Standard name | |
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Human Ortholog | |
Description | HMG-CoA reductase; catalyzes conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to nuclear envelope; overproduction induces formation of karmellae; forms foci at nuclear periphery upon DNA replication stress; HMG1 has a paralog, HMG2, that arose from the whole genome duplication; human homolog HMGCR can complement yeast hmg1 mutant |
ensLOC | DeepLoc | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | – | 0 | 1 | 0 | 7 | 6 | 2 | 0 | 0 | 0 | 1 | 1 | 4 | 1 | 2 | 1 |
Bud | 0 | 0 | 0 | 1 | 1 | 1 | 3 | 3 | – | 3 | 1 | 3 | 0 | 0 | 1 | 1 | 0 | 0 | 3 | 4 | 1 | 1 | 4 | 5 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | – | 3 | 5 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 1 | 0 | 4 | 5 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 10 | 6 | 9 | 4 | 21 | 11 | 18 | 13 | – | 4 | 6 | 4 | 6 | 5 | 17 | 8 | 7 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Endoplasmic Reticulum | 10 | 3 | 5 | 4 | 2 | 1 | 2 | 1 | – | 0 | 1 | 0 | 12 | 2 | 3 | 1 | 3 | 2 | 16 | 18 | 54 | 16 | 29 | 15 |
Endosome | 1 | 0 | 1 | 1 | 4 | 1 | 2 | 6 | – | 0 | 0 | 5 | 8 | 1 | 1 | 2 | 1 | 1 | 2 | 2 | 3 | 1 | 5 | 11 |
Golgi | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | – | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 2 | 3 | 2 | 2 | 1 |
Mitochondria | 0 | 8 | 12 | 9 | 18 | 24 | 31 | 35 | – | 84 | 72 | 33 | 0 | 0 | 1 | 4 | 2 | 1 | 4 | 5 | 3 | 3 | 11 | 11 |
Nucleus | 24 | 20 | 6 | 2 | 5 | 35 | 40 | 70 | – | 112 | 104 | 86 | 0 | 8 | 12 | 6 | 6 | 0 | 1 | 10 | 1 | 2 | 3 | 2 |
Nuclear Periphery | 316 | 123 | 238 | 125 | 152 | 186 | 231 | 284 | – | 170 | 151 | 177 | 90 | 53 | 63 | 27 | 14 | 6 | 426 | 191 | 236 | 96 | 198 | 152 |
Nucleolus | 10 | 6 | 15 | 7 | 26 | 44 | 74 | 107 | – | 79 | 73 | 89 | 15 | 2 | 17 | 3 | 2 | 2 | 1 | 0 | 1 | 1 | 3 | 6 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 2 | – | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | – | 0 | 0 | 0 | 2 | 1 | 4 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Vac/Vac Membrane | 195 | 109 | 80 | 52 | 76 | 69 | 54 | 80 | – | 45 | 23 | 52 | 50 | 31 | 48 | 23 | 14 | 11 | 20 | 37 | 11 | 14 | 52 | 67 |
Unique Cell Count | 451 | 237 | 298 | 171 | 245 | 303 | 364 | 506 | 400 | 346 | 364 | 152 | 95 | 142 | 57 | 37 | 20 | 481 | 283 | 325 | 143 | 318 | 281 | |
Labelled Cell Count | 569 | 276 | 367 | 205 | 306 | 373 | 459 | 602 | 500 | 438 | 452 | 195 | 115 | 178 | 75 | 49 | 23 | 481 | 283 | 325 | 143 | 318 | 281 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 14.4 | 13.0 | 13.7 | 14.6 | 13.6 | 12.1 | 11.6 | 11.4 | – | 9.1 | 9.7 | 10.8 | 14.4 | 14.8 | 15.2 | 8.8 | 8.1 | 12.0 | 14.9 | 16.6 | 16.3 |
Std Deviation (1e-4) | 4.5 | 3.5 | 3.3 | 3.6 | 3.4 | 2.7 | 3.3 | 3.0 | – | 3.3 | 3.6 | 3.1 | 3.1 | 3.2 | 3.9 | 2.8 | 2.4 | 3.5 | 4.0 | 4.5 | 3.9 |
Intensity Change (Log2) | – | – | – | 0.1 | -0.0 | -0.18 | -0.24 | -0.26 | – | -0.59 | -0.49 | -0.34 | 0.08 | 0.12 | 0.16 | -0.64 | -0.75 | -0.18 | 0.13 | 0.29 | 0.25 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 0 | 2.8 | 0.4 | 1.2 | -0.4 | – | -2.0 | -1.1 | -1.8 | 0.5 | 0 | 3.7 | 0 | 0 | 0 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 3.3 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0.6 | 1.7 | 2.0 | 2.3 | 1.7 | – | 6.4 | 6.3 | 2.6 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 4.6 | 4.5 | 5.5 | – | 9.1 | 9.4 | 8.0 | 0 | 0 | 3.2 | 0 | 0 | 0 |
Nuclear Periphery | -1.7 | -4.6 | -5.0 | -4.6 | -6.8 | – | -9.9 | -9.4 | -8.3 | -4.7 | -4.7 | -7.5 | -5.2 | -5.6 | -5.1 |
Nucleolus | -0.5 | 2.4 | 3.9 | 5.7 | 6.2 | – | 5.6 | 5.9 | 6.8 | 1.9 | 0 | 2.6 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0.8 | 1.1 | -1.2 | -3.8 | -3.8 | – | -5.3 | -7.0 | -4.0 | 1.3 | 1.1 | 1.5 | 2.1 | 1.4 | 2.7 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 13.6578 | 12.1428 | 13.0989 | 10.8182 | 11.8708 | 12.2794 | 14.4153 | 17.5498 | 15.7674 | 16.8519 | 14.3247 | 15.1691 | 13.4747 | 17.6308 | 15.298 | 15.7169 | 14.2493 | 14.8318 |
Actin | 0.0144 | 0.0002 | 0.0168 | 0.0059 | 0.0062 | 0.0006 | 0.0235 | 0.0005 | 0.0005 | 0.0038 | 0.0087 | 0.0051 | 0.0027 | 0.0002 | 0.0205 | 0.0006 | 0.0011 | 0.0002 |
Bud | 0.0001 | 0 | 0.0002 | 0.0001 | 0.0001 | 0 | 0.0001 | 0 | 0 | 0.0002 | 0.0001 | 0.0001 | 0.0002 | 0 | 0.0008 | 0 | 0.0006 | 0 |
Bud Neck | 0.0024 | 0.0002 | 0.0042 | 0.0004 | 0.001 | 0.0001 | 0.0004 | 0.0001 | 0.0001 | 0.0004 | 0.0002 | 0.0005 | 0.0003 | 0 | 0.0002 | 0.0001 | 0.0003 | 0.0001 |
Bud Periphery | 0.0002 | 0.0001 | 0.0005 | 0.0004 | 0.0003 | 0.0001 | 0.0002 | 0.0002 | 0.0002 | 0.0007 | 0.0001 | 0.0002 | 0.0007 | 0.0002 | 0.0011 | 0.0004 | 0.0019 | 0 |
Bud Site | 0.0008 | 0.0001 | 0.001 | 0.0003 | 0.0001 | 0 | 0.0007 | 0 | 0 | 0.0018 | 0.0002 | 0.0001 | 0.0003 | 0 | 0.0036 | 0 | 0.0012 | 0 |
Cell Periphery | 0.0002 | 0.0003 | 0.0006 | 0.0005 | 0.0002 | 0.0002 | 0.0002 | 0.0005 | 0.0006 | 0.0008 | 0.0001 | 0.0001 | 0.0009 | 0.0017 | 0.0008 | 0.0003 | 0.0007 | 0 |
Cytoplasm | 0.0037 | 0.01 | 0.0017 | 0.0027 | 0.002 | 0.0005 | 0.003 | 0.0005 | 0.0007 | 0.0003 | 0.0005 | 0.0001 | 0.0224 | 0.0003 | 0.0109 | 0.0002 | 0.0009 | 0.0003 |
Cytoplasmic Foci | 0.0014 | 0.0002 | 0.0008 | 0.0028 | 0.0005 | 0.0003 | 0.0118 | 0 | 0.0045 | 0.0011 | 0.0078 | 0.0012 | 0.009 | 0 | 0.0039 | 0 | 0.0014 | 0.0001 |
Eisosomes | 0.0002 | 0 | 0.0006 | 0.0001 | 0.0001 | 0 | 0.0003 | 0 | 0 | 0.0001 | 0 | 0 | 0.0007 | 0 | 0.0001 | 0 | 0.0001 | 0.0002 |
Endoplasmic Reticulum | 0.0087 | 0.0396 | 0.0517 | 0.0858 | 0.0486 | 0.0092 | 0.042 | 0.2841 | 0.2353 | 0.254 | 0.1143 | 0.0677 | 0.056 | 0.403 | 0.3075 | 0.2678 | 0.5308 | 0.0402 |
Endosome | 0.0063 | 0.0025 | 0.0047 | 0.0077 | 0.0125 | 0.0016 | 0.0146 | 0.001 | 0.0029 | 0.0032 | 0.0056 | 0.0017 | 0.0488 | 0.001 | 0.0183 | 0.001 | 0.0353 | 0.0002 |
Golgi | 0.0017 | 0 | 0.002 | 0.0043 | 0.002 | 0.0002 | 0.0044 | 0.0001 | 0.0008 | 0.0031 | 0.0055 | 0.0038 | 0.0023 | 0.0002 | 0.0195 | 0.0002 | 0.0048 | 0.0001 |
Lipid Particles | 0.0017 | 0.0002 | 0.0017 | 0.0194 | 0.0012 | 0.0002 | 0.0162 | 0.0004 | 0.0125 | 0.0064 | 0.0088 | 0.0003 | 0.0356 | 0.0005 | 0.0018 | 0.0003 | 0.0062 | 0.0002 |
Mitochondria | 0.0026 | 0.0003 | 0.0022 | 0.0055 | 0.003 | 0.0004 | 0.0013 | 0.0008 | 0.0011 | 0.0398 | 0.0017 | 0.002 | 0.0022 | 0.0008 | 0.0078 | 0.001 | 0.0237 | 0.0003 |
None | 0.001 | 0.0001 | 0.0009 | 0.0007 | 0.0006 | 0.0001 | 0.0013 | 0.0001 | 0.0005 | 0.0001 | 0.0001 | 0 | 0.1248 | 0.0001 | 0.0008 | 0.0001 | 0.0014 | 0.0233 |
Nuclear Periphery | 0.8308 | 0.7389 | 0.7824 | 0.7686 | 0.8089 | 0.9205 | 0.7777 | 0.6399 | 0.6633 | 0.6142 | 0.7702 | 0.8815 | 0.6146 | 0.5225 | 0.5325 | 0.6717 | 0.3355 | 0.8896 |
Nucleolus | 0.0008 | 0.0009 | 0.001 | 0.0007 | 0.0015 | 0.0003 | 0.0005 | 0 | 0.0001 | 0.0002 | 0.0001 | 0 | 0.0012 | 0 | 0.0001 | 0 | 0.0009 | 0.0019 |
Nucleus | 0.0909 | 0.1638 | 0.082 | 0.0271 | 0.0691 | 0.0373 | 0.0394 | 0.0077 | 0.0061 | 0.0122 | 0.0146 | 0.0027 | 0.0124 | 0.0101 | 0.0067 | 0.004 | 0.0037 | 0.0041 |
Peroxisomes | 0.0003 | 0 | 0.0003 | 0.004 | 0.0001 | 0.0001 | 0.0011 | 0 | 0.0001 | 0.0052 | 0.0051 | 0.001 | 0.0007 | 0 | 0.001 | 0 | 0.0007 | 0 |
Punctate Nuclear | 0.0032 | 0.0004 | 0.0013 | 0.0015 | 0.0016 | 0.0012 | 0.0137 | 0 | 0.0005 | 0.0001 | 0.0002 | 0.0001 | 0.0177 | 0.0001 | 0.0014 | 0.0001 | 0.0004 | 0.0032 |
Vacuole | 0.0017 | 0.0174 | 0.0057 | 0.0257 | 0.0075 | 0.0066 | 0.0024 | 0.0088 | 0.0082 | 0.0062 | 0.0041 | 0.0018 | 0.0062 | 0.0082 | 0.0071 | 0.0041 | 0.0149 | 0.0006 |
Vacuole Periphery | 0.0272 | 0.0248 | 0.0376 | 0.0356 | 0.0331 | 0.0205 | 0.0451 | 0.0553 | 0.062 | 0.0461 | 0.0523 | 0.03 | 0.0402 | 0.0511 | 0.0536 | 0.048 | 0.0338 | 0.0353 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 39.9178 | 38.3331 | 43.4766 | 51.5701 | 37.7428 | 33.7981 | 43.4064 | 50.1921 | 47.9035 | 48.0421 |
Translational Efficiency | 0.6508 | 0.6644 | 0.7976 | 0.6477 | 0.5517 | 0.7021 | 0.6129 | 0.4528 | 0.5763 | 0.5187 |
Dataset | Hit |
---|---|
Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✔ |
Translational Efficiency | ✘ |
R1 | R2 | R1 & R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 |
497 | 1379 | 1149 | 1017 | 890 | 2132 | 2599 | 2110 | 1387 | 3511 | 3748 | 3127 |
R1 | R2 | R1 & R2 | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | |
Mean | 1138.96 | 1486.13 | 1593.68 | 1485.87 | 1071.75 | 1364.86 | 1589.40 | 1554.90 | 1095.83 | 1412.49 | 1590.71 | 1532.45 |
Standard Deviation | 199.99 | 307.56 | 288.65 | 271.91 | 232.52 | 264.43 | 252.45 | 274.63 | 223.75 | 288.31 | 264.08 | 275.65 |
Intensity Change Log 2 | — | 0.383843 | 0.484645 | 0.383591 | — | 0.348785 | 0.568514 | 0.536853 | — | 0.366953 | 0.525914 | 0.459927 |
R1 | R2 | R1 & R2 | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | |
Actin | 0.002505 | 0.000767 | 0.000664 | 0.000583 | 0.002119 | 0.000695 | 0.000445 | 0.000319 | 0.002257 | 0.000723 | 0.000512 | 0.000405 |
Bud Neck | 0.000877 | 0.000852 | 0.002934 | 0.006815 | 0.001843 | 0.000375 | 0.000755 | 0.001168 | 0.001497 | 0.000562 | 0.001423 | 0.003005 |
Bud Site | 0.001823 | 0.000344 | 0.000275 | 0.002950 | 0.001869 | 0.000455 | 0.000177 | 0.000189 | 0.001853 | 0.000411 | 0.000207 | 0.001087 |
Cell Periphery | 0.000180 | 0.000293 | 0.000081 | 0.000232 | 0.000635 | 0.000233 | 0.000073 | 0.000093 | 0.000472 | 0.000257 | 0.000075 | 0.000138 |
Cytoplasm | 0.003004 | 0.000321 | 0.000282 | 0.003290 | 0.003360 | 0.000786 | 0.000514 | 0.000449 | 0.003232 | 0.000604 | 0.000443 | 0.001373 |
Cytoplasmic Foci | 0.003677 | 0.000602 | 0.000696 | 0.003075 | 0.001608 | 0.000554 | 0.000361 | 0.000334 | 0.002349 | 0.000573 | 0.000464 | 0.001226 |
Eisosomes | 0.000010 | 0.000026 | 0.000015 | 0.000012 | 0.000027 | 0.000007 | 0.000005 | 0.000004 | 0.000021 | 0.000015 | 0.000008 | 0.000007 |
Endoplasmic Reticulum | 0.123359* | 0.062181 | 0.004403 | 0.014295 | 0.130897* | 0.067041 | 0.021995 | 0.021250 | 0.128196* | 0.065132 | 0.016602 | 0.018988 |
Endosome | 0.018437 | 0.005367 | 0.001707 | 0.009006 | 0.009762 | 0.005987 | 0.003077 | 0.003213 | 0.012871 | 0.005744 | 0.002657 | 0.005097 |
Golgi | 0.004494 | 0.000462 | 0.000245 | 0.003938 | 0.001276 | 0.000593 | 0.000314 | 0.000348 | 0.002429 | 0.000542 | 0.000293 | 0.001515 |
Lipid Particles | 0.011042 | 0.012062 | 0.001770 | 0.006521 | 0.011597 | 0.006698 | 0.001305 | 0.003445 | 0.011398 | 0.008805 | 0.001448 | 0.004446 |
Mitochondria | 0.004102 | 0.009607 | 0.002986 | 0.004891 | 0.016152 | 0.006175 | 0.002188 | 0.001711 | 0.011834 | 0.007523 | 0.002432 | 0.002745 |
Mitotic Spindle | 0.007661 | 0.000118 | 0.002459 | 0.028271 | 0.000802 | 0.000436 | 0.001028 | 0.001233 | 0.003260 | 0.000311 | 0.001467 | 0.010027 |
None | 0.002495 | 0.001200 | 0.000397 | 0.000787 | 0.008069 | 0.001710 | 0.000394 | 0.000520 | 0.006072 | 0.001509 | 0.000395 | 0.000606 |
Nuclear Periphery | 0.366049* | 0.701239* | 0.667279* | 0.466071* | 0.570975* | 0.724440* | 0.812986* | 0.713787* | 0.497545* | 0.715327* | 0.768317* | 0.633222* |
Nuclear Periphery Foci | 0.427869* | 0.127787 | 0.228165* | 0.372474* | 0.174898 | 0.161974 | 0.138221 | 0.231517* | 0.265544* | 0.148547 | 0.165795 | 0.277361* |
Nucleolus | 0.002789 | 0.003206 | 0.046408 | 0.024294 | 0.010742 | 0.002593 | 0.001908 | 0.004220 | 0.007892 | 0.002834 | 0.015550 | 0.010749 |
Nucleus | 0.004667 | 0.002002 | 0.030880 | 0.020238 | 0.024782 | 0.005248 | 0.005843 | 0.003356 | 0.017574 | 0.003973 | 0.013518 | 0.008847 |
Peroxisomes | 0.000408 | 0.000374 | 0.000693 | 0.000499 | 0.002011 | 0.000244 | 0.000070 | 0.000076 | 0.001437 | 0.000295 | 0.000261 | 0.000213 |
Vacuole | 0.010468 | 0.033926 | 0.003005 | 0.018950 | 0.015213 | 0.007114 | 0.004312 | 0.005283 | 0.013513 | 0.017645 | 0.003912 | 0.009728 |
Vacuole Periphery | 0.004082 | 0.037266 | 0.004656 | 0.012808 | 0.011365 | 0.006640 | 0.004031 | 0.007485 | 0.008755 | 0.018669 | 0.004222 | 0.009217 |
R1 | R2 | R1 & R2 | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UBP2_WT | UBP14_WT | UBP2UBP14_WT | UBP2UBP14_UBP2 | UBP2UBP14_UBP14 | UBP2_WT | UBP14_WT | UBP2UBP14_WT | UBP2UBP14_UBP2 | UBP2UBP14_UBP14 | UBP2_WT | UBP14_WT | UBP2UBP14_WT | UBP2UBP14_UBP2 | UBP2UBP14_UBP14 | |
Actin | 0.90 | 0.94 | 0.96 | 1.03 | 0.39 | 5.36 | 5.01 | 6.79 | 2.60 | 0.85 | 2.18 | 2.35 | 2.59 | 2.94 | 0.87 |
Bud Neck | 0.42 | -4.84 | -7.37 | -7.74 | -5.09 | 2.66 | 1.85 | 0.93 | -3.59 | -1.77 | 2.61 | 0.10 | -3.79 | -8.27 | -5.36 |
Bud Site | 1.69 | 1.72 | -0.90 | -3.55 | -3.59 | 2.45 | 2.98 | 3.02 | 1.19 | 0.30 | 2.94 | 3.30 | 1.26 | -2.71 | -3.45 |
Cell Periphery | -2.54 | 2.73 | -1.55 | 0.79 | -4.71 | 4.08 | 5.86 | 5.63 | 4.49 | -1.40 | 3.34 | 6.27 | 5.08 | 4.41 | -4.56 |
Cytoplasm | 2.07 | 2.08 | 0.07 | -3.59 | -3.61 | 2.86 | 3.11 | 3.25 | 1.60 | 0.93 | 3.49 | 3.62 | 2.26 | -2.81 | -3.20 |
Cytoplasmic Foci | 2.34 | 2.28 | 0.23 | -4.92 | -4.93 | 2.62 | 3.02 | 3.05 | 0.82 | -0.22 | 3.36 | 3.55 | 1.85 | -3.63 | -4.09 |
Eisosomes | -2.99 | -0.78 | -0.51 | 3.34 | 0.45 | 4.35 | 3.97 | 5.01 | 2.95 | 0.42 | 2.16 | 3.52 | 4.49 | 4.72 | 0.45 |
Endoplasmic Reticulum | 5.75 | 12.08 | 10.85 | 11.31 | -4.94 | 8.27 | 15.19 | 15.23 | 12.60 | 0.43 | 10.10 | 19.20 | 18.64 | 16.64 | -1.37 |
Endosome | 6.17 | 8.08 | 4.03 | -3.40 | -7.19 | 3.33 | 6.53 | 6.48 | 3.95 | -0.33 | 6.77 | 10.21 | 7.38 | 0.90 | -5.40 |
Golgi | 2.29 | 2.41 | 0.26 | -3.43 | -3.66 | 1.43 | 2.15 | 2.18 | 0.96 | -0.25 | 2.70 | 3.10 | 1.23 | -2.65 | -3.53 |
Lipid Particles | -0.42 | 4.19 | 1.71 | 2.89 | -3.25 | 3.44 | 7.89 | 5.85 | 3.84 | -4.05 | 2.06 | 8.68 | 5.48 | 5.03 | -5.06 |
Mitochondria | -2.77 | 0.62 | -0.55 | 3.03 | -1.98 | 5.59 | 8.27 | 8.56 | 6.27 | 1.32 | 3.16 | 7.50 | 7.05 | 6.70 | -0.85 |
Mitotic Spindle | 2.62 | 1.93 | -4.18 | -8.91 | -8.11 | 1.30 | -0.78 | -1.23 | -2.08 | -0.42 | 2.78 | 1.75 | -3.92 | -8.97 | -7.61 |
None | 1.66 | 2.61 | 2.13 | 1.12 | -2.44 | 3.32 | 4.05 | 3.98 | 4.01 | -1.04 | 3.65 | 4.57 | 4.39 | 4.03 | -2.24 |
Nuclear Periphery | -22.51* | -19.23 | -5.77 | 21.37* | 16.92 | -13.16 | -21.69 | -12.29 | 1.57 | 15.55 | -22.78 | -28.58 | -13.36 | 13.08 | 21.71 |
Nuclear Periphery Foci | 21.53* | 13.61 | 3.65 | -27.70* | -14.41 | 2.03 | 6.14 | -8.42 | -12.67 | -17.98* | 16.30 | 13.72 | -1.48 | -26.80 | -22.55 |
Nucleolus | 0.38 | -10.85 | -6.29 | -6.90 | 4.18 | 4.83 | 5.26 | 3.51 | -1.79 | -2.54 | 4.50 | -4.33 | -1.78 | -6.73 | 2.49 |
Nucleus | 1.81 | -7.62 | -5.32 | -7.96 | 2.64 | 5.43 | 5.19 | 5.99 | 1.59 | 2.26 | 5.75 | 1.53 | 3.35 | -5.16 | 3.11 |
Peroxisomes | 0.62 | -1.32 | -0.86 | -2.18 | 0.40 | 2.76 | 3.01 | 3.00 | 6.62 | -0.60 | 2.81 | 2.86 | 2.85 | 0.52 | -0.01 |
Vacuole | -6.35 | 3.30 | -2.53 | 4.14 | -7.84 | 4.01 | 5.39 | 4.94 | 2.14 | -1.26 | -1.85 | 6.23 | 2.08 | 5.73 | -7.18 |
Vacuole Periphery | -12.58 | -0.39 | -4.37 | 9.26 | -5.43 | 4.35 | 7.02 | 3.14 | -0.93 | -4.02 | -7.92 | 5.25 | -0.44 | 7.98 | -6.57 |