Standard name
Human Ortholog
Description Lyso-phosphatidylcholine acyltransferase; required for normal phospholipid content of mitochondrial membranes; major determinant of the final acyl chain composition of the mitochondrial-specific phospholipid cardiolipin; mutations in human ortholog tafazzin (TAZ) cause Barth syndrome, a rare X-linked disease characterized by skeletal and cardiomyopathy and bouts of cyclic neutropenia; a specific splice variant of human TAZ can complement yeast null mutant
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches – – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – 0 0 0 0
Bud – – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – 0 0 0 0
Bud Neck – – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – 0 0 0 0
Bud Site – – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery – – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – 0 0 0 0
Cytoplasm – – 0.89 0.79 0.85 0.69 0.68 0.69 0.58 0.54 0.48 0.57 0.97 0.99 0.98 0.82 0.93 0.86 – – 0.45 0.75 0.81 0.78
Endoplasmic Reticulum – – 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0.08 – – 0 0 0 0
Endosome – – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 – – 0 0 0 0
Golgi – – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – 0 0 0 0
Mitochondria – – 0 0.17 0.06 0.32 0.42 0.3 0.53 0.66 0.65 0.49 0 0 0 0.05 0 0 – – 0.26 0.08 0 0
Nucleus – – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – 0 0 0 0
Nuclear Periphery – – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – 0 0 0 0
Nucleolus – – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – 0 0 0 0
Peroxisomes – – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – 0 0 0 0
SpindlePole – – 0 0 0.05 0.05 0 0 0 0 0 0.12 0 0 0 0 0 0 – – 0.07 0 0 0
Vac/Vac Membrane – – 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0.08 0 0 – – 0 0 0.05 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches – – 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 – – 3 0 2 3
Bud – – 0 0 0 7 10 11 1 0 1 3 0 0 0 1 1 0 – – 2 0 0 4
Bud Neck – – 0 0 0 3 2 2 1 1 1 1 2 0 1 1 0 0 – – 2 0 0 3
Bud Site – – 0 0 0 0 5 2 0 2 2 0 0 0 0 0 0 0 – – – – – –
Cell Periphery – – 1 2 1 1 1 1 0 0 1 4 0 1 1 4 1 2 – – 0 0 0 1
Cytoplasm – – 108 96 131 158 269 273 78 82 62 88 179 262 324 117 87 113 – – 61 29 149 182
Endoplasmic Reticulum – – 0 0 1 0 0 2 1 0 0 1 2 1 0 10 2 11 – – 0 0 0 0
Endosome – – 3 3 3 6 1 16 2 0 1 1 1 2 1 6 3 6 – – 3 0 2 3
Golgi – – 0 1 0 0 0 0 0 0 0 0 1 1 0 0 1 0 – – 4 0 1 4
Mitochondria – – 5 20 10 73 169 118 71 100 85 75 0 0 0 7 2 3 – – 35 3 7 9
Nucleus – – 1 0 1 1 4 1 1 0 0 0 1 0 2 1 0 1 – – 1 0 0 3
Nuclear Periphery – – 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 – – 0 0 0 0
Nucleolus – – 0 1 2 0 0 1 1 0 0 0 0 0 0 0 0 0 – – 0 0 0 0
Peroxisomes – – 2 0 0 1 0 0 1 0 0 1 0 0 0 1 0 0 – – 0 0 0 0
SpindlePole – – 5 3 8 11 7 16 0 6 4 19 0 0 1 3 1 2 – – 9 1 2 4
Vac/Vac Membrane – – 2 5 6 9 8 16 1 7 1 1 0 0 2 12 4 5 – – 3 0 9 6
Unique Cell Count 122 121 155 228 398 397 135 152 130 154 184 265 329 142 94 131 136 39 184 234
Labelled Cell Count 127 131 163 272 477 459 158 198 158 194 186 267 332 163 102 143 136 39 184 234


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) – – 4.2 4.2 7.4 3.3 3.1 3.6 4.0 2.7 2.9 8.0 5.1 5.1 4.9 5.9 5.9 5.9 – 5.0 5.6
Std Deviation (1e-4) – – 2.1 2.4 7.7 1.8 1.5 3.2 4.5 0.5 1.9 9.0 1.3 1.4 1.2 1.7 2.1 1.9 – 1.5 1.8
Intensity Change (Log2) – – – 0.01 0.83 -0.31 -0.43 -0.2 -0.07 -0.63 -0.52 0.95 0.28 0.29 0.25 0.51 0.5 0.51 – 0.28 0.43


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm -2.0 -1.0 -4.0 -4.5 -4.3 -5.5 -6.2 -6.9 -5.7 3.1 4.6 4.7 -1.4 1.0 -0.5
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3.3
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0.9 0 0 0 0 0 0 8.1 0 0 0 0.3 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0.4 0 0 0 0 0 0 2.4 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 2.5 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 3.0703 0.681 0.764 1.6714 1.5489 0.8366 0.3581 -0.8063 -1.0602 -1.0042 -0.6277 -0.2418 -0.6609 -1.4791 -1.6915 -1.4727 -0.5502 -1.3758
Actin 0.1073 0.0023 0.0211 0.0813 0.0241 0.018 0.1353 0.0053 0.0062 0.004 0.0003 0.0126 0.1275 0.0149 0.0632 0.0001 0.012 0.036
Bud 0.0013 0.0016 0.02 0.0044 0.0028 0.0008 0.0097 0.0031 0.0023 0.0017 0.0002 0.0008 0.0018 0.0004 0.0011 0.0016 0.0042 0.0008
Bud Neck 0.028 0.0007 0.0049 0.002 0.0012 0.0099 0.0075 0.0022 0.0071 0.027 0.0002 0.0273 0.003 0.0006 0.0032 0.0004 0.0009 0.0019
Bud Periphery 0.0016 0.0015 0.0183 0.0103 0.0185 0.0014 0.011 0.0039 0.0025 0.0046 0.0003 0.0014 0.0021 0.0004 0.0011 0.0011 0.003 0.0011
Bud Site 0.0438 0.0321 0.0304 0.0351 0.0022 0.0038 0.0503 0.0327 0.0257 0.0008 0.0001 0.0019 0.0156 0.0175 0.0038 0.0012 0.0063 0.001
Cell Periphery 0.0027 0.0009 0.0011 0.0019 0.0006 0.0006 0.0019 0.0014 0.0007 0.0003 0.0001 0.0005 0.0012 0.0009 0.0006 0.0001 0.0005 0.0002
Cytoplasm 0.0745 0.2534 0.1764 0.1523 0.0941 0.2616 0.1367 0.3958 0.3231 0.2916 0.3535 0.4824 0.1551 0.2942 0.3933 0.3366 0.1352 0.4281
Cytoplasmic Foci 0.0492 0.0255 0.0322 0.0185 0.1677 0.0355 0.0744 0.0433 0.0545 0.068 0.0547 0.0596 0.0783 0.0165 0.025 0.0411 0.0458 0.0483
Eisosomes 0.001 0.0004 0.0005 0.0013 0.0003 0.0003 0.0022 0.0002 0.0002 0.0001 0 0.0001 0.0012 0.0003 0.0008 0 0.0001 0.0001
Endoplasmic Reticulum 0.019 0.0032 0.0103 0.0091 0.0024 0.0046 0.0043 0.0074 0.005 0.0036 0.0057 0.0066 0.0257 0.0078 0.0024 0.003 0.0044 0.0042
Endosome 0.0631 0.0255 0.0451 0.0569 0.0623 0.0173 0.0903 0.0383 0.0426 0.1071 0.1191 0.0379 0.0644 0.0108 0.0143 0.0852 0.2036 0.0422
Golgi 0.0174 0.0085 0.0074 0.0129 0.0224 0.0039 0.0324 0.0077 0.0049 0.021 0.006 0.0129 0.0156 0.0021 0.0081 0.0015 0.0886 0.0058
Lipid Particles 0.0317 0.0015 0.0088 0.0106 0.0533 0.0043 0.0452 0.0054 0.0059 0.019 0.0027 0.0158 0.0168 0.0007 0.0023 0.0005 0.0075 0.0139
Mitochondria 0.0085 0.004 0.0056 0.0317 0.0161 0.0052 0.0774 0.0044 0.0096 0.0675 0.0028 0.0432 0.0257 0.0009 0.0204 0.0009 0.0682 0.0011
None 0.3823 0.625 0.5795 0.4248 0.4333 0.5837 0.2548 0.4345 0.487 0.3598 0.3705 0.2576 0.36 0.6198 0.4481 0.4696 0.3948 0.3969
Nuclear Periphery 0.0593 0.0006 0.0088 0.0314 0.002 0.0148 0.0028 0.0011 0.0013 0.0017 0.0292 0.0144 0.04 0.0009 0.0011 0.003 0.0007 0.0015
Nucleolus 0.0307 0.0007 0.0016 0.0045 0.001 0.0008 0.011 0.0004 0.0005 0.0004 0.0008 0.0016 0.0013 0.0002 0.0001 0.0003 0.0002 0.0003
Nucleus 0.0283 0.0025 0.0035 0.008 0.0025 0.0099 0.0062 0.0017 0.0015 0.0015 0.0382 0.0063 0.0142 0.001 0.0007 0.0027 0.0004 0.0009
Peroxisomes 0.0246 0.0022 0.0118 0.0045 0.0672 0.0122 0.0236 0.0013 0.0045 0.0044 0.0008 0.0031 0.0099 0.0008 0.0076 0.0004 0.0037 0.0065
Punctate Nuclear 0.015 0.0034 0.0025 0.0034 0.0216 0.0081 0.0032 0.0009 0.0018 0.0019 0.0016 0.0015 0.0318 0.0006 0.0012 0.0006 0.0004 0.0054
Vacuole 0.0064 0.0041 0.0084 0.0785 0.0033 0.002 0.0166 0.0081 0.0117 0.0114 0.0084 0.0079 0.0056 0.008 0.0011 0.0434 0.0159 0.0031
Vacuole Periphery 0.0043 0.0004 0.0018 0.0167 0.0012 0.0012 0.003 0.0008 0.0013 0.0028 0.0047 0.0046 0.0031 0.0009 0.0006 0.0065 0.0037 0.0007

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 21.6637 12.05 13.4124 19.2899 15.6044 25.0198 15.6648 18.2085 22.5353 23.0862
Translational Efficiency 0.7806 0.8519 1.0134 0.7304 0.8861 0.8051 0.851 0.6345 0.7447 0.8976

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
313 158 1291 102 1886 401 109 477 2199 559 1400 579

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 611.22 729.90 725.23 873.19 630.78 693.35 826.82 827.31 628.00 703.68 733.14 835.39
Standard Deviation 75.27 90.22 97.46 114.69 76.69 92.59 111.69 107.70 76.79 93.38 102.33 110.35
Intensity Change Log 2 — 0.256007 0.246747 0.514604 — 0.136447 0.390436 0.391291 — 0.196524 0.321510 0.453294

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000220 0.000350 0.000942 0.004204 0.000065 0.000961 0.000587 0.004508 0.000087 0.000788 0.000914 0.004455
Bud Neck 0.035084 0.040586 0.010218 0.038245 0.011257 0.026699 0.003330 0.030727 0.014649 0.030624 0.009682 0.032051
Bud Site 0.006496 0.027126 0.027728 0.153231* 0.002981 0.009642 0.017802 0.038038 0.003482 0.014583 0.026956 0.058331
Cell Periphery 0.000265 0.000147 0.000181 0.001320 0.000176 0.000293 0.000332 0.000175 0.000189 0.000252 0.000193 0.000377
Cytoplasm 0.499748* 0.382229* 0.481548* 0.190492* 0.594361* 0.496051* 0.320252* 0.336390* 0.580894* 0.463880* 0.468990* 0.310688*
Cytoplasmic Foci 0.194055* 0.200589* 0.061714 0.099872 0.101199 0.156633 0.139640 0.068929 0.114416 0.169057 0.067782 0.074380
Eisosomes 0.000219 0.000116 0.000053 0.000250 0.000124 0.000134 0.000193 0.000094 0.000138 0.000129 0.000064 0.000121
Endoplasmic Reticulum 0.000360 0.000790 0.001661 0.006553 0.000475 0.000372 0.004853 0.001738 0.000458 0.000490 0.001910 0.002586
Endosome 0.006252 0.023546 0.007400 0.029417 0.003482 0.012164 0.017866 0.026718 0.003876 0.015381 0.008215 0.027193
Golgi 0.001016 0.001379 0.003486 0.005719 0.000894 0.001688 0.003669 0.010653 0.000912 0.001600 0.003500 0.009784
Lipid Particles 0.004555 0.004057 0.002155 0.005176 0.002973 0.003295 0.005959 0.001922 0.003198 0.003510 0.002451 0.002495
Mitochondria 0.003690 0.010199 0.004748 0.000957 0.002215 0.010069 0.014570 0.009685 0.002425 0.010105 0.005513 0.008147
Mitotic Spindle 0.002394 0.012937 0.011415 0.015494 0.000828 0.002701 0.033595 0.023770 0.001051 0.005594 0.013142 0.022312
None 0.011219 0.001633 0.005682 0.001364 0.005328 0.003501 0.002103 0.002623 0.006167 0.002973 0.005403 0.002401
Nuclear Periphery 0.000261 0.000553 0.000705 0.001182 0.000311 0.000354 0.000997 0.000954 0.000304 0.000410 0.000728 0.000994
Nuclear Periphery Foci 0.000192 0.000534 0.000602 0.004699 0.000199 0.000227 0.001269 0.000633 0.000198 0.000314 0.000654 0.001350
Nucleolus 0.003311 0.005651 0.000818 0.000537 0.000846 0.003058 0.001007 0.000766 0.001197 0.003791 0.000833 0.000726
Nucleus 0.190646* 0.187877* 0.324351* 0.123645 0.243156* 0.207390* 0.299363* 0.194290* 0.235682* 0.201875* 0.322405* 0.181845*
Peroxisomes 0.005477 0.016130 0.007677 0.016553 0.002027 0.010224 0.008219 0.026133 0.002518 0.011893 0.007719 0.024445
Vacuole 0.034109 0.082012 0.045173 0.298192* 0.026424 0.053600 0.119295 0.217431* 0.027518 0.061630 0.050944 0.231658*
Vacuole Periphery 0.000430 0.001561 0.001741 0.002898 0.000678 0.000947 0.005099 0.003823 0.000643 0.001121 0.002003 0.003660

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.61 -3.26 -2.80 -2.41 -1.66 -1.32 -2.80 -1.55 -0.83 -1.20 -1.51 -5.06 -1.81 -1.09 -1.12
Bud Neck -0.30 4.02 1.97 2.08 -1.98 -3.26 6.37 -2.18 1.22 -4.48 -3.68 3.37 -1.43 2.08 -3.21
Bud Site -2.98 -6.00 -3.40 -1.92 -2.20 -3.10 -1.32 -5.83 -3.60 -1.29 -4.45 -7.83 -6.60 -3.43 -1.45
Cell Periphery 1.98 1.63 -1.03 -1.51 -1.41 -1.85 -3.65 2.31 2.51 4.72 -1.38 0.07 -0.29 0.81 -0.31
Cytoplasm 4.77 2.09 11.30 5.49 11.19 6.76 12.13 21.62 10.48 0.07 9.31 13.63 24.37 10.90 12.33
Cytoplasmic Foci -0.17 12.68 11.47 9.15 1.67 -6.33 -1.38 11.08 12.02 5.10 -6.84 11.65 14.70 15.10 3.58
Eisosomes 2.44 4.81 1.32 -0.50 -2.46 -0.54 -2.79 1.72 4.16 5.11 0.24 4.41 1.95 2.83 -4.07
Endoplasmic Reticulum -3.84 -10.23 -6.21 -5.62 -4.81 0.65 -1.93 -10.01 -9.86 1.13 -1.32 -7.27 -10.62 -9.98 -3.23
Endosome -4.05 -0.54 -2.22 2.24 -2.04 -4.28 -3.72 -4.38 -0.48 0.41 -6.06 -4.87 -4.84 0.70 -2.89
Golgi -0.70 -2.39 -0.67 -0.39 0.89 -1.42 -1.33 -2.49 -1.94 -1.03 -1.57 -2.85 -2.56 -2.02 -0.82
Lipid Particles 0.37 3.28 0.70 0.39 -1.90 -0.79 -2.65 3.15 3.55 3.61 -0.95 2.22 2.74 3.42 0.11
Mitochondria -0.86 -0.27 1.77 1.39 3.57 -1.93 -1.10 -1.53 1.28 0.77 -2.17 -1.85 -1.11 1.67 0.52
Mitotic Spindle -1.69 -3.76 -2.37 -1.30 -1.60 -1.38 -2.05 -3.69 -3.11 0.91 -2.25 -5.38 -4.40 -2.90 -1.27
None 2.46 1.49 1.65 -1.36 0.50 1.74 4.18 3.36 0.81 -1.36 3.18 0.90 3.49 -0.02 1.86
Nuclear Periphery -3.20 -11.85 -6.59 -5.57 -5.15 -1.03 -5.86 -11.97 -10.71 -1.72 -2.54 -13.46 -13.41 -11.66 -8.49
Nuclear Periphery Foci -2.99 -7.83 -3.37 -2.93 -2.97 -0.78 -5.87 -7.36 -6.49 2.57 -2.76 -9.35 -5.73 -4.88 -3.28
Nucleolus -0.63 1.15 1.25 2.50 1.60 -1.71 -0.13 0.61 1.81 0.86 -2.21 1.18 1.41 2.83 0.65
Nucleus -0.09 -11.16 -0.18 -0.09 5.95 3.00 -2.60 1.40 -1.11 3.03 3.17 -11.48 1.37 -1.19 9.18
Peroxisomes -3.44 -1.02 -0.09 2.93 0.53 -3.00 -1.96 -2.83 -0.45 -1.44 -4.41 -4.07 -2.85 0.29 -1.33
Vacuole -5.29 -4.52 -12.53 -9.99 -11.86 -5.42 -7.26 -21.24 -17.97 -6.40 -7.77 -10.93 -24.43 -20.01 -20.93
Vacuole Periphery -3.22 -2.77 -1.33 0.78 0.84 -1.02 -1.21 -1.48 -1.08 0.73 -2.06 -2.49 -1.62 -0.86 0.09
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Lyso-phosphatidylcholine acyltransferase; required for normal phospholipid content of mitochondrial membranes; major determinant of the final acyl chain composition of the mitochondrial-specific phospholipid cardiolipin; mutations in human ortholog tafazzin (TAZ) cause Barth syndrome, a rare X-linked disease characterized by skeletal and cardiomyopathy and bouts of cyclic neutropenia; a specific splice variant of human TAZ can complement yeast null mutant
Localization
Cell Percentages cytoplasm (48%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Taz1

Taz1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Taz1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available