Standard name
Human Ortholog
Description Protein with homology to human PDCD5; PDCD5 is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overproduction suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene; protein abundance increases in response to DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.99 0.99 0.99 0.97 0.91 0.87 – 0.66 0.7 0.66 0.69 0.64 0.99 0.99 0.99 0.9 0.93 0.91 0.96 0.93 0.93 0.94 0.95 0.94
Endoplasmic Reticulum 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.11 – 0.12 0.27 0.27 0.31 0.37 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0.08 0.06 – 0.25 0.13 0.14 0.07 0 0 0 0 0.09 0.06 0.12 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 – 1 1 1 1 0 0 0 0 0 0 0 0 2 1 0 0 1
Bud 0 0 8 1 1 2 – 2 6 6 9 9 0 1 0 0 0 0 0 0 2 0 1 7
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 1 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 2 2 2 2 3 9 – 9 8 22 23 26 2 0 3 3 8 3 0 0 0 0 0 0
Cytoplasm 370 283 584 447 505 665 – 660 531 593 517 587 644 809 887 235 263 245 352 270 559 360 484 512
Endoplasmic Reticulum 1 1 0 3 4 7 – 11 9 14 11 22 7 5 3 8 8 4 0 0 4 1 3 3
Endosome 0 0 0 0 0 0 – 0 0 0 0 2 2 0 0 1 1 0 2 0 3 0 1 0
Golgi 1 1 0 0 0 0 – 0 0 0 0 0 0 0 1 1 0 0 0 2 0 1 2 2
Mitochondria 2 2 6 19 24 84 – 120 209 243 232 341 0 0 0 3 1 0 1 0 2 0 0 0
Nucleus 2 2 2 2 4 2 – 25 16 32 28 37 0 5 3 9 6 11 3 4 8 8 5 7
Nuclear Periphery 0 0 0 0 0 1 – 10 5 10 2 2 0 0 0 0 0 0 0 0 0 0 1 0
Nucleolus 0 0 0 0 0 0 – 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0
Vac/Vac Membrane 0 0 4 3 42 47 – 246 99 127 55 38 3 2 5 24 17 33 1 2 7 2 5 6
Unique Cell Count 374 286 592 463 558 767 1002 763 905 750 924 650 816 893 262 282 268 366 290 599 382 513 545
Labelled Cell Count 378 291 606 477 583 817 1086 884 1049 878 1064 658 822 902 284 304 296 366 290 599 382 513 545


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 10.6 13.2 7.3 8.9 8.9 7.9 – 7.7 7.1 6.9 6.8 6.5 12.4 13.3 13.0 14.5 14.4 13.1 11.0 12.1 12.4
Std Deviation (1e-4) 1.7 2.5 1.5 1.6 1.6 1.5 – 1.6 1.7 1.5 1.6 1.4 2.3 2.3 2.1 3.8 3.3 3.4 2.0 2.4 2.3
Intensity Change (Log2) – – – 0.29 0.29 0.11 – 0.08 -0.04 -0.07 -0.09 -0.15 0.77 0.88 0.84 1.0 0.98 0.85 0.6 0.74 0.77

WT3RAP60RAP140RAP220RAP380RAP460RAP540RAP620RAP700051015WT3HU80HU120HU160051015WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3051015WT1AF100AF140AF180051015
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 – 0 -1.0 -1.4 -0.2 -0.7 0 0 0 0 0 0
Bud Neck 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 – 0 0 3.2 3.7 3.5 0 0 0 0 0 0
Cytoplasm -2.3 -6.2 -8.0 – -15.3 -13.9 -15.3 -14.1 -15.9 0.7 0.9 1.3 -6.1 -4.3 -5.3
Endoplasmic Reticulum 0 0 0 – 0 0 3.0 0 3.8 0 0 0 0 0 0
Endosome 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 3.3 3.5 7.3 – 7.8 13.2 13.1 14.2 16.2 0 0 0 0 0 0
Nucleus 0 0 0 – 3.2 2.8 4.1 4.2 4.4 0 0 0 0 0 0
Nuclear Periphery 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 5.9 5.2 – 12.7 8.5 8.9 5.9 4.0 0 0 0 6.4 4.8 7.8

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 7.0128 9.1985 7.7113 7.019 7.2937 7.9621 5.8143 7.6201 6.7232 6.2648 5.4759 6.7634 7.7113 10.1178 8.3814 8.2655 8.7838 8.4214
Actin 0.006 0.0004 0.0045 0.0096 0.0018 0.0051 0.0032 0.0018 0.0146 0.0141 0.0033 0.0018 0.0397 0.0005 0.0196 0.007 0.0214 0.0024
Bud 0.0006 0.0002 0.0009 0.0011 0.0001 0.0002 0.0014 0.0022 0.0023 0.001 0.0015 0.0002 0.0011 0.0001 0.0006 0.0002 0.0009 0.0001
Bud Neck 0.0014 0.0002 0.0007 0.0155 0.0007 0.0014 0.0016 0.0002 0.0009 0.0015 0.0009 0.0012 0.0038 0.0002 0.0008 0.0008 0.0017 0.0125
Bud Periphery 0.0007 0 0.0006 0.0011 0.0001 0.0002 0.0004 0.001 0.0031 0.0009 0.0023 0.0001 0.0015 0 0.0006 0.0003 0.0007 0.0001
Bud Site 0.0018 0.0007 0.0058 0.0176 0.0002 0.0004 0.0022 0.0099 0.0017 0.0007 0.0023 0.0001 0.0033 0.0004 0.001 0.0005 0.0051 0.0002
Cell Periphery 0.0001 0 0.0001 0.0003 0 0 0.0001 0 0.0001 0.0001 0.0003 0 0.0002 0 0.0001 0 0.0001 0
Cytoplasm 0.8237 0.9822 0.9195 0.8182 0.8585 0.9185 0.8476 0.966 0.9064 0.8651 0.8195 0.9309 0.7636 0.987 0.9236 0.8949 0.7483 0.9201
Cytoplasmic Foci 0.0276 0.0014 0.0105 0.016 0.028 0.0065 0.031 0.0028 0.0076 0.0148 0.0098 0.0115 0.0261 0.0016 0.0052 0.0112 0.0515 0.0101
Eisosomes 0.0001 0 0 0.0001 0 0 0 0 0 0 0.0001 0 0.0003 0 0.0001 0.0001 0.0001 0
Endoplasmic Reticulum 0.0056 0.0008 0.0016 0.0017 0.0019 0.0037 0.0071 0.0012 0.002 0.0032 0.0044 0.0022 0.0091 0.0006 0.0039 0.002 0.0032 0.0039
Endosome 0.0269 0.0005 0.0167 0.0416 0.0199 0.0182 0.0315 0.0021 0.0087 0.0247 0.0561 0.0105 0.0257 0.0002 0.0058 0.0098 0.0519 0.0172
Golgi 0.0053 0 0.0058 0.0219 0.0189 0.0035 0.0105 0.0001 0.0057 0.0094 0.0122 0.0029 0.0062 0 0.0072 0.0155 0.0532 0.0017
Lipid Particles 0.0088 0 0.0032 0.003 0.0176 0.0043 0.0099 0 0.0015 0.012 0.0021 0.0039 0.0087 0 0.0009 0.0064 0.0107 0.0006
Mitochondria 0.0135 0.0001 0.0063 0.0167 0.0021 0.0039 0.0024 0.0001 0.0115 0.0047 0.0428 0.0007 0.0097 0.0001 0.0041 0.0221 0.0093 0.0005
None 0.0141 0.0021 0.0018 0.0014 0.0014 0.0027 0.0078 0.0035 0.0081 0.003 0.0028 0.004 0.014 0.0034 0.0078 0.0068 0.0016 0.0027
Nuclear Periphery 0.01 0.0009 0.0014 0.002 0.0028 0.0059 0.0061 0.001 0.0026 0.0022 0.0061 0.002 0.0226 0.0006 0.002 0.002 0.0027 0.0029
Nucleolus 0.0022 0 0.0001 0.0014 0.0001 0.0003 0.0012 0 0.0002 0.0001 0.0002 0.0001 0.0015 0 0 0 0.0001 0.0001
Nucleus 0.0202 0.0098 0.0124 0.0206 0.026 0.0195 0.0167 0.0066 0.016 0.0217 0.021 0.0226 0.0339 0.0046 0.0147 0.0135 0.0232 0.0206
Peroxisomes 0.0143 0 0.0053 0.0057 0.0126 0.0021 0.0116 0.0001 0.0023 0.0179 0.0014 0.0016 0.0139 0.0001 0.0007 0.0048 0.0098 0.0009
Punctate Nuclear 0.0128 0.0003 0.0007 0.001 0.0066 0.0021 0.004 0.0006 0.003 0.0013 0.0014 0.0028 0.0105 0.0004 0.0006 0.0007 0.0029 0.0025
Vacuole 0.0028 0.0003 0.0014 0.0025 0.0005 0.0009 0.0026 0.0006 0.0011 0.0012 0.0066 0.0006 0.0032 0.0002 0.0005 0.0005 0.0011 0.0007
Vacuole Periphery 0.0016 0 0.0005 0.0009 0.0002 0.0007 0.0008 0.0001 0.0004 0.0004 0.003 0.0002 0.0014 0 0.0002 0.0007 0.0006 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 142.3341 150.884 145.3841 134.5513 155.1463 128.4075 137.7582 122.9455 162.4468 136.4773
Translational Efficiency 1.9461 1.7308 1.5807 2.2202 1.5468 2.2961 1.6631 2.1887 1.3741 1.4547

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1484 1017 242 1403 327 1180 2697 1826 1811 2197 2939 3229

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 950.37 1047.17 1241.45 1374.06 904.10 1109.69 1327.76 1306.03 942.02 1080.75 1320.65 1335.59
Standard Deviation 138.40 178.74 169.24 233.26 151.58 170.54 202.37 220.09 141.99 177.15 201.25 228.41
Intensity Change Log 2 — 0.139934 0.385465 0.531884 — 0.295602 0.554440 0.530634 — 0.217926 0.470318 0.531275

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000342 0.000745 0.000749 0.001867 0.001786 0.000647 0.000110 0.000620 0.000603 0.000692 0.000163 0.001161
Bud Neck 0.000547 0.000862 0.001994 0.004540 0.003427 0.002014 0.001985 0.007164 0.001067 0.001481 0.001986 0.006024
Bud Site 0.002841 0.005057 0.003815 0.020120 0.042449 0.010936 0.003428 0.022001 0.009992 0.008214 0.003459 0.021183
Cell Periphery 0.000105 0.000070 0.000204 0.000140 0.000613 0.000082 0.000038 0.000098 0.000197 0.000076 0.000052 0.000116
Cytoplasm 0.808565 0.821694 0.448324 0.540881 0.675473 0.775039 0.672341 0.563621 0.784534 0.796636 0.653896 0.553741
Cytoplasmic Foci 0.044459 0.029256 0.009679 0.012476 0.116055 0.063709 0.003748 0.015750 0.057386 0.047761 0.004236 0.014327
Eisosomes 0.000017 0.000011 0.000019 0.000014 0.000056 0.000020 0.000004 0.000015 0.000024 0.000016 0.000005 0.000015
Endoplasmic Reticulum 0.001346 0.000703 0.002534 0.000830 0.008171 0.001295 0.000295 0.001339 0.002578 0.001021 0.000479 0.001118
Endosome 0.002332 0.002179 0.001134 0.010417 0.004089 0.004049 0.000790 0.022715 0.002650 0.003184 0.000818 0.017372
Golgi 0.000376 0.001010 0.000193 0.004522 0.001687 0.002851 0.001041 0.010478 0.000613 0.001999 0.000972 0.007890
Lipid Particles 0.000724 0.000796 0.000918 0.001207 0.001796 0.000923 0.000274 0.000966 0.000918 0.000864 0.000327 0.001071
Mitochondria 0.000473 0.000462 0.000329 0.005054 0.002428 0.001762 0.000968 0.009915 0.000826 0.001160 0.000915 0.007803
Mitotic Spindle 0.000330 0.004853 0.004428 0.096992 0.006901 0.009279 0.012612 0.122254 0.001516 0.007230 0.011938 0.111278
None 0.005783 0.006386 0.006184 0.013087 0.001696 0.003052 0.012350 0.008503 0.005045 0.004595 0.011842 0.010495
Nuclear Periphery 0.000134 0.000136 0.000631 0.000604 0.000204 0.000161 0.000515 0.000934 0.000146 0.000150 0.000525 0.000791
Nuclear Periphery Foci 0.003781 0.003339 0.003411 0.002921 0.004275 0.002669 0.000632 0.002244 0.003870 0.002979 0.000861 0.002538
Nucleolus 0.000282 0.000492 0.000119 0.000371 0.000760 0.000248 0.000234 0.001293 0.000368 0.000361 0.000225 0.000892
Nucleus 0.091912 0.084922 0.444136 0.197073 0.076621 0.057469 0.265560 0.093125 0.089151 0.070177 0.280264 0.138290
Peroxisomes 0.000220 0.000654 0.000105 0.001400 0.001567 0.001699 0.000195 0.003258 0.000463 0.001215 0.000187 0.002451
Vacuole 0.034973 0.035975 0.070982 0.077856 0.048008 0.061520 0.022698 0.098707 0.037327 0.049695 0.026673 0.089648
Vacuole Periphery 0.000459 0.000400 0.000113 0.007628 0.001939 0.000575 0.000182 0.015000 0.000726 0.000494 0.000176 0.011797

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -0.70 -3.86 -1.11 0.20 3.15 3.68 6.62 5.72 1.12 -2.12 -0.02 2.73 1.19 0.80 -2.80
Bud Neck -3.96 -8.15 -8.26 -6.77 0.22 2.06 2.11 1.05 -1.45 -1.46 -1.46 -6.39 -7.80 -4.30 -2.30
Bud Site -3.59 -4.48 -4.72 -1.97 -1.22 6.37 8.25 7.12 1.76 -4.57 1.47 6.70 2.11 0.63 -5.88
Cell Periphery 3.07 -6.71 -0.98 -4.97 6.48 8.11 8.62 8.47 2.06 -1.79 7.68 8.27 7.27 -1.42 -2.67
Cytoplasm 1.41 26.18 40.91 35.45 -5.87 -5.66 8.72 8.26 22.08 -0.11 1.22 38.74 40.49 39.10 2.86
Cytoplasmic Foci 5.46 14.75 19.92 13.04 2.75 6.65 15.63 15.04 20.05 -8.50 3.39 25.72 24.00 23.43 -8.26
Eisosomes 3.03 -3.91 2.27 -1.60 5.64 6.85 9.56 8.63 5.53 -8.03 4.54 9.98 7.51 3.69 -7.36
Endoplasmic Reticulum 2.90 -4.40 3.64 1.58 7.32 5.30 6.19 6.21 1.65 0.38 4.32 6.41 7.09 1.89 3.74
Endosome 0.88 2.91 1.28 0.44 -0.27 0.71 9.39 0.69 0.22 -4.29 -0.82 11.55 -0.21 0.31 -4.84
Golgi -1.49 1.38 -1.08 0.58 -1.61 -1.18 4.70 0.21 1.21 -2.98 -2.75 1.88 -2.17 1.28 -3.04
Lipid Particles -0.18 -5.12 -5.77 -3.11 0.67 3.51 6.56 4.76 0.15 -6.66 0.52 3.22 -2.15 -2.09 -9.92
Mitochondria 0.25 0.32 -1.03 -1.38 -1.49 0.58 1.22 0.43 -0.29 -2.02 -0.38 0.50 -1.21 -0.87 -2.13
Mitotic Spindle -2.97 -1.60 -8.49 -6.61 -3.63 -0.47 -1.45 -5.24 -6.26 -5.90 -3.58 -7.47 -12.31 -9.05 -7.08
None -0.02 0.16 -2.42 -2.85 -2.52 -2.07 -25.97 -9.70 -6.72 8.63 1.12 -9.96 -3.65 -6.62 8.27
Nuclear Periphery -2.38 -14.37 -28.06 -26.35 -3.42 0.42 -15.26 -12.53 -20.77 1.73 -2.00 -35.20 -32.48 -32.39 -0.21
Nuclear Periphery Foci 1.21 -1.60 5.55 3.58 4.63 2.55 6.61 5.83 6.56 -3.48 2.76 11.13 9.17 7.12 -3.83
Nucleolus -1.03 1.54 -0.38 0.93 -2.43 1.47 1.44 0.70 -1.84 -1.83 -0.37 1.18 -0.45 0.10 -2.02
Nucleus 0.46 -20.47 -22.64 -21.92 12.33 2.71 -36.67 -9.67 -21.53 39.19 4.94 -55.08 -22.78 -29.41 34.81
Peroxisomes -2.18 1.93 -0.36 1.88 -1.51 -0.29 4.18 1.99 1.98 -1.12 -2.74 4.46 0.21 2.32 -1.36
Vacuole -4.92 -7.73 -28.12 -23.12 -6.77 -4.54 -3.09 -23.80 -22.03 -26.08 -9.47 -11.51 -41.13 -31.95 -31.19
Vacuole Periphery 0.46 1.40 -1.09 -1.45 -1.94 2.82 3.77 -0.41 -2.91 -3.70 1.32 3.07 -2.27 -3.26 -4.23
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein with homology to human PDCD5; PDCD5 is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overproduction suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene; protein abundance increases in response to DNA replication stress
Localization
Cell Percentages cytoplasm (97%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Sdd2

Sdd2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Sdd2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available