Standard name | |
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Human Ortholog | |
Description | Mitochondrial acetyl-coenzyme A carboxylase; catalyzes production of malonyl-CoA in mitochondrial fatty acid biosynthesis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress; genetic and comparative analysis suggests that translation begins at a non-canonical (Ile) start codon at -372 relative to the annotated start codon |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 10 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | – | 0 | 0 | 2 | 2 | 1 | – | – | – | 4 | 17 | 13 | 14 | 26 | 24 |
Bud | 6 | 12 | 30 | 21 | 25 | 15 | 31 | 41 | 31 | – | 11 | 19 | 19 | 12 | 28 | – | – | – | 0 | 2 | 3 | 4 | 5 | 9 |
Bud Neck | 2 | 2 | 8 | 0 | 6 | 3 | 3 | 3 | 1 | – | 0 | 0 | 2 | 3 | 2 | – | – | – | 1 | 5 | 3 | 8 | 6 | 12 |
Bud Site | 2 | 1 | 5 | 1 | 2 | 8 | 9 | 15 | 15 | – | 6 | 8 | 1 | 0 | 4 | – | – | – | – | – | – | – | – | – |
Cell Periphery | 3 | 3 | 4 | 1 | 1 | 1 | 2 | 2 | 4 | – | 1 | 3 | 8 | 7 | 0 | – | – | – | 0 | 2 | 1 | 0 | 0 | 1 |
Cytoplasm | 27 | 139 | 127 | 110 | 72 | 76 | 91 | 93 | 50 | – | 16 | 28 | 227 | 329 | 380 | – | – | – | 4 | 36 | 17 | 23 | 25 | 20 |
Endoplasmic Reticulum | 10 | 5 | 1 | 4 | 3 | 3 | 3 | 4 | 3 | – | 3 | 3 | 2 | 6 | 2 | – | – | – | 0 | 1 | 3 | 3 | 3 | 5 |
Endosome | 30 | 26 | 17 | 4 | 26 | 7 | 9 | 14 | 0 | – | 0 | 0 | 42 | 70 | 19 | – | – | – | 53 | 59 | 40 | 40 | 56 | 53 |
Golgi | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 1 | 1 | 0 | 0 | – | – | – | 5 | 6 | 4 | 2 | 7 | 7 |
Mitochondria | 32 | 129 | 138 | 222 | 202 | 319 | 438 | 465 | 357 | – | 219 | 314 | 86 | 33 | 182 | – | – | – | 132 | 247 | 217 | 231 | 282 | 263 |
Nucleus | 1 | 0 | 1 | 0 | 3 | 3 | 7 | 7 | 1 | – | 0 | 1 | 0 | 0 | 0 | – | – | – | 0 | 1 | 1 | 1 | 1 | 0 |
Nuclear Periphery | 2 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | – | 4 | 3 | 1 | 0 | 0 | – | – | – | 2 | 0 | 1 | 1 | 0 | 0 |
Nucleolus | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 5 | 3 | – | 2 | 3 | 0 | 0 | 1 | – | – | – | 0 | 0 | 1 | 1 | 1 | 1 |
Peroxisomes | 3 | 24 | 15 | 8 | 35 | 4 | 26 | 23 | 6 | – | 1 | 1 | 34 | 46 | 9 | – | – | – | 20 | 15 | 19 | 16 | 19 | 26 |
SpindlePole | 30 | 26 | 52 | 18 | 68 | 40 | 83 | 74 | 22 | – | 20 | 22 | 49 | 35 | 32 | – | – | – | 13 | 26 | 33 | 32 | 35 | 32 |
Vac/Vac Membrane | 20 | 43 | 6 | 6 | 18 | 17 | 12 | 13 | 10 | – | 4 | 8 | 18 | 18 | 17 | – | – | – | 3 | 26 | 10 | 23 | 18 | 19 |
Unique Cell Count | 149 | 337 | 323 | 320 | 356 | 410 | 569 | 603 | 409 | 235 | 340 | 409 | 492 | 552 | 250 | 458 | 386 | 417 | 503 | 494 | ||||
Labelled Cell Count | 180 | 412 | 405 | 396 | 464 | 497 | 715 | 760 | 504 | 287 | 414 | 492 | 561 | 677 | 250 | 458 | 386 | 417 | 503 | 494 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 5.0 | 3.9 | 3.4 | 3.4 | 3.8 | 3.4 | 3.2 | 3.3 | 2.8 | – | 3.4 | 2.9 | 4.2 | 4.5 | 3.7 | – | – | – | 4.3 | 4.5 | 5.0 |
Std Deviation (1e-4) | 0.7 | 0.6 | 1.3 | 1.1 | 1.4 | 1.1 | 1.1 | 1.1 | 0.6 | – | 5.5 | 3.2 | 1.0 | 1.2 | 1.0 | – | – | – | 1.1 | 1.3 | 1.6 |
Intensity Change (Log2) | – | – | – | -0.0 | 0.14 | -0.01 | -0.09 | -0.07 | -0.3 | – | -0.01 | -0.22 | 0.3 | 0.38 | 0.1 | – | – | – | 0.34 | 0.38 | 0.55 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Actin | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud Neck | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud Site | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cell Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cyto | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Endoplasmic Reticulum | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Endosome | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Golgi | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Mitochondria | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nuclear Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nuc | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nucleolus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Peroxisomes | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
SpindlePole | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Vac | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cortical Patches | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cytoplasm | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nucleus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Vacuole | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 3.9541 | 3.2532 | 3.1009 | 2.8412 | 3.3521 | 3.0748 | 0.1287 | -1.1974 | -0.8365 | -1.064 | -0.4616 | -0.7448 | 3.9494 | 3.5988 | 3.1516 | 3.2504 | 3.5852 | 3.8345 |
Actin | 0.0986 | 0.012 | 0.028 | 0.0088 | 0.0258 | 0.0237 | 0.0062 | 0.0187 | 0.0146 | 0.0048 | 0.0028 | 0.0184 | 0.0523 | 0.0295 | 0.0456 | 0.0163 | 0.0343 | 0.0153 |
Bud | 0.0024 | 0.003 | 0.0038 | 0.0049 | 0.0052 | 0.0012 | 0.0015 | 0.003 | 0.0113 | 0.0381 | 0.0006 | 0.0056 | 0.0019 | 0.0071 | 0.0081 | 0.0071 | 0.003 | 0.0022 |
Bud Neck | 0.0085 | 0.0032 | 0.0098 | 0.0083 | 0.0033 | 0.0287 | 0.0058 | 0.0026 | 0.0051 | 0.0018 | 0.0013 | 0.0074 | 0.0016 | 0.0057 | 0.0028 | 0.0031 | 0.0011 | 0.0085 |
Bud Periphery | 0.0065 | 0.0062 | 0.0142 | 0.0137 | 0.0251 | 0.0037 | 0.0023 | 0.0047 | 0.0082 | 0.018 | 0.0018 | 0.0101 | 0.0047 | 0.0128 | 0.0113 | 0.0258 | 0.0133 | 0.0052 |
Bud Site | 0.0135 | 0.0532 | 0.0343 | 0.0165 | 0.0124 | 0.004 | 0.0118 | 0.04 | 0.0538 | 0.0085 | 0.0013 | 0.0019 | 0.0056 | 0.0617 | 0.0314 | 0.0026 | 0.0022 | 0.0018 |
Cell Periphery | 0.0074 | 0.0076 | 0.0106 | 0.0069 | 0.008 | 0.0111 | 0.0007 | 0.0022 | 0.0017 | 0.0026 | 0.001 | 0.0013 | 0.0042 | 0.0051 | 0.0019 | 0.0054 | 0.0017 | 0.0037 |
Cytoplasm | 0.0887 | 0.2095 | 0.1882 | 0.0984 | 0.1423 | 0.1317 | 0.0149 | 0.0685 | 0.0819 | 0.0925 | 0.0354 | 0.0975 | 0.0778 | 0.1221 | 0.0682 | 0.1061 | 0.0862 | 0.1101 |
Cytoplasmic Foci | 0.0928 | 0.1324 | 0.0973 | 0.079 | 0.1046 | 0.1188 | 0.145 | 0.1425 | 0.0922 | 0.1114 | 0.1668 | 0.1097 | 0.1671 | 0.143 | 0.1581 | 0.1107 | 0.1963 | 0.1689 |
Eisosomes | 0.0022 | 0.0015 | 0.0018 | 0.0016 | 0.0019 | 0.001 | 0.0006 | 0.0009 | 0.0008 | 0.0005 | 0.0001 | 0.0004 | 0.0012 | 0.0016 | 0.0023 | 0.0003 | 0.0044 | 0.0007 |
Endoplasmic Reticulum | 0.0308 | 0.02 | 0.0138 | 0.0088 | 0.0419 | 0.019 | 0.0044 | 0.0078 | 0.0064 | 0.0067 | 0.0045 | 0.0104 | 0.0054 | 0.0028 | 0.0035 | 0.005 | 0.0031 | 0.0039 |
Endosome | 0.1588 | 0.1255 | 0.1026 | 0.074 | 0.1454 | 0.1269 | 0.1836 | 0.2234 | 0.1456 | 0.1665 | 0.1793 | 0.1563 | 0.1636 | 0.1665 | 0.1083 | 0.1349 | 0.1066 | 0.1233 |
Golgi | 0.0521 | 0.0453 | 0.0431 | 0.0292 | 0.0724 | 0.0569 | 0.0538 | 0.0686 | 0.0703 | 0.0486 | 0.0543 | 0.0371 | 0.079 | 0.0744 | 0.0629 | 0.0635 | 0.0433 | 0.0618 |
Lipid Particles | 0.0652 | 0.019 | 0.0279 | 0.023 | 0.036 | 0.0379 | 0.0812 | 0.0445 | 0.027 | 0.0618 | 0.0514 | 0.0349 | 0.051 | 0.01 | 0.0171 | 0.0081 | 0.0252 | 0.0294 |
Mitochondria | 0.1355 | 0.113 | 0.2201 | 0.3882 | 0.2209 | 0.2514 | 0.277 | 0.1927 | 0.3011 | 0.2445 | 0.3105 | 0.2967 | 0.1622 | 0.1691 | 0.2766 | 0.3142 | 0.2343 | 0.1908 |
None | 0.1342 | 0.1937 | 0.1444 | 0.1694 | 0.0773 | 0.1212 | 0.0623 | 0.1106 | 0.0953 | 0.1386 | 0.0217 | 0.1351 | 0.1079 | 0.1473 | 0.0941 | 0.1411 | 0.1242 | 0.205 |
Nuclear Periphery | 0.0154 | 0.0025 | 0.0016 | 0.0045 | 0.0073 | 0.0025 | 0.03 | 0.0027 | 0.0135 | 0.0028 | 0.0731 | 0.003 | 0.0042 | 0.001 | 0.0083 | 0.0009 | 0.0004 | 0.0008 |
Nucleolus | 0.0042 | 0.0009 | 0.0014 | 0.002 | 0.0071 | 0.001 | 0.0053 | 0.0019 | 0.0042 | 0.0029 | 0.0016 | 0.0036 | 0.001 | 0.0012 | 0.0011 | 0.0008 | 0.0004 | 0.0007 |
Nucleus | 0.0073 | 0.0017 | 0.0022 | 0.0034 | 0.0094 | 0.0019 | 0.0304 | 0.002 | 0.0161 | 0.0035 | 0.0143 | 0.0072 | 0.0026 | 0.0023 | 0.0039 | 0.001 | 0.0006 | 0.0101 |
Peroxisomes | 0.036 | 0.0289 | 0.036 | 0.028 | 0.0167 | 0.0355 | 0.0439 | 0.034 | 0.025 | 0.0218 | 0.0473 | 0.023 | 0.0793 | 0.0203 | 0.0822 | 0.0366 | 0.109 | 0.0467 |
Punctate Nuclear | 0.0043 | 0.002 | 0.0025 | 0.0069 | 0.0163 | 0.0083 | 0.0128 | 0.0022 | 0.0079 | 0.0046 | 0.0029 | 0.0067 | 0.0164 | 0.0023 | 0.0028 | 0.0009 | 0.0011 | 0.0015 |
Vacuole | 0.0289 | 0.0151 | 0.013 | 0.0185 | 0.0158 | 0.0098 | 0.0177 | 0.0205 | 0.0122 | 0.0134 | 0.0151 | 0.0245 | 0.0081 | 0.0113 | 0.0052 | 0.0115 | 0.0053 | 0.0067 |
Vacuole Periphery | 0.0069 | 0.0038 | 0.0033 | 0.0059 | 0.0051 | 0.0037 | 0.0088 | 0.0059 | 0.0058 | 0.006 | 0.0128 | 0.0093 | 0.0028 | 0.003 | 0.0043 | 0.0042 | 0.0039 | 0.0028 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 8.0522 | 8.2043 | 9.0745 | 10.4934 | 11.7871 | 6.9227 | 10.291 | 11.3033 | 10.4495 | 12.5021 |
Translational Efficiency | – | – | – | – | – | – | – | – | – | – |
Dataset | Hit |
---|---|
Protein Concentration | ✔ |
Protein Localization | ✔ |
Gene Expression | ✘ |
Translational Efficiency | – |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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