Standard name
Human Ortholog
Description Dual-specificity protein phosphatase; maintains low levels of both basal and induced cell integrity pathway signaling by dephosphorylation of the Slt2p MAPK; reciprocally regulated by Slt2p through phosphorylation; minor role with Ptp2p in the adaptive response to pheromone through the dephosphorylation of the Fus3p MAPK with major contribution by Ptp3p; inhibits the nuclear accumulation of Fus3p; two isoforms exist as the result of alternative translation initiation starts
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.08 0 0 0 0 0 0
Cytoplasm 0.95 0.98 0.95 0.93 0.98 0.95 0.86 0.86 0.69 0.77 0.57 0.66 0.99 1.0 0.99 0.96 0.94 0.88 0.93 0.91 0.84 0.95 0.9 0.92
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0.06 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.06 0 0 0.12 0 0.23 0.26 0.32 0.5 0.51 0.57 0.54 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0.05 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 1 0 1 0
Bud 1 0 0 2 2 0 0 3 0 3 1 0 2 0 1 1 0 0 4 0 0 1 1 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 1 1 1 2 1 1 2 0 1 3 1 2 1 0 0 3 2 4 0 0 0 0 0 0
Cytoplasm 274 122 109 100 87 155 197 178 101 171 83 100 225 223 269 129 113 46 277 115 109 115 169 127
Endoplasmic Reticulum 0 1 1 1 0 0 0 0 0 0 3 1 2 0 0 10 7 2 0 0 1 0 3 5
Endosome 0 0 0 1 1 0 1 0 0 0 1 0 0 0 1 1 3 0 3 0 2 1 2 0
Golgi 0 0 0 1 0 0 0 0 0 0 0 0 0 1 0 1 1 0 2 0 0 0 1 1
Mitochondria 16 1 3 13 4 38 59 66 73 113 83 81 0 3 0 5 0 1 2 0 1 0 1 0
Nucleus 2 0 0 3 0 3 1 1 0 0 1 1 0 0 0 0 0 3 0 0 0 0 0 0
Nuclear Periphery 2 1 2 1 0 0 1 0 0 0 0 0 0 0 1 0 0 0 0 1 1 0 0 0
Nucleolus 1 0 1 0 0 0 1 0 0 1 0 0 0 0 0 2 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 1 1 0 0 0 0 0 1 0 0 0 0 0
Vac/Vac Membrane 3 1 1 1 0 0 7 3 1 6 1 3 0 0 0 2 6 2 1 6 3 0 0 0
Unique Cell Count 287 124 115 108 89 164 228 208 147 223 145 151 228 224 271 135 120 52 299 127 131 121 188 138
Labelled Cell Count 300 127 118 125 95 197 269 251 176 297 174 189 231 227 272 154 132 58 299 127 131 121 188 138


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.8 5.8 5.4 4.9 5.3 4.6 4.2 4.1 4.5 3.9 4.1 3.8 5.8 5.4 5.6 7.1 9.1 8.8 6.8 7.4 8.7
Std Deviation (1e-4) 0.6 1.2 1.4 1.3 1.7 1.4 1.6 1.0 1.9 1.5 1.4 1.5 0.9 1.1 1.1 1.9 3.3 2.5 1.5 1.6 1.8
Intensity Change (Log2) – – – -0.13 -0.03 -0.23 -0.37 -0.39 -0.27 -0.48 -0.41 -0.51 0.09 0.01 0.05 0.4 0.75 0.71 0.33 0.44 0.68


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm -0.7 1.1 -0.1 -2.4 -2.5 -5.3 -4.2 -6.8 -5.6 2.1 2.9 2.8 0.3 -0.2 -1.5
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 2.5 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 2.7 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.0007 1.5515 1.1727 1.0887 1.0047 1.4475 2.1143 2.738 2.3619 2.1799 2.1918 2.0448 3.2482 3.0783 2.8384 2.9202 2.4655 2.9749
Actin 0.0171 0.0003 0.0074 0.0009 0.0402 0.0047 0.0457 0.0234 0.0227 0.0669 0.035 0.0007 0.1114 0.0002 0.0442 0.0006 0.0002 0.0176
Bud 0.0002 0.003 0.0021 0.0001 0.0001 0.0007 0.001 0.0021 0.0034 0.0003 0.003 0.0004 0.0011 0 0.0008 0.0001 0 0.0001
Bud Neck 0.0031 0.0002 0.0008 0.0002 0.0012 0.0027 0.0259 0.0002 0.0023 0.0002 0.0016 0.0009 0.0064 0.0001 0.0012 0.0001 0.0001 0.0004
Bud Periphery 0.0004 0.0009 0.0034 0.0001 0.0001 0.0009 0.0019 0.0015 0.0064 0.0003 0.0049 0.0005 0.0018 0 0.0011 0 0 0.0001
Bud Site 0.0011 0.0033 0.0082 0.0002 0.0003 0.0018 0.0099 0.0132 0.0112 0.0009 0.0117 0.0001 0.0053 0.0003 0.0024 0.0001 0 0.0001
Cell Periphery 0.0002 0.0003 0.0003 0.0001 0.0001 0.0002 0.0014 0.0002 0.0005 0.0001 0.0002 0.0001 0.0005 0.0002 0.0003 0 0 0.0001
Cytoplasm 0.5129 0.6422 0.6047 0.6515 0.6055 0.6778 0.3255 0.4779 0.4926 0.5156 0.599 0.6729 0.4054 0.7433 0.5323 0.6878 0.675 0.5949
Cytoplasmic Foci 0.0227 0.0072 0.0126 0.0109 0.0061 0.0124 0.0441 0.0083 0.0189 0.0052 0.0523 0.0084 0.0286 0.0031 0.0139 0.0131 0.0018 0.0071
Eisosomes 0.0003 0.0001 0.0001 0.0001 0.0007 0.0001 0.0005 0.0001 0.0002 0.0001 0.0003 0 0.0008 0 0.0009 0 0 0.0001
Endoplasmic Reticulum 0.0041 0.0043 0.0033 0.0057 0.0027 0.0016 0.0081 0.0021 0.0033 0.0016 0.0016 0.0027 0.0061 0.0018 0.0029 0.0019 0.0008 0.0023
Endosome 0.0087 0.0039 0.0053 0.0067 0.0017 0.0043 0.0471 0.0026 0.0131 0.0016 0.0173 0.0039 0.0196 0.0004 0.0071 0.0144 0.0003 0.0018
Golgi 0.0041 0.0003 0.0017 0.0004 0.0016 0.0016 0.0245 0.003 0.0065 0.002 0.0162 0.0001 0.0124 0.0001 0.0047 0.0006 0 0.0008
Lipid Particles 0.0038 0.0005 0.0062 0.0005 0.0026 0.0039 0.0186 0.0016 0.0072 0.0003 0.02 0.0001 0.0133 0.0001 0.0081 0.0004 0 0.0002
Mitochondria 0.0056 0.0002 0.0079 0.0002 0.0012 0.001 0.0084 0.0027 0.0024 0.0005 0.0081 0.0001 0.0046 0.0001 0.0088 0.0002 0.0001 0.0002
None 0.3925 0.3268 0.3182 0.317 0.318 0.2719 0.3993 0.4489 0.385 0.4018 0.1966 0.3061 0.3447 0.2481 0.3365 0.2419 0.3206 0.3712
Nuclear Periphery 0.0016 0.0008 0.001 0.0013 0.0011 0.0017 0.004 0.0003 0.0024 0.0004 0.0008 0.0003 0.0036 0.0003 0.0073 0.0006 0.0001 0.0007
Nucleolus 0.0003 0.0002 0.0003 0.0001 0.0001 0.0018 0.0022 0.0001 0.0018 0 0.0003 0.0001 0.0008 0 0.0027 0 0 0
Nucleus 0.0029 0.0021 0.0019 0.0017 0.0024 0.0031 0.0028 0.0007 0.0049 0.0005 0.001 0.0009 0.0023 0.0011 0.0069 0.0011 0.0005 0.0005
Peroxisomes 0.0147 0.0001 0.0114 0.0002 0.0119 0.003 0.0197 0.01 0.0049 0.0007 0.0257 0.0001 0.0115 0 0.0089 0.0339 0 0.0009
Punctate Nuclear 0.0017 0.0006 0.0012 0.0009 0.002 0.0036 0.0034 0.0004 0.0039 0.0002 0.003 0.0009 0.0174 0.0003 0.0069 0.0005 0.0001 0.0005
Vacuole 0.0015 0.0025 0.0017 0.0009 0.0004 0.0011 0.0048 0.0005 0.0056 0.0007 0.0011 0.0005 0.0016 0.0005 0.0014 0.0019 0.0001 0.0003
Vacuole Periphery 0.0006 0.0002 0.0003 0.0002 0.0001 0.0002 0.0013 0.0001 0.0008 0.0001 0.0003 0.0001 0.0007 0 0.0008 0.0006 0 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 9.758 17.4461 12.4479 13.3524 19.4641 9.0024 15.9436 11.9056 13.3854 12.7701
Translational Efficiency 0.6636 0.7475 0.814 0.6741 0.4981 0.7981 0.7986 1.0311 0.67 0.8071

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1885 1115 2266 1149 1075 1703 160 257 2960 2818 2426 1406

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 699.09 752.99 935.09 913.06 771.31 824.85 1051.52 963.16 725.32 796.42 942.77 922.22
Standard Deviation 95.69 107.01 112.12 124.43 93.95 107.04 105.29 133.82 101.21 112.65 115.36 127.67
Intensity Change Log 2 — 0.107153 0.419627 0.385231 — 0.096821 0.447094 0.320465 — 0.101742 0.434100 0.351620

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000066 0.000278 0.000246 0.003498 0.000069 0.000311 0.000506 0.001269 0.000067 0.000298 0.000263 0.003091
Bud Neck 0.013911 0.013603 0.004932 0.010768 0.007336 0.020881 0.001761 0.003962 0.011523 0.018001 0.004723 0.009524
Bud Site 0.010633 0.013250 0.006463 0.098204 0.002867 0.022995 0.004286 0.082861 0.007813 0.019139 0.006319 0.095399
Cell Periphery 0.000140 0.000087 0.000051 0.000268 0.000045 0.000111 0.000226 0.000202 0.000105 0.000101 0.000062 0.000256
Cytoplasm 0.646587* 0.592595* 0.590649* 0.437786* 0.675618* 0.541789* 0.431377* 0.396792* 0.657130* 0.561892* 0.580144* 0.430293*
Cytoplasmic Foci 0.098583 0.129776 0.006165 0.029854 0.080892 0.131250 0.014328 0.058101 0.092158 0.130667 0.006704 0.035017
Eisosomes 0.000077 0.000049 0.000011 0.000045 0.000039 0.000075 0.000100 0.000040 0.000063 0.000065 0.000017 0.000044
Endoplasmic Reticulum 0.000603 0.000667 0.001015 0.002125 0.000264 0.000391 0.005910 0.001988 0.000480 0.000500 0.001338 0.002100
Endosome 0.003265 0.016315 0.000861 0.028089 0.002932 0.018296 0.006132 0.026936 0.003144 0.017512 0.001209 0.027878
Golgi 0.000781 0.003071 0.000105 0.021843 0.000264 0.003189 0.000133 0.042676 0.000593 0.003142 0.000107 0.025651
Lipid Particles 0.002084 0.002292 0.000318 0.002787 0.000936 0.001934 0.003216 0.004580 0.001667 0.002076 0.000509 0.003115
Mitochondria 0.001153 0.003068 0.000542 0.025497 0.000414 0.005391 0.000267 0.009622 0.000885 0.004472 0.000523 0.022595
Mitotic Spindle 0.003312 0.008510 0.008183 0.078209 0.001104 0.021246 0.001799 0.053725 0.002510 0.016207 0.007762 0.073733
None 0.006348 0.006012 0.007090 0.010698 0.002764 0.003276 0.005482 0.008613 0.005047 0.004358 0.006984 0.010317
Nuclear Periphery 0.000438 0.000314 0.001080 0.000819 0.000219 0.000252 0.001901 0.000774 0.000358 0.000277 0.001134 0.000811
Nuclear Periphery Foci 0.000346 0.001009 0.000586 0.001340 0.000268 0.000350 0.006548 0.001474 0.000318 0.000611 0.000979 0.001364
Nucleolus 0.001040 0.001456 0.000201 0.000288 0.000438 0.001341 0.000371 0.000142 0.000821 0.001387 0.000212 0.000262
Nucleus 0.170549* 0.091890 0.334033* 0.108143 0.163231* 0.090136 0.247184* 0.142955* 0.167891* 0.090830 0.328306* 0.114507
Peroxisomes 0.000978 0.006348 0.000180 0.005038 0.001513 0.007320 0.000291 0.015574 0.001172 0.006935 0.000188 0.006964
Vacuole 0.038124 0.107438 0.037109 0.125248 0.058423 0.128044 0.267988* 0.146228 0.045496 0.119891 0.052336 0.129083
Vacuole Periphery 0.000984 0.001970 0.000180 0.009453 0.000363 0.001419 0.000194 0.001485 0.000758 0.001637 0.000180 0.007996

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -6.76 -2.60 -5.81 -4.23 -4.35 -4.40 -8.56 -7.34 -3.18 -1.18 -6.83 -2.99 -6.47 -4.52 -4.56
Bud Neck 0.44 7.05 4.48 3.76 -2.59 -7.05 4.72 2.92 10.39 -3.50 -4.34 7.01 4.33 8.40 -2.55
Bud Site -1.24 3.25 -4.99 -4.46 -6.91 -9.54 -2.70 -2.66 1.22 -2.22 -6.91 2.00 -6.24 -2.26 -7.16
Cell Periphery 3.42 5.56 0.73 -3.13 -5.81 -6.08 -8.15 -5.05 -0.18 2.70 0.55 4.30 -1.29 -2.04 -5.84
Cytoplasm 6.36 18.18 29.74 19.08 14.96 13.48 17.73 22.70 14.76 1.09 14.37 23.64 37.22 23.31 16.28
Cytoplasmic Foci -5.28 31.00 27.91 24.18 -4.73 -8.88 18.51 16.33 25.44 0.06 -9.54 36.99 32.73 36.90 -4.76
Eisosomes 4.01 9.61 3.85 -0.63 -20.10 -6.18 -7.63 -5.87 1.53 3.91 -0.28 9.89 2.02 2.86 -18.78
Endoplasmic Reticulum -1.37 -9.57 -12.19 -11.90 -4.89 -3.93 -9.62 -11.16 -10.69 2.77 -0.93 -14.76 -17.03 -17.50 -4.98
Endosome -10.32 11.14 -1.89 6.71 -4.32 -13.01 -2.67 -0.55 8.46 0.55 -16.63 10.67 -2.03 10.17 -4.48
Golgi -3.31 3.31 -2.76 -0.50 -3.58 -5.68 3.65 -1.64 -0.41 -1.69 -5.94 3.69 -3.34 -0.58 -3.96
Lipid Particles -0.62 6.32 1.04 1.63 -4.47 -6.15 -5.54 -2.30 0.46 1.54 -2.00 6.35 -0.15 1.42 -4.73
Mitochondria -1.85 5.62 -2.39 -1.02 -2.80 -4.40 3.33 -1.57 3.03 -1.82 -4.49 4.61 -2.64 0.17 -2.93
Mitotic Spindle -2.45 -3.64 -7.29 -5.49 -5.56 -7.06 -1.45 -3.28 -0.44 -2.49 -7.04 -4.62 -8.19 -3.60 -5.94
None 0.62 -0.68 -1.78 -1.81 -1.61 -0.60 -1.51 -5.07 -4.03 -3.60 1.25 -3.32 -4.26 -4.63 -2.24
Nuclear Periphery 0.44 -6.35 -9.03 -21.29 -6.44 -3.14 -13.57 -12.05 -11.73 -1.11 0.41 -10.53 -13.84 -25.10 -7.03
Nuclear Periphery Foci -3.18 -3.25 -6.98 -1.47 -5.84 -2.60 -8.51 -7.95 -7.49 5.61 -3.00 -7.55 -10.34 -7.27 -3.61
Nucleolus -0.56 3.68 3.56 6.31 -0.80 -3.28 2.31 1.99 3.84 -0.51 -1.70 3.92 3.80 6.02 -0.83
Nucleus 13.94 -33.41 -6.78 -17.24 21.26 12.64 -5.10 -7.24 -12.32 -0.81 19.63 -35.65 -9.59 -22.22 20.02
Peroxisomes -6.66 8.31 0.13 6.13 -2.18 -6.42 3.26 -0.12 4.15 -1.40 -9.64 6.41 0.29 8.59 -2.61
Vacuole -16.11 -9.31 -31.46 -19.77 -27.47 -13.97 -14.61 -15.57 -11.56 0.93 -23.18 -11.40 -34.46 -22.81 -27.62
Vacuole Periphery -1.84 3.84 -1.01 0.46 -2.83 -5.44 1.65 0.81 7.12 -1.13 -3.42 4.13 -1.25 0.57 -2.86
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Dual-specificity protein phosphatase; maintains low levels of both basal and induced cell integrity pathway signaling by dephosphorylation of the Slt2p MAPK; reciprocally regulated by Slt2p through phosphorylation; minor role with Ptp2p in the adaptive response to pheromone through the dephosphorylation of the Fus3p MAPK with major contribution by Ptp3p; inhibits the nuclear accumulation of Fus3p; two isoforms exist as the result of alternative translation initiation starts
Localization
Cell Percentages cytoplasm (80%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Msg5

Msg5


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Msg5-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available