Standard name
Human Ortholog
Description Subunit of heterohexameric prefoldin; prefoldin binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin; prefoldin complex also localizes to chromatin of actively transcribed genes in the nucleus and facilitates transcriptional elongation
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0.06 0.05 0 0 0 0 0 0
Cytoplasm 0.98 0.99 0.96 0.96 0.93 0.86 – 0.71 0.64 0.66 0.56 0.57 1.0 0.99 0.99 0.91 0.94 0.94 0.96 0.94 0.91 0.88 0.92 0.89
Endoplasmic Reticulum 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0.09 0.31 0.11 0.38 – 0.46 0.6 0.55 0.65 0.64 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 – 0.05 0 0 0 0 0 0 0 0.06 0 0.06 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 1 0 0 – 0 0 1 1 2 0 0 0 0 0 0 1 0 1 2 2 1
Bud 2 1 10 0 1 2 – 6 8 10 9 19 0 0 1 0 0 0 0 0 0 1 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 2 1 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 5 8 1 5 8 7 – 10 8 10 18 12 6 5 6 3 7 4 0 0 0 0 0 0
Cytoplasm 520 295 225 333 380 405 – 431 285 345 268 292 161 359 322 101 112 82 532 290 217 103 253 228
Endoplasmic Reticulum 3 0 1 0 2 3 – 3 1 6 9 2 0 1 2 3 2 0 1 0 0 0 4 4
Endosome 2 0 0 0 8 1 – 3 1 4 1 4 0 0 1 0 0 0 1 1 2 0 4 3
Golgi 0 1 0 0 0 0 – 0 0 0 0 0 0 1 0 2 0 0 3 4 0 3 2 3
Mitochondria 4 2 20 109 45 177 – 280 266 284 310 328 1 0 2 3 3 2 2 3 6 1 1 1
Nucleus 0 0 1 0 3 0 – 3 2 2 0 1 0 0 0 1 3 3 0 1 0 0 0 1
Nuclear Periphery 0 1 0 0 0 0 – 7 3 1 2 2 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 1 1 0 0 – 0 1 0 0 1 0 0 0 0 0 0 0 0 0 0 1 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 3 4 0 0 9 4 – 28 16 13 18 7 0 0 3 7 2 5 8 1 3 1 2 6
Unique Cell Count 530 299 235 348 410 471 603 444 520 476 513 161 361 326 111 119 87 555 308 239 117 276 256
Labelled Cell Count 539 312 259 449 456 599 772 591 676 636 671 168 366 337 120 129 96 555 308 239 117 276 256


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.3 7.5 4.9 5.2 5.9 5.0 – 5.0 4.5 4.8 4.5 4.4 7.0 7.2 7.2 9.8 8.6 9.0 7.2 7.3 7.5
Std Deviation (1e-4) 4.7 1.1 1.0 1.6 1.5 1.1 – 1.4 1.2 1.2 1.3 1.2 0.9 1.2 1.3 2.0 1.9 1.8 1.8 1.4 1.5
Intensity Change (Log2) – – – 0.08 0.27 0.03 – 0.03 -0.13 -0.03 -0.11 -0.16 0.52 0.57 0.55 1.01 0.81 0.88 0.56 0.58 0.61


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 -1.6 -3.9 – -7.7 -9.0 -8.7 -10.7 -10.7 2.7 3.1 2.3 -1.8 -0.7 -0.6
Endoplasmic Reticulum 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 6.5 1.0 8.1 – 10.3 0 0 0 0 -3.4 -5.6 -4.8 -2.0 -2.2 -2.0
Nucleus 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 – 3.4 2.9 0 3.0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.5465 2.0097 1.7795 1.3336 1.5336 1.9487 1.1148 1.7434 1.5575 1.3675 1.2801 1.6619 1.7093 2.9408 2.2538 1.9432 2.6661 2.4114
Actin 0.0154 0.0003 0.0143 0.0052 0.0193 0.0058 0.0233 0.0009 0.0112 0.0027 0.0108 0.0041 0.0087 0.0002 0.0001 0.0005 0.0018 0.0002
Bud 0.0008 0.0002 0.0008 0.0006 0.0066 0.0005 0.0015 0.0009 0.0057 0.009 0.0004 0.0006 0.0002 0.0001 0.0001 0.0003 0.0005 0.0001
Bud Neck 0.0026 0.0002 0.0008 0.0005 0.0052 0.0011 0.0051 0.0002 0.0026 0.0016 0.0004 0.0006 0.0011 0.0001 0.0001 0.0002 0.0007 0.0004
Bud Periphery 0.0017 0.0002 0.0007 0.0004 0.0055 0.0004 0.0033 0.0004 0.0028 0.0216 0.0005 0.0006 0.0002 0.0001 0.0001 0.0003 0.0004 0.0001
Bud Site 0.0029 0.0013 0.0049 0.0012 0.0113 0.0003 0.0217 0.0026 0.0122 0.0037 0.0008 0.0003 0.0011 0.0012 0.0002 0.0002 0.0004 0.0001
Cell Periphery 0.0003 0.0002 0.0002 0.0001 0.0002 0.0001 0.0007 0.0001 0.0016 0.0003 0.0001 0.0001 0.0003 0.0002 0.0001 0.0002 0.0001 0
Cytoplasm 0.6418 0.8436 0.7432 0.7695 0.7651 0.7921 0.7005 0.8802 0.7702 0.7394 0.6577 0.8672 0.6694 0.8563 0.783 0.7402 0.884 0.8021
Cytoplasmic Foci 0.0371 0.0196 0.0278 0.0294 0.0256 0.021 0.0318 0.0265 0.0283 0.0352 0.0373 0.0204 0.0199 0.0066 0.0063 0.0111 0.0133 0.0063
Eisosomes 0.0002 0.0001 0.0002 0.0002 0.0002 0 0.0015 0 0.0002 0.0001 0.0001 0 0.0002 0 0 0 0 0
Endoplasmic Reticulum 0.0069 0.0015 0.0023 0.0022 0.0057 0.0031 0.0106 0.0022 0.0068 0.0037 0.0019 0.0036 0.006 0.0019 0.0023 0.0127 0.0022 0.0015
Endosome 0.0341 0.0112 0.0151 0.0227 0.027 0.021 0.0253 0.0169 0.0308 0.0566 0.0342 0.0153 0.0082 0.0051 0.0035 0.0084 0.013 0.0041
Golgi 0.0088 0.0005 0.0017 0.0026 0.0048 0.0021 0.0067 0.0014 0.0058 0.0164 0.0195 0.0019 0.0018 0.0003 0.0004 0.0003 0.0005 0.0002
Lipid Particles 0.0162 0.0001 0.0032 0.006 0.0019 0.0014 0.0097 0.0003 0.0017 0.0008 0.0297 0.0013 0.0045 0.0001 0.0001 0.0005 0 0
Mitochondria 0.0033 0.0003 0.0018 0.0354 0.0035 0.001 0.0083 0.0005 0.0048 0.0094 0.032 0.0095 0.0008 0.0001 0.0002 0.0003 0.0013 0.0002
None 0.1927 0.1149 0.1654 0.1004 0.0751 0.1343 0.1285 0.0594 0.1004 0.0867 0.1267 0.0622 0.2576 0.124 0.201 0.2167 0.0782 0.1825
Nuclear Periphery 0.0071 0.0005 0.0032 0.0031 0.0231 0.0023 0.0025 0.0006 0.0021 0.0011 0.0082 0.0015 0.0025 0.0004 0.0003 0.001 0.0004 0.0002
Nucleolus 0.0024 0.0001 0.0003 0.0002 0.0008 0.0001 0.0005 0.0003 0.0003 0.0002 0.0004 0.0001 0.0032 0.0001 0 0.0001 0 0
Nucleus 0.0046 0.0013 0.0042 0.002 0.0059 0.001 0.0017 0.001 0.0016 0.0017 0.0062 0.0013 0.0048 0.0007 0.0006 0.0009 0.0009 0.0005
Peroxisomes 0.0077 0.0001 0.0029 0.0056 0.0028 0.0066 0.0101 0.0015 0.0021 0.0017 0.0235 0.0021 0.0029 0 0 0.0002 0.0001 0
Punctate Nuclear 0.0084 0.0005 0.0025 0.0082 0.0044 0.0031 0.0012 0.0008 0.001 0.0004 0.0048 0.0044 0.0044 0.0002 0.0001 0.0003 0.0002 0.0001
Vacuole 0.0041 0.0031 0.004 0.0031 0.0038 0.0022 0.0047 0.0027 0.0067 0.0059 0.0029 0.0021 0.0019 0.002 0.0012 0.0051 0.0016 0.0009
Vacuole Periphery 0.001 0.0004 0.0006 0.0013 0.0021 0.0007 0.0009 0.0006 0.0011 0.0018 0.0018 0.0006 0.0004 0.0002 0.0002 0.0005 0.0005 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 31.7647 14.9451 28.8338 44.609 30.3463 26.7344 33.2441 28.5569 28.2158 41.0637
Translational Efficiency 2.6053 6.071 2.9311 1.6036 2.6164 3.2484 2.1397 3.1495 2.3788 2.391

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
188 616 2419 922 341 2037 1962 1481 529 2653 4381 2403

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 782.31 902.81 1010.48 1048.17 721.00 893.33 985.49 1036.97 742.79 895.53 999.29 1041.27
Standard Deviation 90.55 123.40 120.82 173.92 117.03 111.41 124.71 153.51 112.26 114.38 123.20 161.74
Intensity Change Log 2 — 0.206682 0.369228 0.422060 — 0.309194 0.450842 0.524303 — 0.256757 0.408947 0.472002

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000149 0.000546 0.000060 0.000896 0.000197 0.000468 0.000176 0.001150 0.000180 0.000486 0.000112 0.001052
Bud Neck 0.015871 0.008782 0.001047 0.002344 0.009830 0.009743 0.001362 0.002275 0.011977 0.009520 0.001188 0.002302
Bud Site 0.014786 0.037896 0.005057 0.024400 0.015005 0.021950 0.013296 0.022343 0.014927 0.025653 0.008746 0.023132
Cell Periphery 0.000181 0.000128 0.000030 0.000111 0.000191 0.000083 0.000037 0.000063 0.000188 0.000093 0.000033 0.000082
Cytoplasm 0.510158* 0.569283* 0.833929* 0.711986* 0.537743* 0.591323* 0.820022* 0.730139* 0.527940* 0.586205* 0.827701* 0.723174*
Cytoplasmic Foci 0.312589* 0.234225* 0.025499 0.078275 0.235506* 0.212588* 0.035727 0.053783 0.262900* 0.217612* 0.030079 0.063180
Eisosomes 0.000179 0.000061 0.000007 0.000024 0.000155 0.000084 0.000009 0.000020 0.000163 0.000078 0.000008 0.000022
Endoplasmic Reticulum 0.000825 0.000649 0.000359 0.000865 0.001217 0.000447 0.000277 0.000574 0.001078 0.000494 0.000323 0.000686
Endosome 0.035878 0.029118 0.001492 0.004016 0.032806 0.025205 0.002754 0.006463 0.033898 0.026113 0.002057 0.005524
Golgi 0.006418 0.008447 0.000156 0.001122 0.003792 0.009270 0.000192 0.003222 0.004725 0.009079 0.000172 0.002416
Lipid Particles 0.004866 0.003045 0.000383 0.001149 0.006547 0.001526 0.000357 0.000592 0.005950 0.001879 0.000371 0.000806
Mitochondria 0.001476 0.002056 0.000562 0.001445 0.005717 0.003087 0.000086 0.004036 0.004210 0.002848 0.000349 0.003042
Mitotic Spindle 0.001876 0.000922 0.003151 0.004507 0.001295 0.003881 0.003048 0.012149 0.001502 0.003194 0.003104 0.009217
None 0.000349 0.000488 0.002475 0.000563 0.002007 0.000621 0.001187 0.001462 0.001418 0.000590 0.001898 0.001117
Nuclear Periphery 0.000090 0.000055 0.000216 0.000215 0.000445 0.000042 0.000128 0.000165 0.000319 0.000045 0.000177 0.000184
Nuclear Periphery Foci 0.000768 0.000552 0.000748 0.003311 0.000851 0.000208 0.001558 0.001311 0.000821 0.000288 0.001111 0.002078
Nucleolus 0.001853 0.000247 0.000107 0.000097 0.001130 0.000207 0.000086 0.000134 0.001387 0.000216 0.000098 0.000120
Nucleus 0.013688 0.011799 0.069009 0.027464 0.028958 0.012770 0.036297 0.024513 0.023531 0.012544 0.054359 0.025645
Peroxisomes 0.003153 0.003611 0.000127 0.001073 0.002309 0.003171 0.000487 0.002236 0.002609 0.003273 0.000289 0.001790
Vacuole 0.071890 0.085589 0.055413 0.134668 0.112139 0.100672 0.082772 0.132400 0.097835 0.097170 0.067666 0.133270
Vacuole Periphery 0.002958 0.002501 0.000172 0.001467 0.002159 0.002657 0.000141 0.000968 0.002443 0.002621 0.000158 0.001159

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.87 5.08 -3.06 -0.85 -3.47 -1.70 0.65 -1.43 -0.54 -1.51 -2.42 2.94 -2.41 -0.85 -2.71
Bud Neck 2.56 5.54 5.22 7.05 -3.12 0.01 6.23 5.79 13.76 -2.00 1.79 8.30 7.73 15.57 -3.52
Bud Site -5.53 3.43 -1.30 4.92 -6.46 -3.19 2.04 -0.22 3.07 -2.38 -5.46 4.54 -1.05 4.76 -6.54
Cell Periphery 2.44 9.31 4.76 1.75 -9.59 6.12 8.85 8.02 6.56 -3.38 7.10 12.22 9.20 4.34 -9.72
Cytoplasm -2.78 -15.23 -7.63 -6.86 14.88 -3.83 -17.32 -10.87 -12.08 10.26 -5.00 -23.48 -13.19 -13.53 17.79
Cytoplasmic Foci 4.85 19.84 16.31 18.89 -14.06 2.09 20.06 18.28 35.48 -6.38 5.00 27.81 23.95 39.25 -14.99
Eisosomes 4.78 7.03 6.42 6.61 -9.37 3.44 8.15 7.77 6.15 -4.44 5.16 10.78 10.06 7.01 -9.26
Endoplasmic Reticulum 0.79 2.04 0.46 -0.49 -2.71 3.14 3.91 3.26 0.42 -0.85 3.28 4.25 3.08 -0.27 -1.95
Endosome 1.47 8.18 7.77 11.47 -7.30 2.11 8.90 8.27 15.99 -3.33 2.75 12.04 11.22 20.02 -5.68
Golgi -1.32 5.86 5.20 8.16 -1.91 -6.12 5.65 2.41 8.89 -2.59 -5.59 8.10 5.05 12.14 -3.03
Lipid Particles 1.11 4.01 3.25 1.47 -7.53 4.17 5.08 4.95 8.71 -3.19 4.45 6.35 5.86 3.49 -7.40
Mitochondria -0.47 1.79 0.93 1.14 -0.51 0.78 1.72 1.06 0.89 -2.40 0.63 1.85 1.19 1.54 -2.26
Mitotic Spindle 0.54 -0.56 -0.97 -2.96 -0.80 -2.09 -1.05 -3.96 -2.48 -3.51 -1.52 -1.27 -3.86 -2.77 -3.48
None -0.68 -14.10 -1.70 -0.48 15.80 1.60 0.97 0.94 -1.36 0.09 1.47 -0.73 0.85 -1.30 4.01
Nuclear Periphery 1.49 -8.39 -5.51 -9.15 2.08 2.61 1.61 1.57 -14.45 -0.49 2.74 0.61 0.95 -16.71 2.61
Nuclear Periphery Foci 0.43 -0.26 -4.47 -8.33 -7.43 4.33 -4.54 -2.45 -10.63 2.68 2.76 -2.10 -5.24 -12.63 -5.42
Nucleolus 0.97 1.03 1.04 2.04 3.37 1.68 1.88 1.83 3.27 -1.92 1.61 1.74 1.74 4.11 -0.57
Nucleus 0.81 -23.14 -6.16 -8.14 19.58 4.49 -3.37 0.37 -10.37 7.93 4.46 -13.90 -1.75 -13.77 21.04
Peroxisomes -0.35 4.65 3.55 5.15 -4.42 -1.97 5.37 1.79 3.78 -2.29 -1.50 7.26 3.59 6.16 -3.41
Vacuole -2.13 -1.43 -13.62 -13.39 -15.48 1.82 -0.72 -7.74 -14.13 -9.92 0.29 0.14 -13.37 -19.09 -18.94
Vacuole Periphery 0.68 4.13 2.37 2.58 -1.12 -1.45 7.31 5.22 8.62 -3.05 -0.49 7.63 4.64 6.67 -2.08
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit of heterohexameric prefoldin; prefoldin binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin; prefoldin complex also localizes to chromatin of actively transcribed genes in the nucleus and facilitates transcriptional elongation
Localization
Cell Percentages cytoplasm (87%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Pfd1

Pfd1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Pfd1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available