Standard name
Description Component of Rpd3L histone deacetylase complex; involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance

Micrographs

Sub-cellular Localization

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 0.05 0.06 0 0 0 0 0.08 0.10 0.14 0.11 0.10 0.07 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0.07 0 0 0 0.27 0 0.07 0.19 0.14 0.15 0.13 0 0 0 0 0.05 0.06 0 0 0 0 0 0
Nucleus 0.83 0.91 0.94 0.97 0.95 0.82 0.83 0.81 0.77 0.75 0.72 0.73 0.86 0.85 0.81 0.83 0.82 0.88 0.67 0.80 0.77 0.71 0.62 0.58
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.37 0.12 0.07 0 0.05 0.19 0.13 0.21 0.28 0.24 0.30 0.35 0.14 0.12 0.10 0 0 0 0.27 0.10 0.15 0.20 0.22 0.25
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0.05 0.06
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0
Bud 0 0 0 0 0 2 1 3 4 2 2 7 0 0 0 1 0 0 1 2 0 0 4 3
Bud Neck 0 0 0 0 1 0 1 2 0 1 7 6 0 0 0 0 0 0 0 0 1 1 2 1
Bud Site 0 1 0 1 0 13 3 13 6 12 15 20 0 1 2 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0
Cytoplasm 2 8 3 3 7 15 21 35 9 16 8 7 17 27 46 36 24 16 0 2 0 1 1 2
Endoplasmic Reticulum 1 1 0 1 0 1 0 0 0 0 0 0 1 0 0 12 8 5 0 0 0 0 1 2
Endosome 2 1 2 1 0 0 2 3 1 1 0 0 0 0 1 1 2 1 1 5 1 1 5 4
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 2 3 1 0 0 1
Mitochondria 8 42 3 4 4 110 20 44 77 67 71 81 8 1 2 13 11 13 2 8 0 1 3 7
Nucleus 287 517 227 222 337 336 379 511 317 365 344 445 187 225 261 265 191 191 240 490 197 184 204 157
Nuclear Periphery 1 3 4 1 1 2 8 5 7 2 4 4 0 0 2 2 1 2 0 1 0 0 1 0
Nucleolus 127 67 18 8 16 78 57 135 114 118 141 214 30 33 33 1 2 1 96 62 37 50 72 67
Peroxisomes 0 0 0 0 0 0 1 0 0 0 0 0 0 1 2 0 0 0 0 1 0 0 0 0
SpindlePole 1 3 7 1 5 5 13 9 2 7 9 9 2 4 6 3 2 1 3 8 3 3 11 7
Vac/Vac Membrane 2 3 2 0 2 0 5 6 3 2 2 4 0 0 1 13 14 6 8 18 9 9 16 15
Unique Cell Count 346 570 241 230 355 409 455 631 410 486 476 608 218 264 321 320 232 217 360 611 257 260 330 273
Labelled Cell Count 431 646 266 242 373 562 511 766 540 593 603 797 245 293 356 348 255 236 360 611 257 260 330 273

Yeast GFP Assignment

(Huh et al. Nature 2003 425:686 )

Nucleus

Protein Abundance

Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.9 6.5 7.2 6.9 7.2 4.9 6.4 6.2 5.6 5.7 5.7 5.6 6.7 7.4 7.0 7.2 7.1 6.8 6.1 6.4 7.0
Std Deviation (1e-4) 1.1 1.1 1.3 1.6 1.5 1.3 1.5 1.4 1.5 1.2 1.3 1.2 1.7 1.9 1.9 1.8 1.7 1.6 1.7 1.6 1.9
Intensity Change (Log2) -0.05 0.02 -0.54 -0.17 -0.2 -0.34 -0.34 -0.33 -0.35 -0.09 0.05 -0.03 0.01 -0.02 -0.07 -0.23 -0.17 -0.04

Localization Change

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 2.8 2.8 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 0 0 0 0 0 0 2.3 1.8 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 3.0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 8.3 2.2 3.3 6.6 5.4 5.7 5.3 1.7 0 0 2.0 2.2 2.8
Nucleus -1.6 -5.4 -0.5 2.0 -2.0 -2.3 -2.9 -0.5 3.2 -0.8 4.5 -3.7 -5.1 -4.4 -4.2
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus -1.9 -1.5 4.0 2.0 4.8 6.2 5.5 6.7 8.2 2.2 1.9 1.1 -4.6 -3.6 -3.8
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 -0.9 0 0 -1.1 -0.8 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 2.6 2.8 0