| Standard name | |
|---|---|
| Description | Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintaining Cdc55p in the cytoplasm where it promotes mitotic entry; involved in mitotic exit through Cdc14p regulation; interacts with silencing proteins at telomeres; has a role in Bcy1p localization; implicated in mRNA nuclear export; ZDS1 has a paralog, ZDS2, that arose from the whole genome duplication |
Micrographs
Sub-cellular Localization
Yeast GFP Assignment
Protein Abundance
Localization Change
External localization resources
| ensLOC | DeepLoc | |||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
| Cortical Patches | 18 | 2 | 13 | 4 | 16 | 1 | 8 | 4 | 1 | 8 | 3 | 2 | 0 | 0 | 0 | – | 7 | 3 | 16 | 1 | 28 | 3 | 8 | 11 |
| Bud | 11 | 4 | 14 | 8 | 21 | 11 | 25 | 28 | 30 | 37 | 25 | 31 | 0 | 0 | 1 | – | 5 | 3 | 10 | 3 | 6 | 2 | 4 | 9 |
| Bud Neck | 2 | 0 | 2 | 0 | 5 | 3 | 3 | 3 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | – | 7 | 0 | 8 | 1 | 16 | 5 | 9 | 11 |
| Bud Site | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 5 | 0 | 2 | 2 | 2 | 0 | 0 | 0 | – | 0 | 0 | – | – | – | – | – | – |
| Cell Periphery | 26 | 0 | 37 | 41 | 33 | 23 | 43 | 39 | 28 | 43 | 62 | 51 | 14 | 14 | 22 | – | 18 | 17 | 8 | 0 | 25 | 4 | 7 | 8 |
| Cytoplasm | 173 | 46 | 314 | 309 | 501 | 360 | 569 | 726 | 449 | 492 | 366 | 426 | 115 | 115 | 167 | – | 411 | 223 | 164 | 59 | 229 | 76 | 150 | 231 |
| Endoplasmic Reticulum | 4 | 2 | 1 | 0 | 1 | 4 | 8 | 4 | 5 | 10 | 6 | 3 | 1 | 1 | 2 | – | 27 | 15 | 3 | 0 | 14 | 2 | 3 | 6 |
| Endosome | 0 | 0 | 2 | 1 | 6 | 2 | 6 | 1 | 1 | 1 | 1 | 5 | 0 | 0 | 0 | – | 4 | 1 | 0 | 2 | 3 | 0 | 2 | 2 |
| Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 2 |
| Mitochondria | 0 | 1 | 4 | 7 | 30 | 73 | 173 | 200 | 185 | 247 | 240 | 275 | 0 | 0 | 0 | – | 14 | 8 | 1 | 1 | 11 | 8 | 8 | 12 |
| Nucleus | 2 | 1 | 2 | 1 | 1 | 2 | 1 | 3 | 4 | 2 | 1 | 1 | 0 | 0 | 1 | – | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 |
| Nuclear Periphery | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 5 | 4 | 4 | 0 | 1 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
| Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Peroxisomes | 0 | 0 | 1 | 0 | 2 | 0 | 0 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
| SpindlePole | 3 | 0 | 1 | 0 | 8 | 0 | 3 | 8 | 3 | 5 | 0 | 6 | 0 | 0 | 0 | – | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 3 |
| Vac/Vac Membrane | 0 | 0 | 0 | 1 | 7 | 1 | 3 | 8 | 4 | 3 | 1 | 3 | 0 | 0 | 0 | – | 1 | 1 | 1 | 0 | 1 | 1 | 4 | 7 |
| Unique Cell Count | 197 | 53 | 335 | 317 | 547 | 401 | 704 | 879 | 568 | 676 | 526 | 602 | 116 | 116 | 171 | 426 | 233 | 215 | 74 | 350 | 109 | 203 | 314 | |
| Labelled Cell Count | 240 | 57 | 392 | 372 | 631 | 480 | 843 | 1038 | 714 | 855 | 707 | 806 | 131 | 131 | 193 | 497 | 274 | 215 | 74 | 350 | 109 | 203 | 314 | |
Yeast GFP Assignment
Protein Abundance
| Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean Cell GFP Intensity (1e-4) | 5.3 | 4.5 | 5.0 | 5.1 | 5.0 | 4.3 | 4.0 | 4.4 | 4.1 | 3.9 | 4.0 | 4.0 | 6.1 | 6.1 | 6.2 | 4.7 | 5.2 | 6.0 | 6.9 | 6.7 | 7.0 |
| Std Deviation (1e-4) | 0.6 | 0.4 | 1.2 | 1.5 | 1.7 | 1.4 | 1.1 | 1.2 | 1.3 | 1.0 | 1.1 | 1.0 | 0.6 | 0.6 | 1.0 | 1.2 | 0.9 | 1.1 | 1.9 | 1.4 | 1.4 |
| Intensity Change (Log2) | – | – | – | 0.01 | 0.0 | -0.22 | -0.34 | -0.2 | -0.28 | -0.35 | -0.35 | -0.35 | 0.28 | 0.28 | 0.3 | -0.09 | 0.06 | 0.26 | 0.46 | 0.4 | 0.47 |
Localization Change
| Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Actin | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Bud | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Bud Neck | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Bud Site | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Cell Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Cyto | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Endoplasmic Reticulum | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Endosome | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Golgi | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Mitochondria | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Nuclear Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Nuc | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Nucleolus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Peroxisomes | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| SpindlePole | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Vac | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Cortical Patches | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Cytoplasm | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Nucleus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Vacuole | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
External localization resources
