Standard name
Human Ortholog
Description Dolichol phosphate mannose (Dol-P-Man) synthase of ER membrane; catalyzes formation of Dol-P-Man from Dol-P and GDP-Man; required for biosynthesis of glycosyl phosphatidylinositol (GPI) membrane anchor, as well as O-mannosylation and protein N- and O-linked glycosylation; human homolog DPM1 can complement yeast mutant strains
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.09 0.06 0.13 0.09 0.17 0.11 0.07 0.07 0.06 0.07 0.07 0.09 0.06 0.08 0 0.13 0.22 0.17 0 0 0 0 0 0
Bud 0.05 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0.09 0.07 0.14 0.09 0.1 0.08 0.05 0.05 0.05 0.05 0 0.07 0.06 0.16 0.22 0.19 0.19 0.09 0 0 0 0 0 0
Cytoplasm 0.14 0.11 0.06 0.09 0.07 0.12 0.13 0.16 0.17 0.13 0.12 0.15 0 0 0 0.2 0.19 0.2 0 0 0 0 0 0
Endoplasmic Reticulum 0.63 0.92 0.88 0.86 0.78 0.78 0.76 0.48 0.64 0.55 0.67 0.63 0.89 0.89 0.89 0 0 0 0.82 0.92 0.9 0.89 0.89 0.83
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0.05 0 0 0.05 0 0 0 0 0 0 0 0 0.05 0 0 0.38 0.36 0.49 0 0 0 0 0 0
Mitochondria 0.25 0 0 0 0.07 0.11 0.14 0.15 0.16 0.13 0.27 0.23 0 0 0 0.06 0.08 0.07 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.05 0 0 0 0.06 0 0 0.2 0.11 0.2 0.08 0.05 0 0 0 0.06 0 0.06 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 5 8 20 19 69 23 25 25 22 34 20 41 7 25 6 16 30 14 2 1 2 3 4 9
Bud 3 1 4 4 11 4 3 16 15 11 3 8 1 0 1 4 7 2 2 0 0 0 1 4
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0
Bud Site 0 0 0 0 0 0 0 0 1 1 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 5 9 22 19 42 17 17 16 18 24 10 31 7 52 60 24 26 7 1 1 5 2 5 10
Cytoplasm 8 14 9 19 30 26 47 56 59 61 35 65 5 13 12 25 26 16 2 3 1 1 5 13
Endoplasmic Reticulum 36 122 137 186 323 169 273 168 224 255 199 280 101 282 243 5 4 2 69 135 151 143 217 266
Endosome 0 0 0 0 1 0 0 6 2 7 1 1 0 0 0 2 1 0 0 1 0 0 0 2
Golgi 3 0 2 10 17 0 2 2 0 5 4 3 6 8 1 48 49 40 0 0 0 2 0 0
Mitochondria 14 0 4 9 27 24 50 52 57 60 80 101 0 0 0 8 11 6 2 0 4 3 1 2
Nucleus 0 0 0 0 0 0 0 1 0 1 1 1 0 0 0 0 2 1 0 0 0 0 0 0
Nuclear Periphery 0 0 0 1 1 5 17 7 8 9 13 17 0 0 0 0 0 0 0 0 0 0 1 0
Nucleolus 0 0 0 0 1 0 1 1 0 1 1 0 0 0 0 1 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 3 1 1 2 24 4 14 70 39 91 23 22 3 1 2 8 6 5 1 2 0 2 4 6
Unique Cell Count 57 133 156 216 412 216 359 347 349 460 299 444 113 318 274 126 137 81 85 148 168 161 245 321
Labelled Cell Count 77 155 199 269 546 272 449 420 445 560 390 570 130 381 325 141 162 93 85 148 168 161 245 321


Endoplasmic Reticulum

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 17.5 24.6 16.5 17.2 14.7 12.3 11.4 11.8 11.6 11.3 11.4 11.3 21.6 21.9 22.1 24.1 24.3 26.1 23.7 23.9 25.5
Std Deviation (1e-4) 4.9 4.0 2.7 3.3 2.5 2.0 2.2 2.3 2.1 2.5 2.5 2.3 3.9 3.7 3.8 6.6 5.8 7.2 4.5 4.4 5.4
Intensity Change (Log2) – – – 0.05 -0.17 -0.43 -0.54 -0.49 -0.51 -0.54 -0.54 -0.56 0.39 0.4 0.42 0.55 0.55 0.66 0.52 0.53 0.62


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -1.3 1.1 -0.6 -2.2 -2.0 -2.5 -2.1 -2.2 -1.3 -1.8 -1.7 -4.4 0 2.1 0.9
Bud 0 0 0 0 1.1 0.9 0 0 0 0 0 0 0 1.1 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery -1.6 -1.3 -1.9 -3.7 -3.7 -3.4 -3.6 -4.3 -2.7 -2.1 0.6 2.0 1.1 1.1 -1.2
Cytoplasm 1.1 0.6 2.0 2.5 3.2 3.4 2.5 2.0 2.9 -0.5 -0.8 -0.6 3.6 3.5 3.3
Endoplasmic Reticulum -0.5 -2.6 -2.4 -3.0 -8.4 -5.4 -7.3 -4.9 -5.8 0.4 0.3 0.3 -14.0 -14.5 -12.7
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 1.8 1.7 0 0 0 0 0 0 0 0 0 0 8.0 7.8 9.2
Mitochondria 0.8 1.9 3.1 3.9 4.1 4.4 3.7 6.3 5.7 0 0 0 1.6 2.1 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 2.8 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 2.7 0 0 5.8 4.0 5.8 3.2 2.4 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 22.6109 23.6754 23.7385 23.7599 20.639 22.3024 20.9281 24.3039 21.7987 21.815 21.2101 21.7831 24.5137 23.9381 24.3944 22.5243 22.5099 22.8826
Actin 0.0211 0.0005 0.0018 0.0003 0.0002 0.0018 0.0058 0.0012 0.0093 0.0193 0.0035 0.0012 0.0029 0.0042 0.0035 0.0001 0.0002 0.0014
Bud 0.0004 0 0.0004 0.0001 0 0 0.0001 0 0.0002 0.0001 0.0001 0 0.0001 0 0.0007 0 0 0
Bud Neck 0.0004 0.0003 0.0007 0.0004 0.0002 0.0025 0.0006 0.0005 0.0008 0.0005 0.0008 0.0004 0.0005 0.0003 0.0005 0.0002 0.0002 0.0005
Bud Periphery 0.0012 0.0001 0.0018 0.0006 0.0001 0.0002 0.0004 0.0001 0.0006 0.0003 0.0006 0.0001 0.0003 0.0001 0.0041 0.0001 0.0001 0.0001
Bud Site 0.0012 0.0002 0.0002 0 0 0 0.0003 0.0004 0.0013 0.0003 0.0001 0 0.0003 0.0001 0.0005 0 0 0
Cell Periphery 0.0165 0.0184 0.0296 0.0207 0.0176 0.0108 0.0125 0.0255 0.0129 0.0114 0.01 0.0073 0.0211 0.0238 0.03 0.0136 0.0069 0.0081
Cytoplasm 0.0128 0.006 0.0084 0.0023 0.0032 0.0033 0.0171 0.0056 0.0048 0.0018 0.008 0.003 0.0074 0.0058 0.0051 0.0011 0.0023 0.0022
Cytoplasmic Foci 0.0084 0.002 0.0012 0.0008 0.0008 0.0008 0.0127 0.0033 0.0051 0.0037 0.0022 0.002 0.0022 0.0014 0.0011 0.0002 0.0002 0.0009
Eisosomes 0.0012 0.0003 0.0022 0.0006 0.0008 0.0006 0.0007 0.0006 0.0005 0.0012 0.0011 0.0003 0.0008 0.0003 0.0017 0.0002 0.0004 0.0007
Endoplasmic Reticulum 0.7233 0.7812 0.8141 0.8083 0.8566 0.8819 0.7902 0.7582 0.8222 0.8421 0.8175 0.861 0.7366 0.8102 0.7806 0.9551 0.9641 0.8857
Endosome 0.0141 0.0053 0.0058 0.0038 0.0037 0.0046 0.0153 0.0066 0.0148 0.0053 0.01 0.0094 0.01 0.0036 0.0034 0.0013 0.0017 0.0069
Golgi 0.0174 0.0177 0.0121 0.0181 0.0142 0.0127 0.0176 0.0236 0.0291 0.0184 0.0211 0.0196 0.0407 0.0208 0.0199 0.0024 0.009 0.0323
Lipid Particles 0.1413 0.1546 0.0976 0.1243 0.0898 0.0681 0.0692 0.1635 0.076 0.0836 0.1084 0.0818 0.1277 0.1175 0.1282 0.0164 0.007 0.0516
Mitochondria 0.0043 0.0002 0.0015 0.0019 0.0002 0.0003 0.0011 0.0003 0.0015 0.004 0.0021 0.001 0.0003 0.0001 0.0003 0 0.0001 0.0008
None 0.0017 0.0001 0.0003 0.0001 0.0003 0.0001 0.0151 0.0002 0.0003 0.0008 0.0002 0.0002 0.0002 0.0001 0.0001 0.0001 0.0001 0.0001
Nuclear Periphery 0.0212 0.0047 0.0083 0.0035 0.0062 0.0068 0.0269 0.0035 0.0069 0.0035 0.0074 0.0064 0.0326 0.0058 0.0085 0.0055 0.0049 0.0055
Nucleolus 0.0001 0.0001 0.0001 0.0001 0 0 0.0002 0 0.0001 0 0.0001 0.0002 0.0001 0 0.0001 0 0 0
Nucleus 0.0007 0.0002 0.0004 0.0001 0.0002 0.0003 0.002 0.0001 0.0007 0.0001 0.0003 0.0012 0.0006 0.0001 0.0003 0.0001 0.0001 0.0001
Peroxisomes 0.0008 0 0 0 0 0 0.0011 0.0001 0.004 0.0007 0.0001 0 0 0 0 0 0 0
Punctate Nuclear 0.0009 0.0001 0.0001 0 0.0001 0.0001 0.0026 0.0001 0.0004 0.0002 0.0002 0.0002 0.0002 0.0001 0.0001 0 0 0.0001
Vacuole 0.0093 0.0074 0.0112 0.0129 0.0052 0.0044 0.0067 0.0063 0.0072 0.0021 0.0041 0.0034 0.0127 0.0054 0.01 0.0032 0.0023 0.0023
Vacuole Periphery 0.0016 0.0004 0.002 0.001 0.0007 0.0007 0.0019 0.0004 0.0013 0.0006 0.002 0.0012 0.0027 0.0003 0.0014 0.0003 0.0004 0.0006

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 220.9554 175.4376 147.4792 143.7648 185.0543 207.1167 179.5555 147.7697 153.1766 172.7041
Translational Efficiency 1.7585 2.0699 1.8503 2.3148 2.5112 2.4806 1.8945 2.5904 2.1062 2.3136

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✔
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2721 1551 170 1241 2433 1541 333 1537 5154 3092 503 2778

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1590.31 1940.50 2744.62 2598.17 1906.97 1786.60 2665.89 2693.49 1739.79 1863.80 2692.50 2650.91
Standard Deviation 259.81 381.75 468.53 488.84 304.80 329.94 367.09 507.48 323.24 365.07 405.94 501.48
Intensity Change Log 2 — 0.287120 0.787298 0.708188 — -0.094065 0.483335 0.498195 — 0.091820 0.629531 0.597487

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000108 0.000950 0.000661 0.003540 0.000111 0.001553 0.001162 0.002075 0.000109 0.001251 0.000993 0.002729
Bud Neck 0.000048 0.000489 0.011053 0.002124 0.000126 0.000685 0.002914 0.000999 0.000085 0.000587 0.005664 0.001501
Bud Site 0.000460 0.002066 0.004237 0.006136 0.000448 0.003464 0.001824 0.003644 0.000454 0.002763 0.002640 0.004757
Cell Periphery 0.008696 0.013299 0.190356* 0.137921* 0.010080 0.013721 0.080303 0.118568* 0.009349 0.013509 0.117497* 0.127213*
Cytoplasm 0.001181 0.001326 0.000135 0.001599 0.000456 0.001248 0.000049 0.000817 0.000838 0.001287 0.000078 0.001166
Cytoplasmic Foci 0.000954 0.002452 0.000246 0.001591 0.000330 0.001602 0.000099 0.001753 0.000660 0.002029 0.000149 0.001681
Eisosomes 0.000227 0.000656 0.002836 0.003160 0.000363 0.000505 0.007084 0.003081 0.000291 0.000581 0.005648 0.003116
Endoplasmic Reticulum 0.973655* 0.923832* 0.591679* 0.578026* 0.965721* 0.942873* 0.786668* 0.629382* 0.969910* 0.933322* 0.720767* 0.606440*
Endosome 0.002687 0.010205 0.014141 0.010369 0.003741 0.006854 0.007976 0.010687 0.003185 0.008535 0.010060 0.010545
Golgi 0.001841 0.009218 0.022466 0.025862 0.003616 0.005249 0.019697 0.035294 0.002679 0.007240 0.020633 0.031081
Lipid Particles 0.004952 0.027053 0.056694 0.174596* 0.011138 0.014503 0.056002 0.147610* 0.007872 0.020798 0.056236 0.159666*
Mitochondria 0.000390 0.000226 0.000122 0.000934 0.000172 0.000742 0.000132 0.001758 0.000287 0.000483 0.000129 0.001390
Mitotic Spindle 0.000074 0.000106 0.000470 0.001678 0.000074 0.000537 0.000272 0.001425 0.000074 0.000321 0.000339 0.001538
None 0.001128 0.000387 0.000023 0.000290 0.000633 0.000258 0.000065 0.000290 0.000894 0.000323 0.000051 0.000290
Nuclear Periphery 0.000421 0.000644 0.007617 0.011027 0.000686 0.000468 0.006675 0.009947 0.000546 0.000556 0.006993 0.010430
Nuclear Periphery Foci 0.000185 0.001469 0.007149 0.003330 0.000296 0.000712 0.001363 0.001780 0.000238 0.001092 0.003319 0.002472
Nucleolus 0.000004 0.000005 0.000015 0.000030 0.000003 0.000121 0.000011 0.000033 0.000003 0.000063 0.000012 0.000031
Nucleus 0.000043 0.000056 0.000179 0.000233 0.000037 0.000132 0.000074 0.000200 0.000040 0.000094 0.000110 0.000214
Peroxisomes 0.002234 0.000877 0.000027 0.001257 0.000779 0.000995 0.000060 0.002743 0.001547 0.000936 0.000049 0.002079
Vacuole 0.000488 0.003637 0.084881 0.031190 0.000924 0.002624 0.025440 0.022601 0.000694 0.003132 0.045529 0.026438
Vacuole Periphery 0.000225 0.001046 0.005013 0.005106 0.000266 0.001152 0.002129 0.005314 0.000244 0.001099 0.003104 0.005221

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.95 -3.95 -4.13 -2.97 -3.42 -2.88 -2.91 -3.60 -0.76 -1.45 -3.97 -3.65 -5.48 -2.71 -3.29
Bud Neck -6.15 -3.43 -9.20 -6.96 2.79 -3.60 -5.29 -9.51 -1.82 3.56 -5.89 -4.82 -12.51 -6.58 3.59
Bud Site -3.48 -3.37 -4.99 -3.39 -1.20 -3.84 -2.41 -4.92 -0.33 -2.26 -5.09 -4.08 -6.92 -2.76 -2.68
Cell Periphery -3.78 -10.32 -23.53 -22.36 2.83 -2.72 -9.64 -23.99 -22.73 -4.49 -4.61 -13.55 -33.62 -31.87* -1.13
Cytoplasm -0.42 4.14 -1.08 -0.57 -3.61 -2.56 3.99 -2.00 1.20 -4.76 -1.67 5.40 -1.56 0.24 -5.35
Cytoplasmic Foci -2.32 3.51 -1.22 1.07 -2.68 -3.55 3.58 -4.21 -0.29 -4.95 -3.69 4.74 -3.34 0.76 -5.27
Eisosomes -4.55 -4.46 -8.57 -7.19 -0.49 -1.37 -4.06 -10.58 -9.69 2.39 -4.14 -4.80 -13.54 -11.87 2.23
Endoplasmic Reticulum 12.46 14.80 43.39* 35.26* 0.47 6.11 12.95 42.43* 37.02* 9.96 13.36 18.77 60.61 50.75* 7.85
Endosome -10.73 -5.05 -13.34 -0.22 1.66 -6.09 -5.16 -13.54 -5.63 -2.86 -12.31 -7.26 -19.30 -3.61 -0.41
Golgi -9.74 -6.52 -19.83 -11.72 -1.00 -3.09 -6.88 -19.29 -17.61 -5.48 -9.85 -9.56 -26.77 -20.77 -4.85
Lipid Particles -10.33 -5.19 -25.43 -21.15 -9.67 -2.05 -5.96 -24.43 -23.57 -9.78 -9.59 -8.07 -35.36 -31.31 -13.92
Mitochondria 2.30 4.31 -1.84 -2.38 -2.74 -2.12 1.23 -2.75 -1.61 -2.81 -1.44 4.32 -3.19 -2.46 -3.64
Mitotic Spindle -1.54 -3.24 -4.60 -4.52 -3.49 -1.48 -6.05 -2.92 -1.58 -2.51 -1.58 -5.58 -5.05 -3.82 -4.19
None 3.04 5.55 4.12 0.66 -6.92 2.60 4.83 2.68 -0.34 -4.71 3.95 7.08 4.89 0.37 -7.42
Nuclear Periphery -4.27 -10.46 -18.73 -18.29 -3.78 4.20 -10.08 -20.49 -21.02 -4.39 -0.30 -14.13 -27.79 -27.73 -5.91
Nuclear Periphery Foci -5.28 -5.82 -7.04 -3.67 3.01 -4.48 -6.75 -16.83 -8.62 -2.38 -6.53 -7.06 -10.82 -5.67 1.78
Nucleolus -0.89 -5.43 -11.22 -9.16 -4.46 -1.34 -5.96 -9.65 1.03 -6.53 -1.35 -7.84 -14.00 0.77 -8.25
Nucleus -1.69 -3.85 -9.02 -7.92 -1.36 -2.09 -4.30 -9.20 -1.23 -6.52 -2.34 -5.17 -12.85 -4.33 -5.57
Peroxisomes 3.69 7.35 2.36 -1.05 -4.27 -0.82 4.82 -3.64 -3.06 -5.17 2.60 8.61 -1.47 -3.24 -6.44
Vacuole -5.34 -10.66 -18.90 -15.88 6.63 -4.09 -9.39 -16.60 -14.62 0.87 -6.75 -13.11 -25.08 -21.39 5.29
Vacuole Periphery -2.92 -6.46 -11.11 -7.78 -0.10 -3.39 -6.96 -9.80 -7.25 -5.57 -4.45 -9.15 -14.37 -10.44 -4.61
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Dolichol phosphate mannose (Dol-P-Man) synthase of ER membrane; catalyzes formation of Dol-P-Man from Dol-P and GDP-Man; required for biosynthesis of glycosyl phosphatidylinositol (GPI) membrane anchor, as well as O-mannosylation and protein N- and O-linked glycosylation; human homolog DPM1 can complement yeast mutant strains
Localization
Cell Percentages ER (99%)
Cell Cycle Regulation No
Subcompartmental Group ER-5

Dpm1

Dpm1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Dpm1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available