Standard name
Human Ortholog
Description FG-nucleoporin component of central core of nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes directly to nucleocytoplasmic transport; involved in regulation of transcription and mitosis; induces membrane tubulation, which may contribute to nuclear pore assembly; NUP53 has a paralog, ASM4, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0.05 0 0 0 0 0 0 0 0.09 0.09 0.13 0.05 0.07 0.05 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0.14 0.11 0.14 0.11 0.28 0.31 0.25 0.34 0.4 0.41 0.32 0 0 0 0.07 0.12 0.05 0 0 0 0.09 0.1 0.12
Nucleus 0.07 0.06 0 0 0 0 0 0 0 0 0.05 0 0.08 0.08 0.05 0.05 0.05 0 0 0 0 0 0 0
Nuclear Periphery 0.79 0.84 0.87 0.84 0.75 0.69 0.7 0.69 0.61 0.59 0.61 0.67 0.75 0.75 0.68 0.7 0.64 0.76 0.87 0.83 0.92 0.8 0.78 0.73
Nucleolus 0 0 0.13 0.26 0.13 0.23 0.24 0.3 0.31 0.32 0.33 0.39 0 0 0 0.05 0.1 0.09 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.34 0.24 0.17 0.1 0.16 0.1 0.06 0.06 0.06 0.05 0 0.05 0.25 0.25 0.33 0.37 0.33 0.38 0 0.06 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 1 0 1 0 0 0 1 0 0 0 0 3 0 0 0 2 0 1 0 5 3
Bud 0 0 0 0 1 0 1 2 4 2 1 2 0 0 0 0 1 0 0 0 0 2 2 3
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 1
Bud Site 0 0 0 0 2 1 3 5 2 1 5 1 2 2 3 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 3 2 9 2 13 10 14 11 6 11 9 7 38 38 54 8 12 5 1 0 0 2 1 1
Endoplasmic Reticulum 0 1 4 1 1 3 2 3 1 1 2 4 2 6 4 1 3 2 0 0 0 2 3 2
Endosome 3 0 13 9 16 15 12 25 3 4 1 8 2 2 6 3 4 2 5 1 5 7 20 26
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 1 0 3 8 9
Mitochondria 8 15 38 35 31 139 172 173 127 186 203 166 4 4 4 10 21 5 5 2 7 29 56 82
Nucleus 18 6 5 6 9 16 18 22 12 17 26 14 32 32 20 7 9 3 4 3 3 1 5 4
Nuclear Periphery 202 91 308 214 213 346 383 487 228 278 300 342 307 311 292 105 115 71 257 91 346 276 455 496
Nucleolus 11 4 47 65 37 114 134 209 117 151 160 199 14 14 6 7 19 8 2 0 1 2 3 5
Peroxisomes 0 0 0 0 1 0 0 1 0 1 1 1 0 0 6 0 0 0 0 0 0 1 4 9
SpindlePole 0 1 0 0 1 2 0 5 1 2 2 1 7 8 18 0 2 0 2 0 1 2 1 2
Vac/Vac Membrane 88 26 60 25 45 48 33 40 24 24 16 26 102 104 142 56 59 36 10 6 5 9 16 23
Unique Cell Count 257 108 354 254 285 501 551 704 373 469 490 514 410 415 430 150 181 94 296 110 376 343 586 678
Labelled Cell Count 333 146 484 358 370 695 772 983 525 679 726 771 510 521 558 197 247 133 296 110 376 343 586 678


Nuclear Periphery

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 10.2 9.1 9.7 9.5 8.9 7.9 7.8 8.2 7.7 7.5 7.6 8.3 8.9 8.9 9.1 9.4 10.3 13.0 9.2 10.3 10.5
Std Deviation (1e-4) 2.2 1.9 2.5 2.8 2.4 2.1 2.1 2.1 2.3 2.4 2.3 2.9 2.1 2.1 2.4 2.0 3.0 3.6 1.9 1.8 1.8
Intensity Change (Log2) – – – -0.02 -0.11 -0.29 -0.31 -0.24 -0.33 -0.37 -0.34 -0.23 -0.12 -0.12 -0.09 -0.04 0.1 0.43 -0.08 0.09 0.12

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP700051015WT3HU80HU120HU160051015WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3051015WT1AF100AF140AF180051015
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 1.4 -0.5 0 -1.1 -0.9 -0.2 -0.7 -1.3 3.9 3.8 5.1 1.6 2.3 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome -0.1 1.2 -0.5 -1.3 -0.1 -2.6 -2.8 -3.9 -2.0 -3.2 -3.2 -2.1 0 -0.9 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 1.1 0.1 6.0 7.1 5.3 7.5 9.2 9.7 7.4 -5.9 -5.9 -6.1 -1.4 0.3 -1.6
Nucleus 0 1.5 1.7 1.7 1.7 1.6 1.9 3.0 1.3 4.1 4.1 2.6 0 0 0
Nuclear Periphery -1.0 -4.0 -6.1 -6.0 -6.3 -7.9 -8.7 -8.2 -6.8 -4.2 -4.2 -6.3 -4.5 -6.3 -2.7
Nucleolus 3.9 -0.1 3.5 4.1 5.9 5.8 6.3 6.5 8.2 -5.0 -5.1 -6.6 -2.9 -0.9 -1.3
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 3.9 0 0 0
Vacuole -2.5 -0.4 -3.2 -5.3 -5.9 -4.4 -5.6 -6.9 -5.8 2.7 2.7 5.1 5.0 4.1 4.5

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 7.5217 7.4632 6.7619 6.3754 7.2331 6.7118 9.1812 9.4465 8.8883 8.6795 8.7619 8.8441 10.2631 9.5296 9.2023 9.57 7.7167 9.1844
Actin 0.0084 0 0.0102 0.0004 0.0008 0.0039 0.008 0.0001 0.0203 0.0114 0.0021 0.0018 0.0001 0.0002 0.0004 0.0006 0.0001 0
Bud 0.0001 0 0.0001 0 0 0.0001 0.0002 0 0.0001 0.0001 0 0 0 0 0 0 0 0
Bud Neck 0.0005 0 0.0007 0 0 0.0001 0.0002 0 0.0005 0.0002 0.0001 0 0 0 0.0002 0.0001 0 0
Bud Periphery 0.0002 0 0.0001 0.0001 0.0001 0.0002 0.0004 0.0001 0.0002 0.0004 0.0002 0.0001 0.0001 0.0001 0.0001 0.0002 0 0
Bud Site 0.0007 0 0.0046 0 0 0.0002 0.0006 0 0.0007 0.0012 0 0 0 0 0.0009 0 0 0
Cell Periphery 0.0001 0 0.0001 0 0.0001 0 0.0001 0 0.0001 0.0001 0 0 0 0 0.0001 0 0 0
Cytoplasm 0.002 0 0.0005 0.0002 0 0.0002 0.0039 0 0.0009 0.0004 0.0067 0 0 0 0 0 0 0
Cytoplasmic Foci 0.0049 0 0.004 0.0007 0.0001 0.0012 0.0074 0 0.0026 0.0079 0.0013 0.0007 0 0 0.0013 0 0 0.0001
Eisosomes 0.0001 0 0.0001 0 0.0001 0 0.0001 0 0.0001 0.0002 0.0002 0 0 0 0 0 0 0
Endoplasmic Reticulum 0.0024 0.0003 0.0008 0.0016 0.0013 0.0004 0.0042 0.0006 0.0016 0.0012 0.0014 0.0002 0.0003 0.0007 0.0004 0.0015 0.0003 0.0001
Endosome 0.0071 0.0001 0.0021 0.0014 0.0014 0.003 0.0131 0.0003 0.0053 0.0041 0.007 0.001 0.0001 0.0001 0.0024 0.0005 0.0003 0.0001
Golgi 0.0022 0 0.0011 0.0004 0.0035 0.0009 0.0038 0.0001 0.0021 0.0039 0.0008 0.001 0.0001 0 0.0012 0.0002 0.0002 0.0002
Lipid Particles 0.0061 0.0001 0.0076 0.0076 0.0045 0.0042 0.0135 0.002 0.0155 0.0066 0.0025 0.0027 0.0005 0.0002 0.0063 0.0007 0.0031 0.0097
Mitochondria 0.0014 0.0002 0.0009 0.001 0.0053 0.0013 0.0044 0.0132 0.0022 0.0181 0.0167 0.0005 0.0007 0.0012 0.0014 0.0019 0.0003 0.0002
None 0.0022 0 0.0005 0.0003 0.0002 0.0004 0.0017 0.0001 0.0008 0.0008 0.0077 0.0001 0.0001 0.0001 0.0002 0.0002 0.0001 0
Nuclear Periphery 0.91 0.9519 0.9108 0.9421 0.9449 0.9459 0.8876 0.928 0.8994 0.8818 0.8917 0.9719 0.9697 0.9318 0.944 0.9509 0.9667 0.9726
Nucleolus 0.0015 0.0006 0.0036 0.0004 0.0005 0.0013 0.0006 0.0003 0.0009 0.0006 0.0009 0.0003 0.0001 0.0005 0.0007 0.0003 0.0003 0.0002
Nucleus 0.012 0.0259 0.0123 0.0109 0.0036 0.0188 0.0063 0.0038 0.0083 0.0079 0.0083 0.0024 0.0009 0.0227 0.0029 0.0029 0.0032 0.0014
Peroxisomes 0.003 0 0.0034 0.0001 0 0.0007 0.009 0 0.0013 0.0103 0.0002 0.0017 0 0 0.0007 0 0 0
Punctate Nuclear 0.0159 0.0002 0.0086 0.0014 0.0005 0.0022 0.0036 0.0003 0.0031 0.0023 0.0153 0.0009 0.0002 0.0001 0.0006 0.0005 0.0007 0.0003
Vacuole 0.001 0.0002 0.0004 0.0008 0.0006 0.0017 0.0042 0.0007 0.0015 0.0006 0.0006 0.0001 0.0001 0.0004 0.0006 0.0005 0.0002 0.0001
Vacuole Periphery 0.0181 0.0204 0.0277 0.0305 0.0325 0.0131 0.0269 0.0503 0.0325 0.0399 0.0363 0.0145 0.027 0.0417 0.0355 0.039 0.0243 0.015

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 13.5221 26.2481 18.4521 20.097 20.5375 8.4949 21.476 19.5621 19.5614 23.6211
Translational Efficiency 3.1437 2.1526 2.0273 1.5186 2.2884 4.4509 1.9371 1.8566 1.7681 1.7386

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✔

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
868 1525 735 106 1838 1027 149 1741 2706 2552 884 1847

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1049.84 1028.13 1092.03 1532.71 902.90 1062.95 1340.61 1250.45 950.03 1042.14 1133.93 1266.65
Standard Deviation 138.34 215.26 210.44 239.10 143.86 162.83 153.20 210.39 157.80 196.60 222.34 222.07
Intensity Change Log 2 — -0.030147 0.056843 0.545915 — 0.235436 0.570251 0.469809 — 0.098748 0.317023 0.511224

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000461 0.000664 0.000629 0.000090 0.000628 0.000688 0.000489 0.000525 0.000574 0.000674 0.000606 0.000500
Bud Neck 0.000654 0.000796 0.001615 0.002077 0.000612 0.000626 0.001361 0.002339 0.000626 0.000728 0.001572 0.002324
Bud Site 0.000371 0.000302 0.000194 0.000386 0.000529 0.000193 0.000216 0.000761 0.000478 0.000258 0.000198 0.000739
Cell Periphery 0.000063 0.000133 0.000040 0.000019 0.000165 0.000155 0.000016 0.000072 0.000132 0.000142 0.000036 0.000069
Cytoplasm 0.000418 0.001160 0.001694 0.000067 0.002096 0.001236 0.000145 0.002692 0.001558 0.001191 0.001433 0.002541
Cytoplasmic Foci 0.001718 0.001867 0.000259 0.010264 0.001311 0.001236 0.000276 0.002333 0.001442 0.001613 0.000262 0.002788
Eisosomes 0.000005 0.000009 0.000006 0.000005 0.000013 0.000012 0.000007 0.000009 0.000010 0.000010 0.000007 0.000008
Endoplasmic Reticulum 0.005281 0.007992 0.004192 0.000571 0.012550 0.009717 0.005858 0.002964 0.010218 0.008686 0.004473 0.002827
Endosome 0.002728 0.002905 0.000646 0.001329 0.003572 0.002523 0.000431 0.001693 0.003301 0.002751 0.000610 0.001672
Golgi 0.001048 0.001384 0.000298 0.000609 0.001290 0.000723 0.000196 0.000972 0.001213 0.001118 0.000281 0.000951
Lipid Particles 0.001381 0.004398 0.000296 0.003107 0.012109 0.005501 0.000501 0.001020 0.008668 0.004842 0.000331 0.001139
Mitochondria 0.006391 0.007995 0.002519 0.000950 0.014356 0.009307 0.001324 0.004589 0.011801 0.008523 0.002317 0.004380
Mitotic Spindle 0.007539 0.003960 0.011211 0.030721 0.001087 0.002159 0.011034 0.023084 0.003157 0.003235 0.011181 0.023522
None 0.000378 0.003134 0.001113 0.000075 0.004295 0.002508 0.000180 0.002701 0.003039 0.002882 0.000956 0.002551
Nuclear Periphery 0.671354 0.517608 0.488807 0.674004 0.502287 0.524613 0.600593 0.589731 0.556518 0.520427 0.507649 0.594568
Nuclear Periphery Foci 0.242316 0.368997 0.322106 0.239472 0.379236 0.339433 0.288913 0.260596 0.335316 0.357100 0.316511 0.259383
Nucleolus 0.015902 0.022376 0.053111 0.007107 0.017773 0.033289 0.036172 0.031406 0.017173 0.026767 0.050256 0.030011
Nucleus 0.029800 0.031463 0.105718 0.003201 0.016777 0.047891 0.048749 0.056660 0.020955 0.038074 0.096116 0.053592
Peroxisomes 0.000477 0.000505 0.000497 0.000399 0.000682 0.000770 0.000767 0.000636 0.000616 0.000612 0.000543 0.000623
Vacuole 0.004999 0.007927 0.001638 0.008559 0.009496 0.006862 0.001248 0.005790 0.008054 0.007498 0.001572 0.005949
Vacuole Periphery 0.006715 0.014424 0.003410 0.016988 0.019136 0.010559 0.001523 0.009426 0.015152 0.012869 0.003092 0.009860

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.07 -2.19 4.53 8.74 7.94 -0.55 1.11 0.60 1.19 -0.74 -1.35 -1.03 0.37 1.86 1.43
Bud Neck -0.84 -5.50 -1.83 -1.71 -0.67 -0.21 -1.03 -6.90 -6.69 -0.82 -1.22 -4.70 -7.07 -6.75 -2.65
Bud Site 0.38 0.13 -0.14 -0.31 -0.21 1.82 0.73 -1.29 -3.13 -1.74 1.56 0.79 -1.59 -2.82 -2.18
Cell Periphery -2.55 0.93 2.07 6.38 3.34 0.12 9.36 5.02 1.27 -6.80 -0.36 6.90 4.01 2.45 -3.67
Cytoplasm -2.97 -2.76 3.46 4.68 3.41 1.17 3.71 -1.40 -2.53 -4.79 0.70 -0.34 -2.14 -2.78 -1.66
Cytoplasmic Foci -0.24 2.10 -1.19 -1.17 -1.38 0.21 3.89 -1.62 -1.63 -3.52 -0.42 4.03 -1.86 -1.60 -3.60
Eisosomes -3.22 -1.61 0.15 1.97 1.19 0.53 2.29 2.37 1.54 -0.81 0.04 2.09 0.90 0.90 -1.11
Endoplasmic Reticulum -2.40 1.05 4.86 14.30 11.81 2.30 4.98 11.50 6.65 2.50 1.96 8.24 10.92 10.37 3.91
Endosome -0.22 2.74 1.45 2.21 -0.99 1.84 8.90 4.33 1.43 -3.80 1.29 8.06 3.79 2.65 -3.62
Golgi -0.77 1.86 0.94 2.16 -1.22 1.35 3.87 0.90 -0.69 -3.38 0.28 4.13 0.82 0.53 -3.31
Lipid Particles -3.56 1.85 -1.18 0.89 -2.07 4.36 9.95 9.38 4.50 -2.52 3.90 10.17 8.93 6.36 -3.94
Mitochondria -0.79 2.02 2.89 8.01 3.41 2.99 9.86 6.72 3.72 -5.22 2.60 8.45 6.02 4.60 -3.24
Mitotic Spindle 1.89 -1.05 -2.28 -2.67 -1.96 -1.48 -1.95 -9.03 -8.43 -2.44 0.08 -3.35 -8.37 -8.44 -4.04
None -4.60 -3.04 2.77 5.12 4.39 2.18 5.92 1.56 -0.38 -3.93 0.17 3.91 0.50 0.38 -2.46
Nuclear Periphery 13.70 13.25 0.09 -5.59 -6.48 -2.13 -4.25 -8.11 -4.98 0.79 4.80 4.65 -3.28 -7.26 -6.64
Nuclear Periphery Foci -14.87 -7.53 0.27 7.16 4.30 4.54 5.44 16.22 9.47 1.81 -3.48 2.38 11.91 15.04 6.52
Nucleolus -2.32 -8.24 1.13 2.42 6.99 -4.83 -2.53 -5.63 -0.24 0.38 -4.84 -8.84 -5.82 -2.11 4.16
Nucleus -0.14 -8.75 5.73 7.82 12.59 -6.70 -3.15 -10.32 -2.33 -1.07 -5.83 -10.95 -8.88 -4.52 5.07
Peroxisomes -0.20 -0.43 0.12 0.23 0.35 -0.96 -0.73 -0.05 0.48 0.52 0.03 0.29 -0.38 -0.41 -0.54
Vacuole -1.91 2.38 -0.93 -0.21 -1.81 1.82 7.86 2.95 0.46 -4.48 0.56 8.58 1.66 1.10 -5.32
Vacuole Periphery -3.93 2.07 -1.64 -0.42 -2.22 4.79 13.60 6.20 0.73 -7.50 1.70 11.20 3.86 2.28 -6.20
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description FG-nucleoporin component of central core of nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes directly to nucleocytoplasmic transport; involved in regulation of transcription and mitosis; induces membrane tubulation, which may contribute to nuclear pore assembly; NUP53 has a paralog, ASM4, that arose from the whole genome duplication
Localization
Cell Percentages nuclear periphery (90%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Nup53

Nup53


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Nup53-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available