Standard name
Human Ortholog
Description Minor isoform of pyruvate decarboxylase; key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde, regulation is glucose- and ethanol-dependent, repressed by thiamine, involved in amino acid catabolism
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.81 0.81 0.88 0.89 0.88 0.87 0.86 – 0.81 0.79 0.7 0.82 0.77 0.9 0.9 0.43 0.54 0.58 0.65 0.68 0.62 0.57 0.79 0.73
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.08 0 0 0 0 0.1 0.09 – 0.28 0.19 0.41 0.22 0.06 0 0 0 0 0 0.07 0 0.07 0 0 0
Nucleus 0.06 0.09 0.07 0.08 0.05 0 0 – 0 0 0 0 0.09 0.1 0.09 0.17 0.17 0.09 0.12 0.14 0.11 0.22 0.05 0.06
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.12 0.15 0.05 0 0.09 0 0 – 0 0 0 0 0.11 0 0.05 0.49 0.39 0.43 0.06 0.08 0.1 0.06 0.07 0.09
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 1 – 0 1 0 0 0 0 0 0 0 0 1 1 3 0 0 0
Bud 0 0 0 0 0 2 4 – 6 2 7 6 0 0 0 0 0 0 6 4 1 0 0 0
Bud Neck 0 1 2 5 7 4 12 – 7 9 4 14 0 0 0 0 0 0 3 1 2 0 0 0
Bud Site 0 0 0 0 0 1 0 – 1 1 4 1 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 1 0 2 0 1 4 – 0 3 3 2 0 0 0 2 3 1 0 0 2 0 0 0
Cytoplasm 201 180 170 304 280 347 470 – 263 262 354 478 27 27 95 62 90 118 169 166 125 13 35 41
Endoplasmic Reticulum 1 0 0 0 1 0 0 – 0 3 4 0 0 0 0 5 4 3 1 0 0 0 0 0
Endosome 0 1 2 2 1 3 5 – 0 0 0 1 0 0 1 4 5 8 2 2 1 0 0 0
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 1 1 0 0 0 0 0 0 0
Mitochondria 20 2 1 5 1 40 48 – 90 64 206 126 2 0 0 4 1 1 17 7 14 0 0 1
Nucleus 15 19 14 26 17 16 14 – 6 7 9 3 3 3 9 24 29 19 30 35 22 5 2 3
Nuclear Periphery 0 0 0 0 0 0 0 – 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 1 0 – 0 1 0 0 1 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 1 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 1 1 1 1 1 5 12 – 8 6 8 15 0 0 0 0 2 0 6 1 1 0 1 0
Vac/Vac Membrane 29 34 9 9 28 16 12 – 7 10 5 12 4 0 5 70 64 88 16 18 20 1 3 4
Unique Cell Count 248 223 194 342 319 399 544 325 331 504 585 35 30 105 144 166 205 262 244 201 24 45 56
Labelled Cell Count 267 240 199 354 336 436 582 388 370 605 658 37 30 110 172 199 238 262 244 201 24 45 56


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.0 4.9 5.5 4.9 5.3 5.1 4.4 – 3.9 3.9 3.4 3.6 4.5 5.3 6.8 8.7 8.8 8.4 – – –
Std Deviation (1e-4) 2.0 1.5 3.8 1.5 1.4 13.1 1.3 – 5.7 1.3 1.0 1.0 1.1 1.8 10.6 3.0 3.6 2.8 – – –
Intensity Change (Log2) – – – -0.15 -0.05 -0.11 -0.32 – -0.49 -0.49 -0.7 -0.61 -0.29 -0.04 0.31 0.66 0.68 0.61 – – –

WT3RAP60RAP140RAP220RAP300RAP460RAP540RAP620RAP700051015WT3HU80HU120HU160051015WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3051015WT1051015
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.4 0 -0.2 -0.4 – -2.0 -2.5 -4.8 -1.9 -1.6 0.4 0.7 -8.7 -7.1 -6.7
Endoplasmic Reticulum 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 4.3 0 – 0 0 0 0 0 0 0 0 0 0
Nucleus 0.2 -0.9 -1.7 -2.9 – -3.1 -2.9 -3.6 0 0 0 0.4 2.7 3.0 0.7
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Vacuole -1.2 1.8 -0.4 -1.8 – -1.6 -1.0 0 -1.9 0 0 0 9.4 8.0 8.9

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration -0.6658 -0.0589 -0.2176 -0.0511 -0.8824 -0.4051 -0.2904 -0.3157 -0.3881 -0.7067 -1.1147 -0.8973 -1.1379 -1.0205 -1.2034 -1.3497 -0.6651 -1.1315
Actin 0.0012 0.0004 0.0002 0.0001 0.0009 0.0007 0.0284 0.0001 0.0115 0.0003 0.0106 0.0016 0.0343 0.0001 0.0146 0.0495 0.0412 0.0074
Bud 0.0021 0.0007 0.0003 0.0012 0.0075 0.0007 0.0008 0.0007 0.0009 0.0002 0.0015 0.0032 0.0007 0.0005 0.0022 0.0002 0.0025 0.0003
Bud Neck 0.0006 0.0005 0.0002 0.0008 0.0016 0.0021 0.0051 0.0002 0.0008 0.0001 0.0018 0.0041 0.0039 0.0001 0.003 0.0003 0.0019 0.0092
Bud Periphery 0.0014 0.0011 0.0002 0.0016 0.0038 0.001 0.0016 0.0003 0.0013 0.0002 0.0018 0.0015 0.0017 0.0002 0.0015 0.0002 0.0054 0.0002
Bud Site 0.0029 0.0015 0.0021 0.0002 0.0038 0.0002 0.0045 0.0042 0.005 0.0008 0.0007 0.0003 0.0047 0.0038 0.0096 0.0004 0.0021 0.0002
Cell Periphery 0.0002 0.0001 0 0 0.0001 0 0.0002 0.0001 0.0003 0 0.0002 0.0002 0.0002 0.0001 0.0003 0.0001 0.0002 0.0001
Cytoplasm 0.0886 0.1502 0.0782 0.054 0.0982 0.1071 0.0488 0.0761 0.0805 0.0391 0.0821 0.1021 0.0513 0.1599 0.1218 0.203 0.1417 0.1784
Cytoplasmic Foci 0.0129 0.0119 0.0047 0.0033 0.0044 0.0108 0.0336 0.0013 0.0258 0.0076 0.0052 0.0164 0.0335 0.0051 0.0079 0.0064 0.0146 0.0188
Eisosomes 0.0002 0.0002 0.0001 0 0.0001 0.0001 0.0003 0.0001 0.0007 0.0001 0.0005 0.0001 0.0003 0.0001 0.0004 0.0006 0.0004 0.0001
Endoplasmic Reticulum 0.0015 0.0021 0.0011 0.0006 0.0012 0.0008 0.0031 0.0024 0.0009 0.0006 0.0033 0.001 0.0027 0.0012 0.0018 0.0008 0.004 0.0021
Endosome 0.0063 0.0017 0.0033 0.0007 0.0007 0.0014 0.0418 0.001 0.0186 0.0408 0.0243 0.0032 0.0119 0.0012 0.0051 0.001 0.0159 0.0029
Golgi 0.0009 0.0001 0.0001 0 0.0001 0.0001 0.0097 0 0.004 0.0084 0.0055 0.0004 0.0051 0 0.0015 0.0009 0.0107 0.001
Lipid Particles 0.0027 0.0003 0.0005 0.0001 0.0001 0.0004 0.0153 0.0001 0.0053 0.0014 0.0104 0.0011 0.0228 0.0001 0.002 0.0007 0.0094 0.0022
Mitochondria 0.0033 0.0005 0.0007 0.001 0.0004 0.0005 0.0082 0.0002 0.0079 0.0053 0.0787 0.0011 0.0022 0.0001 0.0014 0.001 0.0047 0.0004
None 0.7182 0.7015 0.7604 0.6903 0.7384 0.7223 0.6543 0.8397 0.737 0.7291 0.6892 0.7796 0.7423 0.7652 0.7219 0.7212 0.6762 0.6703
Nuclear Periphery 0.0056 0.0051 0.0039 0.0024 0.0016 0.0022 0.0201 0.0048 0.003 0.0026 0.0138 0.0026 0.0065 0.0013 0.0054 0.0008 0.0029 0.0035
Nucleolus 0.0024 0.0012 0.0014 0.0019 0.002 0.0019 0.0051 0.0007 0.0019 0.0012 0.0022 0.0025 0.0015 0.0003 0.0027 0.0002 0.0005 0.0011
Nucleus 0.1267 0.1051 0.1223 0.1847 0.1256 0.1247 0.0715 0.0658 0.0721 0.1485 0.0513 0.0489 0.034 0.0559 0.0771 0.0032 0.0479 0.0826
Peroxisomes 0.0056 0.0004 0.0002 0.0002 0.0002 0.0005 0.0167 0 0.0079 0.001 0.0023 0.0021 0.0278 0 0.0013 0.0008 0.0081 0.0007
Punctate Nuclear 0.0144 0.0128 0.0184 0.0558 0.0089 0.0219 0.0247 0.0015 0.0125 0.0094 0.0073 0.0265 0.0108 0.0028 0.0172 0.0083 0.0082 0.0177
Vacuole 0.0018 0.0022 0.0013 0.0009 0.0005 0.0005 0.0043 0.0007 0.0016 0.0023 0.004 0.0012 0.0012 0.0015 0.001 0.0003 0.0011 0.0007
Vacuole Periphery 0.0005 0.0004 0.0002 0.0003 0.0001 0.0001 0.0021 0.0001 0.0003 0.001 0.0034 0.0002 0.0005 0.0003 0.0003 0.0001 0.0005 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 462.3604 568.3905 805.9057 315.6437 532.252 579.4229 449.2968 441.59 608.1423 300.9746
Translational Efficiency 0.7196 0.6469 0.4844 1.3435 0.7045 0.6551 1.1218 1.5042 0.9541 1.4827

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1100 298 175 793 1724 1781 207 518 2824 2079 382 1311

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 638.29 751.65 3954.07 943.88 695.41 715.05 1023.61 951.22 673.16 720.30 2366.10 946.78
Standard Deviation 140.22 132.15 6377.01 490.83 96.84 125.04 237.57 293.97 118.99 126.73 4559.85 424.13
Intensity Change Log 2 — 0.235849 2.631054 0.564391 — 0.040180 0.557730 0.451915 — 0.137140 1.900039 0.506840

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000166 0.000805 0.001053 0.003662 0.000083 0.000568 0.000974 0.000619 0.000115 0.000602 0.001010 0.002460
Bud Neck 0.008365 0.027272 0.006366 0.013151 0.007955 0.028215 0.005338 0.006731 0.008114 0.028080 0.005809 0.010615
Bud Site 0.005054 0.011940 0.004630 0.023519 0.003813 0.011499 0.005752 0.015873 0.004296 0.011563 0.005238 0.020498
Cell Periphery 0.000500 0.000201 0.002227 0.000280 0.000147 0.000160 0.000221 0.000249 0.000284 0.000166 0.001140 0.000267
Cytoplasm 0.439487 0.283429 0.141953 0.326104 0.467931 0.398090 0.166774 0.339004 0.456851 0.381655 0.155403 0.331201
Cytoplasmic Foci 0.074197 0.189668 0.021258 0.015864 0.120889 0.144586 0.006227 0.031298 0.102702 0.151048 0.013113 0.021962
Eisosomes 0.000112 0.000148 0.000097 0.000045 0.000070 0.000100 0.000085 0.000075 0.000086 0.000107 0.000091 0.000056
Endoplasmic Reticulum 0.001876 0.001924 0.005413 0.004946 0.000602 0.000841 0.010077 0.002657 0.001098 0.000996 0.007940 0.004042
Endosome 0.002922 0.017848 0.003378 0.006812 0.005519 0.012971 0.003780 0.013978 0.004508 0.013670 0.003596 0.009644
Golgi 0.000475 0.003499 0.000561 0.003395 0.001509 0.003369 0.000137 0.007254 0.001106 0.003388 0.000331 0.004920
Lipid Particles 0.005540 0.007835 0.002332 0.001129 0.004027 0.005379 0.002351 0.002363 0.004617 0.005731 0.002342 0.001617
Mitochondria 0.003713 0.008188 0.001848 0.003158 0.005244 0.013435 0.000924 0.015015 0.004647 0.012683 0.001347 0.007843
Mitotic Spindle 0.001908 0.009574 0.004550 0.030536 0.003061 0.015898 0.010323 0.021600 0.002612 0.014992 0.007679 0.027005
None 0.028323 0.004316 0.004179 0.008638 0.008555 0.006317 0.006651 0.008500 0.016255 0.006030 0.005518 0.008584
Nuclear Periphery 0.000917 0.000763 0.001724 0.001821 0.000521 0.000919 0.002476 0.001473 0.000675 0.000896 0.002131 0.001683
Nuclear Periphery Foci 0.000905 0.000979 0.003762 0.001402 0.000398 0.000364 0.002082 0.002673 0.000595 0.000452 0.002852 0.001904
Nucleolus 0.003139 0.002604 0.001506 0.000852 0.001626 0.002609 0.000958 0.001822 0.002215 0.002608 0.001209 0.001235
Nucleus 0.397923 0.332845 0.733446 0.481146 0.342970 0.298813 0.661966 0.406324 0.364375 0.303691 0.694712 0.451582
Peroxisomes 0.001516 0.034904 0.000967 0.001859 0.003310 0.010878 0.001046 0.001210 0.002611 0.014322 0.001010 0.001603
Vacuole 0.022203 0.059889 0.058307 0.066325 0.020900 0.043184 0.111629 0.113923 0.021408 0.045578 0.087201 0.085132
Vacuole Periphery 0.000759 0.001369 0.000442 0.005356 0.000871 0.001805 0.000230 0.007360 0.000827 0.001743 0.000327 0.006148

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.85 -8.06 -2.65 -1.53 -0.63 -1.47 -8.20 -8.07 -0.21 3.69 -1.68 -11.59 -3.31 -1.56 -0.10
Bud Neck -3.91 -0.07 -1.11 3.51 -1.05 -10.59 -0.88 0.62 10.74 1.31 -11.38 -0.76 -0.83 10.55 -0.02
Bud Site -2.21 -0.52 -4.25 -1.14 -3.90 -5.96 -2.35 -3.24 0.39 -1.57 -6.27 -2.36 -5.48 -1.17 -4.03
Cell Periphery 5.35 -1.51 5.66 -0.77 1.76 -0.78 -4.05 -1.83 -1.25 2.65 5.66 -1.65 3.56 -3.17 1.81
Cytoplasm 8.95 19.01 15.79 2.43 -6.60 7.28 26.31 16.06 10.74 -8.20 9.04 32.28 23.67 14.24 -10.55
Cytoplasmic Foci -8.91 9.19 17.52 14.48 2.60 -3.65 28.09 22.92 25.29 -4.76 -9.11 25.26 29.47 30.95 0.18
Eisosomes -1.86 0.53 3.11 5.94 2.59 -4.34 -4.37 -1.02 3.39 3.69 -2.49 -2.07 2.54 6.03 4.53
Endoplasmic Reticulum -0.49 -4.38 -10.76 -9.55 -0.87 -2.88 -11.58 -10.06 -9.36 7.38 0.85 -11.76 -16.13 -16.90 4.85
Endosome -5.83 -0.60 -0.44 5.63 0.17 -6.77 2.17 0.12 4.95 -1.09 -9.50 1.50 0.62 9.00 -0.53
Golgi -3.63 -0.90 -1.28 2.40 -0.99 -3.29 4.64 -0.60 1.03 -1.95 -4.90 3.93 -0.76 2.80 -2.29
Lipid Particles -1.58 3.51 8.79 5.03 2.25 -2.30 3.01 5.21 8.47 2.47 -2.12 4.37 9.68 10.70 3.41
Mitochondria -1.88 2.05 2.24 2.98 0.65 -4.56 3.89 0.06 3.45 -2.12 -5.49 4.30 1.47 6.44 -1.99
Mitotic Spindle -1.98 -1.74 -5.80 -1.72 -4.64 -5.02 -3.00 -4.62 -1.59 0.20 -5.64 -3.22 -7.28 -2.11 -1.33
None 7.90 8.36 7.57 -1.69 -3.62 2.38 3.80 0.43 -1.67 -3.03 7.60 9.18 7.10 -1.06 -4.21
Nuclear Periphery 0.91 -6.22 -13.02 -10.47 -3.97 -1.93 -12.83 -12.76 -6.82 2.81 -1.23 -13.94 -18.92 -9.46 -0.10
Nuclear Periphery Foci -0.25 -3.85 -3.28 -2.29 2.93 0.69 -4.60 -3.27 -3.38 1.65 1.95 -5.97 -5.68 -6.84 3.35
Nucleolus 0.88 3.37 4.64 5.53 2.73 -3.35 2.99 2.32 5.14 0.05 -1.27 4.38 5.72 8.75 2.01
Nucleus 2.88 -12.60 -6.32 -6.97 8.38 4.09 -12.29 -5.72 -8.21 7.08 6.48 -17.69 -9.80 -14.24 10.39
Peroxisomes -6.13 2.55 1.94 6.27 -0.02 -7.42 4.55 5.47 11.81 0.30 -10.26 5.20 5.23 12.41 0.07
Vacuole -5.91 -4.94 -17.16 -10.40 -5.73 -9.87 -9.53 -16.66 -14.60 -1.75 -10.65 -10.51 -24.18 -20.33 -4.21
Vacuole Periphery -1.77 2.13 -1.23 -0.50 -1.68 -3.06 3.19 -1.74 -0.61 -2.57 -3.75 3.70 -1.94 -0.37 -2.87
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Minor isoform of pyruvate decarboxylase; key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde, regulation is glucose- and ethanol-dependent, repressed by thiamine, involved in amino acid catabolism
Localization
Cell Percentages cytoplasm (30%), nucleus (20%), mixed (42%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Pdc5

Pdc5


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Pdc5-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available