 -3.30 -6.23 -6.46 7.68 12.36 10.07 -11.25 -4.10 3.04 12.78 6.49
Eisosomes -2.49 1.63 -4.74 -0.95 -5.58 -2.42 0.08 -4.95 -3.32 -5.16 -1.87 0.91 -6.35 -4.81 -6.28
Endoplasmic Reticulum -4.01 2.89 -3.19 -1.94 -3.49 -7.35 -8.83 -5.87 -1.25 1.57 -7.66 -6.85 -6.16 -1.96 -3.95
Endosome -5.20 -1.85 -4.78 2.75 -4.07 -11.20 -11.16 -2.44 10.62 10.65 -12.04 -10.55 -5.47 10.53 6.92
Golgi -7.08 -1.49 -7.59 3.32 -6.80 -8.29 -4.23 -6.49 1.06 -1.77 -11.97 -2.46 -9.94 2.43 -7.93
Lipid Particles -5.25 0.50 -2.63 3.15 -2.84 -5.60 -5.37 2.85 7.04 6.52 -7.26 -3.54 0.05 7.11 3.28
Mitochondria 9.42 2.03 12.47 -3.63 11.62 15.16 16.30 7.40 -8.81 -11.96 19.13 12.17 13.99 -8.79 1.27
Mitotic Spindle -1.96 -4.52 -3.41 0.99 -2.93 -1.52 -5.90 -0.46 1.12 5.75 -2.94 -5.77 -3.08 0.68 2.22
None -2.76 2.25 -7.45 -2.91 -9.72 -0.44 -0.84 -2.44 -0.77 -0.37 -1.25 1.39 -6.37 -1.35 -7.05
Nuclear Periphery -5.08 -2.55 -5.95 0.98 -3.64 -1.34 -5.21 -0.58 1.06 5.15 -2.74 -5.28 -3.75 0.91 4.21
Nuclear Periphery Foci -4.57 -3.31 -5.14 2.95 -3.08 -3.87 -5.09 -0.43 3.79 5.06 -4.97 -5.18 -3.79 4.09 4.45
Nucleolus -2.67 -1.49 -5.26 1.90 -4.03 -3.17 -3.65 -1.04 3.01 3.56 -3.67 -3.70 -3.68 3.19 3.01
Nucleus -2.15 1.06 -1.80 0.97 -2.42 -2.90 -6.69 -1.85 2.04 3.74 -3.00 -5.96 -2.26 2.21 0.85
Peroxisomes -3.44 1.70 1.61 4.20 -0.06 -4.54 -5.02 4.90 9.38 8.12 -5.41 -1.73 4.84 9.55 7.57
Vacuole -4.63 -5.09 -7.30 -0.92 -5.77 -9.49 -11.42 -7.39 1.45 6.04 -10.85 -11.56 -10.35 1.22 -1.28
Vacuole Periphery -4.96 -4.36 -9.56 -7.76 -8.41 -6.22 -9.61 -10.74 -5.92 1.38 -8.08 -9.36 -14.64 -8.36 -8.05
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Mitochondrial inner membrane protein; exposed to the mitochondrial matrix; associates with mitochondrial ribosomes; NOT required for respiratory growth; homolog of human Letm1, a protein implicated in Wolf-Hirschhorn syndrome
Localization
Cell Percentages mitochondrion (100%)
Cell Cycle Regulation No
Subcompartmental Group mito-3

Ylh47

Ylh47


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ylh47-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available