Standard name
Human Ortholog
Description Protein that regulates expression of Fo-F1 ATP synthase subunits; involved in the regulation of mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; functions with Nca3p
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 – – – – – –
Cell Periphery 0 0.05 0.05 0 0 0 0 0 0 0 0 0 – 0 0 0.08 0.13 0.11 0 0 0 0 0 0
Cytoplasm 0 0 0.06 0 0.09 0 0 0.07 0 0 0.05 0 – 0.15 0.16 0.09 0 0.05 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0.06 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0.05 0 0 0 0 0 0
Endosome 0 0 0.05 0 0.14 0 0.05 0.05 0 0 0 0 – 0 0.06 0.07 0 0 0 0.05 0 0 0.07 0.06
Golgi 0 0.09 0.36 0.24 0.16 0 0 0 0 0 0 0.06 – 0.38 0.22 0.4 0.45 0.42 0 0.07 0.05 0.13 0.14 0.08
Mitochondria 0.9 0.79 0.42 0.79 0.62 0.78 0.8 0.76 0.91 0.84 0.89 0.94 – 0.59 0.49 0.08 0.11 0.1 0.81 0.71 0.77 0.62 0.52 0.59
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0.05 0 – 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.12 0.24 0.35 0.09 0.23 0.18 0.19 0.14 0.11 0.2 0.06 0.14 – 0.12 0.17 0.3 0.36 0.29 0 0.08 0.06 0 0.08 0.08
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 1 2 0 0 1 0 3 0 0 1 0 – 2 0 2 6 8 1 9 1 1 1 3
Bud 3 5 1 2 0 2 3 4 0 2 3 0 – 0 0 5 3 6 0 6 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 1 0 0 0 0
Bud Site 0 0 0 0 0 1 0 2 2 0 1 0 – 0 0 2 0 1 – – – – – –
Cell Periphery 4 21 5 4 1 2 7 1 1 3 5 5 – 0 1 18 27 24 0 0 0 0 0 0
Cytoplasm 2 12 6 7 16 8 10 24 11 7 11 6 – 12 16 20 3 11 0 2 0 1 3 1
Endoplasmic Reticulum 9 4 6 5 4 7 3 3 1 1 3 1 – 3 4 9 9 11 2 1 0 0 1 3
Endosome 1 10 5 8 24 10 16 17 4 3 0 2 – 1 6 14 7 8 7 18 5 2 7 6
Golgi 5 35 38 49 28 4 3 12 2 2 3 9 – 30 22 86 96 89 8 30 8 6 13 8
Mitochondria 207 304 44 160 110 209 232 253 241 174 190 139 – 46 48 17 23 21 197 297 124 33 50 65
Nucleus 0 2 2 2 0 4 8 8 5 4 1 3 – 0 2 3 4 2 0 2 1 0 3 0
Nuclear Periphery 9 7 1 3 1 12 10 12 5 7 10 3 – 0 1 1 2 4 5 3 0 0 1 1
Nucleolus 2 9 2 3 2 7 6 5 10 5 8 3 – 0 2 1 2 3 0 2 0 0 0 1
Peroxisomes 0 4 0 2 4 1 1 0 1 0 2 2 – 1 1 7 7 9 4 6 4 1 2 1
SpindlePole 0 0 4 1 4 2 3 9 3 3 2 0 – 2 1 6 3 6 1 2 0 0 0 1
Vac/Vac Membrane 28 94 37 19 40 49 56 45 28 41 13 20 – 9 17 63 76 62 8 32 9 2 7 8
Unique Cell Count 229 386 105 202 177 267 291 331 265 207 213 148 78 98 213 214 213 243 419 161 54 97 111
Labelled Cell Count 270 508 153 265 234 319 358 398 314 252 253 193 106 121 254 268 265 243 419 161 54 97 111


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.9 8.1 8.2 7.4 7.9 6.6 6.7 7.0 6.1 6.5 5.9 6.2 – 8.3 8.4 9.4 9.7 9.4 6.7 9.1 8.4
Std Deviation (1e-4) 0.9 1.4 1.3 1.4 2.0 1.3 1.3 1.5 1.2 1.8 1.7 1.3 – 1.9 1.9 2.1 2.2 1.8 0.7 1.8 1.8
Intensity Change (Log2) – – – -0.15 -0.05 -0.32 -0.29 -0.23 -0.42 -0.34 -0.48 -0.39 – 0.03 0.03 0.19 0.25 0.19 -0.28 0.16 0.04

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 – 0 0 1.2 2.2 1.9
Cytoplasm 0 1.0 0 0 0.5 0 0 -0.2 0 – 2.2 2.4 1.1 0 -0.2
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 – 0 0 0 0 -0.2
Endosome 0 2.4 0 0.3 0.2 0 0 0 0 – 0 0.4 0.6 0 0
Golgi -2.2 -3.9 -9.5 -10.1 -9.1 -9.9 -8.8 -8.7 -6.1 – 0.3 -2.1 0.7 1.5 1.0
Mitochondria 6.6 3.3 6.8 7.2 6.6 10.1 7.7 9.0 9.1 – 2.3 1.0 -7.2 -6.4 -6.7
Nucleus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0
Vacuole -5.6 -2.3 -3.5 -3.3 -4.9 -5.6 -3.0 -6.7 -4.1 – -3.7 -2.9 -1.0 0 -1.1

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 4.6162 5.3326 5.5948 5.2356 5.2123 5.6045 4.6582 4.8961 4.676 4.419 4.8961 4.8952 5.6641 5.9661 5.3942 6.1152 5.8797 5.5109
Actin 0.003 0.0101 0.0066 0.0007 0.0011 0.0016 0.0296 0.0071 0.0026 0.0012 0.0017 0.0018 0.0833 0.0148 0.0189 0.0134 0.0066 0.0121
Bud 0.0001 0.0057 0.0011 0.0003 0.0004 0.0004 0.0008 0.0018 0.0011 0.0003 0.0003 0.0014 0.0009 0.0011 0.0012 0.0005 0.0001 0.0005
Bud Neck 0.0001 0.0005 0.0025 0.0002 0.0002 0.001 0.0012 0.0004 0.0001 0.0001 0.0009 0.0001 0.0009 0.0014 0.0008 0.0007 0.0001 0.0011
Bud Periphery 0.0002 0.0069 0.0032 0.0016 0.0015 0.0009 0.0014 0.0041 0.0019 0.0006 0.001 0.0047 0.0025 0.0019 0.0035 0.0009 0.0002 0.0014
Bud Site 0.0002 0.0177 0.0066 0.0003 0.0004 0.0005 0.0043 0.0075 0.0067 0.0011 0.0014 0.0001 0.0023 0.0132 0.0194 0.0014 0.0005 0.0008
Cell Periphery 0.0001 0.0007 0.0018 0.0017 0.0001 0.0003 0.0004 0.0007 0.0003 0.0001 0.0006 0.0001 0.0014 0.0015 0.0046 0.0003 0.0001 0.0009
Cytoplasm 0.0001 0.0009 0.0028 0 0.0002 0.0005 0.0023 0.0016 0.0053 0.001 0.0054 0.0001 0.0024 0.0018 0.0016 0.0036 0.0001 0.0078
Cytoplasmic Foci 0.0036 0.0158 0.0244 0.0003 0.0067 0.0063 0.0203 0.0198 0.0062 0.0048 0.0097 0.0034 0.0097 0.0235 0.0052 0.0271 0.014 0.0092
Eisosomes 0.0002 0.0004 0.0013 0.0003 0.0001 0.0002 0.0004 0.0002 0.0003 0.0001 0.0002 0.0001 0.0009 0.0005 0.0038 0.0003 0.0001 0.0004
Endoplasmic Reticulum 0.0001 0.0014 0.0008 0.0001 0.0002 0.0002 0.001 0.0006 0.0009 0.0001 0.0009 0.0001 0.0248 0.0005 0.0067 0.0007 0 0.0033
Endosome 0.017 0.1556 0.0354 0.0026 0.0224 0.0325 0.0455 0.0639 0.0265 0.0343 0.0314 0.0177 0.0603 0.0595 0.0248 0.0714 0.0022 0.0326
Golgi 0.0314 0.062 0.0607 0.0013 0.0233 0.0154 0.045 0.0508 0.0243 0.0067 0.0206 0.0306 0.0257 0.0376 0.0394 0.1076 0.0042 0.0467
Lipid Particles 0.0097 0.0419 0.0086 0.0006 0.0076 0.0071 0.017 0.0074 0.0043 0.0033 0.0134 0.0055 0.0501 0.0166 0.0023 0.0197 0.0058 0.0129
Mitochondria 0.9267 0.6142 0.8135 0.9821 0.9247 0.9191 0.7811 0.7825 0.9055 0.9045 0.8643 0.9249 0.6408 0.7724 0.8437 0.7023 0.9025 0.8506
None 0.0001 0.0005 0.0006 0.0001 0.0001 0.0001 0.0053 0.0003 0.001 0.0001 0.0182 0.0001 0.0029 0.0016 0.0006 0.0003 0.0001 0.0008
Nuclear Periphery 0 0.0011 0.0011 0.0001 0.0001 0.0003 0.0032 0.0011 0.0003 0.0001 0.0012 0.0001 0.0206 0.0002 0.0072 0.0002 0 0.0073
Nucleolus 0.0001 0.0008 0.0004 0.0002 0.0001 0.0002 0.0014 0.0014 0.0002 0.0001 0.006 0.0001 0.0006 0.0008 0.0004 0.0005 0 0.0002
Nucleus 0.0001 0.0006 0.0004 0.0001 0.0001 0.0002 0.0043 0.0006 0.0002 0.0001 0.0027 0.0001 0.0039 0.0004 0.0005 0.0002 0 0.0006
Peroxisomes 0.005 0.0097 0.0098 0.0016 0.0058 0.0051 0.0249 0.0231 0.0059 0.0373 0.0042 0.0041 0.0327 0.0207 0.0061 0.0374 0.0619 0.0052
Punctate Nuclear 0 0.0003 0.0001 0 0.0001 0 0.001 0.0001 0.0001 0 0.0021 0 0.0012 0.0002 0 0.0002 0.0004 0.0006
Vacuole 0.0008 0.0257 0.0068 0.0022 0.0017 0.0039 0.0052 0.0159 0.003 0.0027 0.0109 0.0027 0.0124 0.021 0.0055 0.0045 0.0004 0.0022
Vacuole Periphery 0.0013 0.0275 0.0116 0.0036 0.0032 0.0042 0.0045 0.0092 0.0036 0.0011 0.0028 0.0023 0.0196 0.0088 0.0038 0.0069 0.0007 0.0029

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 12.2203 10.6578 8.6994 10.6575 7.7289 10.7241 16.7029 16.3645 14.3318 12.2649
Translational Efficiency 0.5957 0.6968 0.8253 0.6722 0.7353 0.7273 0.7658 0.62 0.7833 0.6027

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1089 1587 2850 1230 1527 1428 215 664 2616 3015 3065 1894

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 707.68 866.89 1049.51 915.35 755.61 797.97 945.91 866.49 735.66 834.25 1042.24 898.22
Standard Deviation 87.92 134.17 142.82 131.78 99.56 120.67 140.81 123.24 97.79 132.50 145.11 130.94
Intensity Change Log 2 — 0.292752 0.568547 0.371226 — 0.078693 0.324061 0.197541 — 0.186185 0.447477 0.284152

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000821 0.001064 0.001998 0.035148 0.000295 0.000827 0.003405 0.001100 0.000514 0.000952 0.002097 0.023212
Bud Neck 0.010073 0.001201 0.001235 0.005928 0.002766 0.003307 0.058105 0.012461 0.005808 0.002199 0.005224 0.008218
Bud Site 0.012014 0.005591 0.011822 0.203689 0.005719 0.009554 0.021545 0.042702 0.008340 0.007468 0.012504 0.147250
Cell Periphery 0.000610 0.000530 0.000377 0.003162 0.000595 0.000463 0.001208 0.000468 0.000601 0.000498 0.000435 0.002217
Cytoplasm 0.007505 0.000730 0.001917 0.036145 0.001233 0.003416 0.022146 0.013330 0.003844 0.002002 0.003336 0.028147
Cytoplasmic Foci 0.047670 0.013568 0.014839 0.035940 0.013044 0.018682 0.096676 0.051549 0.027458 0.015990 0.020580 0.041412
Eisosomes 0.000093 0.000041 0.000036 0.000223 0.000038 0.000050 0.000335 0.000075 0.000061 0.000046 0.000057 0.000171
Endoplasmic Reticulum 0.001071 0.000377 0.000921 0.003278 0.000626 0.000615 0.003247 0.003510 0.000811 0.000490 0.001084 0.003360
Endosome 0.066563 0.034116 0.027092 0.036197 0.042127 0.065774 0.100322 0.105601 0.052299 0.049110 0.032229 0.060529
Golgi 0.100368 0.052171 0.067849 0.080656 0.048861 0.058238 0.055322 0.068982 0.070303 0.055045 0.066970 0.076563
Lipid Particles 0.006950 0.000990 0.000330 0.000289 0.001434 0.002691 0.035891 0.004664 0.003730 0.001795 0.002824 0.001823
Mitochondria 0.657894 0.839159 0.720113 0.439907 0.811253 0.737913 0.326181 0.372389 0.747412 0.791206 0.692480 0.416236
Mitotic Spindle 0.007666 0.004912 0.028458 0.029043 0.004228 0.009705 0.039487 0.071393 0.005659 0.007182 0.029231 0.043890
None 0.001268 0.000258 0.000574 0.000758 0.000355 0.000726 0.003611 0.000529 0.000735 0.000480 0.000787 0.000677
Nuclear Periphery 0.000520 0.000084 0.000556 0.000088 0.000247 0.000172 0.005331 0.002381 0.000361 0.000126 0.000891 0.000892
Nuclear Periphery Foci 0.000585 0.000164 0.000601 0.000203 0.000203 0.000425 0.004122 0.001977 0.000362 0.000288 0.000848 0.000825
Nucleolus 0.000843 0.000474 0.000199 0.000127 0.000332 0.000831 0.022150 0.001930 0.000545 0.000643 0.001739 0.000759
Nucleus 0.002559 0.000730 0.000283 0.001234 0.000447 0.001458 0.040908 0.005199 0.001326 0.001075 0.003133 0.002624
Peroxisomes 0.032350 0.007172 0.003194 0.026719 0.009672 0.013540 0.041268 0.018103 0.019112 0.010188 0.005865 0.023699
Vacuole 0.016588 0.015396 0.044362 0.037428 0.018067 0.034061 0.066408 0.137391 0.017451 0.024236 0.045908 0.072473
Vacuole Periphery 0.025988 0.021271 0.073246 0.023838 0.038458 0.037550 0.052334 0.084266 0.033267 0.028981 0.071779 0.045023

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -0.89 -2.74 -10.69 -10.60 -10.25 -2.21 -1.80 -4.41 -0.98 1.31 -2.47 -3.95 -10.72 -10.49 -9.80
Bud Neck 5.24 5.25 2.33 -8.24 -8.72 -0.52 -5.46 -5.76 -5.36 4.44 3.99 0.56 -2.42 -8.12 -3.14
Bud Site 4.05 0.07 -25.52 -26.62 -25.73 -2.35 -3.75 -9.05 -7.79 -3.73 0.79 -3.52 -25.95 -26.05 -25.00
Cell Periphery 0.54 2.26 -6.61 -6.71 -7.39 0.68 -1.80 0.65 -0.03 2.57 0.77 1.35 -5.94 -6.75 -7.13
Cytoplasm 5.26 4.19 -10.87 -15.18 -14.57 -2.35 -4.08 -6.63 -4.94 1.61 2.50 0.50 -13.94 -15.26 -14.42
Cytoplasmic Foci 12.53 12.41 3.53 -9.72 -9.54 -3.86 -7.88 -10.70 -8.91 4.13 7.98 4.06 -6.44 -12.82 -9.67
Eisosomes 7.24 8.31 -9.31 -14.55 -15.17 -3.02 -5.58 -8.02 -4.44 4.88 4.04 0.64 -12.56 -14.73 -12.24
Endoplasmic Reticulum 2.93 0.49 -3.79 -5.38 -4.15 0.06 -3.69 -4.07 -4.12 -0.34 2.26 -1.26 -5.76 -6.70 -4.95
Endosome 7.75 10.21 7.21 -0.68 -3.86 -5.66 -5.99 -10.85 -6.42 -0.63 1.11 8.08 -2.52 -3.71 -10.49
Golgi 8.29 5.80 3.17 -5.43 -2.48 -2.23 -0.66 -3.25 -1.66 -1.50 4.41 0.94 -1.31 -5.31 -2.20
Lipid Particles 4.63 5.39 5.40 1.71 0.22 -1.39 -5.84 -2.74 -1.51 5.20 2.72 1.21 2.66 -0.14 1.62
Mitochondria -15.20 -5.29 15.25 32.93 23.63 7.04 20.24 30.05 23.79 -1.85 -5.59 6.63 33.06 38.85 27.35
Mitotic Spindle 1.97 -9.91 -8.81 -10.76 -0.23 -3.88 -4.52 -10.29 -9.29 -3.18 -1.60 -13.18 -13.84 -13.11 -4.61
None 3.20 2.21 1.54 -4.40 -1.62 -1.61 -2.29 -2.69 0.85 2.17 1.50 -0.32 0.41 -1.49 0.91
Nuclear Periphery 1.61 -0.14 1.58 -0.26 7.83 0.80 -3.10 -2.37 -2.46 1.55 1.88 -2.98 -1.57 -2.43 -0.02
Nuclear Periphery Foci 2.51 -0.11 2.25 -0.76 3.77 -1.37 -3.46 -6.06 -4.76 1.80 0.71 -3.50 -3.71 -4.16 0.04
Nucleolus 1.14 4.10 4.89 1.15 1.11 -2.14 -4.00 -3.48 -2.23 3.74 -0.46 -3.06 -1.17 -0.48 2.50
Nucleus 2.02 2.79 1.30 -1.16 -2.69 -2.30 -5.18 -3.19 -2.44 4.49 0.57 -2.69 -2.09 -2.55 0.51
Peroxisomes 8.25 10.25 1.55 -7.29 -9.65 -1.83 -5.70 -3.13 -1.60 3.87 5.18 8.78 -2.04 -6.60 -9.52
Vacuole 0.64 -12.96 -7.61 -8.14 1.30 -6.58 -6.12 -17.00 -14.27 -6.63 -4.52 -15.45 -17.11 -14.60 -7.90
Vacuole Periphery 2.09 -15.39 0.90 -1.07 16.12 0.29 -1.84 -8.35 -8.72 -3.97 2.16 -13.57 -4.26 -6.31 8.43
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein that regulates expression of Fo-F1 ATP synthase subunits; involved in the regulation of mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; functions with Nca3p
Localization
Cell Percentages mitochondrion (96%)
Cell Cycle Regulation No
Subcompartmental Group mito-2

Nca2

Nca2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Nca2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available