Standard name
Human Ortholog
Description Subunit of the telomeric Ku complex (Yku70p-Yku80p); involved in telomere length maintenance, structure and telomere position effect; required for localization of telomerase ribonucleoprotein to nucleus via interaction with the TLC1 guide RNA; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 – 0 0 0 0 – 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Bud 0 0 – 0 0 0 0 – 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 – 0 0 0 0 – 0 0 0 0 – – – 0 0 0 0 0 0 0.07 0 0
Bud Site 0 0 – 0 0 0 0 – 0 0 0 0 – – – 0 0 0 – – – – – –
Cell Periphery 0 0 – 0 0 0 0 – 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Cytoplasm 0.1 0.05 – 0 0.15 0.1 0.13 – 0.06 0.08 0.11 0.07 – – – 0.07 0.07 0 0.06 0 0.05 0 0.15 0.24
Endoplasmic Reticulum 0 0 – 0 0 0 0 – 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Endosome 0 0 – 0.21 0 0 0 – 0 0 0 0 – – – 0 0 0 0.05 0 0 0 0 0
Golgi 0 0 – 0 0 0 0 – 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Mitochondria 0.39 0 – 0.08 0 0.2 0.29 – 0.45 0.56 0.7 0.58 – – – 0 0 0 0.05 0 0.05 0 0 0
Nucleus 0.6 0.73 – 0.62 0.62 0.66 0.61 – 0.73 0.68 0.48 0.64 – – – 0.83 0.84 0.84 0.51 0.71 0.43 0 0.41 0.29
Nuclear Periphery 0 0 – 0 0 0 0 – 0 0 0 0 – – – 0 0 0 0 0 0.06 0 0 0
Nucleolus 0 0 – 0 0 0 0 – 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 – 0 0 0 0 – 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 – 0 0 0 0 – 0 0 0 0 – – – 0 0 0 0.05 0 0 0 0 0
Vac/Vac Membrane 0.1 0.28 – 0.08 0.19 0.15 0.08 – 0.06 0.05 0.05 0 – – – 0.1 0.1 0.12 0.16 0.12 0.29 0 0.3 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 – 0 0 0 0 – 0 0 0 0 – – – 0 0 0 0 1 0 0 0 0
Bud 0 0 – 0 0 1 0 – 1 1 3 2 – – – 0 2 0 2 5 1 0 0 0
Bud Neck 0 0 – 0 2 1 1 – 0 1 1 0 – – – 0 0 0 1 0 0 0 0 0
Bud Site 1 0 – 0 0 0 0 – 0 1 2 3 – – – 0 0 1 – – – – – –
Cell Periphery 0 1 – 0 0 0 0 – 0 0 0 0 – – – 1 0 0 0 0 0 0 0 0
Cytoplasm 17 12 – 1 11 12 13 – 3 9 14 7 – – – 26 22 14 11 4 2 0 1 1
Endoplasmic Reticulum 0 1 – 0 0 0 0 – 0 0 0 1 – – – 8 10 8 1 0 0 0 0 0
Endosome 2 2 – 5 1 1 0 – 0 0 0 0 – – – 0 1 5 9 7 1 0 0 0
Golgi 0 1 – 0 0 0 0 – 0 0 0 0 – – – 1 1 3 0 2 0 0 0 0
Mitochondria 69 4 – 2 2 23 30 – 22 61 88 60 – – – 11 4 1 9 5 2 0 0 0
Nucleus 105 182 – 15 46 76 62 – 36 73 60 67 – – – 294 280 267 106 195 23 0 4 1
Nuclear Periphery 1 1 – 0 0 0 0 – 0 0 1 2 – – – 1 3 1 6 2 3 0 0 0
Nucleolus 3 0 – 1 0 0 1 – 0 0 0 1 – – – 1 1 1 5 6 0 0 0 0
Peroxisomes 0 0 – 0 0 0 0 – 0 0 0 0 – – – 0 1 0 0 0 0 0 0 0
SpindlePole 0 3 – 0 1 1 0 – 1 0 0 0 – – – 1 0 0 11 6 1 0 0 0
Vac/Vac Membrane 17 70 – 2 14 17 8 – 3 5 6 4 – – – 37 33 37 34 32 15 0 3 0
Unique Cell Count 176 248 24 74 116 102 49 108 126 104 353 332 319 209 275 54 1 12 6
Labelled Cell Count 215 277 26 77 132 115 66 151 175 147 381 358 338 209 275 54 1 12 6


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.1 5.6 – 5.9 6.1 4.9 5.1 – 3.7 3.9 3.7 3.6 – – – 8.5 8.5 8.6 – – –
Std Deviation (1e-4) 0.7 1.0 – 2.0 1.9 1.4 1.9 – 0.4 0.8 0.8 0.7 – – – 1.7 1.8 1.8 – – –
Intensity Change (Log2) – – – – – – – – – – – – – – – – – – – – –


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – – – –
Bud Neck – – – – – – – – – – – – – – –
Bud Site – – – – – – – – – – – – – – –
Cell Periphery – – – – – – – – – – – – – – –
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – – – –
Endosome – – – – – – – – – – – – – – –
Golgi – – – – – – – – – – – – – – –
Mitochondria – – – – – – – – – – – – – – –
Nuclear Periphery – – – – – – – – – – – – – – –
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – – – –
Peroxisomes – – – – – – – – – – – – – – –
SpindlePole – – – – – – – – – – – – – – –
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – – – –
Cytoplasm – – – – – – – – – – – – – – –
Nucleus – – – – – – – – – – – – – – –
Vacuole – – – – – – – – – – – – – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.6963 0.0097 0.1652 -0.2379 0.2103 0.0248 -0.2858 -0.1569 -0.2876 -0.3093 0.0063 -0.1873 -0.1955 -0.1519 -0.5975 -0.5789 -0.802 -0.2773
Actin 0.04 0.0004 0.0159 0.004 0.0121 0.0031 0.0186 0.0007 0.0234 0.0106 0.0311 0.0146 0.0229 0.0003 0.0051 0.0229 0.0003 0.0109
Bud 0.0006 0.0001 0.0002 0.0001 0.0022 0.0001 0.0003 0.0003 0.0006 0.0003 0.0002 0.0002 0.0099 0.0001 0.0035 0.0002 0 0.0029
Bud Neck 0.0061 0.0006 0.0012 0.0005 0.0046 0.002 0.0049 0.0007 0.0107 0.0004 0.0015 0.0032 0.0023 0.001 0.002 0.0011 0.0008 0.0043
Bud Periphery 0.0013 0.0001 0.0002 0.0002 0.0047 0.0002 0.0004 0.0008 0.0018 0.0008 0.0002 0.0005 0.0046 0.0001 0.0033 0.0002 0 0.0016
Bud Site 0.003 0.0004 0.0017 0.0005 0.0323 0.0002 0.0155 0.0068 0.0084 0.0005 0.0006 0.0003 0.003 0.0012 0.0033 0.0005 0.0002 0.0013
Cell Periphery 0.0003 0 0.0001 0.0001 0.0016 0.0001 0.0005 0.0004 0.0007 0.0001 0.0001 0.0001 0.0005 0.0001 0.0002 0 0 0.0002
Cytoplasm 0.0527 0.0742 0.041 0.0257 0.0457 0.0305 0.0457 0.0758 0.0616 0.0333 0.0203 0.0745 0.0628 0.1265 0.064 0.0677 0.1338 0.0455
Cytoplasmic Foci 0.0163 0.0034 0.0094 0.002 0.0076 0.0043 0.0252 0.0036 0.0076 0.0024 0.0217 0.0023 0.0226 0.0021 0.0089 0.0026 0.0035 0.0064
Eisosomes 0.0006 0.0001 0.0003 0.0001 0.0003 0.0001 0.0004 0 0.0002 0.0006 0.0002 0.0002 0.0003 0 0.0002 0.0003 0 0.0001
Endoplasmic Reticulum 0.0101 0.0041 0.004 0.0015 0.004 0.0016 0.0057 0.0066 0.0055 0.0013 0.0013 0.0072 0.0051 0.005 0.0036 0.0019 0.0018 0.0032
Endosome 0.0397 0.0041 0.0053 0.0045 0.023 0.0034 0.0086 0.0039 0.009 0.0081 0.0443 0.016 0.0316 0.0018 0.0072 0.0024 0.0024 0.0059
Golgi 0.0119 0.0001 0.0012 0.0015 0.0032 0.0015 0.0039 0.0005 0.0022 0.0039 0.0532 0.003 0.0102 0.0001 0.0024 0.0033 0 0.0031
Lipid Particles 0.0222 0.0006 0.004 0.0089 0.0053 0.0053 0.0114 0.0023 0.0105 0.0581 0.0203 0.002 0.0189 0.0002 0.0061 0.0071 0.0001 0.0042
Mitochondria 0.0139 0.0006 0.0015 0.0102 0.0585 0.0041 0.0026 0.0013 0.0021 0.0684 0.0078 0.0139 0.005 0.0005 0.002 0.0149 0.0004 0.0023
None 0.0711 0.1315 0.0781 0.0693 0.0165 0.0564 0.0902 0.1293 0.1246 0.0536 0.0783 0.1182 0.1017 0.1294 0.101 0.0454 0.1262 0.0185
Nuclear Periphery 0.0845 0.0745 0.1081 0.08 0.0338 0.0373 0.068 0.0448 0.0855 0.0158 0.0221 0.036 0.0662 0.0373 0.0502 0.0334 0.0658 0.0262
Nucleolus 0.0064 0.0053 0.0067 0.0063 0.0181 0.0108 0.0042 0.0082 0.0057 0.0027 0.0055 0.0099 0.0046 0.006 0.0047 0.0032 0.0064 0.0146
Nucleus 0.5589 0.6374 0.6557 0.7527 0.675 0.7748 0.6426 0.6746 0.5994 0.642 0.6385 0.6371 0.5801 0.626 0.6865 0.7043 0.6179 0.8039
Peroxisomes 0.0151 0.0001 0.0042 0.0056 0.0052 0.0019 0.0174 0.0017 0.0033 0.0037 0.0322 0.001 0.0143 0.0001 0.0026 0.0081 0 0.0025
Punctate Nuclear 0.0346 0.0599 0.0591 0.0245 0.0288 0.0606 0.0302 0.0338 0.033 0.0901 0.018 0.056 0.0269 0.0601 0.0407 0.0793 0.0388 0.039
Vacuole 0.0061 0.0018 0.001 0.0011 0.016 0.0012 0.0025 0.0033 0.0028 0.0012 0.0012 0.0025 0.0048 0.0019 0.0017 0.0007 0.001 0.0027
Vacuole Periphery 0.005 0.0007 0.0011 0.0008 0.0015 0.0006 0.0014 0.0008 0.0014 0.002 0.0011 0.0014 0.002 0.0005 0.0008 0.0004 0.0005 0.0007

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 5.1846 1.6358 3.2369 8.987 5.1404 7.925 6.6157 9.4885 9.3232 8.8853
Translational Efficiency – – – – – – – – – –

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency –

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
233 1433 281 1528 1813 1800 231 201 2046 3233 512 1729

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 682.75 728.23 1073.44 831.40 666.89 735.30 987.99 906.75 668.70 732.17 1034.89 840.16
Standard Deviation 68.80 94.79 123.10 124.09 86.16 93.55 116.18 119.71 84.52 94.17 127.34 125.92
Intensity Change Log 2 — 0.093037 0.652812 0.284185 — 0.140884 0.567048 0.443256 — 0.116878 0.611071 0.364978

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000136 0.000410 0.001789 0.000763 0.000135 0.000133 0.001243 0.001626 0.000135 0.000256 0.001543 0.000863
Bud Neck 0.000835 0.006762 0.005746 0.012280 0.002613 0.005281 0.006608 0.007085 0.002410 0.005937 0.006135 0.011676
Bud Site 0.000163 0.001741 0.001539 0.009779 0.000399 0.001143 0.002036 0.014830 0.000372 0.001408 0.001763 0.010366
Cell Periphery 0.000141 0.000104 0.000094 0.000259 0.000083 0.000085 0.000100 0.000232 0.000090 0.000094 0.000097 0.000256
Cytoplasm 0.146282* 0.115415* 0.003715 0.122295* 0.136325* 0.118973* 0.015297 0.093932 0.137459* 0.117396* 0.008941 0.118997*
Cytoplasmic Foci 0.054386 0.028967 0.000241 0.001994 0.018699 0.020535 0.000393 0.007091 0.022763 0.024272 0.000310 0.002587
Eisosomes 0.000074 0.000047 0.000061 0.000025 0.000033 0.000032 0.000060 0.000048 0.000037 0.000039 0.000060 0.000028
Endoplasmic Reticulum 0.002069 0.005336 0.018419 0.007954 0.001939 0.003184 0.020213 0.009608 0.001954 0.004138 0.019228 0.008147
Endosome 0.002323 0.002839 0.000762 0.001303 0.001440 0.003612 0.001020 0.002239 0.001541 0.003270 0.000878 0.001412
Golgi 0.000379 0.001546 0.000110 0.000270 0.000268 0.000915 0.000083 0.013348 0.000281 0.001195 0.000098 0.001790
Lipid Particles 0.020356 0.008574 0.000972 0.000587 0.006170 0.007727 0.000989 0.000992 0.007785 0.008102 0.000980 0.000634
Mitochondria 0.004834 0.009030 0.001340 0.003114 0.002081 0.008163 0.000971 0.001992 0.002395 0.008548 0.001173 0.002983
Mitotic Spindle 0.000102 0.008796 0.000128 0.014227 0.001834 0.004723 0.000662 0.031289 0.001637 0.006529 0.000369 0.016210
None 0.020051 0.014998 0.001152 0.009907 0.019368 0.009621 0.006745 0.025530 0.019446 0.012004 0.003675 0.011723
Nuclear Periphery 0.004214 0.008051 0.001885 0.004378 0.005044 0.009646 0.003714 0.002735 0.004950 0.008939 0.002710 0.004187
Nuclear Periphery Foci 0.005175 0.006444 0.000941 0.001709 0.003136 0.003124 0.001967 0.001402 0.003368 0.004595 0.001404 0.001673
Nucleolus 0.022957 0.020856 0.004183 0.002142 0.016579 0.015863 0.003838 0.001356 0.017305 0.018076 0.004027 0.002051
Nucleus 0.707429* 0.749007* 0.941265* 0.788412* 0.779354* 0.776580* 0.915084* 0.755133* 0.771163* 0.764358* 0.929453* 0.784543*
Peroxisomes 0.001972 0.004040 0.000403 0.000762 0.001624 0.002964 0.000353 0.000206 0.001664 0.003441 0.000380 0.000697
Vacuole 0.005508 0.006056 0.015015 0.016944 0.002657 0.006989 0.018408 0.028771 0.002982 0.006575 0.016546 0.018319
Vacuole Periphery 0.000613 0.000982 0.000242 0.000898 0.000220 0.000707 0.000215 0.000556 0.000265 0.000829 0.000230 0.000858

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.77 -11.77 -6.20 -4.00 7.09 -0.17 -10.89 -6.76 -6.77 0.15 -4.53 -16.61 -9.24 -7.63 7.00
Bud Neck -7.87 -8.75 -13.58 -6.91 -6.12 -3.74 -4.17 -6.53 -4.12 -0.99 -5.59 -6.59 -11.76 -8.72 -6.19
Bud Site -6.88 -6.71 -6.90 -5.40 -4.68 -4.09 -4.31 -2.58 -2.37 -1.94 -6.96 -7.16 -7.18 -6.21 -5.05
Cell Periphery 1.62 1.11 -1.99 -4.37 -3.64 -0.15 -2.90 -5.36 -5.24 -2.81 -0.68 -3.01 -5.69 -5.51 -4.02
Cytoplasm 2.39 11.60 4.45 4.41 -22.84 2.81 24.60 9.15 7.38 -6.40 3.87 29.81 9.58 7.05 -22.04
Cytoplasmic Foci 4.13 9.30 9.10 13.57 -4.12 -0.68 14.70 10.55 10.52 -1.75 -0.48 17.15 16.05 18.59 -4.33
Eisosomes 3.58 0.69 6.20 5.35 6.25 1.00 -5.54 -6.72 -7.10 -1.01 -0.49 -6.96 -0.41 0.08 6.85
Endoplasmic Reticulum -4.98 -13.59 -13.38 -10.56 6.17 -4.40 -11.57 -10.80 -9.75 2.90 -8.61 -18.29 -22.15 -16.34 7.71
Endosome -0.79 2.06 1.69 4.63 -1.55 -2.98 0.98 -2.02 1.70 -2.93 -3.72 2.31 1.29 4.84 -1.69
Golgi -2.78 1.37 1.20 3.72 -0.51 -1.91 4.95 -0.93 -0.66 -1.01 -3.56 4.70 -0.43 2.00 -1.12
Lipid Particles 3.04 5.16 5.26 9.92 2.70 -1.56 7.66 7.35 8.56 -0.92 -0.38 9.31 9.81 13.63 2.70
Mitochondria -1.35 1.02 0.65 5.77 -2.18 -6.60 4.68 0.70 6.54 -1.77 -7.97 2.72 -0.16 7.55 -2.59
Mitotic Spindle -5.22 -1.68 -6.60 -1.26 -6.45 -2.59 1.09 -2.64 -2.10 -2.79 -4.67 1.61 -6.08 -3.04 -6.89
None 1.44 5.92 3.98 6.39 -13.47 5.72 6.67 1.74 -1.32 -2.96 4.79 10.92 8.00 4.96 -5.85
Nuclear Periphery -3.53 2.27 -2.22 2.29 -9.53 -4.48 0.43 -0.77 3.99 -1.06 -5.16 2.44 -1.91 4.25 -5.44
Nuclear Periphery Foci -1.47 1.99 2.66 5.73 0.23 0.13 2.12 2.21 1.86 -0.01 -2.26 2.28 3.92 5.97 0.34
Nucleolus 0.14 4.58 5.18 13.15 3.52 1.59 9.38 11.15 10.80 1.64 0.29 10.73 12.70 17.21 3.74
Nucleus -1.98 -11.60 -5.38 -6.88 14.38 0.06 -12.83 0.51 0.48 7.35 0.93 -19.51 -4.25 -5.68 15.70
Peroxisomes -3.04 2.87 2.78 7.49 0.03 -2.43 4.14 4.52 6.54 1.95 -4.11 4.57 4.16 9.09 -0.04
Vacuole -0.88 -5.83 -11.44 -11.99 -2.63 -3.98 -7.16 -7.61 -7.21 -4.88 -5.30 -9.79 -15.32 -13.63 -4.12
Vacuole Periphery -0.86 0.81 0.27 1.89 -1.03 -4.65 0.07 -0.75 3.22 -0.73 -5.26 0.19 -1.11 1.89 -1.20
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit of the telomeric Ku complex (Yku70p-Yku80p); involved in telomere length maintenance, structure and telomere position effect; required for localization of telomerase ribonucleoprotein to nucleus via interaction with the TLC1 guide RNA; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
Localization
Cell Percentages nucleus (90%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-3

Yku70

Yku70


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Yku70-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available