Standard name
Human Ortholog
Description Second largest subunit of DNA polymerase II (DNA polymerase epsilon); required for maintenance of fidelity of chromosomal replication; essential motif in C-terminus is required for formation of the four-subunit Pol epsilon; expression peaks at the G1/S phase boundary; Cdc28p substrate
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.46 0.35 0.51 0.41 0.17 0.1 0.08 0.13 0.09 – 0.13 0.09 0.17 0.29 0.4 0.54 0.57 0.53 0.33 0.25 0.38 0.27 0.35 0.41
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 – 0 0 0.1 0.22 0.08 0 0 0 0.07 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.06 0.11 0 0.38 – 0.38 0.2 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.12 0.17 0.39 0.45 0.61 0.75 0.76 0.73 0.69 – 0.6 0.65 0.22 0.08 0.11 0.21 0.13 0.17 0.31 0.42 0.27 0.24 0.14 0.11
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.08 0.06 0.08 0 0 0
Vac/Vac Membrane 0.44 0.57 0.17 0.19 0.28 0.17 0.14 0.15 0.07 – 0.12 0.17 0.58 0.6 0.49 0.4 0.43 0.46 0.12 0.12 0.18 0.38 0.39 0.33
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 2 2 1 0 0 1 1 – 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Bud 1 1 0 1 0 0 4 5 8 – 14 3 0 1 0 0 0 0 6 13 7 6 9 18
Bud Neck 0 0 0 2 5 1 0 1 0 – 1 0 0 0 0 0 0 0 2 2 3 1 2 3
Bud Site 0 0 0 0 1 1 5 0 6 – 1 4 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 2 1 0 0 0 1 0 – 0 0 0 0 0 3 1 3 0 0 0 0 0 0
Cytoplasm 82 74 137 129 86 66 76 90 47 – 96 63 59 144 202 137 140 153 74 67 147 49 105 182
Endoplasmic Reticulum 3 1 11 2 1 0 2 1 0 – 0 0 0 1 7 9 7 11 0 0 2 4 2 8
Endosome 7 7 0 1 2 4 8 15 1 – 1 13 37 110 42 1 1 2 15 12 5 1 4 5
Golgi 1 0 0 0 0 0 0 0 0 – 0 0 0 0 0 1 2 3 1 0 0 0 3 1
Mitochondria 8 7 0 2 2 37 103 18 193 – 283 140 8 2 2 4 1 1 0 1 7 3 8 16
Nucleus 22 35 107 140 315 492 683 498 351 – 445 451 78 42 57 53 32 49 70 115 107 43 42 51
Nuclear Periphery 0 0 0 0 0 0 0 1 2 – 0 1 0 0 0 1 0 0 3 1 0 0 2 2
Nucleolus 1 1 0 0 0 1 12 6 5 – 6 9 2 12 4 0 0 0 3 4 2 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 1 3 5 2 8 10 4 – 5 3 0 2 0 1 0 0 19 17 30 2 3 3
Vac/Vac Membrane 78 120 46 59 145 110 123 103 35 – 87 120 207 300 244 103 106 131 28 31 68 69 117 146
Unique Cell Count 178 210 271 313 517 653 902 683 507 738 695 355 502 500 256 246 286 230 273 391 185 304 448
Labelled Cell Count 203 246 306 342 563 714 1024 750 653 939 807 391 614 558 313 290 353 230 273 391 185 304 448


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.4 6.0 6.5 5.9 6.5 5.5 5.6 6.1 4.6 – 4.7 5.3 6.6 6.8 6.8 12.7 12.7 13.0 5.7 5.5 6.0
Std Deviation (1e-4) 1.1 1.1 0.7 0.7 0.9 0.7 0.9 0.9 0.8 – 0.8 0.9 1.3 1.4 1.2 2.4 2.6 2.4 1.0 0.9 1.3
Intensity Change (Log2) – – – -0.15 0.0 -0.25 -0.2 -0.09 -0.49 – -0.46 -0.29 0.01 0.07 0.06 0.96 0.97 1.0 -0.18 -0.23 -0.12

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP620RAP700051015WT3HU80HU120HU160051015WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3051015WT1AF100AF140AF180051015
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Cytoplasm -2.3 -10.0 -13.5 -15.8 -12.2 -12.9 – -12.5 -14.3 -9.1 -6.0 -2.7 0.7 1.4 0.7
Endoplasmic Reticulum -2.8 0 0 0 0 0 – 0 0 0 0 -2.3 -0.3 -0.8 -0.1
Endosome 0 0 0 0 0 0 – 0 0 5.5 8.3 4.9 0 0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Mitochondria 0 0 4.0 5.8 2.7 0 – 0 8.0 0 0 0 0 0 0
Nucleus 1.3 5.7 10.4 11.2 9.7 8.0 – 5.9 7.2 -4.8 -10.5 -9.1 -4.7 -6.8 -5.9
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Vacuole 0.6 3.4 0 -1.4 -0.7 -4.4 – -2.2 0.1 10.4 11.4 8.7 5.9 6.5 7.3

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.8579 2.465 2.2101 1.7706 1.1333 1.6417 1.6697 2.7534 2.781 1.9791 1.8979 2.0582 2.791 4.4729 3.8739 3.941 2.9641 3.5243
Actin 0.0088 0.0002 0.0026 0.0002 0.0002 0.0042 0.0224 0.0007 0.0087 0.0126 0.0021 0.0044 0.0443 0.0008 0.0012 0 0.0001 0.0259
Bud 0.0001 0.0001 0.0001 0.0001 0 0.0001 0.001 0.0002 0.0024 0.0004 0.0001 0.0005 0.0009 0.0031 0.0006 0 0 0.0005
Bud Neck 0.0011 0.0005 0.0028 0.0005 0.0006 0.0025 0.0014 0.0005 0.0014 0.0006 0.0007 0.0031 0.0012 0.0006 0.0017 0.0002 0.0006 0.0024
Bud Periphery 0.0002 0.0001 0.0002 0 0 0.0001 0.0012 0.0002 0.0013 0.0005 0.0001 0.0007 0.0009 0.0012 0.0004 0 0 0.0006
Bud Site 0.0006 0.0007 0.0063 0.0001 0.0001 0.0001 0.0069 0.0016 0.0069 0.0013 0.0001 0.0009 0.0052 0.0034 0.0092 0.0001 0.0001 0.0003
Cell Periphery 0.0001 0 0.0001 0 0 0 0.0003 0 0.0002 0.0001 0 0.0001 0.0003 0.0001 0.0001 0 0 0
Cytoplasm 0.0552 0.0793 0.0507 0.0832 0.0112 0.0341 0.0733 0.1524 0.1172 0.0764 0.0666 0.0603 0.1157 0.1739 0.1124 0.0554 0.0248 0.0736
Cytoplasmic Foci 0.0049 0.001 0.0056 0.0008 0.0011 0.0013 0.0358 0.0024 0.0043 0.0089 0.0078 0.0121 0.0459 0.0091 0.0098 0.0005 0.0001 0.0052
Eisosomes 0.0001 0 0.0001 0 0 0 0.0003 0 0.0001 0.0002 0 0 0.0002 0 0 0 0 0.0001
Endoplasmic Reticulum 0.0049 0.0048 0.001 0.0073 0.0003 0.0016 0.0051 0.0038 0.0047 0.0047 0.0015 0.0023 0.0068 0.0015 0.0021 0.0004 0.0003 0.005
Endosome 0.0106 0.0018 0.0035 0.0039 0.0002 0.0026 0.0612 0.0055 0.0077 0.0398 0.0065 0.022 0.0294 0.0022 0.0151 0.0002 0.0001 0.0159
Golgi 0.0017 0 0.0003 0 0 0.0002 0.014 0.0025 0.0026 0.0099 0.0057 0.0085 0.0264 0.0003 0.0008 0 0 0.0078
Lipid Particles 0.0023 0.0002 0.0003 0.0001 0 0.0003 0.0136 0.0003 0.0006 0.0033 0.03 0.0089 0.0247 0.0004 0.0004 0 0 0.0007
Mitochondria 0.0009 0.0002 0.0033 0.0002 0.0001 0.0004 0.0123 0.0097 0.0072 0.0258 0.0008 0.0162 0.011 0.0022 0.0005 0.0002 0.0001 0.0072
None 0.0304 0.0139 0.0013 0.036 0.0004 0.015 0.0126 0.005 0.0053 0.0017 0.0004 0.0011 0.0519 0.004 0.0008 0.0003 0.0985 0.0005
Nuclear Periphery 0.0293 0.0149 0.0146 0.0175 0.007 0.012 0.0243 0.0221 0.0311 0.0231 0.016 0.0144 0.0191 0.0151 0.0177 0.0091 0.0069 0.0131
Nucleolus 0.0037 0.0031 0.0045 0.0013 0.0031 0.0056 0.0065 0.0023 0.0188 0.0011 0.0009 0.0053 0.0025 0.0024 0.0043 0.0008 0.0013 0.0025
Nucleus 0.8189 0.8681 0.8812 0.8445 0.9384 0.8982 0.6635 0.7673 0.7588 0.7773 0.8431 0.8095 0.584 0.7693 0.7765 0.8969 0.865 0.8248
Peroxisomes 0.0021 0 0.0004 0 0 0.0001 0.0088 0.0003 0.0004 0.0028 0.0118 0.0078 0.0146 0.0003 0.0006 0 0 0.0071
Punctate Nuclear 0.0205 0.0097 0.0196 0.0025 0.0369 0.0204 0.0245 0.0211 0.0152 0.0038 0.0042 0.0169 0.01 0.009 0.0419 0.0354 0.0017 0.0051
Vacuole 0.0028 0.0011 0.0011 0.0013 0.0002 0.0009 0.0082 0.0017 0.004 0.0035 0.0013 0.0037 0.0039 0.001 0.0034 0.0003 0.0002 0.001
Vacuole Periphery 0.0007 0.0002 0.0005 0.0003 0.0001 0.0002 0.0029 0.0004 0.0012 0.002 0.0003 0.0011 0.0013 0.0003 0.0005 0.0001 0.0001 0.0005

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 38.1128 10.0067 4.2431 18.4853 25.5713 28.2358 10.9609 7.3166 12.3063 28.1693
Translational Efficiency 0.8467 0.6667 1.2351 0.559 0.7571 1.1806 0.6586 0.7035 0.7533 0.7508

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2325 671 1160 355 1624 392 1518 696 3949 1063 2678 1051

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 754.76 827.99 1023.71 1127.40 765.74 869.08 915.33 1067.35 759.28 843.14 962.28 1087.63
Standard Deviation 87.62 165.80 157.80 161.11 94.43 114.48 130.96 164.45 90.64 150.26 152.94 165.78
Intensity Change Log 2 — 0.133595 0.439717 0.578910 — 0.182634 0.257437 0.479107 — 0.158500 0.350797 0.529511

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000068 0.000667 0.000719 0.001744 0.000172 0.000610 0.000271 0.001135 0.000111 0.000646 0.000465 0.001341
Bud Neck 0.004640 0.004176 0.008056 0.013890 0.003380 0.006705 0.008927 0.015159 0.004122 0.005109 0.008550 0.014731
Bud Site 0.001804 0.003087 0.002618 0.044164 0.001638 0.008132 0.007888 0.009926 0.001736 0.004947 0.005605 0.021491
Cell Periphery 0.000104 0.000161 0.000148 0.000380 0.000107 0.000215 0.000368 0.000142 0.000105 0.000181 0.000273 0.000222
Cytoplasm 0.510846 0.276076 0.064402 0.171131 0.274678 0.227004 0.292876 0.211305 0.413723 0.257980 0.193911 0.197735
Cytoplasmic Foci 0.045260 0.019787 0.000487 0.022049 0.025760 0.058983 0.015306 0.005539 0.037241 0.034241 0.008887 0.011116
Eisosomes 0.000027 0.000062 0.000016 0.000063 0.000030 0.000080 0.000063 0.000021 0.000028 0.000069 0.000043 0.000035
Endoplasmic Reticulum 0.001108 0.005589 0.005681 0.015004 0.002839 0.004391 0.002227 0.003876 0.001820 0.005147 0.003723 0.007635
Endosome 0.002798 0.002566 0.000499 0.057703 0.001421 0.006617 0.002844 0.003437 0.002231 0.004060 0.001829 0.021766
Golgi 0.000416 0.000689 0.000084 0.027318 0.000346 0.004003 0.001261 0.001218 0.000387 0.001911 0.000751 0.010034
Lipid Particles 0.002191 0.002281 0.000336 0.002816 0.001785 0.006269 0.003134 0.001222 0.002024 0.003751 0.001922 0.001761
Mitochondria 0.001463 0.005031 0.001366 0.002818 0.001844 0.006846 0.001605 0.001378 0.001620 0.005700 0.001502 0.001864
Mitotic Spindle 0.003350 0.004749 0.005899 0.109505 0.003636 0.010786 0.010284 0.027159 0.003468 0.006975 0.008384 0.054974
None 0.020003 0.014363 0.004209 0.012226 0.009410 0.008919 0.019979 0.017640 0.015647 0.012356 0.013148 0.015812
Nuclear Periphery 0.001041 0.001518 0.001384 0.003200 0.001841 0.001450 0.001376 0.001458 0.001370 0.001493 0.001379 0.002046
Nuclear Periphery Foci 0.003426 0.004880 0.000697 0.012280 0.004310 0.003373 0.000994 0.001215 0.003790 0.004325 0.000865 0.004952
Nucleolus 0.005639 0.005609 0.000611 0.002021 0.005155 0.005179 0.001877 0.000715 0.005440 0.005450 0.001328 0.001156
Nucleus 0.385633 0.628505 0.892678 0.399821 0.652758 0.595020 0.596490 0.669781 0.495487 0.616157 0.724786 0.578596
Peroxisomes 0.001066 0.002297 0.000100 0.008211 0.000787 0.005027 0.001948 0.000383 0.000951 0.003304 0.001147 0.003027
Vacuole 0.008848 0.017616 0.009864 0.082510 0.007853 0.039143 0.028892 0.026886 0.008438 0.025555 0.020650 0.045674
Vacuole Periphery 0.000270 0.000291 0.000145 0.011143 0.000251 0.001248 0.001392 0.000405 0.000262 0.000644 0.000852 0.004032

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -8.90 -12.82 -10.61 -3.97 -3.33 -3.62 -6.72 -7.83 -2.76 -4.10 -9.18 -14.77 -13.01 -4.00 -4.81
Bud Neck -0.23 -7.18 -5.73 -5.61 -3.08 -2.62 -6.04 -5.89 -3.68 -1.63 -1.92 -8.59 -7.94 -6.81 -3.09
Bud Site -3.63 -3.35 -5.43 -4.37 -4.75 -2.90 -4.40 -5.26 -0.04 -0.95 -4.23 -5.41 -7.69 -3.56 -4.19
Cell Periphery -3.49 -2.56 -6.15 -3.50 -3.60 -3.74 -6.76 -3.84 2.28 4.96 -5.13 -6.62 -6.42 0.04 1.89
Cytoplasm 20.83 70.35 38.31 11.01 -7.42 3.34 5.05 12.12 5.28 7.55 17.63 41.77 36.10 11.28 1.59
Cytoplasmic Foci 8.61 23.99 20.04 5.89 -4.76 -5.56 8.91 13.29 10.52 6.21 1.67 22.71 24.37 11.85 3.43
Eisosomes -2.57 4.08 -9.51 -0.31 -11.10 -7.94 -8.79 -0.25 7.85 8.62 -4.47 -7.32 -7.24 2.75 -0.13
Endoplasmic Reticulum -10.57 -15.59 -9.05 -3.18 -2.87 -3.01 -6.46 -5.48 -0.39 0.21 -10.05 -16.84 -11.93 -1.68 -1.75
Endosome 0.20 5.16 -2.61 -2.63 -3.74 -5.46 -2.14 0.82 5.49 2.29 -3.11 2.22 -1.77 0.35 -2.75
Golgi -0.80 5.29 -1.80 -1.65 -2.01 -1.94 -1.02 -0.04 1.92 0.88 -2.08 -0.15 -1.72 0.39 -1.60
Lipid Particles -0.79 8.68 -0.04 0.75 -7.97 -3.90 -0.84 4.13 4.74 2.47 -3.66 1.66 3.57 5.03 0.36
Mitochondria -1.43 -0.67 -2.27 1.07 -2.96 -1.64 -0.11 -0.04 1.66 0.13 -2.13 -0.60 -1.19 1.93 -0.96
Mitotic Spindle -1.44 -2.14 -6.57 -6.04 -5.87 -1.60 -5.66 -5.14 -2.79 -1.37 -2.14 -6.12 -8.31 -6.61 -5.21
None 3.33 14.40 4.66 0.76 -5.12 0.72 -2.16 -3.47 -2.82 -0.43 3.00 5.90 2.34 -1.13 -3.26
Nuclear Periphery -2.98 -4.66 -8.41 -7.03 -7.05 0.97 -4.24 -3.75 -4.93 -0.78 -1.62 -6.99 -8.73 -7.89 -5.12
Nuclear Periphery Foci -2.06 5.07 0.03 1.83 -2.83 0.89 3.07 4.22 1.31 1.26 -1.10 4.75 3.34 2.91 -1.26
Nucleolus -0.09 8.87 7.60 3.67 -1.84 2.27 4.84 6.27 3.58 2.73 0.87 8.97 10.04 4.71 1.63
Nucleus -18.18 -68.50 -8.95 4.30 21.29 3.56 1.36 -3.57 -5.59 -4.55 -10.70 -34.57 -14.08 -2.46 9.68
Peroxisomes -1.38 3.82 -0.26 0.95 -1.90 -3.54 -0.91 4.26 4.24 3.10 -3.36 0.98 1.81 4.04 0.79
Vacuole -6.13 -4.46 -15.54 -13.67 -14.91 -7.42 -15.18 -11.81 -3.07 -2.71 -9.55 -15.48 -18.53 -12.52 -12.55
Vacuole Periphery -0.59 2.85 -2.34 -2.30 -2.53 -2.94 -1.57 0.65 3.05 1.67 -2.98 -1.36 -2.13 -0.22 -0.39
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Second largest subunit of DNA polymerase II (DNA polymerase epsilon); required for maintenance of fidelity of chromosomal replication; essential motif in C-terminus is required for formation of the four-subunit Pol epsilon; expression peaks at the G1/S phase boundary; Cdc28p substrate
Localization
Cell Percentages cytoplasm (33%), nucleus (19%), mixed (40%)
Cell Cycle Regulation Yes
cytoplasm - MA (1.3e-08)
Subcompartmental Group N/A

Dpb2

Dpb2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Dpb2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available