Standard name
Human Ortholog
Description Repressor of translation initiation; binds eIF4G through its RGG domain and inhibits recruitment of the preinitiation complex; also contains an Lsm domain; may have a role in RNA processing; overproduction suppresses null mutation in clathrin heavy chain gene CHC1; forms cytoplasmic foci upon DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0.06 0 0.06 0 0.08 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0.05 0.05 0.06 0 0.05 0 0 0.05 0 0 0 0 0.19 0.09 0.12 0 0 0 0 0 0
Cytoplasm 0.94 0.97 0.97 0.86 0.8 0.71 0.49 0.53 0.45 0.47 0.39 0.41 0.94 0.85 0.87 0.79 0.88 0.87 0.84 0.88 0.64 0.67 0.57 0.67
Endoplasmic Reticulum 0 0 0 0 0 0.07 0.11 0.07 0.08 0.1 0.15 0.11 0.07 0 0 0 0 0 0.09 0 0.12 0.17 0.22 0.22
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0.1 0.15 0.22 0.49 0.38 0.55 0.42 0.56 0.46 0 0 0 0 0 0 0 0 0.12 0.07 0.08 0.05
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0.09 0 0.07 0.07 0.08 0.07 0 0.11 0 0 0 0.07 0 0.05 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 4 6 5 6 9 3 13 9 14 0 14 5 0 1 0 0 1 0 1 2 2
Bud 2 0 0 0 1 0 4 9 7 2 5 4 0 6 2 0 1 1 1 1 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 1 3 0 5 9 14 2 13 8 8 10 8 0 6 3 28 15 16 0 0 0 0 2 0
Cytoplasm 272 141 31 94 159 161 107 135 115 107 80 101 80 147 130 118 141 116 262 133 52 82 102 156
Endoplasmic Reticulum 12 6 0 4 5 17 24 18 20 22 31 26 6 3 4 1 7 2 27 6 9 21 38 51
Endosome 0 0 0 0 2 1 0 3 0 0 0 2 0 5 8 0 1 1 3 0 0 2 2 1
Golgi 1 0 0 0 0 1 0 2 0 0 0 0 0 3 5 0 0 2 2 1 1 2 2 2
Mitochondria 5 1 0 11 29 50 106 98 141 97 115 113 0 0 1 3 7 2 6 0 10 8 13 11
Nucleus 0 0 1 2 1 2 3 1 2 1 1 3 0 1 0 1 1 0 0 0 1 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 1 3 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 5 6 0 0 0 0 0 1 0 0 1
Vac/Vac Membrane 0 1 0 2 17 7 15 17 21 16 4 27 0 1 2 10 5 7 1 6 2 1 8 2
Unique Cell Count 288 146 32 109 199 227 218 255 256 230 204 244 85 173 150 149 161 134 311 151 81 123 180 232
Labelled Cell Count 293 152 32 122 229 258 267 306 320 266 255 298 86 192 166 161 179 147 311 151 81 123 180 232


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 8.2 11.2 8.2 8.3 8.9 7.9 7.0 7.8 6.7 7.3 6.8 7.4 8.6 10.3 10.0 17.0 17.0 16.5 9.3 9.9 10.3
Std Deviation (1e-4) 1.4 2.2 1.6 1.7 1.3 1.8 1.6 1.5 1.6 1.4 1.4 1.5 1.3 1.5 1.6 3.0 3.2 3.6 1.6 1.6 1.6
Intensity Change (Log2) – – – 0.02 0.12 -0.06 -0.23 -0.08 -0.3 -0.17 -0.27 -0.16 0.07 0.32 0.29 1.05 1.05 1.0 0.17 0.26 0.32


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm -1.7 -2.3 -3.1 -5.1 -4.7 -5.5 -5.3 -6.1 -5.9 -0.6 -1.8 -1.6 -2.4 -1.5 -1.6
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 3.0 5.2 4.3 5.9 4.6 5.9 5.0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 5.1265 6.4178 6.1391 5.2156 4.8772 6.1001 5.008 6.0153 5.565 5.0056 5.2746 5.4922 4.4612 6.5703 5.5857 7.8616 5.153 5.8894
Actin 0.0399 0.0012 0.0131 0.0049 0.0168 0.0072 0.0031 0.0009 0.0025 0.0007 0.0005 0.0034 0.0148 0.0169 0.0085 0.014 0.0022 0.0026
Bud 0.0008 0.0004 0.0016 0.0007 0.0016 0.0006 0.0004 0.0016 0.0005 0.0059 0.0011 0.0007 0.0006 0.0012 0.0013 0.0012 0.001 0.0016
Bud Neck 0.001 0.0003 0.0007 0.0004 0.001 0.0014 0.0004 0.0004 0.0005 0.0016 0.0008 0.0012 0.0005 0.0003 0.0007 0.0009 0.0008 0.0018
Bud Periphery 0.001 0.0001 0.0008 0.0007 0.0016 0.0006 0.0004 0.0006 0.0003 0.0029 0.0003 0.0006 0.0009 0.0004 0.001 0.0007 0.0004 0.0008
Bud Site 0.0035 0.0034 0.0043 0.0006 0.0039 0.0007 0.0007 0.0059 0.0007 0.0178 0.0052 0.001 0.0021 0.0019 0.0058 0.0072 0.0005 0.0004
Cell Periphery 0.0006 0.0003 0.0002 0.0002 0.0003 0.0002 0.0003 0.0002 0.0001 0.0002 0.0002 0.0001 0.0003 0.0002 0.0002 0.0003 0.0001 0.0003
Cytoplasm 0.6008 0.8716 0.7763 0.6839 0.5516 0.7308 0.7385 0.8878 0.8181 0.7266 0.8142 0.7802 0.6987 0.8302 0.7672 0.7476 0.6593 0.7199
Cytoplasmic Foci 0.0578 0.0212 0.035 0.0458 0.0715 0.0311 0.0321 0.0266 0.0308 0.0261 0.0517 0.0332 0.0256 0.0276 0.0342 0.0246 0.0696 0.0362
Eisosomes 0.0004 0 0 0 0.0002 0.0001 0 0 0 0 0 0 0.0002 0.0001 0.0001 0.0009 0 0
Endoplasmic Reticulum 0.0573 0.0265 0.0165 0.0188 0.0119 0.03 0.0595 0.0174 0.0251 0.0351 0.0192 0.0422 0.0773 0.0183 0.017 0.0309 0.028 0.0454
Endosome 0.1253 0.054 0.1033 0.179 0.1994 0.1306 0.1081 0.0408 0.0811 0.1496 0.0819 0.0905 0.0866 0.0637 0.1041 0.0863 0.1867 0.1214
Golgi 0.0347 0.0082 0.0164 0.0129 0.0662 0.0257 0.0148 0.0062 0.0135 0.009 0.0067 0.0147 0.0188 0.0106 0.022 0.0145 0.0312 0.0264
Lipid Particles 0.0109 0.0002 0.0008 0.0071 0.0111 0.0015 0.0011 0.0002 0.0003 0.0011 0.0002 0.0007 0.0117 0.0064 0.0006 0.0026 0.0002 0.0006
Mitochondria 0.0237 0.002 0.0066 0.0033 0.0457 0.022 0.008 0.0017 0.0063 0.0029 0.0045 0.0158 0.0118 0.0077 0.0223 0.0455 0.0056 0.0287
None 0.0045 0.0055 0.0099 0.0022 0.0018 0.0015 0.0103 0.0028 0.0089 0.0028 0.0035 0.0033 0.006 0.0013 0.0034 0.0014 0.0012 0.0022
Nuclear Periphery 0.0133 0.001 0.0016 0.002 0.0019 0.0026 0.0081 0.0007 0.0019 0.002 0.0011 0.0016 0.0169 0.0018 0.0016 0.0024 0.0029 0.0024
Nucleolus 0.0002 0 0.0001 0.0001 0.0002 0.0001 0.0001 0 0 0.0001 0.0003 0.0001 0.0007 0.0001 0.0001 0.0001 0 0.0001
Nucleus 0.0034 0.0006 0.0009 0.0009 0.0014 0.0034 0.0033 0.0011 0.001 0.002 0.0018 0.001 0.0099 0.001 0.0012 0.0013 0.0009 0.0018
Peroxisomes 0.0111 0.0001 0.0049 0.0219 0.0027 0.003 0.0003 0.0004 0.0006 0.0002 0.0004 0.0034 0.0034 0.0014 0.0007 0.0018 0.0006 0.0007
Punctate Nuclear 0.0013 0.0001 0.0011 0.0011 0.0006 0.0009 0.0008 0.0002 0.0002 0.0003 0.0007 0.0004 0.0021 0.0002 0.0006 0.0004 0.0003 0.0005
Vacuole 0.0058 0.0024 0.0041 0.0085 0.0051 0.0035 0.0072 0.0036 0.0055 0.0091 0.0042 0.0039 0.0078 0.0064 0.005 0.0121 0.0052 0.0037
Vacuole Periphery 0.0028 0.001 0.0019 0.0051 0.0036 0.0025 0.0024 0.0009 0.002 0.004 0.0015 0.0021 0.0033 0.0023 0.0023 0.0034 0.0035 0.0025

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 65.1534 58.2432 57.8576 63.4911 61.9932 67.2179 65.0635 80.4546 67.0943 67.1546
Translational Efficiency 2.3937 2.8085 2.1677 2.01 2.1691 2.4226 1.9655 1.8853 1.9747 1.841

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2728 951 2983 1901 1537 1241 2228 1302 4265 2192 5211 3203

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1063.14 1076.62 1175.93 1314.21 981.07 1054.41 1224.26 1186.63 1033.56 1064.05 1196.59 1262.35
Standard Deviation 130.19 154.63 160.33 210.04 133.00 147.76 160.58 199.98 137.00 151.18 162.21 215.33
Intensity Change Log 2 — 0.018178 0.145471 0.305864 — 0.104008 0.319482 0.274442 — 0.060007 0.231605 0.290869

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000282 0.000673 0.000599 0.000931 0.000254 0.000784 0.000408 0.000345 0.000272 0.000735 0.000517 0.000693
Bud Neck 0.001020 0.001186 0.002252 0.001530 0.001201 0.001695 0.001553 0.003040 0.001085 0.001474 0.001953 0.002144
Bud Site 0.013833 0.038307 0.020989 0.034241 0.015271 0.033735 0.019184 0.016868 0.014351 0.035719 0.020217 0.027179
Cell Periphery 0.000266 0.000344 0.000376 0.001277 0.000305 0.001485 0.000312 0.000118 0.000280 0.000990 0.000348 0.000806
Cytoplasm 0.496311* 0.437302* 0.660799* 0.695908* 0.388476* 0.447812* 0.521314* 0.412186* 0.457450* 0.443252* 0.601161* 0.580577*
Cytoplasmic Foci 0.303583* 0.350682* 0.095631 0.084548 0.352802* 0.343064* 0.137499 0.114204 0.321320* 0.346369* 0.113532 0.096603
Eisosomes 0.000070 0.000030 0.000022 0.000014 0.000060 0.000053 0.000012 0.000011 0.000067 0.000043 0.000018 0.000013
Endoplasmic Reticulum 0.027523 0.022220 0.006606 0.006536 0.049516 0.016664 0.017871 0.004642 0.035449 0.019075 0.011422 0.005766
Endosome 0.016055 0.026926 0.016376 0.013482 0.027570 0.023279 0.031794 0.040979 0.020205 0.024861 0.022968 0.024660
Golgi 0.064223 0.044052 0.012824 0.022078 0.048731 0.049495 0.013799 0.011358 0.058640 0.047133 0.013241 0.017720
Lipid Particles 0.006195 0.002987 0.009028 0.012134 0.006185 0.004546 0.007454 0.005500 0.006191 0.003869 0.008355 0.009437
Mitochondria 0.008504 0.001993 0.001212 0.000867 0.006585 0.004718 0.000638 0.002964 0.007813 0.003536 0.000967 0.001720
Mitotic Spindle 0.000431 0.002029 0.003386 0.005589 0.000456 0.003038 0.001461 0.015818 0.000440 0.002600 0.002563 0.009747
None 0.001797 0.000775 0.000406 0.000142 0.000743 0.000947 0.000128 0.001518 0.001417 0.000873 0.000287 0.000701
Nuclear Periphery 0.000091 0.000119 0.000361 0.000072 0.000184 0.000095 0.000335 0.000630 0.000124 0.000105 0.000350 0.000299
Nuclear Periphery Foci 0.000459 0.000970 0.001498 0.002801 0.000636 0.000719 0.002684 0.003809 0.000523 0.000828 0.002005 0.003211
Nucleolus 0.000143 0.000236 0.000319 0.000173 0.000124 0.000217 0.000162 0.001114 0.000137 0.000226 0.000252 0.000555
Nucleus 0.003525 0.001869 0.006879 0.002454 0.003261 0.002626 0.004173 0.009678 0.003430 0.002297 0.005722 0.005391
Peroxisomes 0.000761 0.000943 0.001010 0.001189 0.000759 0.001579 0.000671 0.001454 0.000761 0.001303 0.000865 0.001297
Vacuole 0.024633 0.042302 0.147326 0.098144 0.051670 0.041094 0.219038* 0.335797* 0.034376 0.041618 0.177987 0.194749
Vacuole Periphery 0.030294 0.024055 0.012101 0.015889 0.045213 0.022355 0.019511 0.017966 0.035670 0.023093 0.015269 0.016733

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.91 -3.50 -4.11 -1.45 -1.86 -5.23 -4.11 -1.24 3.62 0.93 -6.41 -4.53 -4.27 0.30 -1.57
Bud Neck -1.67 -8.21 -6.22 -3.70 4.03 -3.10 -1.84 -7.11 -5.37 -5.37 -4.07 -7.30 -9.03 -5.73 -2.27
Bud Site -11.40 -6.91 -12.97 1.68 -7.72 -9.47 -3.34 -0.74 7.64 1.67 -14.90 -7.57 -11.13 5.15 -5.52
Cell Periphery -2.87 -3.79 -6.86 -6.21 -6.03 -1.55 -0.10 10.48 1.81 8.42 -1.65 -3.26 -5.85 0.50 -5.02
Cytoplasm 5.32 -21.46 -23.82 -22.06 -4.22 -5.47 -13.78 -2.51 2.63 9.69 1.86 -23.43 -17.26 -16.22 2.75
Cytoplasmic Foci -5.46 44.63 44.69 33.14 3.52 1.16 33.85 36.28 31.25 5.80 -4.21 54.64 56.78 46.70 6.79
Eisosomes 7.72 10.72 13.35 4.94 3.66 1.14 13.03 13.13 7.62 1.43 5.28 15.59 17.89 8.82 3.87
Endoplasmic Reticulum 1.87 13.03 12.30 6.36 0.22 9.20 9.21 14.09 7.48 9.28 7.99 14.64 18.75 9.32 7.00
Endosome -7.25 -0.55 3.21 8.68 3.56 3.00 -2.84 -4.98 -7.11 -2.94 -4.78 -3.72 -3.10 1.43 -0.25
Golgi 8.52 36.29* 23.79 9.95 -6.71 -0.33 22.76 22.27 19.16 3.06 6.97 42.39 32.14 19.57 -3.78
Lipid Particles 8.71 -5.11 -6.77 -10.77 -3.28 3.37 -2.82 0.91 -1.21 2.63 7.19 -5.77 -5.38 -9.17 -1.68
Mitochondria 13.81 17.71 17.07 3.73 1.65 2.06 10.66 4.88 2.29 -2.85 8.01 20.59 14.61 3.97 -1.88
Mitotic Spindle -2.12 -5.00 -4.59 -2.74 -1.77 -2.73 -4.53 -7.25 -5.86 -6.82 -3.44 -6.04 -8.55 -6.13 -6.53
None 2.10 3.74 4.65 1.93 2.23 -0.45 6.97 -1.02 -0.52 -2.15 1.48 4.74 2.50 0.71 -1.43
Nuclear Periphery -0.77 -2.58 0.48 1.26 2.76 2.01 -1.93 -6.20 -7.23 -3.30 0.57 -3.29 -5.33 -5.49 0.38
Nuclear Periphery Foci -3.39 -6.21 -7.62 -5.74 -3.96 -0.58 -8.05 -7.12 -6.76 -2.40 -2.84 -10.17 -10.43 -8.98 -4.37
Nucleolus -0.70 -4.74 -1.23 0.49 3.06 -1.34 -3.74 -4.17 -3.61 -4.01 -1.21 -5.34 -4.30 -2.48 -3.04
Nucleus 7.93 -10.77 1.65 -3.00 9.32 2.72 -4.08 -9.32 -10.08 -8.09 7.41 -11.31 -7.09 -9.73 -0.92
Peroxisomes -2.90 -4.52 -4.46 -2.24 -1.74 -4.07 1.52 -4.74 0.31 -5.22 -4.63 -2.84 -6.51 -0.07 -5.05
Vacuole -5.85 -30.63 -22.76 -13.85 8.97 2.87 -30.21 -35.50 -36.95 -13.28 -3.30 -43.61 -37.70 -34.08 -3.87
Vacuole Periphery 3.25 14.65 10.11 4.71 -2.92 8.83 11.12 12.17 3.80 2.55 8.43 17.56 15.67 5.99 -0.39
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Repressor of translation initiation; binds eIF4G through its RGG domain and inhibits recruitment of the preinitiation complex; also contains an Lsm domain; may have a role in RNA processing; overproduction suppresses null mutation in clathrin heavy chain gene CHC1; forms cytoplasmic foci upon DNA replication stress
Localization
Cell Percentages cytoplasm (99%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-5

Scd6

Scd6


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Scd6-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available