Standard name | |
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Description | Protein involved in cytochrome c oxidase (Complex IV) assembly; involved in delivery of copper to Complex IV; also required for efficient formation of respiratory supercomplexes comprised of Complexes III and IV; localizes to the mitochondrial intermembrane space; ortholog implicated in cardiac defects in zebrafish and human; transcription is induced in response to the DNA-damaging agent MMS; protein abundance increases in response to DNA replication stress |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 1 | 0 | 0 | 0 | 0 | – | 10 | 7 | 7 | 6 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 |
Bud | 1 | 0 | 4 | 3 | 5 | 1 | – | 7 | 6 | 12 | 8 | 15 | 2 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 3 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 1 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 6 | 10 | 1 | 5 | 10 | 11 | – | 25 | 33 | 39 | 21 | 50 | 3 | 7 | 6 | 3 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 393 | 331 | 128 | 232 | 407 | 451 | – | 399 | 400 | 351 | 304 | 342 | 242 | 380 | 420 | 40 | 25 | 26 | 394 | 320 | 124 | 82 | 274 | 307 |
Endoplasmic Reticulum | 1 | 7 | 1 | 3 | 10 | 19 | – | 17 | 3 | 18 | 7 | 20 | 1 | 0 | 4 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 2 | 2 |
Endosome | 0 | 0 | 0 | 0 | 1 | 0 | – | 0 | 3 | 7 | 2 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 1 | 3 | 2 | 1 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 2 | 0 | 0 | 4 | 2 |
Mitochondria | 2 | 0 | 3 | 6 | 4 | 28 | – | 50 | 158 | 101 | 150 | 209 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Nucleus | 14 | 3 | 2 | 0 | 2 | 2 | – | 9 | 6 | 13 | 6 | 7 | 2 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 |
Nuclear Periphery | 0 | 1 | 0 | 1 | 0 | 0 | – | 2 | 3 | 1 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | – | 1 | 3 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | – | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vac/Vac Membrane | 1 | 0 | 0 | 0 | 11 | 16 | – | 35 | 55 | 25 | 15 | 13 | 0 | 1 | 2 | 0 | 2 | 1 | 5 | 3 | 0 | 0 | 4 | 6 |
Unique Cell Count | 404 | 339 | 130 | 236 | 426 | 500 | 498 | 561 | 496 | 427 | 542 | 245 | 381 | 426 | 40 | 27 | 28 | 408 | 342 | 130 | 90 | 297 | 333 | |
Labelled Cell Count | 418 | 353 | 139 | 250 | 450 | 528 | 556 | 678 | 576 | 520 | 676 | 251 | 388 | 436 | 45 | 28 | 32 | 408 | 342 | 130 | 90 | 297 | 333 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 9.4 | 11.4 | 6.0 | 7.4 | 8.1 | 7.0 | – | 6.7 | 6.0 | 6.7 | 5.9 | 5.6 | 10.0 | 10.8 | 10.3 | 13.3 | 13.8 | 14.0 | 8.6 | 10.2 | 10.1 |
Std Deviation (1e-4) | 1.4 | 1.6 | 1.0 | 1.0 | 1.5 | 1.2 | – | 1.3 | 1.2 | 7.4 | 1.3 | 1.2 | 1.6 | 1.6 | 1.4 | 4.0 | 2.3 | 3.5 | 1.2 | 1.6 | 1.8 |
Intensity Change (Log2) | – | – | – | 0.3 | 0.43 | 0.22 | – | 0.16 | -0.0 | 0.15 | -0.02 | -0.1 | 0.74 | 0.85 | 0.77 | 1.14 | 1.2 | 1.22 | 0.52 | 0.76 | 0.75 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | – | 2.2 | 2.4 | 2.9 | 2.1 | 3.3 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | -0.1 | -1.5 | -3.1 | – | -5.1 | -6.6 | -6.6 | -6.5 | -7.9 | 0.3 | 1.6 | 0.1 | 0.8 | -1.8 | -1.7 |
Endoplasmic Reticulum | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 1.5 | – | 2.8 | 6.3 | 4.9 | 7.3 | 8.0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0 | 0 | – | 3.1 | 3.7 | 2.6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |